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Ureshino Hiroshi  嬉野 博志

Researcher Number 00807464
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-5034-3699
Affiliation (Current) 2025: 佐賀大学, 医学部, 特任教授
Affiliation (based on the past Project Information) *help 2023: 広島大学, 原爆放射線医科学研究所, 准教授
2022: 広島大学, 原爆放射線医科学研究所, 共同研究講座准教授
2019 – 2021: 佐賀大学, 医学部, 病院講師
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related
Keywords
Principal Investigator
無治療寛解維持 / 慢性骨髄性白血病 / CML幹細胞 / DNAメチル化 / 癌抑制遺伝子 / DNAメチル化阻害剤 / DNAメチル化阻害薬 / イマチニブ / 白血病幹細胞 / Treatment free remission … More / KIRアリル多型 / TKI / HLA / KIR / HLA多型 / T細胞免疫 / KIR遺伝子多型 / NK細胞免疫 Less
  • Research Projects

    (2 results)
  • Research Products

    (81 results)
  • Co-Researchers

    (12 People)
  •  Treatment strategy for elimination of CML stem cell using novel DNMT inhibitorPrincipal Investigator

    • Principal Investigator
      嬉野 博志
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Hiroshima University
      Saga University
  •  Can allelic polymorphisms of KIRs predict TFR in CML?Principal Investigator

    • Principal Investigator
      Ureshino Hiroshi
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Saga University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] KIR3DL1-HLA-Bw status in CML is associated with achievement of TFR: the POKSTIC trial, a multicenter observational study2024

    • Author(s)
      Ureshino H、Ueda Y、Fujisawa S、Usuki K、Tanaka H、Okada M、Kowata S、Murai K、Hirose A、Shindo M、Kumagai T、Takeoka T、Kamachi K、Kidoguchi K、Shindo T、Iyama S、Inamura J、Nakao T、Kobayashi T、Kawata E、Ohkawara H、Ikezoe T、Kawaguchi A、Kimura S
    • Journal Title

      Blood Neoplasia

      Volume: 1 Issue: 1 Pages: 100001-100001

    • DOI

      10.1016/j.bneo.2024.100001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-23K07811
  • [Journal Article] Reprogramming of pyrimidine nucleotide metabolism supports vigorous cell proliferation of normal and malignant T cells2024

    • Author(s)
      Watanabe Tatsuro、Yamamoto Yuta、Kurahashi Yuki、Kawasoe Kazunori、Kidoguchi Keisuke、Ureshino Hiroshi、Kamachi Kazuharu、Yoshida-Sakai Nao、Fukuda-Kurahashi Yuki、Nakamura Hideaki、Okada Seiji、Sueoka Eisaburo、Kimura Shinya
    • Journal Title

      Blood Advances

      Volume: 8 Issue: 6 Pages: 1345-1358

    • DOI

      10.1182/bloodadvances.2023011131

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Facial nerve palsy and hypopituitarism associated with immunoglobulin G4-related disease in an elderly man2024

    • Author(s)
      Doi-Fujita Ayako、Edahiro Taro、Ureshino Hiroshi、Yoshida Tetsumi、Ichinohe Tatsuo
    • Journal Title

      The American Journal of the Medical Sciences

      Volume: 367 Issue: 3 Pages: e35-e36

    • DOI

      10.1016/j.amjms.2023.11.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL2023

    • Author(s)
      Kurahashi Yuki、Watanabe Tatsuro、Yamamoto Yuta、Ureshino Hiroshi、Kamachi Kazuharu、Yoshida-Sakai Nao、Fukuda-Kurahashi Yuki、Yamashita Satoshi、Hattori Naoko、Nakamura Hideaki、Kawaguchi Atsushi、Ushijima Toshikazu、Sueoka Eisaburo、Kimura Shinya
    • Journal Title

      Blood Advances

      Volume: 7 Issue: 8 Pages: 1545-1559

    • DOI

      10.1182/bloodadvances.2022008362

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K08756
  • [Journal Article] Benefit of the Reduced Dose Combination of Azacitidine and Venetoclax in an Elderly Patient With Acute Myeloid Leukemia2023

    • Author(s)
      Fujino Keita、Ureshino Hiroshi、Yoshida Tetsumi、Ichinohe Tatsuo
    • Journal Title

      Cureus

      Volume: 1 Pages: 1-1

    • DOI

      10.7759/cureus.39481

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] A novel anticancer quinolone, (R)-WAC-224, has anti-leukemia activities against acute myeloid leukemia2023

    • Author(s)
      Mino Tatsuji、Ureshino Hiroshi、Ueshima Taichi、Kashimoto Naoki、Yamaguchi Tomonori、Naka Kazuhito、Inaba Toshiya、Ichinohe Tatsuo
    • Journal Title

