Nakano Masataka 中野正隆

Researcher Number	00816225
Other IDs
Affiliation (based on the past Project Information) *help	2023: 金沢大学, 薬学系, 助教 2018 – 2021: 金沢大学, 薬学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 転写後制御 / 転写後修飾 / 薬物代謝 / RNA修飾 / 転写後遺伝子発現制御 / m6A修飾 / 核内受容体 / RNA編集

Regulation of expression of drug metabolizing enzymes by RNA modificationPrincipal Investigator
- Principal Investigator
  
  Nakano Masataka
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kanazawa University
RNA editing-mediated regulation of PXR and CARPrincipal Investigator
- Principal Investigator
  
  Nakano Masataka
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kanazawa University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver2023
- Author(s)
  Kurosawa Kiamu、Nakano Masataka、Yokoseki Itsuki、Nagaoka Mai、Takemoto Seiya、Sakai Yoshiyuki、Kobayashi Kaoru、Kazuki Yasuhiro、Fukami Tatsuki、Nakajima Miki
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 215 Pages: 115733-115733
- DOI
  10.1016/j.bcp.2023.115733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07013
[Journal Article] NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction2023
- Author(s)
  Mitamura Rei、Nakano Masataka、Isono Motoki、Kurosawa Kiamu、Fukami Tatsuki、Nakajima Miki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 51 Issue: 10 Pages: 1230-1237
- DOI
  10.1124/dmd.122.001065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07013
[Journal Article] A-to-I RNA editing and m6A modification modulating expression of drug-metabolizing enzymes2022
- Author(s)
  Nakano Masataka、Nakajima Miki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: - Issue: 5 Pages: 624-633
- DOI
  10.1124/dmd.121.000390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07013, KAKENHI-PROJECT-21H02624
[Journal Article] Identification of miRNAs that regulate human CYP2B6 expression2021
- Author(s)
  Nakano Masataka、Iwakami Chika、Fukami Tatsuki、Nakajima Miki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 38 Pages: 100388-100388
- DOI
  10.1016/j.dmpk.2021.100388
- NAID
  210000165776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07013
[Journal Article] Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor2021
- Author(s)
  Takemoto Seiya、Nakano Masataka、Nozaki Kaori、Fukami Tatsuki、Nakajima Miki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 37 Pages: 100367-100367
- DOI
  10.1016/j.dmpk.2020.11.002
- NAID
  210000159780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02573, KAKENHI-PROJECT-20K07013, KAKENHI-PROJECT-21H02624
[Journal Article] m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 22021
- Author(s)
  Takemoto Seiya、Nakano Masataka、Fukami Tatsuki、Nakajima Miki
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 193 Pages: 114766-114766
- DOI
  10.1016/j.bcp.2021.114766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07013, KAKENHI-PROJECT-21H02624
[Journal Article] The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression2021
- Author(s)
  Ondo Kyoko、Isono Motoki、Nakano Masataka、Hashiba Shiori、Fukami Tatsuki、Nakajima Miki
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 189 Pages: 114402-114402
- DOI
  10.1016/j.bcp.2020.114402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07013, KAKENHI-PROJECT-21H02624
[Journal Article] Methylation of adenosine at the N6 position post-transcriptionally regulates hepatic P450s expression2020
- Author(s)
  Nakano Masataka、Ondo Kyoko、Takemoto Seiya、Fukami Tatsuki、Nakajima Miki
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 171 Pages: 113697-113697
- DOI
  10.1016/j.bcp.2019.113697
- Data Source
  KAKENHI-PROJECT-20K07013
[Journal Article] Adenosine deaminases acting on RNA downregulate the expression of constitutive androstane receptor in the human liver-derived cells by attenuating splicing2019
- Author(s)
  Nakano M, Fukami T, Nakajima M.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 370 (3) Issue: 3 Pages: 408-415
- DOI
  10.1124/jpet.119.260109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02573, KAKENHI-PROJECT-18K14901
[Journal Article] microRNA による薬物代謝制御に関する最新知見2019
- Author(s)
  中野正隆、中島美紀
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 印刷中
- NAID
  130007678390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14901
[Journal Article] RNA editing enzymes modulate the expression of hepatic CYP2B6, CYP2C8, and other P450 isoforms.2019
- Author(s)
  Kaori Nozaki, Masataka Nakano, Chika Iwakami, Tatsuki Fukami, and Miki Nakajima.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 印刷中 Issue: 6 Pages: 639-647
- DOI
  10.1124/dmd.119.086702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14901, KAKENHI-PROJECT-18H02573
[Journal Article] Current knowledge of microRNA-mediated regulation of drug metabolism in humans.2018
- Author(s)
  Masataka Nakano and Miki Nakajima
- Journal Title
  
