NI JUNJUN 倪軍軍

Researcher Number	00783953
Affiliation (based on the past Project Information) *help	2017 – 2020: 九州大学, 歯学研究院, 助教
Review Section/Research Field	Principal Investigator Functional basic dentistry Except Principal Investigator Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator 歯学 / Cathepsin E / Microglia / Alzheimer's disease / mitochondria / microglia / lysosomal leakage / cathepsin B Except Principal Investigator 脳炎症 / 時計遺伝 … More / 網羅的遺伝子解析 / ジンジバリス菌 / アルツハイマー病 / 炎症性反応 / 時計遺伝子 / ミクログリア Less

Possible involvement of impaired intrinsic microglial clock in Periodontotis-associated exacerbation of Alzheimer's disease
- Principal Investigator
  
  Nakanishi Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Yasuda Women's University
The enzymatic activity of Cathepsin E in Abeta degradationPrincipal Investigator
- Principal Investigator
  
  NI JUNJUN
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Kyushu University

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response2021
- Author(s)
  Nakanishi Hiroshi、Ni Junjun、Nonaka Saori、Hayashi Yoshinori
- Journal Title
  
  Neurochemistry International
  
  Volume: 142 Pages: 104905-104905
- DOI
  10.1016/j.neuint.2020.104905
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09896, KAKENHI-PROJECT-18K19650
[Journal Article] Generation of CSF1-Independent Ramified Microglia-Like Cells from Leptomeninges In Vitro2020
- Author(s)
  Tanaka J, Takahashi H, Yano H, Nakanishi H.
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 1 Pages: 24-37
- DOI
  10.3390/cells10010024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09333, KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-20K21465
[Journal Article] Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer’s disease.2020
- Author(s)
  Nakanishi H., Nonaka S., Wu Z.
- Journal Title
  
  CNS & Neurol Disod. Drug Targets
  
  Volume: 19 Issue: 7 Pages: 495-502
- DOI
  10.2174/1871527319666200708125130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] . Involvement of cathepsins in innate and adaptive immune responses in periodontitis.2020
- Author(s)
  Yan X, Wu Z, Wang B, Yu T, Hu Y, Wang S, Deng C, Zhao B, Nakanishi H, Zhang X.
- Journal Title
  
  Evid Based Complement Alternat Med.
  
  Volume: 2020 Issue: 1 Pages: 4517587-4517587
- DOI
  10.1155/2020/4517587
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] Neural stem cell?specific ITPA deficiency causes neural depolarization and epilepsy2020
- Author(s)
  Koga Yuichiro、Tsuchimoto Daisuke、Hayashi Yoshinori、Abolhassani Nona、Yoneshima Yasuto、Sakumi Kunihiko、Nakanishi Hiroshi、Toyokuni Shinya、Nakabeppu Yusaku
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 22
- DOI
  10.1172/jci.insight.140229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09896, KAKENHI-PROJECT-18K06960, KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-16H06276
[Journal Article] Secreted gingipains from Porphyromonas gingivalis induce microglial migration through endosomal signaling by protease-activated receptor 2.2020
- Author(s)
  Nonaka S, Nakanishi H.
- Journal Title
  
  Neurochem. Int.
  
  Volume: 140 Pages: 104840-104840
- DOI
  10.1016/j.neuint.2020.104840
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging.2020
- Author(s)
  Nakanishi H.
- Journal Title
  
  Neural Regener Res
  
  Volume: 15 Issue: 1 Pages: 25-29
- DOI
  10.4103/1673-5374.264444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] Cathepsin regulation on microglial function.2020
- Author(s)
  Nakanishi H.
- Journal Title
  
  Biophys Biochim Acta Proteins Proteom.
  
  Volume: 1868 Issue: 9 Pages: 140465-140465
- DOI
  10.1016/j.bbapap.2020.140465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] Mutations of beta-amyloid precursor protein after the consequence of Alzheimer's disease pathogenesis.2019
- Author(s)
  Li NM, Liu KF, Qiu YJ, Zhang HH, Nakanishi H, Qing H.
- Journal Title
  
  Neural Regen Res.
  
  Volume: 14 Issue: 4 Pages: 658-665
- DOI
  10.4103/1673-5374.247469
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] Microglial clearance of focal apoptotic synapses.2019
- Author(s)
  Nonaka S, Nakanishi H.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 707 Pages: 134317-134317
- DOI
  10.1016/j.neulet.2019.134317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.2019
- Author(s)
  Ni J, Wu Z, Meng J, Saito T, Saido TC, Qing H, Nakanishi H.
- Journal Title
  
  J. Neuroinflamm.
  
  Volume: 16 Issue: 1 Pages: 173-173
- DOI
  10.1186/s12974-019-1562-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.2019
- Author(s)
  Harada Y, Zhang J, Imari K, Yamasaki R, Ni J, Wu Z, Yamamoto K, Kira JI, Nakanishi H, Hayashi Y.
- Journal Title
  