      Investigational New Drugs

      Volume: 41 Issue: 5 Pages: 751-760

    • DOI

      10.1007/s10637-023-01393-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-21K19353, KAKENHI-PROJECT-23K27440
  • [Journal Article] Challenging Diagnosis of Lytic Bone Lesions Between Multiple Myeloma and Bone Metastasis of Primary Breast Cancer2023

    • Author(s)
      Edahiro Tao、Ureshino Hiroshi、Yoshida Tetsumi、Fukushima Noriyasu、Ichinohe Tatsuo
    • Journal Title

      Cureus

      Volume: 1 Pages: 1-1

    • DOI

      10.7759/cureus.48880

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia2023

    • Author(s)
      Kamachi Kazuharu、Ureshino Hiroshi、Watanabe Tatsuro、Yoshida-Sakai Nao、Fukuda-Kurahashi Yuki、Kawasoe Kazunori、Hoshiko Toshimi、Yamamoto Yuta、Kurahashi Yuki、Kimura Shinya
    • Journal Title

      Cancer Research Communications

      Volume: 3 Issue: 2 Pages: 297-308

    • DOI

      10.1158/2767-9764.crc-22-0259

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-21K16245
  • [Journal Article] Type II Cryoglobulinemic Membranoproliferative Glomerulonephritis Caused by Mucosa-associated Lymphoid Tissue Lymphoma2023

    • Author(s)
      Sugihara Ayano、Ureshino Hiroshi、Yamasaki Masatora、Fukuda Makoto、Yoshihara Maki、Nonaka Eriko、Miyazaki Mariko、Fujita Mai、Ishii Keitaro、Kamachi Kazuharu、Sano Haruhiko、Okamoto Sho、Itamura Hidekazu、Yoshimura Mariko、Katsuya Hiroo、Ando Toshihiko、Aoki Shigehisa、Ubara Yoshifumi、Kimura Shinya
    • Journal Title

      Intern. Med.

      Volume: 62 Issue: 13 Pages: 1983-1988

    • DOI

      10.2169/internalmedicine.0756-22

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2023-07-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-23K15327
  • [Journal Article] Late graft failure with donor-derived GPI-deficient cells in a mixed chimera following allogeneic bone marrow transplantation for severe aplastic anemia2023

    • Author(s)
      Katsuya Hiroo、Yamaguchi Kyosuke、Dung Trung Cao、Sano Haruhiko、Itamura Hidekazu、Okamoto Sho、Yoshimura Mariko、Ureshino Hiroshi、Ando Toshihiko、Zaimoku Yoshitaka、Nakao Shinji、Kimura Shinya
    • Journal Title

      Bone Marrow Transplantation

      Volume: 58 Issue: 4 Pages: 465-468

    • DOI

      10.1038/s41409-023-01923-7

    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study2023

    • Author(s)
      Nishi H、Horikoshi S、Ohta K、Yoshida T、Fukushima N、Oshita K、Munenaga S、Edahiro T、Ureshino H、Shigeishi H、Yoshioka Y、Konishi M、Ide N、Ogawa Y、Marukawa R、Shintani T、Ino N、Kajiya M、Kakimoto N、Ohge H、Ichinohe T、Kawaguchi H
    • Journal Title

      Journal of Personalized Medicine

      Volume: 13 Issue: 11 Pages: 1603-1603

    • DOI

      10.3390/jpm13111603

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-21K16970
  • [Journal Article] A Combination of Alectinib and DNA-Demethylating Agents Synergistically Inhibits Anaplastic-Lymphoma-Kinase-Positive Anaplastic Large-Cell Lymphoma Cell Proliferation2023

    • Author(s)
      Kawasoe Kazunori、Watanabe Tatsuro、Yoshida-Sakai Nao、Yamamoto Yuta、Kurahashi Yuki、Kidoguchi Keisuke、Ureshino Hiroshi、Kamachi Kazuharu、Fukuda-Kurahashi Yuki、Kimura Shinya
    • Journal Title

      Cancers

      Volume: 15 Issue: 20 Pages: 5089-5089

    • DOI

      10.3390/cancers15205089

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Alveolar rhabdomyosarcoma with massive bone marrow infiltration and disseminated intravascular coagulation mimicking acute leukemia2022

    • Author(s)
      Sugihara Ayano、Katsuya Hiroo、Ureshino Hiroshi、Kido Shinichi、Kimura Shinya
    • Journal Title

      eJHaem

      Volume: 3 Issue: 3 Pages: 1062-1063

    • DOI

      10.1002/jha2.447

    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Coexistence of gastric and pulmonary MALT lymphoma and a clonally related, disseminated large B cell lymphoma with conspicuous angiotropism2022

