Kimura Ryuichi 木村龍一

Researcher Number	00781759
Affiliation (Current)	2025: 熊本大学, 生命資源研究・支援センター, 特任助教
Affiliation (based on the past Project Information) *help	2024: 熊本大学, 生命資源研究・支援センター, 特任助教 2020 – 2023: 京都大学, 医学研究科, 特定助教 2017 – 2019: 東北大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 56030:Urology-related / Basic Section 56040:Obstetrics and gynecology-related / General medical chemistry Except Principal Investigator Biology of Cells to Organisms, and related fields
Keywords	Principal Investigator RNA-seq / 核内構造体 / 精子エピゲノム / 精原細胞 / 空間トランスクリプトーム / 発達障害 / ヒストン修飾 / 精子 / 脱メチル化薬剤 / 精子低メチル化 … More / 精子形成 / DNAメチル化 / 経世代エピゲノム / 脳神経疾患 / 発現制御 / 老化 / 発生・分化 / 加齢 / 神経発達障害 … More Except Principal Investigator 老化 / 発生・分化 / 遺伝子 / 性比 / 脳計測科学 / 基盤・社会脳科学 / 脳科学 / 性比バイアス / 精子形成 / Pax6 Less

Analysis of RNA controling nuclear phase separationPrincipal Investigator
- Principal Investigator
  
  木村龍一
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kumamoto University
加齢により生じる精原細胞エピゲノム変化の時空間的制御Principal Investigator
- Principal Investigator
  
  木村龍一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kyoto University
オーファン核内構造体を構成するRNAの包括的解析Principal Investigator
- Principal Investigator
  
  木村龍一
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Disease predisposition in offspring based on sperm epigenetic variation.Principal Investigator
- Principal Investigator
  
  Kimura Ryuichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
  Tohoku University
The role of Pax6 in spermatogenesis and determination of sex bias in the mouse
- Principal Investigator
  
  Osumi Noriko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Biology of Cells to Organisms, and related fields
- Research Institution
  Tohoku University
Sperm DNA methylation for a risk of offspring's disorderPrincipal Investigator
- Principal Investigator
  
  Kimura Ryuichi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] 遺伝子医学 31号「エピゲノムの経世代影響」2019
- Author(s)
  木村龍一, 吉崎嘉一, 大隅典子
- Total Pages
  168
- Publisher
  株式会社　メディカルドゥ
- ISBN
  9784909508058
- Data Source
  KAKENHI-PROJECT-19K18627
[Book] 医学のあゆみ 268巻3号「自閉スペクトラム症発症リスクとエピジェネティクス」2019
- Author(s)
  木村龍一, 稲田仁, 大隅典子
- Total Pages
  70
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19K18627
[Journal Article] Photo-isolation chemistry for high-resolution and deep spatial transcriptome with mouse tissue sections2022
- Author(s)
  Honda Mizuki、Kimura Ryuichi、Harada Akihito、Maehara Kazumitsu、Tanaka Kaori、Ohkawa Yasuyuki、Oki Shinya
- Journal Title
  
  STAR Protocols
  
  Volume: 3 Issue: 2 Pages: 101346-101346
- DOI
  10.1016/j.xpro.2022.101346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09522, KAKENHI-PROJECT-22K19275, KAKENHI-PLANNED-21H05292, KAKENHI-PUBLICLY-21H05755, KAKENHI-PUBLICLY-22H05594, KAKENHI-PROJECT-20H00456, KAKENHI-PUBLICLY-21H00232, KAKENHI-PUBLICLY-22H04676, KAKENHI-PUBLICLY-22H04696, KAKENHI-PROJECT-19H03424
[Journal Article] Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF.2021
- Author(s)
  Yoshizaki Kaichi, Kimura Ryuichi, Kobayashi Hisato, Oki Shinya, Kikkawa Takako, Mai Lingling, Koike Kohei, Mochizumi Kentaro, Inada Hitoshi, Matsui Yasuhisa, Kono Tomohiro, Osumi Noriko
- Journal Title
  
  EMBO Reports
  
  Volume: 22(2) Issue: 2
- DOI
  10.15252/embr.202051524
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08060, KAKENHI-PROJECT-20K07237, KAKENHI-PROJECT-19K18627, KAKENHI-INTERNATIONAL-16K21734, KAKENHI-ORGANIZER-16H06524, KAKENHI-PLANNED-16H06530, KAKENHI-PROJECT-19H03424, KAKENHI-PROJECT-18KT0024
[Journal Article] Detection of <scp>REST</scp> expression in the testis using epitope‐tag knock‐in mice generated by genome editing2021
- Author(s)
  Kimura Ryuichi、U. Inoue Yukiko、Kikkawa Takako、Tatehana Misako、Morimoto Yuki、Inada Hitoshi、Oki Shinya、Inoue Takayoshi、Osumi Noriko
- Journal Title
  