  Expert Opinion on Drug Metabolism & Toxicology
  
  Volume: 14 Issue: 5 Pages: 493-504
- DOI
  10.1080/17425255.2018.1472237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14901, KAKENHI-PROJECT-18H02573
[Presentation] ADARによるヒトAKR1C3の発現制御がドキソルビシンの薬効に与える影響2024
- Author(s)
  谷川豊夏、森田倖規、竹本誠也、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] Regulation of human hepatic UGT1A6 expression by A-to-I RNA editing2023
- Author(s)
  Shuji Takeuchi, Masataka Nakano, Tatsuki Fukami, and Miki Nakajima
- Organizer
  2023 International Joint Meeting of 23rd ICCP450/38th JSSX
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] microRNAs as regulators of human drug-metabolizing enzymes2023
- Author(s)
  Masataka Nakano and Miki Nakajima
- Organizer
  The 39th Annual Metting of KSOT/KEMS
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] Regulation of hepatic BSEP expression by A to I RNA editing enzymes2023
- Author(s)
  Gakuto Maeyama, Motoki Isono, Masataka Nakano, Tatsuki Fukami, Yuichiro Higuchi, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu, and Miki Nakajima.
- Organizer
  2023 International Joint Meeting of 23rd ICCP450/38th JSSX
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] RNA 編集酵素 ADARs によるヒト肝臓中 UGT1A6 発現制御とそのメカニズム解明2023
- Author(s)
  竹内秀次、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] m6A修飾によるヒト抗酸化酵素ヘムオキシゲナーゼ-1の発現制御2023
- Author(s)
  松本慎之介、中野匠、中野正隆、深見達基、中島美紀
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] m6A modification-related enzymes METTL3 and ALKBH5 modulate CYP1A1 induction by upregulating ARNT expression in human lung cells.2021
- Author(s)
  Takumi Nakano, Masataka, Nakano, Tatsuki Fukami, and Miki Nakajima.
- Organizer
  第36回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] RNAメチル化転移酵素によるヒトCYP2B6の発現制御2021
- Author(s)
  磯野元輝、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会北陸支部第133回例会
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] Epitranscriptional regulation of drug-metabolizing enzymes.2021
- Author(s)
  Miki Nakajima and Masataka Nakano.
- Organizer
  第36回日本薬物動態学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] m6A modification enhances sensitivity of human lung cancer A549 cells to paclitaxel by attenuating MRP7 expression.2021
- Author(s)
  Takuto Inamoto, Masataka Nakano, Tatsuki Fukami, and Miki Nakajima.
- Organizer
  第36回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] RNAメチル化がヒト肝におけるCYP2B6発現量に与える影響2021
- Author(s)
  磯野元輝、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] Effects of m6A modification on hepatic drug and lipid metabolism properties by regulation of carboxylesterase 2.2021
- Author(s)
  Seiya Takemoto, Masataka Nakano, Tatsuki Fukami, Miki Nakajima.
- Organizer
  第36回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-20K07013
[Presentation] Regulation of human drug metabolizing enzymes by two prevalent post-transcriptional modifications, A-to-I editing and methylation of adenosine.2019
- Author(s)
  Masataka Nakano and Miki Nakajima.
- Organizer
  第34回日本薬物動態学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] Cytochrome P450 3A4 is down-regulated by RNA editing enzymes-mediated post-transcriptional repression of human pregnane X receptor expression.2019
- Author(s)
  Seiya Takemoto, Masataka Nakano, Tatsuki Fukami, and Miki Nakajima.
- Organizer
  第34回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] A-to-I RNA editing modulates the expression of human pregnane X receptor.2019
- Author(s)
  Seiya Takemoto, Masataka Nakano, Tatsuki Fukami, Miki Nakajima.
- Organizer
  12th International ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] Effects of RNA editing on expression and function of human aldo-keto reductase family 1 member C (AKR1C)2019
- Author(s)
  Koki Morita, Masataka Nakano, Tatsuki Fukami, Miki Nakajima
- Organizer
  12th International ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] Significance of transporter-mediated uptake of UDP-glucuronic acid into endoplasmic reticulum for UDP-glucuronosyltransferase activity.2018
- Author(s)
  Kyoko Ondo, Hiroshi Arakawa, Masataka Nakano, Tatsuki Fukami, and Miki Nakajima.