    • Author(s)
      Yoshida-Sakai Nao、Oe Kensuke、Kimura Yoshizo、Ureshino Hiroshi、Nomiyama Keita、Hashiguchi Michitoshi、Jojima Hiroto、Imamura Yutaka、Ohshima Koichi、Okamura Takashi
    • Journal Title

      Annals of Hematology

      Volume: 101 Issue: 6 Pages: 1383-1385

    • DOI

      10.1007/s00277-022-04752-8

    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia2022

    • Author(s)
      Kamachi Kazuharu、Ureshino Hiroshi、Watanabe Tatsuro、Yoshida Nao、Yamamoto Yuta、Kurahashi Yuki、Fukuda-Kurahashi Yuki、Hayashi Yoshihiro、Hirai Hideyo、Yamashita Satoshi、Ushijima Toshikazu、Okada Seiji、Kimura Shinya
    • Journal Title

      Cancer Letters

      Volume: 526 Pages: 273-283

    • DOI

      10.1016/j.canlet.2021.11.032

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-21H02956
  • [Journal Article] HLA-haploidentical peripheral blood stem cell transplantation with post-transplantation cyclophosphamide for adult T-cell leukemia2022

    • Author(s)
      石井 敬太郎、吉村 麻里子、嬉野 博志、安藤 寿彦、久保田 寧、木村 晋也、岡本 翔、藤田 真衣、杉原 綾乃、長家 聡明、西岡 敦二郎、蒲池 和晴、板村 英和、勝屋 弘雄
    • Journal Title

      Rinsho Ketsueki

      Volume: 63 Issue: 5 Pages: 333-340

    • DOI

      10.11406/rinketsu.63.333

    • ISSN
      0485-1439, 1882-0824
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Successful combination treatment with azacitidine and venetoclax for a patient with acute myeloid leukemia undergoing hemodialysis2022

    • Author(s)
      Edahiro Taro、Ureshino Hiroshi、Chishaki Ren、Fujino Keita、Mino Tatsuji、Yoshida Tetsumi、Fukushima Noriyasu、Ichinohe Tatsuo
    • Journal Title

      Leukemia & Lymphoma

      Volume: 63 Issue: 14 Pages: 3511-3512

    • DOI

      10.1080/10428194.2022.2123230

    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Successful combination treatment with azacitidine and venetoclax as a bridging therapy for third allogenic stem cell transplantation in a patient with 11q23/MLL‐rearranged complex karyotype acute myeloid leukemia2022

    • Author(s)
      Edahiro Taro、Ureshino Hiroshi、Chishaki Ren、Fujino Keita、Mino Tatsuji、Yoshida Tetsumi、Fukushima Noriyasu、Ichinohe Tatsuo
    • Journal Title

      eJHaem

      Volume: 4 Issue: 1 Pages: 273-275

    • DOI

      10.1002/jha2.630

    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Eosinophilic cystitis mimicking hemorrhagic cystitis in relapsed follicular lymphoma2022

    • Author(s)
      Nagaie Toshiaki、Kamachi Kazuharu、Kitamura Hiroaki、Ureshino Hiroshi、Akashi Michiaki、Nishimura Kazushige、Meiri Hiroyuki、Kimura Shinya、Miyahara Masaharu
    • Journal Title

      International Cancer Conference Journal

      Volume: 11 Issue: 4 Pages: 298-301

    • DOI

      10.1007/s13691-022-00565-8

    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Higher neutrophil counts are associated with successful tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia2022

    • Author(s)
      Ureshino Hiroshi、Kamachi Kazuharu、Sano Haruhiko、Okamoto Sho、Itamura Hidekazu、Yoshimura Mariko、Katsuya Hiroo、Ando Toshihiko、Kimura Shinya
    • Journal Title

      Hematology

      Volume: 27 Issue: 1 Pages: 1171-1175

    • DOI

      10.1080/16078454.2022.2135857

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-20K08756
  • [Journal Article] HLA Polymorphisms Are Associated with Treatment-Free Remission Following Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia2021

    • Author(s)
      Ureshino H, Shindo T, Tanaka H, Saji H, Kimura S
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 20 Issue: 1 Pages: 142-149

    • DOI

      10.1158/1535-7163.mct-20-0336

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-19K17860, KAKENHI-PROJECT-19K08812
  • [Journal Article] Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects2021

    • Author(s)
      Ureshino Hiroshi、Kurahashi Yuki、Watanabe Tatsuro、Yamashita Satoshi、Kamachi Kazuharu、Yamamoto Yuta、Fukuda-Kurahashi Yuki、Yoshida-Sakai Nao、Hattori Naoko、Hayashi Yoshihiro、Kawaguchi Atsushi、Tohyama Kaoru、Okada Seiji、Harada Hironori、Ushijima Toshikazu、Kimura Shinya
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 20 Issue: 8 Pages: 1412-1421

