Tahara Shinya 田原進也

Researcher Number	00783060
Other IDs	https://orcid.org/0000-0003-3979-3135
Affiliation (Current)	2025: 東北大学, 薬学研究科, 助教
Affiliation (based on the past Project Information) *help	2024: 東北大学, 薬学研究科, 助教 2020 – 2022: 東北大学, 薬学研究科, 助教 2019: 大阪大学, 理学研究科, 特別研究員(PD)
Review Section/Research Field	Principal Investigator Basic Section 34020:Analytical chemistry-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 32010:Fundamental physical chemistry-related
Keywords	Principal Investigator 液-液相分離 / ラマン顕微鏡 / 熱力学的パラメーター / 蛍光寿命イメージング / 溶媒環境 / タンパク質変性 / 無標識観測 / タンパク質凝集 / 凝集 / ポリQ病 … More / 神経変性疾患 / 蛍光異方性 / 自家蛍光 / 水素結合ネットワーク / 電荷分布変化 / タンパク質ダイナミクス / 再構成 / 微生物型ロドプシン / ロドプシン再構成 / グロイオバクターロドプシン / 紫外共鳴ラマン分光 / ロドプシン / タンパク質構造変化 / 超高速ダイナミクス / 光受容タンパク質 Less

Research Projects
(3 results)
Research Products
(9 results)

Quantitative analyses of intermolecular interactions inside protein droplets formed via liquid-liquid phase separation using Raman microscopyPrincipal Investigator
- Principal Investigator
  
  田原進也
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 34020:Analytical chemistry-related
- Research Institution
  Tohoku University
Label-free analyses of the surrounding environment around proteins in droplets formed via liquid-liquid phase separation using fluorescence lifetime and anisotropy microscopyPrincipal Investigator
- Principal Investigator
  
  Tahara Shinya
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Tohoku University
Mechanism of protein structural changes prior to photoisomerizationPrincipal Investigator
- Principal Investigator
  
  Tahara Shinya
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 32010:Fundamental physical chemistry-related
- Research Institution
  Tohoku University
  Osaka University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Label-Free Autofluorescence Lifetime Reveals the Structural Dynamics of Ataxin-3 Inside Droplets Formed via Liquid-Liquid Phase Separation2023
- Author(s)
  Uchu Matsuura, Shinya Tahara, Shinji Kajimoto, Takakazu Nakabayashi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 6389-6389
- DOI
  10.1038/s41598-023-33268-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15238, KAKENHI-PROJECT-23K23857
[Journal Article] Nonbonded Atomic Contacts Drive Ultrafast Helix Motions in Myoglobin2020
- Author(s)
  Shinya Tahara, Misao Mizuno, and Yasuhisa Mizutani
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 124 Issue: 26 Pages: 5407-5414
- DOI
  10.1021/acs.jpcb.0c04772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18J01307, KAKENHI-PROJECT-19K15504, KAKENHI-PROJECT-20H02693
[Presentation] PolyQ chain length dependence of liquid-liquid phase separation and aggregation dynamics of a neurodegeneration-related protein ataxin-32022
- Author(s)
  Uchu Matsuura, Shinya Tahara, Shinji Kajimoto, Takakazu Nakabayashi
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K15238
[Presentation] 自家蛍光測定による液滴内の病原性蛋白質の変性ダイナミクスの観測2022
- Author(s)
  松浦宇宙, 田原進也, 梶本真司, 田原進也
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K15238
[Presentation] 蛍光寿命測定による液-液相分離に伴う粘性変化の追跡2022
- Author(s)
  永井海地, 田原進也, 松浦宇宙, 杉本瑞樹, 佐々木栄太, 梶本真司, 花岡健二郎, 中林孝和
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K15238
[Presentation] Quantitative analysis of time-dependent dynamics of FUS LC droplets formed by LLPS using fluorescence lifetime2022
- Author(s)
  Kaichi Nagai, Shinya Tahara, Uchu Matsuura, Mizuki Sugimoto, Eita Sasaki, Shinji Kajimoto, Kenjiro Hanaoka, Takakazu Nakabayashi
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K15238
[Presentation] Direct observation of unfolding dynamics of the amyloidosis-related protein in droplets formed via liquid-liquid phase separation by autofluorescence measurement2022
- Author(s)
  Uchu Matsuura, Shinya Tahara, Shinji Kajimoto, Takakazu Nakabayashi
- Organizer
  第16回分子科学討論会
- Data Source
  KAKENHI-PROJECT-21K15238
[Presentation] 先端的分光法によるタンパク質の病原性発現機構の解析2021
- Author(s)
  田原進也
- Organizer
  日本薬学会東北支部　第9回物理・分析若手研究者セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K15238
[Presentation] Triggers of Primary Protein Dynamics in Photoreceptor Proteins2020
- Author(s)
  田原進也
- Organizer
  第58回日本生物物理学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K15504

Tahara Shinya 田原 進也

Research Projects

Research Products

Quantitative analyses of intermolecular interactions inside protein droplets formed via liquid-liquid phase separation using Raman microscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Label-free analyses of the surrounding environment around proteins in droplets formed via liquid-liquid phase separation using fluorescence lifetime and anisotropy microscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of protein structural changes prior to photoisomerizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Label-Free Autofluorescence Lifetime Reveals the Structural Dynamics of Ataxin-3 Inside Droplets Formed via Liquid-Liquid Phase Separation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nonbonded Atomic Contacts Drive Ultrafast Helix Motions in Myoglobin2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] PolyQ chain length dependence of liquid-liquid phase separation and aggregation dynamics of a neurodegeneration-related protein ataxin-32022

Author(s)

Organizer

Data Source

[Presentation] 自家蛍光測定による液滴内の病原性蛋白質の変性ダイナミクスの観測2022

Author(s)

Organizer

Data Source

[Presentation] 蛍光寿命測定による液-液相分離に伴う粘性変化の追跡2022

Author(s)

Organizer

Data Source

[Presentation] Quantitative analysis of time-dependent dynamics of FUS LC droplets formed by LLPS using fluorescence lifetime2022

Author(s)

Organizer

Data Source

[Presentation] Direct observation of unfolding dynamics of the amyloidosis-related protein in droplets formed via liquid-liquid phase separation by autofluorescence measurement2022

Author(s)

Organizer

Data Source

[Presentation] 先端的分光法によるタンパク質の病原性発現機構の解析2021

Author(s)

Organizer

Data Source

[Presentation] Triggers of Primary Protein Dynamics in Photoreceptor Proteins2020

Author(s)

Organizer

Data Source

Tahara Shinya 田原進也