Kamba Keisuke 神庭圭佑

Researcher Number	00795049
Other IDs
Affiliation (based on the past Project Information) *help	2022 – 2023: 京都大学, エネルギー理工学研究所, 研究員 2017 – 2019: 京都大学, エネルギー理工学研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Physical pharmacy
Keywords	Principal Investigator 阻害 / グルコース / ウイルスベクター / 癌 / 選択的標識 / タンパク質複合体 / Vif / HIV / APOBEC3G / 相互作用 / NMR / 生体分子

Development of cancer selective infectious virus vector that slows tumor growthPrincipal Investigator
- Principal Investigator
  
  神庭圭佑
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyoto University
Inactivation mechanism of HIV Vif protein using host cellular proteins against human anti-viral factorPrincipal Investigator
- Principal Investigator
  
  Kamba Keisuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University

All 2024 2023 2022 2019 2018 2017

All Journal Article Presentation

[Journal Article] Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway2024
- Author(s)
  Keisuke Kamba, Li Wan, Satoru Unzai, Ryo Morishita, Akifumi Takaori-Kondo, Takashi Nagata, Masato Katahira
- Journal Title
  
  Biophys. J.
  
  Volume: 123 Issue: 3 Pages: 294-306
- DOI
  10.1016/j.bpj.2023.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15558, KAKENHI-PROJECT-23K05664, KAKENHI-PROJECT-20K06524, KAKENHI-PUBLICLY-23H04069
[Journal Article] Selection and characterization of aptamers targeting the Vif-CBFβ-ELOB-ELOC-CUL5 complex2024
- Author(s)
  Kazuyuki Kumagai, Keisuke Kamba2, Takuya Suzuki, Yuto Sekikawa, Chisato Yuki, Michiaki Hamada, Kayoko Nagata, Akifumi Takaori-Kondo, Li Wan, Masato Katahira, Takashi Nagata, Taiichi Sakamoto
- Journal Title
  
  J Biochem.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15558
[Journal Article] NMR characterization of the structure of the intrinsically disordered region of human origin recognition complex subunit 1, hORC1, and of its interaction with G-quadruplex DNAs2023
- Author(s)
  Afaf Eladl, Yudai Yamaoki, Keisuke Kamba, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Shou Waga, Takashi Nagata, Masato Katahira
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 683 Pages: 149112-149112
- DOI
  10.1016/j.bbrc.2023.10.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15558, KAKENHI-PROJECT-23K05664, KAKENHI-PROJECT-20K06524, KAKENHI-PUBLICLY-22H05596
[Journal Article] An insight into the dependence of the deamination rate of human APOBEC3F on the length of single-stranded DNA, which is affected by the concentrations of APOBEC3F and single-stranded DNA2019
- Author(s)
  Wan Li、Kamba Keisuke、Nagata Takashi、Katahira Masato
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: In Press Issue: 2 Pages: 129346-129346
- DOI
  10.1016/j.bbagen.2019.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19397, KAKENHI-PROJECT-17K15434, KAKENHI-PUBLICLY-17H05878, KAKENHI-PROJECT-17K07307
[Journal Article] The C-terminal cytidine deaminase domain of APOBEC3G itself undergoes intersegmental transfer for a target search, as revealed by real-time NMR monitoring2018
- Author(s)
  Kamba Keisuke、Nagata Takashi、Katahira Masato
- Journal Title
  