    • DOI

      10.1158/1535-7163.mct-20-1125

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-19H04355
  • [Journal Article] Low-dose dasatinib in older patients with chronic myeloid leukaemia in chronic phase (DAVLEC): a single-arm, multicentre, phase 2 trial2021

    • Author(s)
      Murai K, Ureshino H, Kumagai T, Tanaka H, Nishiwaki K, Wakita S, Inokuchi K, Fukushima T, Yoshida C, Uoshima N, Kiguchi T, Mita M, Aoki J, Kimura S, Karimata K, Usuki K, Shimono J, Chinen Y, Kuroda J, Matsuda Y, Nakao K, Ono T, Fujimaki K, Shibayama H, Sakamoto J, Kimura S.
    • Journal Title

      Lancet Haematol

      Volume: 8 Issue: 12 Pages: e902-e911

    • DOI

      10.1016/s2352-3026(21)00333-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-20K07150, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-21K16245
  • [Journal Article] Immune Thrombocytopenia Exacerbation After COVID-19 Vaccination in a Young Woman2021

    • Author(s)
      Fujita Mai、Ureshino Hiroshi、Sugihara Ayano、Nishioka Atsujiro、Kimura Shinya
    • Journal Title

      Cureus

      Volume: 13

    • DOI

      10.7759/cureus.17942

    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Dasatinib-Blinatumomab for Ph-Positive ALL2021

    • Author(s)
      Kazuharu Kamachi, Hiroshi Ureshino
    • Journal Title

      N Engl J Med.

      Volume: 384 Issue: 4 Pages: 384-384

    • DOI

      10.1056/nejmc2033785

    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Journal Article] Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome2021

    • Author(s)
      Kidoguchi Keisuke、Kubota Yasushi、Fujimoto Shun、Sakata Yasuhisa、Kizuka-Sano Haruna、Yamaguchi Kyosuke、Ureshino Hiroshi、Katsuya Hiroo、Ando Toshihiko、Esaki Motohiro、Kimura Shinya
    • Journal Title

      Intern. Med.

      Volume: 60 Issue: 10 Pages: 1601-1605

    • DOI

      10.2169/internalmedicine.6468-20

    • NAID

      130008038542

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-05-15
    • Language
      English
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Adult T‐cell leukemia‐lymphoma acquires resistance to <scp>DNA</scp> demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism2021

    • Author(s)
      Yoshida‐Sakai Nao、Watanabe Tatsuro、Yamamoto Yuta、Ureshino Hiroshi、Kamachi Kazuharu、Kurahashi Yuki、Fukuda‐Kurahashi Yuki、Kimura Shinya
    • Journal Title

      International Journal of Cancer

      Volume: 150 Issue: 7 Pages: 1184-1197

    • DOI

      10.1002/ijc.33901

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-21K16245
  • [Journal Article] Treatment-free remission and immunity in chronic myeloid leukemia2021

    • Author(s)
      Ureshino Hiroshi
    • Journal Title

      International Journal of Hematology

      Volume: in press Issue: 5 Pages: 642-647

    • DOI

      10.1007/s12185-021-03117-7

    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Journal Article] Efficacy and safety of ponatinib for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: a case series from a single institute2021

    • Author(s)
      Kidoguchi K, Ureshino H, Kizuka-Sano H, Yamaguchi K, Katsuya H, Kubota Y, Ando T, Miura M, Takahashi N, Kimura S.
    • Journal Title

      Int J Hematol.

      Volume: 114 Issue: 2 Pages: 199-204

    • DOI

      10.1007/s12185-021-03156-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07150, KAKENHI-PROJECT-21K16245
  • [Journal Article] Pain relief differentiated according to the length of time that preoperative skin traction was carried out for hip fractures: A systematic review and meta-analysis2021

    • Author(s)
      Kobayashi Takaomi、Ureshino Hiroshi、Morimoto Tadatsugu、Sonohata Motoki、Mawatari Masaaki
    • Journal Title

      International Journal of Orthopaedic and Trauma Nursing

      Volume: 43 Pages: 100886-100886

    • DOI

      10.1016/j.ijotn.2021.100886

    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Journal Article] Allelic polymorphisms of KIRs and antitumor immunity against chronic myeloid leukemia2020

    • Author(s)
      Shindo Takero、Ureshino Hiroshi、Kojima Hiroto、Tanaka Hidenori、Kimura Shinya
    • Journal Title

      Immunological Medicine

      Volume: in press Issue: 2 Pages: 1-8

    • DOI

      10.1080/25785826.2020.1796062

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17860, KAKENHI-PROJECT-19K08812
  • [Journal Article] Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-21002020

