OSAWA Takashi 大澤昂志

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Osawa Takashi 大澤昂志

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Researcher Number	00783226
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院薬学研究科, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 大阪大学, 大学院薬学研究科, 助教 2020 – 2021: 大阪大学, 薬学研究科, 助教 2017 – 2018: 徳島文理大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (II) / Basic Section 37010:Bio-related chemistry / Drug development chemistry
Keywords	Principal Investigator 核酸化学 / 人工核酸 / 核酸医薬 / 細胞膜透過 / 膜モジュレータ / 有機化学 / ペプチド / 分子マシン

Cell Membrane Permeation of Oligonucleotides Controlled by Membrane Modulator MoleculesArea Organizer
- Area Organizer
  
  大澤昂志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
細胞膜をゆらす核酸医薬の膜透過機構の総合理解と膜透過学の創成Principal Investigator
- Principal Investigator
  
  大澤昂志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Osaka University
核酸の膜透過を誘導するリン酸部修飾の探索と膜モジュレータ分子の機能評価Principal Investigator
- Principal Investigator
  
  大澤昂志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Osaka University
Development of efficient synthetic methods for artificial nucleic acids aimed at improving activity and reducing toxicity of oligonucleotide medicinesPrincipal Investigator
- Principal Investigator
  
  大澤昂志
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka University
Development and evaluation of 2',3'-bridged nucleic acid with constrained conformation of sugar and phosphate backbonePrincipal Investigator
- Principal Investigator
  
  Osawa Takashi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka University
Synthesis and properties of artificilal nucleic acids with spiroketal moiety based on the control of the conformation of sugar and phosphate backbonePrincipal Investigator
- Principal Investigator
  
  Osawa Takashi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokushima Bunri University

All 2024 2023 2022 2021 2020 2018 2017

All Journal Article Presentation

[Journal Article] Development of simple purification method for oligonucleotides synthesized using phosphoramidite for 5′-end modification as capping reagent2024
- Author(s)
  Ren Qin、Osawa Takashi、Obika Satoshi
- Journal Title
  
  Tetrahedron
  
  Volume: 150 Pages: 133774-133774
- DOI
  10.1016/j.tet.2023.133774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K04930
[Journal Article] Synthesis of Coumarin-Conjugated Oligonucleotides <i>via</i> Knoevenagel Condensation to Prepare an Oligonucleotide Library2024
- Author(s)
  Osawa Takashi、Obika Satoshi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 2 Pages: 143-148
- DOI
  10.1248/cpb.c23-00295
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K04930
[Journal Article] 強塩基処理できないオリゴ核酸の3'-アミノリンカー修飾法の開発2023
- Author(s)
  大澤昂志
- Journal Title
  
  日本核酸化学会誌
  
  Volume: 7 Pages: 3-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K04930
[Journal Article] Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3′,4′-Tetrahydropyran-Bridged Nucleic Acid2023
- Author(s)
  Osawa Takashi、Akino Taiki、Obika Satoshi
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 89 Issue: 1 Pages: 269-280
- DOI
  10.1021/acs.joc.3c02019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K04930
[Journal Article] Post‐Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex‐Forming Ability2023
- Author(s)
  Mikami Atsushi、Mori Shohei、Osawa Takashi、Obika Satoshi
- Journal Title
  
  Chemistry A European Journal
  
  Volume: 29 Issue: 63
- DOI
  10.1002/chem.202301928
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K04930, KAKENHI-PROJECT-22KJ2142
[Journal Article] Synthesis and properties of oligonucleotides bearing thymidine derivatives with 1,6-dioxaspiro[4.5]decane skeleton2021
- Author(s)
  Osawa Takashi、Kawaguchi Miho、Jang Ye-Jin、Ito Yuta、Hari Yoshiyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 31 Pages: 115966-115966
- DOI
  10.1016/j.bmc.2020.115966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15401
[Journal Article] The effect of the base triplets adjacent to a T-CG or 5-methylC-CG triplet in the triplex DNA2021
- Author(s)
  Hari Yoshiyuki、Ito Yuta、Hama Chisa、Osawa Takashi
- Journal Title
  
  HETEROCYCLES
  
  Volume: 103 Issue: 1 Pages: 322-322
- DOI
  10.3987/com-20-s(k)16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15401
[Journal Article] New cleavable spacers for tandem synthesis of multiple oligonucleotides2021
- Author(s)
  Hari Yoshiyuki、Yamamoto Kazuki、Fuchi Yasufumi、Okabe Masaya、Osawa Takashi、Ito Yuta
- Journal Title
  
