Masubuchi Nami 増渕菜弥

Researcher Number	00791641
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 非常勤助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 特任助教 2020: 順天堂大学, 医学(系)研究科(研究院), 特任助教 2018 – 2019: 順天堂大学, 医学(系)研究科(研究院), 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 翻訳後修飾 / Calreticulin / サイトカイン受容体 / 分子シャペロン / calreticulin / 骨髄増殖性腫瘍 / サイトカイン / トロンボポエチン受容体

Elucidation of receptor maturation mechanism that causes myeloproliferative neoplasmsPrincipal Investigator
- Principal Investigator
  
  Masubuchi Nami
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Search for target molecules for myeloproliferative neoplasmsPrincipal Investigator
- Principal Investigator
  
  Masubuchi Nami
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University

All 2022 2021 2019 2018

All Journal Article Presentation

[Journal Article] A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation2022
- Author(s)
  Watari Hiromi、Kageyama Hiromu、Masubuchi Nami、Nakajima Hiroya、Onodera Kako、Focia Pamela J.、Oshiro Takumi、Matsui Takashi、Kodera Yoshio、Ogawa Tomohisa、Yokoyama Takeshi、Hirayama Makoto、Hori Kanji、Freymann Douglas M.、Imai Misa、Komatsu Norio、Araki Marito、Tanaka Yoshikazu、Sakai Ryuichi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 7262-7262
- DOI
  10.1038/s41467-022-34921-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06036, KAKENHI-PROJECT-21K08405, KAKENHI-PROJECT-21K18321, KAKENHI-PROJECT-21K19201, KAKENHI-PROJECT-22K20589, KAKENHI-PROJECT-19KK0178, KAKENHI-PUBLICLY-21H05712, KAKENHI-PROJECT-19H00918, KAKENHI-PROJECT-23K23695, KAKENHI-PROJECT-23K24176
[Journal Article] Phase 1 Clinical Trial of PPMX‐T003, a Novel Human Monoclonal Antibody Specific for Transferrin Receptor 1, to Evaluate Its Safety, Pharmacokinetics, and Pharmacodynamics2022
- Author(s)
  Ogama Yoichiro、Kumagai Yuji、Komatsu Norio、Araki Marito、Masubuchi Nami、Akiyoshi Hiroko、Matsuura Tadashi、Kirisako Hiromi、Kyoya Akiko、Nomura Fumiko、Ohira Yuta、Yokokawa Takuya、Yamamoto Yukiya
- Journal Title
  
  Clinical Pharmacology in Drug Development
  
  Volume: 0 Issue: 6 Pages: 1-9
- DOI
  10.1002/cpdd.1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08405
[Journal Article] Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety2021
- Author(s)
  Watari Hiromi、Kageyama Hiromu、Masubuchi Nami、Nakajima Hiroya、Onodera Kako、Focia Pamela J.、Oshiro Takumi、Matsui Takashi、Kodera Yoshio、Ogawa Tomohisa、Yokoyama Takeshi、Hirayama Makoto、Hori Kanji、Freymann Douglas M.、Komatsu Norio、Araki Marito、Tanaka Yoshikazu、Sakai Ryuichi
- Journal Title
  
