Morimoto Satoru 森本悟

Researcher Number	00816952
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 殿町先端研究教育連携スクエア, 特任准教授 2025: 三重大学, 医学系研究科, リサーチアソシエイト
Affiliation (based on the past Project Information) *help	2023 – 2024: 慶應義塾大学, 殿町先端研究教育連携スクエア, 特任准教授 2022 – 2023: 慶應義塾大学, 医学部(信濃町), 助教 2018 – 2023: 三重大学, 医学系研究科, リサーチアソシエイト 2021 – 2022: 慶應義塾大学, 医学部(信濃町), 特任講師 2019 – 2020: 慶應義塾大学, 医学部(信濃町), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 52020:Neurology-related / Transformative Research Areas, Section (III) / Medium-sized Section 52:General internal medicine and related fields / Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator アデノシンA2A受容体 / Gタンパク質 / ドパミンD2受容体 / 運動ニューロン / ALS / pluripotent stem cells / mass spectrometry / phosphorylation / tau / Kii ALS/PDC … More Except Principal Investigator … More 筋萎縮性側索硬化症 / ヒトiPSC / アストログリア / 脊髄運動ニューロン / ヒトiPS細胞 / ミクログリア / アストロサイト / ALS / 認知症 / パーキンソン症候群 / パーキンソン認知症複合 / 非ドメイン型バイオポリマー / 神経変性疾患 / 天然変性タンパク質 / Heroタンパク質 / RFC1 / CANVAS / 脊髄小脳変性症 / ロピニロール / トランスクリプトーム / プロテオーム解析 / 体液由来細胞外小胞 / ロピニロール塩酸塩 / グリア細胞 / 14Cグルコース / ペントースリン酸経路 / 代謝コンパートメント / 脳梗塞 / ニューロン / パプア / グアム島 / 紀伊半島 / メタゲノム / レジストリ / プロテオミクス / 腸内細菌叢 / エピゲノミクス / 遺伝子解析 / フィールド調査 / プロテイノパチー / PDC / Immunomagnetic Reduction / PET タウ / アミロイドβ / タウ / PET / SIMOA / 血液バイオマーカー Less

新規動物モデル、iPS細胞モデルを用いたCANVASの病態解明
- Principal Investigator
  
  土井宏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Yokohama City University
ALS運動ニューロン標的iPS細胞創薬から同定された薬物のグリア細胞疾患修飾作用
- Principal Investigator
  
  高橋慎一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Keio University
D2R-mediated Gs/Gi rebalancing in ALS motor neuronsPrincipal Investigator
- Principal Investigator
  
  森本悟
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Keio University
Mechanism and application of Hero proteins
- Principal Investigator
  
  泊幸秀
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
A novel treatment of cerebral infarction with neuroprotective astrocytes induced by inflammatory microglia
- Principal Investigator
  
  TAKAHASHI Shinichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Keio University
Comprehensive analysis of tau protein phosphorylation in pluripotent stem cells and human brainPrincipal Investigator
- Principal Investigator
  
  Morimoto Satoru
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Mie University
New blood biomarker for Kii ALS/PDC
- Principal Investigator
  
  KOKUBO Yasumasa
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Mie University
ALS/PDC - 世界3大多発地での環境と遺伝子の cross talk -
- Principal Investigator
  
  小久保康昌
- Project Period (FY)
  2018 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Mie University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] Annual Review 神経20222022
- Author(s)
  森本　悟、髙橋愼一、岡野栄之
- Total Pages
  200
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22K07500
[Book] Annual Review 神経20212021
- Author(s)
  髙橋愼一、森本悟、岡野栄之
- Total Pages
  300
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Questioning the cycad theory of Kii ALS/PDC causation.2024
- Author(s)
  Yasumasa Kokubo, Satoru Morimoto, and Mari Yoshida
- Journal Title
  
  Nature review neurology
  
  Volume: 20 Issue: 3 Pages: 194-194
- DOI
  10.1038/s41582-024-00936-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-18K07368
[Journal Article] iPS細胞を用いたドラッグ・リポジショニングによるALS治療の探索―ロピニロール塩酸塩の作用とメカニズム―2023
- Author(s)
  髙橋愼一、森本悟、加藤玖里純、岡野栄之
- Journal Title
  