    • Author(s)
      Watanabe Tatsuro、Yamashita Satoshi、Ureshino Hiroshi、Kamachi Kazuharu、Kurahashi Yuki、Fukuda-Kurahashi Yuki、Yoshida Nao、Hattori Naoko、Nakamura Hideaki、Sato Akemi、Kawaguchi Atsushi、Sueoka-Aragane Naoko、Kojima Kensuke、Okada Seiji、Ushijima Toshikazu、Kimura Shinya、Sueoka Eisaburo
    • Journal Title

      Blood

      Volume: 136 Issue: 7 Pages: 871-884

    • DOI

      10.1182/blood.2019003084

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K07700, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-17K09928, KAKENHI-PROJECT-19K17860
  • [Journal Article] Vascular events may predict the prognosis of patients with chronic myeloid leukemia2020

    • Author(s)
      Ureshino Hiroshi、Kamachi Kazuharu
    • Journal Title

      International Journal of Hematology

      Volume: 112 Issue: 2 Pages: 263-263

    • DOI

      10.1007/s12185-020-02889-8

    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Journal Article] Reconstitution of NK Cells Expressing KIR3DL1 Is Associated With Reduced NK Cell Activity and Relapse of CML After Allogeneic Hematopoietic Stem Cell Transplantation2020

    • Author(s)
      Ureshino H, Shindo T, Sano H, Kubota Y, Ando T, Kidoguchi K, Kusaba K, Itamura H, Kojima H, Kusunoki Y, Miyazaki Y, Kojima K, Tanaka H, Saji H, Oshima K, Kimura S
    • Journal Title

      International Journal of Hematology

      Volume: 111 Issue: 5 Pages: 733-738

    • DOI

      10.1007/s12185-019-02809-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K17860, KAKENHI-PROJECT-16K09851, KAKENHI-PROJECT-19K08812
  • [Journal Article] Treatment-free remission after first-line dasatinib discontinuation in patients with chronic myeloid leukaemia (first-line DADI trial): a single-arm, multicentre, phase 2 trial2020

    • Author(s)
      Kimura Shinya、Imagawa Jun、Murai Kazunori、Hino Masayuki、Kitawaki Toshio、Okada Masaya、Tanaka Hideo、Shindo Motohiro、Kumagai Takashi、Ikezoe Takayuki、Uoshima Nobuhiko、Sato Tsutomu、Watanabe Reiko、Kowata Shugo、Hayakawa Masaya、Hosoki Takaaki、Ikeda Kazuhiko、et al.
    • Journal Title

      The Lancet Haematology

      Volume: 7 Issue: 3 Pages: 218-225

    • DOI

      10.1016/s2352-3026(19)30235-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08365, KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-17K09908, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-19K17860
  • [Journal Article] A methotrexate-associated lymphoproliferative disorder expressing CD10 and BCL6 with the IGH/CCND1 translocation2020

    • Author(s)
      Katsuya Hiroo、Kizuka-Sano Haruna、Yokoo Masako、Kidoguchi Keisuke、Yamaguchi Kyosuke、Nishioka Atsujiro、Ureshino Hiroshi、Kubota Yasushi、Ando Toshihiko、Naito Shinji、Ohshima Koichi、Kimura Shinya
    • Journal Title

      Annals of Hematology

      Volume: 99 Issue: 10 Pages: 2449-2451

    • DOI

      10.1007/s00277-020-04218-9

    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Journal Article] Does Patient Sex Play a Role in Treatment-Free Remission in Chronic Myeloid Leukemia?2020

    • Author(s)
      Ureshino H, Kamachi K, Kimura S
    • Journal Title

      International journal of Hematology

      Volume: in press Issue: 6 Pages: 903-903

    • DOI

      10.1007/s12185-020-02864-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Journal Article] Assessment of estimated glomerular filtration rate in patients with chronic myeloid leukemia following discontinuation of tyrosine kinase inhibitors2020

    • Author(s)
      Okamoto Sho、Ureshino Hiroshi、Kawaguchi Atsushi、Miyazono Motoaki、Ikeda Yuji、Kimura Shinya
    • Journal Title

      International Journal of Hematology

      Volume: 112 Issue: 1 Pages: 41-45

    • DOI

      10.1007/s12185-020-02880-3

    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Journal Article] Surrogate Markers for Treatment-Free Remission in Patients With Chronic Myeloid Leukemia2020

    • Author(s)
      Ureshino Hiroshi、Kamachi Kazuharu、Kimura Shinya
    • Journal Title

      Clinical Lymphoma Myeloma and Leukemia

      Volume: 20 Issue: 12 Pages: 785-790

    • DOI

      10.1016/j.clml.2020.07.004

    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Journal Article] Role of cancer immunology in chronic myelogenous leukemia.2020

    • Author(s)
      Ureshino H, Shindo T, Kimura S
    • Journal Title

      Leuk Res

      Volume: 88 Pages: 196273-196273

    • DOI

      10.1016/j.leukres.2019.106273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08812, KAKENHI-PROJECT-19K17860
  • [Journal Article] Clinical impact of the CONUT score in patients with multiple myeloma2020