- Organizer
  International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] RNA編集がアルド-ケト還元酵素AKR1C分子種の発現および酵素活性に与える影響2018
- Author(s)
  森田倖規、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] Degradation of RNA editing enzyme ADAR1 by cigarette smoke would be a factor of increase in HO-1 expression.2018
- Author(s)
  Masashi Takizawa, Masataka Nakano, Tatsuki Fukami and Miki Nakajima.
- Organizer
  International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] Absolute quantitative analysis of aldo-keto reductase and short-chain dehydrogenase/reductase mRNA levels in human liver.2018
- Author(s)
  Keito Amai, Tatsuki Fukami, Masataka Nakano, Akiko Watanabe, Kengo Watanabe and Miki Nakajima.
- Organizer
  International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] Regulation of drug-metabolizing cytochrome P450s by adenosine deaminase acting on RNA (ADAR) enzymes.2018
- Author(s)
  Kaori Nozaki, Masataka Nakano, Tatsuki Fukami and Miki Nakajima.
- Organizer
  International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] ヒトUGT2A3タンパク質の発現および機能的役割の解明2018
- Author(s)
  阿部貴之、齊藤紗希、古川陽一、畠山雅彦、岡﨑道貴子、Moshe Finel、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] RNA編集酵素ADAR1の発現が喫煙によって低下する機構と生体に与える意義の解明2018
- Author(s)
  瀧澤雅、中野正隆、深見達基、中島美紀
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] RNA 編集酵素 ADAR による薬物代謝型ヒト P450 分子種の制御2018
- Author(s)
  野崎香於利、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] RNA編集がヒトpregnane X receptorの発現に与える影響2018
- Author(s)
  竹本誠也、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] RNA編集酵素ADAR1がヒトCYP7A1の発現に与える影響2018
- Author(s)
  堀内陽生、片山浩樹、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] 喫煙による RNA 編集酵素 ADAR1 の発現低下が及ぼす酸化ストレス感受性亢進メカニズムの解明2018
- Author(s)
  瀧澤雅、中野正隆、深見達基、中島美紀
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] 薬物加水分解酵素カルボキシルエステラーゼおよびアリルアセタミドデアセチラーゼのサルとヒトにおける種差2018
- Author(s)
  本多栞、深見達基、辻口拓也、中野正隆、上原正太郎、山崎浩史、中島美紀
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] RNA methylation and demethylation enzymes modulate CYP2C8 expression in human liver.2018
- Author(s)
  Masataka Nakano, Tatsuki Fukami, and Miki Nakajima.
- Organizer
  International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] ERα is positively regulated by A-to-I RNA editing in breast cancer.2018
- Author(s)
  Koki Morita, Masataka Nakano, Tatsuki Fukami and Miki Nakajima.
- Organizer
  International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14901
[Presentation] カルボニル基の還元反応を触媒する薬物代謝酵素AKRおよびSDRファミリーのヒト肝臓における発現量および機能解析2018
- Author(s)
  天井圭斗、深見達基、中野正隆、渡邉亜紀子、渡邊健悟、中島美紀
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-18K14901

1. 中嶋美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nakano Masataka 中野 正隆

Research Projects

Research Products

Co-Researchers

Regulation of expression of drug metabolizing enzymes by RNA modificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RNA editing-mediated regulation of PXR and CARPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A-to-I RNA editing and m6A modification modulating expression of drug-metabolizing enzymes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of miRNAs that regulate human CYP2B6 expression2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 22021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methylation of adenosine at the N6 position post-transcriptionally regulates hepatic P450s expression2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adenosine deaminases acting on RNA downregulate the expression of constitutive androstane receptor in the human liver-derived cells by attenuating splicing2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] microRNA による薬物代謝制御に関する最新知見2019

Author(s)

Journal Title

NAID

Data Source

[Journal Article] RNA editing enzymes modulate the expression of hepatic CYP2B6, CYP2C8, and other P450 isoforms.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current knowledge of microRNA-mediated regulation of drug metabolism in humans.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] ADARによるヒトAKR1C3の発現制御がドキソルビシンの薬効に与える影響2024

Author(s)

Nakano Masataka 中野正隆