Fukumori Akio 福森亮雄

Researcher Number	00788185
Other IDs
Affiliation (Current)	2025: 大阪医科薬科大学, 薬学部, 教授 2025: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 客員研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 大阪医科薬科大学, 薬学部, 教授 2020: 大阪薬科大学, 薬学部, 教授 2018 – 2019: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 室長 2017: 大阪大学, キャンパスライフ健康支援センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Psychiatric science Except Principal Investigator Basic Section 52030:Psychiatry-related / Basic Section 58010:Medical management and medical sociology-related
Keywords	Principal Investigator アルツハイマー病 / APP / 基質結合部位 / 膜内タンパク分解酵素 / ニカストリン / エクソサイト / 光親和性クロスリンク / 非天然アミノ酸 / アミロイド前駆体蛋白 / プレセニリン / γセクレターゼ / ガンマセクレターゼ … More Except Principal Investigator … More 認知症 / タウ / アルツハイマー / サポート / 服薬支援 / 服薬介助 / 多職種連携 / 介入 / 薬局薬剤師 / 地域包括ケア / 薬剤師 / 薬局 / 介護負担 / 自己免疫 / ウサギ網赤血球系蛋白合成システム / マウス脳ライセート / NMDA受容体抗体 / 精神疾患 / 自己免疫性脳炎 / cell based assay / 膜蛋白 / ラジオリガンドアッセイ / コムギ胚芽由来蛋白合成システム / ウサギ網赤血球由来蛋白合成システム / 抗NMDA受容体抗体 Less

Study and development of ultrastructure-specific molecular model of dementia-related protein
- Principal Investigator
  
  田中稔久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Mie University
基質結合部位を標的とする副作用を抑えたアルツハイマー病の治療薬開発Principal Investigator
- Principal Investigator
  
  福森亮雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Establish a comprehensive pharmacy-based dementia support system and evaluate its effectiveness.
- Principal Investigator
  
  Mitsuko Mitsuko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Development and measurement of anti-NMDA receptor antibody assay in blood to elucidate the etiology of psychiatric disorders
- Principal Investigator
  
  Matsunaga Hidenori
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Osaka General Medical Center
Elucidation of the mechanism of exosite and its application to the treatment of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Fukumori Akio
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center for Geriatrics and Gerontology
  Osaka University

All 2024 2023 2022 2020 2019 2018

All Journal Article Presentation

[Journal Article] APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain2023
- Author(s)
  Yanagida K, Maruyama R, Tagami S, Kudo T, Okochi M, Fukumori A.
- Journal Title
  
  Psychogeriatrics
  
  Volume: 23 Issue: 2 Pages: 311-318
- DOI
  10.1111/psyg.12933
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07559, KAKENHI-PROJECT-23K10903
[Journal Article] Interaction between APOE genotype and diabetes in cognitive decline2020
- Author(s)
  Shinohara Mitsuru、Tashiro Yoshitaka、Suzuki Kaoru、Fukumori Akio、Bu Guojun、Sato Naoyuki
- Journal Title
  
  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
  
  Volume: 12 Issue: 1 Pages: 2425-2435
- DOI
  10.1002/dad2.12006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04154, KAKENHI-PROJECT-18H02725, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K10304
[Journal Article] Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation.2020
- Author(s)
  Trambauer J, Rodriguez Sarmiento RM, Fukumori A, Feederle R, Baumann K, Steiner H.
- Journal Title
  
  EMBO Rep.
  
  Volume: 21 Issue: 1
- DOI
  10.15252/embr.201947996
- Data Source
  KAKENHI-PROJECT-17K10304
[Journal Article] Interaction Between APOE Genotype and Diabetes in Cognitive Decline2020
- Author(s)
  Shinohara M, Tashiro Y, Suzuki K, Fukumori A, Bu G, Sato N.
- Journal Title
  
  Alzheimers Dement (Amst) .
  