  bioRixiv
  
  Volume: -
- DOI
  10.1101/2021.10.29.466502
- Open Access
- Data Source
  KAKENHI-PROJECT-21K08405, KAKENHI-PROJECT-20J11377
[Journal Article] Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface2019
- Author(s)
  Masubuchi Nami、Araki Marito、Yang Yinjie、Hayashi Erina、Imai Misa、Edahiro Yoko、Hironaka Yumi、Mizukami Yoshihisa、Kihara Yoshihiko、Takei Hiraku、Nudejima Mai、Koike Masato、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 34 Issue: 2 Pages: 499-509
- DOI
  10.1038/s41375-019-0564-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16126
[Journal Article] Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation2018
- Author(s)
  Araki Marito、Yang Yinjie、Imai Misa、Mizukami Yoshihisa、Kihara Yoshihiko、Sunami Yoshitaka、Masubuchi Nami、Edahiro Yoko、Hironaka Yumi、Osaga Satoshi、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 1 Pages: 122-131
- DOI
  10.1038/s41375-018-0181-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16100, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859
[Presentation] Endogenous expression of MPLW515L showed a weak oncogenic capacity in UT-7/TPO cells.2022
- Author(s)
  Terumi Baba, Nami Masubuchi, Soji Morishita, Kaho Shioiri, Yoshihiko Kihara, Miki Ando, Marito Araki, Norio Komatsu.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08405
[Presentation] Elucidation of the molecular mechanism for the cleavage of mutant calreticulin.2022
- Author(s)
  Shumpei Yoshikawa, Marito Araki, Yoshihiko Kihara, Nami Masubuchi, Yinjie Yang, Soji Morishita, Misa Imai, Yoko Edahiro, Miki Ando, Norio Komatsu.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08405
[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients.2021
- Author(s)
  Ogata S，Araki M，Kihara Y，Okuda M， Morishita S，Imai M，Masubuchi N，Mori Y，Yinjie Y，Yoshikawa S，Ochiai T，Shirane S， Edahiro Y，Ando J，Komatsu N.
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08405
[Presentation] Marine sponge lectin reveals the mechanism of sugar-chain mediated activation of MPL.2021
- Author(s)
  Watari H，Kageyama H，Nakajia H，Onodera K， Masubuchi N，Oshiro T，Matsui T，Kodera Y， Ogawa T，Hirayama M，Hori K，Yokoyama T， Komatsu N，Araki M，Tanaka Y， Sakai R.
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08405
[Presentation] 変異型CALRはMPLと分泌経路で相互作用し細胞表面で活性化を引き起こす2019
- Author(s)
  増渕菜弥, 荒木真理人, 楊印杰, 林英里奈, 今井美沙, 枝廣陽子, 弘中由美, 水上喜久, 木原慶彦, 小池正人, 大坂顯通, 小松則夫
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16098
[Presentation] 分泌経路における変異型分子シャペロンとサイトカイン受容体の会合による細胞の腫瘍化2019
- Author(s)
  増渕菜弥、荒木真理人、木原慶彦、楊印杰、今井美沙、水上喜久、林英里奈、弘中由美、竹井拓、枝廣陽子、大坂顯通、小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16098
[Presentation] 変異型CALRの多量体化はMPLとの結合と活性化に必須である2018
- Author(s)
  荒木真理人, 楊印杰, 今井美沙, 水上喜久, 木原慶彦, 角南義孝, 増渕菜弥, 枝廣陽子, 弘中由美, 大佐賀智, 大坂顯通, 小松則夫
- Organizer
  第８０回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16098

1. 堂前直 (00321787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 小松則夫 (50186798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. 荒木真理人 (80613843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 松井崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 横山武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Masubuchi Nami 増渕 菜弥

Research Projects

Research Products

Co-Researchers

Elucidation of receptor maturation mechanism that causes myeloproliferative neoplasmsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for target molecules for myeloproliferative neoplasmsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase 1 Clinical Trial of PPMX‐T003, a Novel Human Monoclonal Antibody Specific for Transferrin Receptor 1, to Evaluate Its Safety, Pharmacokinetics, and Pharmacodynamics2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Endogenous expression of MPLW515L showed a weak oncogenic capacity in UT-7/TPO cells.2022

Author(s)

Organizer

Data Source

[Presentation] Elucidation of the molecular mechanism for the cleavage of mutant calreticulin.2022

Author(s)

Organizer

Data Source

[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients.2021

Author(s)

Organizer

Data Source

[Presentation] Marine sponge lectin reveals the mechanism of sugar-chain mediated activation of MPL.2021

Author(s)

Organizer

Data Source

[Presentation] 変異型CALRはMPLと分泌経路で相互作用し細胞表面で活性化を引き起こす2019

Author(s)

Organizer

Data Source

[Presentation] 分泌経路における変異型分子シャペロンとサイトカイン受容体の会合による細胞の腫瘍化2019

Author(s)

Organizer

Data Source

[Presentation] 変異型CALRの多量体化はMPLとの結合と活性化に必須である2018

Author(s)

Organizer

Data Source

Masubuchi Nami 増渕菜弥