Nishihara Tatsuya 西原達哉

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NISHIHARA Tatsuya 西原達哉

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Researcher Number	00773201
Other IDs
Affiliation (Current)	2025: 青山学院大学, 理工学部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 青山学院大学, 理工学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related Except Principal Investigator Basic Section 37010:Bio-related chemistry
Keywords	Principal Investigator 代謝物 / イメージング / 代謝物解析 / DNAバーコード Except Principal Investigator 分子イメージング / 機能性薬剤 / 腫瘍低酸素 / ジスルフィド結合 / セラノスティクス / 低酸素環境 … More / X線照射 / 還元酵素 / 放射線照射 / 人工核酸 / 低酸素細胞 Less

組織内代謝物3次元分布解析を実現する機能性薄層クロマトグラフィーの開発Principal Investigator
- Principal Investigator
  
  西原達哉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Aoyama Gakuin University
High sensitive metabolite detection using DNA barcoding strategyPrincipal Investigator
- Principal Investigator
  
  NISHIHARA Tatsuya
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Aoyama Gakuin University
Drug Design for Hypoxic Theranostics
- Principal Investigator
  
  Tanabe Kazuhito
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Aoyama Gakuin University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Encoding Thiol Metabolite Information into a DNA Sequence by Disulfide Exchange Reaction on Oligodeoxynucleotides for Parallel Analysis of the Metabolite and mRNA2023
- Author(s)
  Motohashi Yuto、Moritani Shuhei、Nishihara Tatsuya、Tanabe Kazuhito
- Journal Title
  
  ChemistrySelect
  
  Volume: 8 Issue: 29
- DOI
  10.1002/slct.202302662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K04966, KAKENHI-PROJECT-23K26779
[Journal Article] DNA Encoding Strategy for the Identification and Quantification of Poorly Reactive Target Metabolite Using Phenylboronic Acid-tethered Oligodeoxynucleotides2023
- Author(s)
  Motohashi Yuto、Nishihara Tatsuya、Tanabe Kazuhito
- Journal Title
  
  Chemistry Letters
  
  Volume: 52 Issue: 9 Pages: 732-735
- DOI
  10.1246/cl.230263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K04966, KAKENHI-PROJECT-23K26779
[Journal Article] Raman Signal Enhancement by DABCYL-Substitution on DNA Aptamer for Identification of Cellular ATP2022
- Author(s)
  Watanabe Hikaru、Maehara Daigo、Nishihara Tatsuya、Tanabe Kazuhito
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 33 Issue: 12 Pages: 2314-2319
- DOI
  10.1021/acs.bioconjchem.2c00541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02863
[Journal Article] Hypoxic X-irradiation as a trigger for reduction of metal ion and azide-alkyne cycloaddition on oligodeoxynucleotides2022
- Author(s)
  Akisawa Kento、Makanai Hiroki、Nishihara Tatsuya、Tanabe Kazuhito
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 92 Pages: 153658-153658
- DOI
  10.1016/j.tetlet.2022.153658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02863
[Journal Article] Preparation of a multifunctional photoactivated prodrug on a streptavidin scaffold bearing a DNA aptamer.2022
- Author(s)
  Motohashi, Y.; Nishihara, T.; Tanabe, K.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 71 Pages: 128819-128819
- DOI
  10.1016/j.bmcl.2022.128819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02863
[Journal Article] Synthesis of Red‐Light‐Responsive Pheophorbide‐a Tryptamine Conjugated Photosensitizers for Photodynamic Therapy2022
- Author(s)
  Pandurang Taur Prakash、Kumar Bintu、Verma Narshimha、Dastidar Debabrata Ghosh、Yamada Risa、Nishihara Tatsuya、Tanabe Kazuhito、Kumar Dalip
- Journal Title
  
  ChemMedChem
  
  Volume: 18 Issue: 1
- DOI
  10.1002/cmdc.202200405
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02863
[Journal Article] Changes of C≡C Triple Bond Vibration that Disclosed Non-Canonical Cytosine Protonation in i-Motif-Forming Oligodeoxynucleotides2021
- Author(s)
  Itaya, R.; Idei, W.; Nakamura, T.; Nishihara, T.; Kurihara, R.; Okamoto, A.; Tanabe, K.
- Journal Title
  
  ACS Omega
  
  Volume: 6 Issue: 47 Pages: 31595-31604
- DOI
  10.1021/acsomega.1c04074
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PROJECT-21K19040, KAKENHI-PROJECT-20H02863
[Journal Article] Phosphonated mesoporous silica nanoparticles bearing ruthenium complexes used as molecular probes for tracking oxygen levels in cells and tissues2021
- Author(s)
  Umehara Yui、Kimura Yu、Kleitz Freddy、Nishihara Tatsuya、Kondo Teruyuki、Tanabe Kazuhito
- Journal Title
  