  Developmental Dynamics
  
  Volume: 251 Issue: 3 Pages: 525-535
- DOI
  10.1002/dvdy.417
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18627, KAKENHI-INTERNATIONAL-16K21734, KAKENHI-PUBLICLY-19H04922, KAKENHI-WRAPUP-21H00447, KAKENHI-PROJECT-19H03318, KAKENHI-PROJECT-20J22054, KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-20K07237, KAKENHI-PROJECT-19H03424
[Journal Article] Comprehensive histochemical profiles of histone modification in male germline cells during meiosis and spermiogenesis: Comparison of young and aged testes in mice2020
- Author(s)
  Tatehana M, Kimura R, Mochizuki K, Inada H, Osumi N
- Journal Title
  
  PLoS One
  
  Volume: eCollection 2020 Issue: 4 Pages: e0230930-e0230930
- DOI
  10.1371/journal.pone.0230930
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18627, KAKENHI-INTERNATIONAL-16K21734, KAKENHI-ORGANIZER-16H06524, KAKENHI-PLANNED-16H06530, KAKENHI-PROJECT-20J22054
[Journal Article] 自閉スペクトラム症発症リスクとエピジェネティクス2019
- Author(s)
  木村龍一、稲田仁、大隅典子
- Journal Title
  
  医学のあゆみ
  
  Volume: 3 Pages: 180-183
- Data Source
  KAKENHI-PROJECT-17K17605
[Journal Article] SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling2018
- Author(s)
  Mochizuki Kentaro, Tando Yukio, Sekinaka Tamotsu, Otsuka Kei, Hayashi Yohei, Kobayashi Misato, Kamio Asuka, Ito-Matsuoka Yumi, Takehara Asuka, Kono Tomohiro, Osumi Noriko, Matsui Yasuhisa
- Journal Title
  
  Development
  
  Volume: 145 Issue: 23 Pages: 1-10
- DOI
  10.1242/dev.164160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K17594, KAKENHI-PROJECT-18K15001, KAKENHI-PROJECT-17J02039, KAKENHI-PROJECT-17K19372, KAKENHI-PROJECT-15H05579, KAKENHI-PUBLICLY-18H04875
[Journal Article] Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Infuence of Epigenetic Alteration in Sperm.2018
- Author(s)
  Kimura, R., Yoshizaki, K. and Osumi, N.
- Journal Title
  
  Adv. Exp. Med. Biol.
  
  Volume: 1012 Pages: 75-81
- DOI
  10.1007/978-981-10-5526-3_8
- ISBN
  9789811055256, 9789811055263
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06530, KAKENHI-PROJECT-15K06694, KAKENHI-PROJECT-17K17605
[Journal Article] Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes2017
- Author(s)
  Maekawa M、Watanabe A、Iwayama Y、Kimura T、Hamazaki K、Balan S、Ohba H、Hisano Y、Nozaki Y、Ohnishi T、Toyoshima M、Shimamoto C、Iwamoto K、Bundo M、Osumi N、Takahashi E、Takashima A、Yoshikawa T
- Journal Title
  
  Transl Psychiatry.
  
  Volume: 7 Issue: 9 Pages: e1229-e1229
- DOI
  10.1038/tp.2017.182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19372, KAKENHI-PLANNED-16H06399, KAKENHI-PLANNED-16H06530, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15H04891, KAKENHI-PROJECT-15K09814
[Journal Article] Early postnatal vocalizations predict sociability and spatial memory in C57BL6/J mice: individual differences in behavioral traits emerge early in development.2017
- Author(s)
  Yoshizaki Kaichi, Koike Kohei, Kimura Ryuichi, Osumi Noriko
- Journal Title
  
