Okabe Keisuke 岡部圭介

Researcher Number	00770702
Affiliation (Current)	2025: 富山大学, 学術研究部医学系, 特命講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 富山大学, 学術研究部医学系, 特命講師 2020: 富山大学, 附属病院, 客員講師 2019: 富山大学, 附属病院, 講師 2018: 富山大学, 附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator メチル化 / エピゲノム / 肥満症 / αケトグルタル酸 / 耐糖能異常 / メタボロミクス / メタボローム / 糖尿病 / 肥満 / ヒストン脱メチル化 … More / エピジェネティクス / 3T3-L1細胞 / 脂肪細胞分化 / 脱メチル化 / NAD Less

Application of Alpha-ketoglutarate for the Treatment of Obesity as an Epigenetic DrugPrincipal Investigator
- Principal Investigator
  
  Okabe Keisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  University of Toyama
NAD mediated mechanism of adipocyte differentiation through epigeneticsPrincipal Investigator
- Principal Investigator
  
  Okabe Keisuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  University of Toyama

All 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter2020
- Author(s)
  Okabe Keisuke、Nawaz Allah、Nishida Yasuhiro、Yaku Keisuke、Usui Isao、Tobe Kazuyuki、Nakagawa Takashi
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 8 Pages: 586179-586179
- DOI
  10.3389/fcell.2020.586179
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20655, KAKENHI-PROJECT-20K22733, KAKENHI-PROJECT-18K16193, KAKENHI-PROJECT-18K17921, KAKENHI-PROJECT-20H03730
[Journal Article] Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice2019
- Author(s)
  Takikawa Akiko、Usui Isao、Fujisaka Shiho、Tsuneyama Koichi、Okabe Keisuke、Nakagawa Takashi、Nawaz Allah、Kado Tomonobu、Jojima Teruo、Aso Yoshimasa、Hayakawa Yoshihiro、Yagi Kunikimi、Tobe Kazuyuki
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: in press Issue: 6 Pages: 1-8
- DOI
  10.1111/jdi.13047
- NAID
  120006980551
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-18K16193, KAKENHI-PROJECT-16K09777, KAKENHI-PROJECT-17K16143, KAKENHI-PROJECT-18K08505, KAKENHI-PROJECT-18K10204, KAKENHI-PLANNED-17H06398
[Journal Article] Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance2018
- Author(s)
  Gulshan Maryam、Yaku Keisuke、Okabe Keisuke、Mahmood Arshad、Sasaki Tsutomu、Yamamoto Masashi、Hikosaka Keisuke、Usui Isao、Kitamura Tadahiro、Tobe Kazuyuki、Nakagawa Takashi
- Journal Title
  
  Aging Cell
  
  Volume: 17 Issue: 4
- DOI
  10.1111/acel.12798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-18K16193, KAKENHI-PROJECT-18K17921, KAKENHI-PROJECT-16K09777
[Journal Article] Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice2018
- Author(s)
  Nawaz Allah、Mehmood Arshad、Kanatani Yukiko、Kado Tomonobu、Igarashi Yoshiko、Takikawa Akiko、Yamamoto Seiji、Okabe Keisuke、Nakagawa Takashi、Yagi Kunimasa、Fujisaka Shiho、Tobe Kazuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1
- DOI
  10.1038/s41598-018-32600-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16193
[Journal Article] NAD metabolism: Implications in aging and longevity2018
- Author(s)
  Yaku Keisuke、Okabe Keisuke、Nakagawa Takashi
- Journal Title
  