  難病と在宅ケア
  
  Volume: 29 Pages: 41-47
- Data Source
  KAKENHI-PROJECT-22K07500
[Journal Article] Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery2023
- Author(s)
  Morimoto Satoru、Takahashi Shinichi、Ito Daisuke et al.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 30 Issue: 6 Pages: 766-780.e9
- DOI
  10.1016/j.stem.2023.04.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15736, KAKENHI-PROJECT-22K07500, KAKENHI-PROJECT-21K06845, KAKENHI-PROJECT-21K07411, KAKENHI-PLANNED-21H05278, KAKENHI-PROJECT-20H00485, KAKENHI-PROJECT-23K21397
[Journal Article] 精神神経医療におけるDisease-Modifying Therapyの現在地と可能性2023
- Author(s)
  曾根大地, 森本悟, 中島振一郎, 品川俊一郎
- Journal Title
  
  精神神経学雑誌
  
  Volume: 125 Pages: 569-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15736
[Journal Article] iPS細胞を用いたドラッグ・リポジショニングによるALS治療の探索 ―ロピニロール塩酸塩の作用とメカニズム―2023
- Author(s)
  髙橋愼一, 森本悟, 加藤玖里純, 岡野栄之
- Journal Title
  
  難病と在宅ケア
  
  Volume: 29 Pages: 41-47
- Data Source
  KAKENHI-PROJECT-22K15736
[Journal Article] 非ドメイン型タンパク質と神経変性疾患2023
- Author(s)
  森本悟
- Journal Title
  
  Medical Science Digest
  
  Volume: 49 Pages: 17-20
- Data Source
  KAKENHI-PROJECT-22K15736
[Journal Article] LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits2023
- Author(s)
  Li Dan、Johmura Yoshikazu、Morimoto Satoru et al.
- Journal Title
  
  Nature Aging
  
  Volume: 3 Issue: 8 Pages: 1001-1019
- DOI
  10.1038/s43587-023-00464-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15736, KAKENHI-PROJECT-23K07345, KAKENHI-PROJECT-19K08267, KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-21K07411, KAKENHI-PROJECT-22K19398, KAKENHI-PROJECT-22K15724, KAKENHI-PROJECT-20H03162, KAKENHI-ORGANIZER-19H05739, KAKENHI-PLANNED-21H05278, KAKENHI-ORGANIZER-23H03834, KAKENHI-PLANNED-23H03835, KAKENHI-PROJECT-20H00485, KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-23K27084, KAKENHI-PROJECT-23K27376
[Journal Article] Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula2023
- Author(s)
  Kobayashi Hiroya、Ueda Koji、Morimoto Satoru、Ishikawa Mitsuru、Leventoux Nicolas、Sasaki Ryogen、Hirokawa Yoshifumi、Kokubo Yasumasa、Okano Hideyuki
- Journal Title
  
  Neurological Sciences
  
  Volume: 44 Issue: 12 Pages: 4511-4516
- DOI
  10.1007/s10072-023-07000-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15736, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-18K07368, KAKENHI-PLANNED-21H05278, KAKENHI-PROJECT-20H00485
[Journal Article] Induced pluripotent stem cells‐based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis2023
- Author(s)
  Okano Hideyuki、Morimoto Satoru、Kato Chris、Nakahara Jin、Takahashi Shinichi
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 167 Issue: 5 Pages: 603-614
- DOI
  10.1111/jnc.16005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15736, KAKENHI-PROJECT-22K07500, KAKENHI-PLANNED-21H05278, KAKENHI-PROJECT-20H00485
[Journal Article] ロピニロール塩酸塩2023
- Author(s)
  森本悟, 髙橋愼一, 岡野栄之
- Journal Title
  
  Clin Neurosci
  
  Volume: 41 Pages: 404-407
- Data Source
  KAKENHI-PROJECT-22K15736
[Journal Article] ロピニロール塩酸塩2023
- Author(s)
  森本悟、髙橋愼一、岡野栄之
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 41 Pages: 404-407
- Data Source
  KAKENHI-PROJECT-22K07500
[Journal Article] Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia (ALS/PDC) adopt the CTE Fold.2023
- Author(s)
  Chao Qi, Bert M Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G. Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, Yoshifumi Hirokawa, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Ryskeldi-Falcon, Mari Yoshida, Masato Hasegawa, Sjors H W Scheres, Michel Goedert.
- Journal Title
  
  PNAS
  
  Volume: 120 Issue: 51
- DOI
  10.1073/pnas.2306767120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-23H00434
[Journal Article] 紀伊ALS2023
- Author(s)
  佐々木良元, 森本悟, 小久保康昌
- Journal Title
  