    • Author(s)
      Okamoto S, Ureshino H*, Kidoguchi K, Kusaba K, Kizuka-Sano H, Sano H, Nishioka A, Yamaguchi K, Kamachi K, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Kawaguchi A, Sueoka E, Kimura S.
    • Journal Title

      Ann Hematol

      Volume: 99 Issue: 1 Pages: 113-119

    • DOI

      10.1007/s00277-019-03844-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09928, KAKENHI-PROJECT-19K17860, KAKENHI-PROJECT-16K09851, KAKENHI-PROJECT-19K08812
  • [Journal Article] J-SKI will be able to elucidate whether the renal function recover or not after discontinuation of tyrosine kinase inhibitors2020

    • Author(s)
      Okamoto Sho、Ureshino Hiroshi、Kimura Shinya
    • Journal Title

      International Journal of Hematology

      Volume: 112 Issue: 3 Pages: 429-430

    • DOI

      10.1007/s12185-020-02945-3

    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Journal Article] Immune Dysregulation Syndrome With De Novo CTLA4 Germline Mutation Responsive to Abatacept Therapy2020

    • Author(s)
      Ureshino H, Koarada S, Kamachi K, Yoshimura M, Yokoo M, Kubota Y, Ando T, Ichinohe T, Morio T, Kimura S
    • Journal Title

      International journal of Hematology

      Volume: in press Issue: 6 Pages: 897-902

    • DOI

      10.1007/s12185-020-02834-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17860, KAKENHI-PROJECT-20K08775
  • [Journal Article] Japan's high-cost medical expense benefit system could be an obstacle to promoting generic imatinib2019

    • Author(s)
      Ureshino Hiroshi、Kamachi Kazuharu、Kimura Shinya
    • Journal Title

      The Lancet Haematology

      Volume: 6 Issue: 10 Pages: e498-e498

    • DOI

      10.1016/s2352-3026(19)30168-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Journal Article] Mogamulizumab for the Treatment of Adult T-cell Leukemia/Lymphoma2019

    • Author(s)
      Ureshino Hiroshi、Kamachi Kazuharu、Kimura Shinya
    • Journal Title

      Clinical Lymphoma Myeloma and Leukemia

      Volume: 19 Issue: 6 Pages: 326-331

    • DOI

      10.1016/j.clml.2019.03.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] Alleic Polymprphisms of KIRs and HLAs Predict Favorable Achievement of Treatment-free remission in CML: Results from the POKSTIC trial, multicenter retrocpective observational study.2023

    • Author(s)
      Hirosh Ureshino
    • Organizer
      28th Congress of the European Hematology Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] Lower-initiating dose of bosutinib for resistant or intolerant to prior therapy chronic myeloid leukemia patients (BOGI trial): a single-arm, multicenter, phase II trial.2023

    • Author(s)
      Hiroshi Ureshino, Naoto Takahashi, Takayuki Ikezoe, Ayako Takamori, Atsushi Kawaguchi, Tatsuo Ichinohe, Shinya Kimura
    • Organizer
      65th Annual Meeting of the American Society of Hematology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] 造血器腫瘍治療薬の新展開、非ホジキンリンパ腫に対する新規薬剤及び治療法の進化2022

    • Author(s)
      嬉野 博志
    • Organizer
      第43回日本臨床薬理学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] 急性骨髄性白血病に対するOR-2100とvenetoclaxの経口剤併用療法の前臨床試験2022

    • Author(s)
      蒲池 和晴、嬉野 博志、川副 和紀、山本 雄大、倉橋 祐樹、渡邉 達郎、木村 晋也
    • Organizer
      第26回日本がん分子標的治療学会学術集会(金沢)
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] THE POTENTIAL USE OF AN ORAL HYPOMETHYLATING AGENT, OR-2100, AS A COMBINATION THERAPY FOR MYELOID MALIGNANCIES,2022

    • Author(s)
      Kazuharu Kamachi , Hiroshi Ureshino , Kazunori Kawasoe , Nao Yoshida-Sakai , Yuta Yamamoto , Yuki Fukuda-Kurahashi , Yuki Kurahashi , Tatsuro Watanabe , Shinya Kimura,
    • Organizer
      2022 EHA congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] OR2100とベネトクラクスによる経口2剤併用療法の急性白血病への効果2022

    • Author(s)
      嬉野博志、渡邉達郎、木村晋也
    • Organizer
      第81回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] Allelic Polymorphisms of Killer Immunoglobulin-like Receptor and Human Leukocyte Antigen Determine Successful Achievement of Treatment-Free Remission in Patients with CML2021

    • Author(s)
      Hiroshi Ureshino
    • Organizer
      第23回John Goldman CMLカンファレンス
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] Cancer Immunology in CML2021