  RSC Advances
  
  Volume: 11 Issue: 10 Pages: 5865-5873
- DOI
  10.1039/d0ra08771h
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02863
[Journal Article] [2] Raman spectra of acetylene-tagged anthraquinone derivatives in various solvents2021
- Author(s)
  Makanai, H.; Nishihara, T.; Tanabe, K.
- Journal Title
  
  Photomedicine and Photobiology
  
  Volume: 42 Pages: 17-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02863
[Journal Article] Monitoring intracellular metal ion complexation with acetylene-tagged ligand by Raman spectroscopy2020
- Author(s)
  Takemura, S.; Watanabe, H.; Nishihara, T.; Okamoto, A.; Tanabe, K.
- Journal Title
  
  RSC Adv.
  
  Volume: 10 Issue: 59 Pages: 36119-36123
- DOI
  10.1039/d0ra06329k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PROJECT-18H03931, KAKENHI-PROJECT-20H02863, KAKENHI-PROJECT-19K22245
[Journal Article] Hybridizing Oligonucleotides with Hydrophobic Peptide Nucleic Acids Assists Their Cellular Uptake through Aggregate Formation.2020
- Author(s)
  Misu, S.; Kurihara, R.; Kaimuma, R.; Sato, R.; Nishihara, T.; Tanabe, K.
- Journal Title
  
  ChemBioChem.
  
  Volume: 21 Issue: 8 Pages: 1140-1143
- DOI
  10.1002/cbic.201900607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02863
[Journal Article] Modulation of cell membrane functionalization by aggregates of oligodeoxynucleotides containing alkyl chain-modified uridines.2020
- Author(s)
  Kainuma, R.; Motohashi, Y.; Nishihara, T.; Kurihara, R.; Tanabe, K.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 18 Issue: 28 Pages: 5406-5413
- DOI
  10.1039/d0ob00943a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02863
[Presentation] 組織内チオール代謝物イメージング及び組成解析を実現するTLC蛍光ラベル化剤の開発2023
- Author(s)
  西原達哉・鈴木我空・西田光輝・塚目莉加・田邉一仁
- Organizer
  日本化学会第104春季年会 (2024)
- Data Source
  KAKENHI-PROJECT-23K04966
[Presentation] 組織内グルタチオンの三次元分布解析を指向した機能化薄層クロマトグラフィーの開発2023
- Author(s)
  西原達哉・西田光輝・塚目莉加・田邉一仁
- Organizer
  第45回日本光医学・光生物学会
- Data Source
  KAKENHI-PROJECT-23K04966
[Presentation] 薄層クロマトグラフィーとラマン分子プローブを用いた生体分子検出手法の確立2023
- Author(s)
  塚目莉加, 西原達哉, 田邉一仁
- Organizer
  第45回日本光医学・光生物学会
- Data Source
  KAKENHI-PROJECT-23K04966
[Presentation] 薄層クロマトグラフィーとラマン分光法を活用したフェロトーシス関連分子群分布解析2023
- Author(s)
  塚目莉加・西原達哉・田邉一仁
- Organizer
  日本化学会第104春季年会 (2024)
- Data Source
  KAKENHI-PROJECT-23K04966
[Presentation] 薄層クロマトグラフィーへの転写技術を活用した組織内代謝物解析2023
- Author(s)
  西原達哉・西田光輝・塚目莉加・鈴木我空・田邉一仁
- Organizer
  第17回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K04966
[Presentation] フェニルボロン酸含有人工核酸を用いた代謝物解析手法の開発2022
- Author(s)
  本橋優人、西原達哉、田邉一仁
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] フェニルボロン酸含有人工核酸を用いた代謝物解析手法の開発2022
- Author(s)
  本橋優人、西原達哉、田邉一仁
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-20H02863
[Presentation] 標的代謝物を定量可能にする人工核酸の開発2022
- Author(s)
  本橋優人、西原達哉、田邉一仁
- Organizer
  第44回日本光医学・光生物学会
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] Detection of cellular metabolite using phenylboronic acid-modified oligonucleotides2022
- Author(s)
  Yuto Motohashi, Tatsuya Nishihara, Kazuhito Tanabe
- Organizer
  第49回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] Development of Method for Preparing Protein-DNA Complexes Using Electrostatic Interaction2022
- Author(s)
  日髙綾太、西原達哉、田邉一仁
- Organizer
  第44回日本光医学・光生物学会
- Data Source
  KAKENHI-PROJECT-20H02863
[Presentation] 細胞内の標的代謝物情報をコード可能にする機能性人工核酸の開発と応用2022
- Author(s)
  本橋優人、盛谷周平、西原達哉、田邉一仁
- Organizer
  日本化学会第103春季年会2023
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] アミノペプチダーゼ活性をコード可能にする機能性核酸の開発2022
- Author(s)
  三尾玲緒斗、西原達哉、田邉一仁
- Organizer
  日本化学会第103春季年会2023
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] 標的代謝物の多検体解析を指向した機能性人工核酸の開発2021
- Author(s)
  西原達哉　本橋優人　盛谷周平　田邉一仁
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] Functional Oligonucleotide Encoding the Metabolite Information2021
- Author(s)
  Tatsuya Nishihara, Yuto Motohashi, Shuhei Moritani, Momoka Yajima, Kazuhito Tanabe
- Organizer
  The 48th International Symposium on Nucleic Acids Chemistry 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] 検体中に含まれるグルタチオン濃度をコード可能にする機能性核酸の開発2021
- Author(s)
  盛谷周平　西原達哉　田邉一仁
- Organizer
  第11回 CSJ化学フェスタ2021
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] 代謝物情報をコード可能にする機能性核酸の開発2021
- Author(s)
  西原達哉　本橋優人　盛谷周平　矢島百華　田邉一仁
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] 代謝物の高感度検出を目指したDNA配列情報へコード可能にする新規ラベル化剤の開発2021
- Author(s)
  矢島百華　西原達哉　田邉一仁
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] 代謝物の超高感度検出を可能にする機能性核酸の開発2021
- Author(s)
  本橋優人　西原達哉　田邉一仁
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] 代謝物の高感度検出を実現する新規ラベル化剤の開発2021
- Author(s)
  矢島百華　西原達哉　田邉一仁
- Organizer
  第11回 CSJ化学フェスタ2021
- Data Source
  KAKENHI-PROJECT-21K14754
[Presentation] SERS-Based detection of intracellular oligonucleotides by using acetylene-tagged Hoechst molecules.2021
- Author(s)
  Makanai, H.; Nishihara, T.; Tanabe, K.
- Organizer
  The 48th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02863
[Presentation] Selective uptake of oligodeoxynucleotides into hypoxic cells: molecular design of modified nucleobase that was activated by nitroreductase.2021
- Author(s)
  Kikuchi, T.; Nishihara, T.; Tanabe, K.
- Organizer
  The 48th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02863
[Presentation] 代謝物応答性人工核酸を用いた標的代謝物の超感度検出法の開発2021
- Author(s)
  本橋優人　盛谷周平　西原達哉　田邉一仁
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21K14754