  Synthesis
  
  Volume: 53 Issue: 23 Pages: 4440-4448
- DOI
  10.1055/a-1538-9883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15401, KAKENHI-PROJECT-20K15963
[Journal Article] Synthesis of Oligonucleotides Containing 2′-N-alkylaminocarbonyl-2′-amino-LNA (2′-urea-LNA) Moieties Using Post-Synthetic Modification Strategy2020
- Author(s)
  Yamashita Shoko、Nishida Kodai、Osawa Takashi、Nakanishi Ayumi、Ito Yuta、Hari Yoshiyuki
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 2 Pages: 346-346
- DOI
  10.3390/molecules25020346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15401
[Journal Article] Synthesis and Hybridizing Property of Oligonucleotides Including 2′-C,4′-C-Ethyleneoxy-Bridged 2′-Deoxyadenosine with an Exocyclic Methylene Unit2020
- Author(s)
  Hari Yoshiyuki、Osawa Takashi、Onishi Yoshinori、Ito Yuta
- Journal Title
  
  HETEROCYCLES
  
  Volume: 101 Issue: 1 Pages: 284-284
- DOI
  10.3987/com-19-s(f)24
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15401
[Journal Article] Synthesis and Properties of Oligonucleotides Containing 3′-O,4′-C-Ethyleneoxy-bridged 5-Methyluridines2018
- Author(s)
  Hari Yoshiyuki、Osawa Takashi、Hitomi Yuka、Wakita Sawako、Kim Han、Dohi Masakazu、Horiba Masahiko、Ito Yuta、Obika Satoshi
- Journal Title
  
  HETEROCYCLES
  
  Volume: 97 Issue: 1 Pages: 306-313
- DOI
  10.3987/com-18-s(t)20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18295
[Journal Article] Synthesis and hybridizing properties of isoDNAs including 3′-O,4′-C-ethyleneoxy-bridged 5-methyluridine derivatives2018
- Author(s)
  Osawa Takashi、Hitomi Yuka、Wakita Sawako、Kim Han、Ito Yuta、Hari Yoshiyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 14 Pages: 3875-3881
- DOI
  10.1016/j.bmc.2018.05.043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18295
[Presentation] リジン側鎖とチオエステルの縮合を基盤としたペプチド-オリゴ核酸コンジュゲート合成法の開発2024
- Author(s)
  ◯村本創、大澤昂志、小比賀聡
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] PACE修飾オリゴ核酸のアミド化による新規リン酸部伸長後修飾法の開発2024
- Author(s)
  ◯藤末大貴、大澤昂志、小比賀聡
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] Synthesis of 2′,3′-bridged nucleic acids with 5,6- or 5,7-membered trans-fused ring skeleton2023
- Author(s)
  ◯Ryota Nakanishi, Takashi Osawa, Satoshi Obika
- Organizer
  FNA Perth 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] 高脂溶性アミダイトをキャッピング試薬として利用する核酸医薬の簡便精製2023
- Author(s)
  ◯仁　欽、大澤昂志、小比賀聡
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] Synthesis of a ligand-conjugated ASOs library based on the Ugi reaction and exploration for novel ligands suitable for delivery of ASOs2023
- Author(s)
  ◯Ryosuke Kita, Takashi Osawa, Yuuya Kasahara, Harumi Yamaguma, Satoshi Obika
- Organizer
  19th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] オリゴ核酸への導入効率向上を目指した架橋型人工核酸アミダイトの設計と合成2023
- Author(s)
  ◯市川彩夏、大澤昂志、三上敦士、仁　欽、小比賀聡
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] Development of a post-elongation modification method of phosphate backbone based on the amidation of phosphonoacetate-modified oligonucleotides2023
- Author(s)
  ◯Daiki Fujisue, Takashi Osawa, Satoshi Obika
- Organizer
  The 50th International Symposium on Nucleic Acids Chemistry (ISNAC2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] 1-オキサスピロ[4.5]デカン構造を有する2′-O-メチル-5-メチルウリジンおよび2′-デオキシ-2′-フルオロウリジン誘導体の合成2023
- Author(s)
  ◯伊藤瑳謡子、矢野夏実、大澤昂志、小比賀聡
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] 構造的に多様なリガンド－オリゴ核酸コンジュゲートの効率的合成法の開発2023
- Author(s)
  ◯大澤昂志、喜多良介、小比賀聡
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] クネーフェナーゲル縮合を基盤としたクマリン誘導体を有するDNAコード化ライブラリー合成法の開発2023
- Author(s)
  ○大澤昂志、小比賀聡
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] アミド結合で連結した3′,4′-架橋型核酸の合成と物性評価2023
- Author(s)
  ◯大澤昂志、秋野泰希、小比賀聡
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] DNAコード化ライブラリーへの応用を志向したクマリン－オリゴ核酸コンジュゲートの合成2023
- Author(s)
  ◯大澤昂志、小比賀聡
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-23K04930
[Presentation] 膵臓がん治療を目的とするアンチセンス核酸医薬の合成および評価2022
- Author(s)
  〇設樂華，児玉和己，國丸颯生，佐々木千愛，芹澤杏萌，三島啓士朗，三上敦士，大澤昂志，下條正仁，山口卓男，小比賀聡
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K15401
[Presentation] Ugi反応を基盤としたDNAコード化ライブラリー合成法の開発2022
- Author(s)
  〇喜多良介，大澤昂志，小比賀聡
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K15401
[Presentation] 1-オキサスピロ[4.5]デカン構造を有するチミジンアナログの合成と物性評価2021
- Author(s)
  〇矢野夏実，大澤昂志，小比賀聡
- Organizer
  第71年会日本薬学会関西支部大会・総会
- Data Source
  KAKENHI-PROJECT-20K15401
[Presentation] 細胞内還元条件で糖部配座が固定化されるアミド架橋型核酸の開発2021
- Author(s)
  〇宮田康介，大澤昂志，小比賀聡
- Organizer
  第71年会日本薬学会関西支部大会・総会
- Data Source
  KAKENHI-PROJECT-20K15401
[Presentation] Synthesis of an amide-linked dinucleotide containing a 3', 4'-bridged nucleic acid and duplex-forming ability of the modified oligonucleotides2021
- Author(s)
  ○Taiki Akino, Takashi Osawa, Satoshi Obika
- Organizer
  The 48th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15401
[Presentation] スピロケタール構造を有するチミジン誘導体の合成2018
- Author(s)
  ○張　睿珍、大澤昂志、伊藤勇太、張　功幸
- Organizer
  第138回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-17K18295
[Presentation] メチレンオキシ架橋をもつチミジンの合成およびそれを導入したオリゴ核酸の二重鎖核酸形成能2018
- Author(s)
  ○金ハン、大澤昂志、土肥正和、伊藤勇太、小比賀聡、張功幸
- Organizer
  第138回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-17K18295
[Presentation] アデニン塩基を持つ3′,4′-EoNAで修飾したオリゴ核酸の合成とその二重鎖形成能2018
- Author(s)
  ○大澤昂志、脇田佐和子、人見優香、金ハン、伊藤勇太、張　功幸
- Organizer
  第138回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-17K18295
[Presentation] Synthesis and properties of oligonucleotides including 2′-C,4′-C-methyleneoxy-bridged thymidines2018
- Author(s)
  ○Takashi Osawa, Han Kim, Misa Shoji, Masakazu Dohi, Yuta Ito, Satoshi Obika, Yoshiyuki Hari
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18295
[Presentation] 3′,4′-エチレンオキシ架橋型核酸の合成とその二重鎖核酸形成能2018
- Author(s)
  ○大澤昂志、脇田佐和子、人見優香、金ハン、伊藤勇太、張　功幸
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-17K18295
[Presentation] 3′,4′-エチレンオキシ架橋型5-メチルウリジンを導入したオリゴ核酸の合成とその相補鎖RNA結合能2017
- Author(s)
  ○大澤　昂志、人見　優香、脇田佐和子、土肥　正和、伊藤　勇太、小比賀　聡、張　功幸
- Organizer
  第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K18295
[Presentation] Synthesis of 3′,4′-ethyleneoxy-bridged 5-methyluridines with a 7′-methyl substituent and duplex-forming ability of their modified oligonucleotides2017
- Author(s)
  ○Takashi Osawa, Yuka Hitomi, Sawako Wakita, Masakazu Dohi, Yuta Ito, Satoshi Obika, Yoshiyuki Hari
- Organizer
  The 44th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18295