  Pain
  
  Volume: 160 Issue: 9 Pages: 2050-2062
- DOI
  10.1097/j.pain.0000000000001596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-16K11477
[Journal Article] Induction of bone repair in rat calvarial defects using a combination of hydroxyapatite with phosphatidylserine liposomes2019
- Author(s)
  Hatakeyama J, Anan H, Hatakeyama Y, Matsumoto N, Takayama F, Wu Z, Matsuzaki E, Minakami M, Izumi T, Nakanishi H
- Journal Title
  
  Journal of Oral Science
  
  Volume: 61 Issue: 1 Pages: 111-118
- DOI
  10.2334/josnusd.17-0488
- NAID
  130007626633
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11032, KAKENHI-PROJECT-17K11728, KAKENHI-PROJECT-18K19650
[Journal Article] Pterostilbene, an active component of the dragon’s blood extract, acts as an antiderpressant in adult rats.2019
- Author(s)
  Yang L, Ran Y, Quan Z, Wang R, Yang Q, Jia Q, Zhang H, Li Y, Peng Y, Liang J, Wang H, Nakanishi H, Deng Y, Qing H.
- Journal Title
  
  Psychopharmacology (Berl)
  
  Volume: 14 Issue: 4 Pages: 658-665
- DOI
  10.1007/s00213-018-5138-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice.2018
- Author(s)
  Ni J, Wu Z, Stoka V, Meng J, Hayashi Y, Peters C, Qing H, Turk V, Nakanishi H. Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice
- Journal Title
  
  Aging Cell
  
  Volume: . Issue: 1
- DOI
  10.1111/acel.12856
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11477, KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-17K17093
[Journal Article] Manipulation of hippocampal CA3 firing via luminopsins modulates spatial and episodic short-term memory, especially working memory, but not long-term memory.2018
- Author(s)
  Song D, Yang Q, Lang Y, Wen Z, Xie Z, Zheng D, Yan T, Deng Y, Nakanishi H, Qing H
- Journal Title
  
  Neurobiol Learn Mem
  
  Volume: 155 Pages: 435-445
- DOI
  10.1016/j.nlm.2018.09.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19650
[Journal Article] Brazilian green propolis prevents cognitive decline into mild cognitive impairment in elderly people living at high altitude.2018
- Author(s)
  Zhu A, Wu Z, Zhong X, Ni J, Li Y, Meng J, Du C, Zhao X, Nakanishi H, Wu S
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 63 Issue: 2 Pages: 551-560
- DOI
  10.3233/jad-170630
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-16H05848, KAKENHI-PROJECT-17K17093
[Journal Article] The critical role of IL-10 in the antineuroinflammatory and antioxidant effects of Rheum tanguticum on activated microglia.2018
- Author(s)
  Meng J, Ni J, Wu Z, Jiang M, Zhu A, Qing H, Nakanishi H.
- Journal Title
  
  Oxid Med Cell Longev
  
  Volume: 2018:1083596 Issue: 1 Pages: 1-12
- DOI
  10.1155/2018/1083596
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-16H05848, KAKENHI-PROJECT-16K11478, KAKENHI-PROJECT-17K17093
[Journal Article] A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.2018
- Author(s)
  Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI.
- Journal Title
  