1. Tanabe Kazuhito (40346086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. 岡本晃充

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nishihara Tatsuya 西原 達哉

NISHIHARA Tatsuya 西原 達哉

Research Projects

Research Products

Co-Researchers

組織内代謝物3次元分布解析を実現する機能性薄層クロマトグラフィーの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

High sensitive metabolite detection using DNA barcoding strategyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug Design for Hypoxic Theranostics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Encoding Thiol Metabolite Information into a DNA Sequence by Disulfide Exchange Reaction on Oligodeoxynucleotides for Parallel Analysis of the Metabolite and mRNA2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA Encoding Strategy for the Identification and Quantification of Poorly Reactive Target Metabolite Using Phenylboronic Acid-tethered Oligodeoxynucleotides2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Raman Signal Enhancement by DABCYL-Substitution on DNA Aptamer for Identification of Cellular ATP2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxic X-irradiation as a trigger for reduction of metal ion and azide-alkyne cycloaddition on oligodeoxynucleotides2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation of a multifunctional photoactivated prodrug on a streptavidin scaffold bearing a DNA aptamer.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of Red‐Light‐Responsive Pheophorbide‐a Tryptamine Conjugated Photosensitizers for Photodynamic Therapy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Changes of C≡C Triple Bond Vibration that Disclosed Non-Canonical Cytosine Protonation in i-Motif-Forming Oligodeoxynucleotides2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphonated mesoporous silica nanoparticles bearing ruthenium complexes used as molecular probes for tracking oxygen levels in cells and tissues2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] [2] Raman spectra of acetylene-tagged anthraquinone derivatives in various solvents2021

Author(s)

Journal Title

Data Source

[Journal Article] Monitoring intracellular metal ion complexation with acetylene-tagged ligand by Raman spectroscopy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hybridizing Oligonucleotides with Hydrophobic Peptide Nucleic Acids Assists Their Cellular Uptake through Aggregate Formation.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modulation of cell membrane functionalization by aggregates of oligodeoxynucleotides containing alkyl chain-modified uridines.2020

Author(s)

Journal Title

Nishihara Tatsuya 西原達哉

NISHIHARA Tatsuya 西原達哉

[Presentation] フェニルボロン酸含有人工核酸を用いた代謝物解析手法の開発2022