  Phys Chem Chem Phys
  
  Volume: 20 Issue: 5 Pages: 2976-2981
- DOI
  10.1039/c7cp05171a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07307, KAKENHI-PROJECT-17K15434, KAKENHI-PUBLICLY-16H00833, KAKENHI-PUBLICLY-17H05878, KAKENHI-PROJECT-26440026
[Presentation] HIV-1 Vif-ヒトE3ユビキチンリガーゼ複合体がAPOBEC3A 及び APOBEC3Cの脱アミノ化に及ぼす影響の解析2023
- Author(s)
  兎澤賢太郎、神庭圭佑、岩岡諒、永田崇、片平正人
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] Investigation on the structure of the DNA-binding region of human origin recognition complex subunit 12023
- Author(s)
  Shou Waga, Yudai Yamaoki, Afaf Eladl, Keisuke Kamba, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Takashi Nagata, Masato Katahira
- Organizer
  The 14th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] HIV-1 Vif directly inhibit against human APOBEC3G deaminases independent of the ubiquitin-proteasome pathway2023
- Author(s)
  Keisuke Kamba, Li Wan, Satoru Unzai, Ryo Morishita, Akifumi Takaori-Kondo, Takashi Nagata, Masato Katahira
- Organizer
  23rd ISMAR Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] HIV-1 Vifと宿主タンパク質の五者複合体による抗ウイルス因子APOBEC3Gの脱アミノ化活性阻害の分子機構の解明2022
- Author(s)
  神庭圭佑、万里、雲財悟、森下了、永田崇、片平正人
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] HIV-1 Vif-ヒトE3ユビキチンリガーゼ複合体はヒト抗ウイルス因子APOBEC3Cの脱アミノ化を阻害する2022
- Author(s)
  兎澤賢太郎、神庭圭佑、岩岡諒、永田崇、片平正人
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] HIV-1 Vifタンパク質によるヒト抗ウイルス因子APOBEC3タンパク質のマルチファセットな無力化: ユビキチン化と脱アミノ化阻害演題名：未知のHIV-1 Gag二量体化制御単位の同定と構造生物学的性質決定2022
- Author(s)
  神庭圭佑、万里、兎澤賢太郎、雲財悟、森下了、永田崇、片平正人
- Organizer
  第60回日本生物物理会年会
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] 未知のHIV-1 Gag二量体化制御単位の同定と構造生物学的性質決定2022
- Author(s)
  小谷治、駒貴明、神庭圭佑、森田泰基、横山勝、土肥直哉、近藤智之、永田崇、足立昭夫、片平正人、野間口雅子、佐藤裕徳
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] HIV-1-Vif: E3ユビキチンリガーゼ複合体を構成するタンパク質とヒトAPOBEC3Gタンパク質の相互作用の加算効果が、脱アミノ化阻害をもたらし得る2022
- Author(s)
  神庭圭佑、万里、兎澤賢太郎、雲財悟、森下了、永田崇、片平正人
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] Investigation on the structure of the DNA-binding region of human origin recognition complex subunit 12022
- Author(s)
  Waga S., Kamba K., Yamaoki Y., Eladl M. M. A. S., Hoshina S., Horinouchi H., Kondo K., Nagata T. and Katahira M.
- Organizer
  The 13th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] Analysis of the dimerization of the Matrix domain of HIV-1 gag protein2022
- Author(s)
  Morita T., Kamba K., Kunjiveedu C. P., Kotani O., Koma T., Yokoyama M., Doi N., Kondo T., Adachi A., Nomaguchi M., Sato H., Nagata T. and Katahira M.
- Organizer
  The 13th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15558
[Presentation] HIV Vifによるユビキチン化を介さないヒトAOBEC3G活性の阻害2019
- Author(s)
  神庭圭佑、万里、雲財悟、森下了、永田崇、片平正人
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] HIV Vif-ヒトE3ユビキチンリガーゼ複合体によるヒト抗ウイルス因子APOBEC3Gの脱アミノ化阻害の分子メカニズム2019
- Author(s)
  神庭圭佑、万里、雲財悟、森下了、永田崇、片平正人
- Organizer
  第57回日本生物物理会年会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] Development of RNAs that bind to the Vif - CBFβ - CUL 5 - ELOB - ELOC complex2019
- Author(s)
  Kumagai K., Suzuki T., Sekikawa Y., Kamba K., Wan L., Nagata K., Takaori-Kondo A., Katahira M., Nagata T. and Sakamoto T.
- Organizer
  The 10th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] An insight into the target search and HIV Vif-dependent inactivation of APOBEC3F and APOBEC3G elucidated by tracking the deamination events2019
- Author(s)
  Kamba K., Wan L., Unzai S., Morishita R. Nagata T. and Katahira M
- Organizer
  8th Asia-Pacific NMR Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] Vif - CBFβ - CUL5 - ELOB - ELOC 複合体に結合するアプタマーの解析2019
- Author(s)
  熊谷紀志, 鈴木拓也, 関川湧斗, 神庭圭佑, 万里, 永田佳代子, 高折晃史, 片平正人, 永田崇, 坂本泰一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] APOBEC3Fと APOBEC3Gの脱アミノ化速度は、それら及びDNAの濃度、さらにDNAの長さに影響を受ける2019
- Author(s)
  神庭圭佑、万里、永田崇、片平正人
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] The effect of the distance between the RNA sequences recognized by two RNA-binding domains on the affinity of the MSI1-RNA interaction2019
- Author(s)
  Tu. W. H., Kamba K., Nagata T. and Katahira M.
- Organizer
  第57回日本生物物理会年会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] HIV Vif-ヒトE3ユビキチンリガーゼ複合体はAPOBEC3Gの脱アミノ化を直接阻害する2018
- Author(s)
  神庭圭佑、汪寧馨、雲財悟、森下了、永田崇、片平正人
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] Characteristics of the C-terminal domain of anti-viral factor APOBEC3G: mechanism behind a target search and inhibition by HIV-1 Vif protein2018
- Author(s)
  Kamba K., Nagata T. and Katahira M.
- Organizer
  The XXVIIIth International Conference on Magnetic Resonance in Biological Systems (ICMRBS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] ヒト抗ウイルス因子APOBEC3Gの標的配列探索と、HIV-VifによるAPOBEC3G阻害メカニズムの研究2018
- Author(s)
  神庭圭佑
- Organizer
  定量生物学の会・第九回年会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] Vif-CBFβ-CUL5-ELOB-ELOC複合体に結合する2'F化したaptamerの取得2018
- Author(s)
  関川湧斗、水澤果那、神庭圭佑、鈴木拓也、万里、片平正人、永田崇、坂本泰一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] Vif-CBFβ-CUL5-ELOB-ELOC複合体に対するアプタマーの取得と解析2018
- Author(s)
  鈴木拓也、万里、関川湧斗、田中陽一郎、神庭圭佑、片平正人、永田崇、坂本泰一
- Organizer
  平成30年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] HIV Vif-ヒトE3ユビキチンリガーゼ複合体によるAPOBEC3タンパク質の脱アミノ化阻害と核酸を含む3者間の分子間相互作用の解析2018
- Author(s)
  神庭圭佑、万里、雲財悟、森下了、高折晃史、永田崇、片平正人
- Organizer
  核酸化学若手フォーラム 2018
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] Vif-CBFβ-CUL5-ELOB-ELOC複合体に対するアプタマーの取得と解析2018
- Author(s)
  鈴木拓也、万里、関川湧斗、田中陽一郎、神庭圭佑、片平正人、永田崇、坂本泰一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] HIV Vif-E3-ユビキチンリガーゼ複合体と核酸の相互作用2018
- Author(s)
  神庭圭佑、永田崇、片平正人
- Organizer
  第18回日本蛋白質科学会年回
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] 脱アミノ化反応の実時間NMR解析で検出するヒト抗HIV因子APOBEC3Gと核酸及び阻害因子間の相互作用2017
- Author(s)
  神庭圭佑、永田崇、片平正人
- Organizer
  第18回若手NMR研究会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] APOBEC3Gのストランド間移動の実時間NMR法検出2017
- Author(s)
  神庭圭佑、永田崇、片平正人
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K15434
[Presentation] ストランド間移動に依存するヒト抗ウイルス因子APOBEC3Gの酵素活性の促進と阻害2017
- Author(s)
  神庭圭佑、永田崇、片平正人
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K15434