  Volume: 12 Pages: 54-63
- DOI
  10.1016/j.semcdb.2020.03.006
- Data Source
  KAKENHI-PROJECT-17K10304
[Journal Article] Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis2019
- Author(s)
  Mentrup Torben、Theodorou Kosta、Cabrera-Cabrera Florencia、Helbig Andreas O.、Happ Kathrin、Gijbels Marion、Gradtke Ann-Christine、Rabe Bjoern、Fukumori Akio、Steiner Harald、Tholey Andreas、Fluhrer Regina、Donners Marjo、Schroeder Bernd
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 216 Issue: 4 Pages: 807-830
- DOI
  10.1084/jem.20171438
- Data Source
  KAKENHI-PROJECT-17K10304
[Journal Article] Two Neuropsychiatric Cases Seropositive for Bornavirus Improved by Ribavirin2018
- Author(s)
  Matsunaga Hidenori、Fukumori Akio、Mori Kohji、Honda Tomoyuki、Uema Takeshi、Tomonaga Keizo
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 71 Issue: 5 Pages: 338-342
- DOI
  10.7883/yoken.JJID.2017.585
- NAID
  130007485755
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2018-09-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19449, KAKENHI-PROJECT-17K10304, KAKENHI-PROJECT-18K19515, KAKENHI-PROJECT-17H05091
[Presentation] 認知症関連蛋白であるタウ蛋白の重合過程における蛋白間分子架橋の影響についての検討2024
- Author(s)
  中嶋美奈、岡田健、柳田寛太、西田沙妃、福森亮雄、田中稔久
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K07011
[Presentation] γ-Secretase exosites as targets for substrate-selective inhibition of intramembrane proteolysis2023
- Author(s)
  Akio Fukumori
- Organizer
  12th General Meeting of the International Proteolysis Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K10903
[Presentation] 自閉症の原因遺伝子であるNLGN4 の切断2023
- Author(s)
  乾菜々美、柳田寛太、新宮愛、山口敬子、岡田健、福森亮雄
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K10903
[Presentation] アミロイドペプチドAβ49の合成研究2023
- Author(s)
  萩原大耀、田中晶子、佐藤浩平、間瀬暢之、福森亮雄、鳴海哲夫
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K10903
[Presentation] L1CAMの膜の内外でのプロテアーゼ切断2023
- Author(s)
  中尾和都、柳田寛太、新宮愛、山口敬子、岡田健、福森亮雄
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K10903
[Presentation] 認知症患者の介護者における介護負担感と服薬介助の関連2022
- Author(s)
  木科早瑛、前田初代、福森亮雄、恩田光子
- Organizer
  第24回医薬品情報学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10316
[Presentation] γ-セクレターゼのエクソサイトでの基質認識はAPP C99の細胞外部位の立体構造変化に感受性がある。2018
- Author(s)
  福森亮雄、丸山理気、舟本聡、工藤喬、Harald Steiner
- Organizer
  第37回　日本認知症学会　学術集会
- Data Source
  KAKENHI-PROJECT-17K10304
[Presentation] Targeting APP substrate binding of γ-secretase as potential therapeuticapproach for Alzheimer's disease2018
- Author(s)
  Akio Fukumori
- Organizer
  Asia Pacific Regional Congress of Biological Psychiatry 2018.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10304

1. Matsunaga Hidenori (70603843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Mitsuko Mitsuko (60301842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 工藤喬 (10273632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 多田敬典 (20464993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 田中惠子 (30217020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 田中稔久 (10294068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 渡邉淳 (90321843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAGAMI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 里直行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 森康治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fukumori Akio 福森 亮雄

Research Projects

Research Products

Co-Researchers

Study and development of ultrastructure-specific molecular model of dementia-related protein

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

基質結合部位を標的とする副作用を抑えたアルツハイマー病の治療薬開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establish a comprehensive pharmacy-based dementia support system and evaluate its effectiveness.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and measurement of anti-NMDA receptor antibody assay in blood to elucidate the etiology of psychiatric disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of exosite and its application to the treatment of Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interaction between APOE genotype and diabetes in cognitive decline2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interaction Between APOE Genotype and Diabetes in Cognitive Decline2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two Neuropsychiatric Cases Seropositive for Bornavirus Improved by Ribavirin2018

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Presentation] 認知症関連蛋白であるタウ蛋白の重合過程における蛋白間分子架橋の影響についての検討2024

Author(s)

Organizer

Data Source

[Presentation] γ-Secretase exosites as targets for substrate-selective inhibition of intramembrane proteolysis2023

Author(s)

Organizer

Data Source

[Presentation] 自閉症の原因遺伝子であるNLGN4 の切断2023

Author(s)

Organizer

Data Source

Fukumori Akio 福森亮雄