  PLoS One
  
  Volume: - Issue: 11 Pages: e0186798-e0186798
- DOI
  10.1371/journal.pone.0186798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06694, KAKENHI-PROJECT-17K19372, KAKENHI-INTERNATIONAL-16K21734, KAKENHI-ORGANIZER-16H06524, KAKENHI-PLANNED-16H06530
[Presentation] Paternal aging affects to phenotypes of offspring through inheritance of hypomethylated DNA elicited in NRSF/REST binding site2019
- Author(s)
  Kimura R., Yoshizaki K., Kikkawa T., Mai L., Oki S., Mochizuki K., Kobayashi H., Inada H., Matsui Y., Kono T., Osumi N.
- Organizer
  14th Asia Epigenome Meeting (AEM) / 3rd Taipei Epigenetics and Chromatin Meeting (TECM)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18627
[Presentation] Paternal aging affects to offspring’s behavior and gene expression possibly through inheritance of hypomethylated DNA elicited in NRSF/REST binding site2019
- Author(s)
  Kimura R., Yoshizaki K., Kikkawa T., Mai L., Oki S., Mochizuki K., Kobayashi H., Inada H., Matsui Y., Kono T., Osumi N.
- Organizer
  International Symposium on Epigenome 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18627
[Presentation] Paternal ageing affects phenotypes of mice progeny possibly through epigenetic alteration in sperm2018
- Author(s)
  Kimura R., Yoshizaki K., Koike T., Oki S., Aoki N., Mochizuki K., Kobayashi H., Kikkawa T., Inada H., Matsui Y., Kono T., Osumi N.
- Organizer
  第41回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K17605
[Presentation] Paternal ageing affects phenotypes of mice progeny possibly through epigenetic alteration in sperm2018
- Author(s)
  木村龍一
- Organizer
  第41回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K17605
[Presentation] Paternal aging affects offspring’s behavior and gene expression possibly through transmission of hypomethylated DNA regions in NRSF/REST binding sites2018
- Author(s)
  木村龍一
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17605
[Presentation] Trans-generational transmission of ASD-like phenotypes possibly via sperm epigenetic alteration caused by paternal age2017
- Author(s)
  Kimura R., Yoshizaki K., Koike T., Oki S., Aoki N., Mochizuki K., Kobayashi H., Kikkawa T., Inada H., Matsui Y., Kono T., Osumi N.
- Organizer
  国際自閉症カンファレンス東京2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17605
[Presentation] 高齢の精子にみられるDNAメチル化異常と子孫の表現型異常との関連2017
- Author(s)
  木村龍一、吉崎嘉一、小池佐、沖真弥、青木七菜、望月健太郎、小林久人、吉川貴子、稲田仁、松居靖久、河野友宏、大隅典子
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K17605
[Presentation] Paternal aging-induced differential DNA methylation in sperm: possible effects on gene expression and behavior in offspring2017
- Author(s)
  Osumi, N.Kimura R, Yoshizaki K, Koike T, Oki S, Mochizuki K, Kikkawa T, Inada H, Matsui Y, Kono T
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19372
[Presentation] Paternal age affects offspring’s behavior possibly via sperm epigenetic alteration established by a transcriptional repressor REST2017
- Author(s)
  Kimura R., Yoshizaki K., Koike T., Oki S., Aoki N., Mochizuki K., Kobayashi H., Kikkawa T., Inada H., Matsui Y., Kono T., Osumi N.
- Organizer
  The International Research Symposium on Regulation of Germ Cell Development in vivo and in vitro
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17605

1. Osumi Noriko (00220343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. TATEHANA Misako

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Jasper Germeraad

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Mai Lingling

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YOSHIZAKI Kaichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 望月研太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山下典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kimura Ryuichi 木村 龍一

Research Projects

Research Products

Co-Researchers

Analysis of RNA controling nuclear phase separationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加齢により生じる精原細胞エピゲノム変化の時空間的制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

オーファン核内構造体を構成するRNAの包括的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Disease predisposition in offspring based on sperm epigenetic variation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of Pax6 in spermatogenesis and determination of sex bias in the mouse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sperm DNA methylation for a risk of offspring's disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 遺伝子医学 31号「エピゲノムの経世代影響」2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 医学のあゆみ 268巻3号 「自閉スペクトラム症発症リスクとエピジェネティクス」2019

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Photo-isolation chemistry for high-resolution and deep spatial transcriptome with mouse tissue sections2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of <scp>REST</scp> expression in the testis using epitope‐tag knock‐in mice generated by genome editing2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive histochemical profiles of histone modification in male germline cells during meiosis and spermiogenesis: Comparison of young and aged testes in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 自閉スペクトラム症発症リスクとエピジェネティクス2019

Author(s)

Journal Title

Data Source

[Journal Article] SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling2018

Author(s)

Journal Title

DOI

Data Source

Kimura Ryuichi 木村龍一

[Book] 医学のあゆみ 268巻3号「自閉スペクトラム症発症リスクとエピジェネティクス」2019