    • Author(s)
      Hiroshi Ureshino
    • Organizer
      第12回日本血液学会国際シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] 日本癌学会学術総会抄録集2021

    • Author(s)
      嬉野博志、渡邉達郎、木村晋也
    • Organizer
      第80回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] First, second, and third attempts at TKI discontinuation in patients with CML2021

    • Author(s)
      藤田真衣, 嬉野博志, 石井敬太郎, 長家聡明, 西岡敦二郎, 蒲池和晴, 岡本翔, 勝屋弘雄, 吉村麻里子, 久保田寧, 安藤寿彦, 木村晋也
    • Organizer
      第83回日本血液学会総会
    • Data Source
      KAKENHI-PROJECT-21K16245
  • [Presentation] A NEW HYPOMETHYLATING AGENT, OR-2100, RESISTS DEGRADATION BY CYTIDINE DEAMINASE, LEADING TO FAVOURABLE ORAL ABSORBABILITY AND ANT-LEUKAEMIA EFFECTS2020

    • Author(s)
      Hiroshi Ureshino, Kazuharu Kamachi, Tatsuro Watanabe, Yuki Kurahashi, Kaoru Tohyama, Seiji Okada, Toshikazu Ushijima, Shinya Kimura
    • Organizer
      25th EHA Congress virtual
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] びまん性大細胞型B細胞リンパ腫に合併した続発性膜性腎症の一例2020

    • Author(s)
      永田 絢子, 力武 修一, 城戸口 啓介, 橋本 優香, 野中 枝理子, 野中 真衣, 福田 誠, 吉原 万貴, 勝屋 弘雄, 嬉野 博志, 高島 毅, 木村 晋也, 宮園 素明
    • Organizer
      第50回日本腎臓学会東部学術大会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 成人T細胞性白血病/リンパ腫に対するDNA脱メチル化剤とEZH2阻害剤の併用療法2020

    • Author(s)
      倉橋祐樹、渡邉達郎、嬉野博志、蒲池和晴、吉田奈央、山本雄大、木村晋也
    • Organizer
      第24回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 成人T細胞性白血病/リンパ腫におけるT細胞受容体シグナル制御分子THEMISのDNAメチル化異常2020

    • Author(s)
      渡邉達郎、嬉野博志、山下聡、牛島俊和、岡田誠治、末岡榮三郎、木村晋也
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 新規DNAメチル化阻害剤OR2100はCDA耐性を獲得し経口吸収性とMDS/AMLへの抗腫瘍効果を有する2020

    • Author(s)
      嬉野博志、渡邉達郎、通山薫、岡田誠治、原田浩徳、牛島俊和、木村晋也
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] HLA POLYMORPHISMS PREDICT TREATMENT-FREE REMISSION FOLLOWING TKI DISCONTINUATION IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA2020

    • Author(s)
      Hiroshi Ureshino, Takero Shindo, Hidenori Tanaka, Hiroo Saji, Shinya Kimura
    • Organizer
      25th EHA Congress virtual
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 成人T細胞性白血病/リンパ腫におけるDNAメチル化異常によるT細胞受容体シグナル制御の破綻2020

    • Author(s)
      渡邉達郎、嬉野博志、倉橋祐樹、蒲池和晴、吉田奈央、山本雄大、末岡榮三郎、木村晋也
    • Organizer
      第24回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 新規経口脱メチル化剤 O R-2100はチロシンキナーゼ阻害剤の効果を高める2020

    • Author(s)
      蒲池和晴、嬉野博志、吉田奈央、山本雄大、倉橋祐樹、渡邊達郎、岡田誠治、木村晋也
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 成人T細胞性白血病/リンパ腫に対するDNA脱メチル化剤とEZH阻害剤の併用効果と標的因子DUSP52020

    • Author(s)
      倉橋祐樹、吉田奈央、嬉野博志、蒲池和晴、山本雄大、渡邊達郎、木村晋也
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 成人T細胞性白血病/リンパ腫におけるT細胞受容体シグナル制御分子のDNAメチル化異常の細胞生物学的意義2020

    • Author(s)
      渡邊達郎、吉田奈央、嬉野博志、蒲池和晴、倉橋祐樹、山本雄大、山下聡、岡田誠治、牛島俊和、末岡栄三郎、木村晋也
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] ATLL細胞株におけるDNA脱メチル化剤耐性獲得機序2020

    • Author(s)
      吉田奈央、渡邉達郎、嬉野博志、倉橋祐樹、蒲池和晴、山本雄大、末岡榮三郎、木村晋也
    • Organizer
      第24回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 新規経口DNA脱メチル化剤OR21はAzacitidine耐性を克服する2020