  Ageing Research Reviews
  
  Volume: 47 Pages: 1-17
- DOI
  10.1016/j.arr.2018.05.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-18K16193, KAKENHI-PROJECT-18K17921
[Journal Article] NAD Metabolism in Cancer Therapeutics2018
- Author(s)
  Yaku Keisuke、Okabe Keisuke、Hikosaka Keisuke、Nakagawa Takashi
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 8 Pages: 622-622
- DOI
  10.3389/fonc.2018.00622
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-18K16193, KAKENHI-PROJECT-18K17921
[Journal Article] Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem-mass spectrometry2018
- Author(s)
  Yaku K、Okabe K、Nakagawa T
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 32 Issue: 6 Pages: 1-11
- DOI
  10.1002/bmc.4205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-16K21051, KAKENHI-PROJECT-18K16193
[Journal Article] Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice2018
- Author(s)
  Okabe Keisuke、Usui Isao、Yaku Keisuke、Hirabayashi Yoshio、Tobe Kazuyuki、Nakagawa Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 504 Issue: 1 Pages: 309-314
- DOI
  10.1016/j.bbrc.2018.08.180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-18K16193, KAKENHI-PROJECT-18K17921, KAKENHI-PROJECT-16K09777
[Presentation] NAD+-αケトグルタル酸によるエピジェネティックな脂肪細胞分化制御2021
- Author(s)
  岡部圭介, 西田康弘, Allah Nawaz, 藤坂志帆, 八木邦公, 角朝信, 五十嵐喜子, 薄井勲, 中川崇, 戸邉一之.
- Organizer
  第41回日本肥満学会・第38回日本肥満症治療学会
- Data Source
  KAKENHI-PROJECT-18K16193
[Presentation] NADは代謝リプログラミングを介して脂肪細胞分化を制御する.2019
- Author(s)
  岡部圭介, 西田康弘, Allah Nawaz, 藤坂志帆, 八木邦公, 角朝信, 五十嵐喜子, 薄井勲, 中川崇, 戸邉一之.
- Organizer
  第92回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16193
[Presentation] Nampt deletion changes metabolism in adipose tissue and prevents diet-induced obesity.2019
- Author(s)
  Okabe K, Nishida Y, Nawaz A, Fujisaka S, Yagi K, Kado A, Igarashi Y, Usui I, Nakagawa T, Tobe K
- Organizer
  American Diabetes Association 79th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16193
[Presentation] NADは代謝リプログラミングを介して前駆脂肪細胞分化を制御する2018
- Author(s)
  5) 岡部圭介, 西田康弘, Allah Nawaz, 藤坂志帆, 八木邦公, 角朝信, 五十嵐喜子, 薄井勲, 中川崇, 戸邉一之
- Organizer
  第30回分子糖尿病学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K16193
[Presentation] NAD合成酵素Namptは代謝リプログラミングを介して前駆脂肪細胞分化を制御する2018
- Author(s)
  3) 岡部圭介, 西田康弘, Allah Nawaz, 藤坂志帆, 八木邦公, 角朝信, 五十嵐喜子, 薄井勲, 中川崇, 戸邉一之
- Organizer
  第23回アディポサイエンス・シンポジウム
- Data Source
  KAKENHI-PROJECT-18K16193
[Presentation] NAD合成酵素Namptは代謝リプログラミングを介して前駆脂肪細胞分化を制御する2018
- Author(s)
  1) 岡部圭介, 西田康弘, Allah Nawaz, 藤坂志帆, 八木邦公, 角朝信, 五十嵐喜子, 薄井勲, 中川崇, 戸邉一之
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K16193
[Presentation] NAD-mediated metabolic reprogramming epigenetically regulates gene expression to promote preadipocyte differentiation2018
- Author(s)
  2) Keisuke Okabe, Yasuhiro Nishida, Allah Nawaz, Shiho Fujisaka, Kunimasa Yagi, Tomonobu Kado, Yoshiko Igarashi, Isao Usui, Takashi Nakagawa, Kazuyuki Tobe
- Organizer
  American Diabetes Association 78th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16193
[Presentation] NADは代謝リプログラミングを介して前駆脂肪細胞分化を制御する2018
- Author(s)
  4) 岡部圭介, 西田康弘, Allah Nawaz, 藤坂志帆, 八木邦公, 角朝信, 五十嵐喜子, 薄井勲, 中川崇, 戸邉一之
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-18K16193

1. 中川崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
2. 常山幸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okabe Keisuke 岡部 圭介

Research Projects

Research Products

Co-Researchers

Application of Alpha-ketoglutarate for the Treatment of Obesity as an Epigenetic DrugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

NAD mediated mechanism of adipocyte differentiation through epigeneticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NAD metabolism: Implications in aging and longevity2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NAD Metabolism in Cancer Therapeutics2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem-mass spectrometry2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] NAD+-αケトグルタル酸によるエピジェネティックな脂肪細胞分化制御2021

Author(s)

Organizer

Data Source

[Presentation] NADは代謝リプログラミングを介して脂肪細胞分化を制御する.2019

Author(s)

Organizer

Data Source

[Presentation] Nampt deletion changes metabolism in adipose tissue and prevents diet-induced obesity.2019

Author(s)

Organizer

Data Source

[Presentation] NADは代謝リプログラミングを介して前駆脂肪細胞分化を制御する2018

Author(s)

Organizer

Data Source

[Presentation] NAD合成酵素Namptは代謝リプログラミングを介して前駆脂肪細胞分化を制御する2018

Author(s)

Organizer

Data Source

[Presentation] NAD合成酵素Namptは代謝リプログラミングを介して前駆脂肪細胞分化を制御する2018

Author(s)

Organizer

Okabe Keisuke 岡部圭介