1. 三木康嗣 (60422979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 篠田渉 (70357193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 川口祥正 (90936808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 笠原勇矢 (10740673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OSAWA Takashi 大澤 昂志

Osawa Takashi 大澤 昂志

Research Projects

Research Products

Co-Researchers

Cell Membrane Permeation of Oligonucleotides Controlled by Membrane Modulator MoleculesArea Organizer

Area Organizer

Project Period (FY)

Research Category

細胞膜をゆらす核酸医薬の膜透過機構の総合理解と膜透過学の創成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核酸の膜透過を誘導するリン酸部修飾の探索と膜モジュレータ分子の機能評価Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of efficient synthetic methods for artificial nucleic acids aimed at improving activity and reducing toxicity of oligonucleotide medicinesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and evaluation of 2',3'-bridged nucleic acid with constrained conformation of sugar and phosphate backbonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthesis and properties of artificilal nucleic acids with spiroketal moiety based on the control of the conformation of sugar and phosphate backbonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of simple purification method for oligonucleotides synthesized using phosphoramidite for 5′-end modification as capping reagent2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of Coumarin-Conjugated Oligonucleotides <i>via</i> Knoevenagel Condensation to Prepare an Oligonucleotide Library2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] 強塩基処理できないオリゴ核酸の3'-アミノリンカー修飾法の開発2023

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3′,4′-Tetrahydropyran-Bridged Nucleic Acid2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Post‐Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex‐Forming Ability2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and properties of oligonucleotides bearing thymidine derivatives with 1,6-dioxaspiro[4.5]decane skeleton2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of the base triplets adjacent to a T-CG or 5-methylC-CG triplet in the triplex DNA2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New cleavable spacers for tandem synthesis of multiple oligonucleotides2021

Author(s)

Journal Title

DOI

OSAWA Takashi 大澤昂志

Osawa Takashi 大澤昂志