1. NAGATA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 片平正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kamba Keisuke 神庭 圭佑

Research Projects

Research Products

Co-Researchers

Development of cancer selective infectious virus vector that slows tumor growthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inactivation mechanism of HIV Vif protein using host cellular proteins against human anti-viral factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selection and characterization of aptamers targeting the Vif-CBFβ-ELOB-ELOC-CUL5 complex2024

Author(s)

Journal Title

Data Source

[Journal Article] NMR characterization of the structure of the intrinsically disordered region of human origin recognition complex subunit 1, hORC1, and of its interaction with G-quadruplex DNAs2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An insight into the dependence of the deamination rate of human APOBEC3F on the length of single-stranded DNA, which is affected by the concentrations of APOBEC3F and single-stranded DNA2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The C-terminal cytidine deaminase domain of APOBEC3G itself undergoes intersegmental transfer for a target search, as revealed by real-time NMR monitoring2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] HIV-1 Vif-ヒトE3ユビキチンリガーゼ複合体がAPOBEC3A 及び APOBEC3Cの脱アミノ化に及ぼす影響の解析2023

Author(s)

Organizer

Data Source

[Presentation] Investigation on the structure of the DNA-binding region of human origin recognition complex subunit 12023

Author(s)

Organizer

Data Source

[Presentation] HIV-1 Vif directly inhibit against human APOBEC3G deaminases independent of the ubiquitin-proteasome pathway2023

Author(s)

Organizer

Data Source

[Presentation] HIV-1 Vifと宿主タンパク質の五者複合体による抗ウイルス因子APOBEC3Gの脱アミノ化活性阻害の分子機構の解明2022

Author(s)

Organizer

Data Source

[Presentation] HIV-1 Vif-ヒトE3ユビキチンリガーゼ複合体は ヒト抗ウイルス因子APOBEC3Cの脱アミノ化を阻害する2022

Author(s)

Organizer

Data Source

[Presentation] HIV-1 Vifタンパク質によるヒト抗ウイルス因子APOBEC3タンパク質のマルチファセットな無力化: ユビキチン化と脱アミノ化阻害演題名：未知のHIV-1 Gag二量体化制御単位の同定と構造生物学的性質決定2022

Author(s)

Organizer

Data Source

[Presentation] 未知のHIV-1 Gag二量体化制御単位の同定と構造生物学的性質決定2022

Author(s)

Organizer

Data Source

[Presentation] HIV-1-Vif: E3ユビキチンリガーゼ複合体を構成するタンパク質とヒトAPOBEC3Gタンパク質の相互作用の加算効果が、脱アミノ化阻害をもたらし得る2022

Author(s)

Organizer

Data Source

[Presentation] Investigation on the structure of the DNA-binding region of human origin recognition complex subunit 12022

Author(s)

Organizer

Data Source

[Presentation] Analysis of the dimerization of the Matrix domain of HIV-1 gag protein2022

Author(s)

Organizer

Data Source

Kamba Keisuke 神庭圭佑

[Presentation] HIV-1 Vif-ヒトE3ユビキチンリガーゼ複合体はヒト抗ウイルス因子APOBEC3Cの脱アミノ化を阻害する2022