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Hasegawa Minami  長谷川 実奈美

ORCIDConnect your ORCID iD *help
Researcher Number 00778764
Other IDs
Affiliation (Current) 2025: 東京慈恵会医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2017 – 2023: 東京慈恵会医科大学, 医学部, 助教
2016: 東京慈恵会医科大学, 医学部, ポスト・ドクトラルフェロー
Review Section/Research Field
Principal Investigator
Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46010:Neuroscience-general-related / Neurochemistry/Neuropharmacology / Neurophysiology / General neuroscience
Keywords
Principal Investigator
TDP-43 / ALS / スプライスバリアント / RBP / 運動ニューロン / 神経変性疾患 / RNAスプライシング / RNA結合タンパク質 / 転写制御 / プロモーター … More / バイオマーカー / RNA品質管理 / 発症リスク / RNA品質管理機構 Less
  • Research Projects

    (4 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (2 People)
  •  ALSにおける運動ニューロン特異的スプライシング制御機構の解明Principal Investigator

    • Principal Investigator
      長谷川 実奈美
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Jikei University School of Medicine
  •  Mechanisms of motor neuron homeostasis and ALS therapeutic strategies focusing on TDP-43 dysfunction.Principal Investigator

    • Principal Investigator
      Hasegawa Minami
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      Jikei University School of Medicine
  •  Elucidation of the mechanism of ALS exacerbation through abnormal activation of the TDP-43 ectopic promoter.Principal Investigator

    • Principal Investigator
      Hasegawa Minami
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Jikei University School of Medicine
  •  RNA品質管理機構の破綻に着目したALS発症リスクの解明Principal Investigator

    • Principal Investigator
      長谷川 実奈美
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Neurophysiology / General neuroscience
    • Research Institution
      Jikei University School of Medicine

All 2023 2022 2021 2020 2019 2016

All Journal Article Presentation Patent

  • [Journal Article] Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress2023

    • Author(s)
      Asako Onda-Ohto, Minami Hasegawa-Ogawa, Hiromasa Matsuno, Tomotaka Shiraishi, Keiko Bono, Hiromi Hiraki, Yumi Kanegae, Yasuyuki Iguchi, Hirotaka James Okano
    • Journal Title

      Molecular Brain

      Volume: 16 Issue: 1 Pages: 62-62

    • DOI

      10.1186/s13041-023-01050-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15719, KAKENHI-PROJECT-22K20696, KAKENHI-PROJECT-23K06812, KAKENHI-PROJECT-18K15468
  • [Journal Article] Characterization of the upstream and intron promoters of the gene encoding TAR DNA-binding protein2021

    • Author(s)
      Minami Hasegawa-Ogawa, Hirotaka James Okano
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 8720-8720

    • DOI

      10.1038/s41598-021-88015-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K15904, KAKENHI-PROJECT-21K07302
  • [Patent] 核酸医薬とその使用2020

    • Inventor(s)
      中村慎吾 森下えら 高田遼平 岡野J洋尚 長谷川実奈美 梨本正之
    • Industrial Property Rights Holder
      中村慎吾 森下えら 高田遼平 岡野J洋尚 長谷川実奈美 梨本正之
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-20K15904
  • [Presentation] Functional analysis and regulatory mechanism of shortened splicing isoforms of TDP-43.2023

    • Author(s)
      Minami Hasegawa-Ogawa, Asako Onda-Ohto, Arisa Funabashi, Takumasa Nakajo, Ayane Ohya, Hirotaka James Okano
    • Organizer
      The 46th Annual Meeting of the Japan Neuroscience Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06812
  • [Presentation] Functional segregation of neuronal ELAVL protein splicing isoforms in human cells and their involvement in ALS pathophysiology.2022

    • Author(s)
      Minami Hasegawa-Ogawa, Asako Onda-Ohto, Hirotaka James Okano
    • Organizer
      Neuro2022
    • Data Source
      KAKENHI-PROJECT-20K15904
  • [Presentation] Pathophysiological study of amyotrophic lateral sclerosis using gene edit human iPS cells2022

    • Author(s)
      Asako Onda-Ohto, Minami Hasegawa-Ogawa, Hiromasa Matsuno, Keiko Bono, Hiromi Hiraki, Yumi Kanegae, Yasuyuki Iguchi, Hirotaka James Okano
    • Organizer
      Neuro2022
    • Data Source
      KAKENHI-PROJECT-20K15904
  • [Presentation] Identification of TARDBP intronic promoter and functional insight.2019

    • Author(s)
      Minami Hasegawa-Ogawa, Hirotaka James Okano
    • Organizer
      Neuro2019
    • Data Source
      KAKENHI-PROJECT-17K14967
  • [Presentation] ALSモデルマウスにおけるRNA代謝解析2016

    • Author(s)
      長谷川実奈美
    • Organizer
      第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-09-08
    • Data Source
      KAKENHI-PROJECT-16H07218
  • 1.  岡野 ジェイムス洋尚 (90338020)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  坊野 恵子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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