  Annals of Neurology
  
  Volume: 84 Issue: 2 Pages: 208-224
- DOI
  10.1002/ana.25279
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11477, KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-17K19663, KAKENHI-PROJECT-17H01391
[Journal Article] Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice2017
- Author(s)
  Liu Yicong、Wu Zhou、Nakanishi Yurika、Ni Junjun、Hayashi Yoshinori、Takayama Fumiko、Zhou Yanmin、Kadawaki Tomoko、Nakanishi Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-017-12173-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11478, KAKENHI-PROJECT-16H05848, KAKENHI-PROJECT-15K11079, KAKENHI-PROJECT-18K19650
[Presentation] An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain2019
- Author(s)
  Junjun Ni、中西博、武洲
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] Involvement of endosomal signaling in gingipain-induced migration, inflammation response and phagocytosis in microglia after activation of PAR2、2019
- Author(s)
  Nonaka S, Iseki A, Amano A, Nakanishi Y, Ni J, Wu Z, Nakanishi H.
- Organizer
  XIV European meeting on glial cells in health and disease (GLIA 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] Cathepsin H deficiency suppresses hypoxic-ischemia-induced hippocampal atrophy in mice through reduced secretion of IFN-beta from microglia2019
- Author(s)
  Ni J, Wu Z, Nakanishi H,
- Organizer
  第24回グリア研究会
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] Secreted gingipains from Porphyromonas gingivalis induce microglia migration through endosomal signaling by protease-activated receptor 22019
- Author(s)
  Nonaka S, Nakanishi H.
- Organizer
  第24回グリア研究会
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] Involvement of reduced microglial BMAL1 expression in excessive neuroinflammation of APP knock-in (APP-KI) mice.2018
- Author(s)
  Ni J, Wu Z, Nonaka S, Saido TC, Nakanishi H
- Organizer
  第23回グリア研究
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] Potential causative role of disrupted intrinsic microglial clock in the excessive neuroinflammation associated with Alzheimer’s disease2018
- Author(s)
  Junjun Ni, Wu Z, Hiroshi Nakanishi
- Organizer
  Glial assembly: a new regulatory machinery of brain function and disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17093
[Presentation] チベット薬Ratanasampilは低酸素によるミクログリアにおける酸化ストレスならびにNF-kappaB活性化に依存した炎症反応を抑制する2018
- Author(s)
  Jie Meng、Junjun Ni、林　良憲、中西　博、朱　愛琴、武　洲
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] Microglia facilitate brain aging and cognitive impairment through cathepsin B-dependent oxidative and inflammatory responses2018
- Author(s)
  Junjun Ni, Zhou Wu, Yoshinori Hayashi, Hiroshi Nakanishi
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K17093
[Presentation] Critical roles of Cathepsin B in chronic neuroinflammation in hypoxic-ischemia, aging and Porphyromonas gingivalis induced Alzheimer’s disease mouse models2018
- Author(s)
  Junjun Ni and Zhou Wu
- Organizer
  Kyudai Oral Bioscience
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17093
[Presentation] Increased expression and altered subcellular distribution of cathepsin B in microglia induces cognitive impairment through oxidative stress and inflammatory response in mice2018
- Author(s)
  Junjun Ni
- Organizer
  Chinese
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17093
[Presentation] ミクログリアにおけるカテプシンBの発現増加及び細胞内分布変化はマウスにおける酸化ストレスや炎症反応による認知障害を誘発する2018
- Author(s)
  Junjun Ni、武　洲、林　良憲、中西　博
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] Involvement of reduced microglial BMAL1 expression in excessive neuroinflammation of APP knock-in (APP-KI) mice2018
- Author(s)
  Junjun Ni, Zhou Wu, Saori Nonaka, Takaomi C Saido, Hiroshi Nakanishi
- Organizer
  第23回グリア研究会
- Data Source
  KAKENHI-PROJECT-17K17093
[Presentation] ミクログリアにおけるカテプシン増大と細胞内の分布変化は、酸化ストレスならびに炎症反応を介して認知障害をもたらす2018
- Author(s)
  Junjuin Ni、武洲、林良憲、中西博
- Organizer
  第71回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] Increased expression and altered subcellular distribution of cathepsin B in microglia induces cognitive impairment through oxidative stress and inflammatory response in mice2018
- Author(s)
  Junjun Ni, Zhou Wu, Yoshinori Hayashi, Hiroshi Nakanishi
- Organizer
  第71回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-17K17093
[Presentation] チベット薬Ratanasampilは、低酸素によるミクログリアにおける酸化ストレスならびにNF-kappaB活性化に依存した炎症反応を抑制する2018
- Author(s)
  孟ジェイ、朱愛琴、Junjuin Ni、林良憲、中西博、武洲
- Organizer
  第71回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] ブラジル産グリーンプロポリスはチベット高原に住む高齢者の全身炎症を軽減して認知機能の低下を防ぐ2018
- Author(s)
  朱　愛琴、Junjun Ni、Jie Meng、中西　博、武　洲
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19650
[Presentation] Microglia facilitate brain aging and cognitive impairment through cathepsinB-dependent Oxidative and inflammatory responses2018
- Author(s)
  Junjun Ni, Zhou Wu, Veronika Stoka, JieMeng, Yoshinori Hayashi, Christoph Peters, Hong Qing, Vito Turk, Hiroshi Nakanishi
- Organizer
  Society of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17093
[Presentation] Disruption of intrinsic circadian clock function of cortical microglia in APP knock-in mice2017
- Author(s)
  Junjun Ni and Hiroshi Nakanishi
- Organizer
  新学術領域研究「グリアアセンブリによる脳機能発現の制御と病態」
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17093
[Presentation] Increased expression and altered subcellular distribution of cathepsin B in microglia induces cognitive impairment through oxidative stress and inflammatory response in mice2017
- Author(s)
  Junjun Ni, Zhou Wu, Hiroshi Nakanishi
- Organizer
  第 22 回グリア研究会
- Data Source
  KAKENHI-PROJECT-17K17093

1. Nakanishi Hiroshi (20155774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
2. 林良憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
3. 武洲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 高橋寿明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NI JUNJUN 倪 軍軍

Research Projects

Research Products

Co-Researchers

Possible involvement of impaired intrinsic microglial clock in Periodontotis-associated exacerbation of Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The enzymatic activity of Cathepsin E in Abeta degradationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of CSF1-Independent Ramified Microglia-Like Cells from Leptomeninges In Vitro2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer’s disease.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] . Involvement of cathepsins in innate and adaptive immune responses in periodontitis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neural stem cell?specific ITPA deficiency causes neural depolarization and epilepsy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Secreted gingipains from Porphyromonas gingivalis induce microglial migration through endosomal signaling by protease-activated receptor 2.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cathepsin regulation on microglial function.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutations of beta-amyloid precursor protein after the consequence of Alzheimer's disease pathogenesis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglial clearance of focal apoptotic synapses.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Induction of bone repair in rat calvarial defects using a combination of hydroxyapatite with phosphatidylserine liposomes2019

Author(s)

Journal Title

DOI

NI JUNJUN 倪軍軍