    • Author(s)
      嬉野博志、蒲池和晴、吉田奈央、倉橋祐樹、渡邉達郎、木村晋也
    • Organizer
      第24回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 腎偶発腫瘍で発見され、イブルチニブ単剤治療により1年半安定状態を得ているFCR後再発小リンパ球性リンパ腫2020

    • Author(s)
      小島研介、嬉野博志、木村晋也
    • Organizer
      第60回リンパ網内系学会総会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] ATLL細胞株のDNAメチル化阻害剤に対する耐性獲得機序2020

    • Author(s)
      吉田奈央、渡邊達郎、倉橋祐樹、嬉野博志、蒲池和晴、山本雄大、木村晋也
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 当院における濾胞性リンパ腫の治療成績2020

    • Author(s)
      長家聡明、勝屋弘雄、安藤れい子、城戸口啓介、佐野遥菜、山口亨祐、蒲池和晴、嬉野博志、久保田寧、安藤寿彦、木村晋也
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 慢性骨髄性白血病のTFR成功はHLAの多型により予測できる2020

    • Author(s)
      嬉野博志、進藤岳郎、木村晋也
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 末梢血幹細胞移植後に急性骨髄性白血病へと系統変化したBCR-ABL(+)急性リンパ性白血病の1例2020

    • Author(s)
      海野晃久、佐野遥菜、安藤寿彦、嬉野博志、吉谷美穂、岡崎智満、吉原由利重、南里安耶、若山一夫、川崎誠司、木村晋也、末岡栄三郎
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] アバタセプトが奏功したCTLA4ハプロ不全症による免疫異常症2020

    • Author(s)
      宮﨑真理子, 嬉野博志, 小荒田秀一, 宮原 正晴, 蒲池和晴, 吉村麻里子, 横尾眞子, 久保田寧, 安藤寿彦, 一戸辰夫, 森尾知宏, 木村晋也
    • Organizer
      第10回日本血液学会九州地方会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 慢性骨髄性白血病に対する新規DNA脱メチル化剤OR2100の効果はp53発現により異なる2020

    • Author(s)
      蒲池和晴、嬉野博志、倉橋祐樹、吉田奈央、山本雄大、渡邉達郎、木村晋也
    • Organizer
      第24回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] Efficacy of OR-21, a new oral DNA methyltransferase inhibitor in chronic myeloid leukemia2019

    • Author(s)
      Kazuharu Kamachi,Hiroshi Ureshino,Yuki Kurahashi, Yuki Kurahashi,Tatsuro Watanabe,Seiji Okada,Shinya Kimura
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] Eficacy of DNA demethylating agents and related molecular targets in adult-T cell leukemia-lymphoma2019

    • Author(s)
      Tatsuro Watanabe,Hiroshi Ureshino,Kazuharu Kamachi, Yuki Kurahashi,Yuki Kurahashi,Satoshi Yamashita,Seiji Okada, Toshikazu Ushijima,Eisaburo Sueoka,Shinya Kimura
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] reatment-Free Remission In Patients With Chronic Myelogenous Leukemia Following First-Line Dasatinib, 1st DADI/IMIDAS42019

    • Author(s)
      Murai K, Kimura S, Imagawa J, Hino M, Kitawaki T, Okada M, Tanaka H, Shindo M, Kumagai T, Ikezoe T, Uoshima N, Sato T, Watanabe R, Kowata S, Hayakawa M, Hosoki T, Ikeda K, Kobayashi T, Kakinoki Y,Nishimoto T, Takezako N, Shibayama H, Takaori A, Nakamae H, Kawaguchi A, Ureshino H, Sakamoto J, Ishida Y
    • Organizer
      24th European Hematology Association Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤の治療効果は KIR と HLA のアレル多型で予測できる2019

    • Author(s)
      進藤岳郎、嬉野博志、木村晋也
    • Organizer
      第78回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 成人 T 細胞白血病/リンパ腫における DNA メチル化異常の細胞生物学的意義と治療標的としての可能性2019

    • Author(s)
      渡邉 達郎、嬉野 博志、山下 聡、牛島 俊和、岡田 誠治、末岡 榮三朗、木村 晋也
    • Organizer
      第78回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 新規デシタビンプロドラッグOR21は分化及びがん抑制遺伝子の発現を誘導する2019

    • Author(s)
      嬉野 博志、渡邉 達郎、通山 薫、岡田 誠治、原田 浩徳、牛島 俊和、木村 晋也
    • Organizer
      第78回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17860
  • [Presentation] 免疫学から見たモガムリズマブの薬理作用2019

    • Author(s)
      嬉野 博志
    • Organizer
      第40回日本臨床薬理学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K17860
  • 1.  HARADA Yuka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  MIURA Masatomo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  木村 晋也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  原田 浩徳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  柴山 浩彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  服部 奈緒子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  末岡 榮三朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  渡邉 達郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 9.  池田 和彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  伊村 明浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  進藤 岳郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  小島 研介
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