  Clin Neurosci
  
  Volume: 41 Pages: 126-128
- Data Source
  KAKENHI-PROJECT-22K15736
[Journal Article] An efficient induction method for human spinal lower motor neurons and high-throughput image analysis at the single cell level2023
- Author(s)
  Setsu Selena、Morimoto Satoru、Nakamura Shiho、Ozawa Fumiko、Tomari Yukihide、Okano Hideyuki
- Journal Title
  
  bioRxiv
  
  Volume: －
- DOI
  10.1101/2023.04.18.537412
- Open Access
- Data Source
  KAKENHI-PROJECT-22K15736
[Journal Article] 前頭側頭型認知症の生物学2022
- Author(s)
  森本悟
- Journal Title
  
  生体の科学
  
  Volume: 73 Pages: 494-495
- Data Source
  KAKENHI-PROJECT-22K15736
[Journal Article] 筋萎縮性側索硬化症（ALS）患者を対象としたロピニロール塩酸塩（ropinirole）投与による医師主導治験2022
- Author(s)
  森本悟, 髙橋愼一, 岡野栄之
- Journal Title
  
  Annual Review 神経 2022
  
  Volume: － Pages: 60-66
- Data Source
  KAKENHI-PROJECT-22K15736
[Journal Article] iPS細胞技術を用いたALSの創薬と臨床試験2022
- Author(s)
  髙橋愼一、森本悟、岡野栄之
- Journal Title
  
  生体の科学 73(5)増大号：革新脳と関連プロジェクトから見えてきた新しい脳科学
  
  Volume: 73 Pages: 476-477
- Data Source
  KAKENHI-PROJECT-22K07500
[Journal Article] APOE alleles with tau and A pathology in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula2022
- Author(s)
  Ryogen Sasaki, Satoru Morimoto, Fumiko Ozawa, Hideyuki Okano, Mari Yoshida, Hiroyuki Ishiura, Shoji Tsuji, Shigeki Kuzuhara, and Yasumasa Kokubo
- Journal Title
  
  Neurology
  
  Volume: 99 Issue: 22
- DOI
  10.1212/wnl.0000000000201156
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-22H04923
[Journal Article] Fusion with heat-resistant obscure (Hero) proteins have the potential to improve the molecular property of recombinant proteins2022
- Author(s)
  Morimoto Eri、Tsuboyama Kotaro、Tomari Yukihide
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 6 Pages: e0270097-e0270097
- DOI
  10.1371/journal.pone.0270097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05278
[Journal Article] Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis2022
- Author(s)
  Ito Daisuke、Morimoto Satoru、Takahashi Shinichi、Okada Kensuke、Nakahara Jin、Okano Hideyuki
- Journal Title
  
  Brain
  
  Volume: 146 Issue: 1 Pages: 13-19
- DOI
  10.1093/brain/awac306
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07500, KAKENHI-PROJECT-23K21397
[Journal Article] iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders2022
- Author(s)
  Okano Hideyuki、Morimoto Satoru
- Journal Title
  
  Cell Stem Cell
  
  Volume: 29 Issue: 2 Pages: 189-208
- DOI
  10.1016/j.stem.2022.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21H05278, KAKENHI-PROJECT-20H00485
[Journal Article] Single transcription factor leads pluripotent stem cells to functional microglia2022
- Author(s)
  Sonn Iki, Ozaki Fumiko, Yoshimatsu Sho, Morimoto Satoru, Watanabe Hirotaka, Okano Hideyuki
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: (in press) Issue: 1 Pages: 1-1
- DOI
  10.1186/s41232-022-00201-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21J00381, KAKENHI-PROJECT-21J12528, KAKENHI-PROJECT-21K15112, KAKENHI-PROJECT-21K08295, KAKENHI-PUBLICLY-21H05633, KAKENHI-PLANNED-21H05278, KAKENHI-PROJECT-23K24216
[Journal Article] An immigrant family with Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex2021
- Author(s)
  Kokubo Y, Morimoto S, Sasaki R, Hasegawa M, Ishiura H, Tsuji S, Yoshida M, Yamazoe N, Miyazaki M, Kuzuhara S.
- Journal Title
  
  Neurol Sci.
  
  Volume: 43(2) Issue: 2 Pages: 1423-1425
- DOI
  10.1007/s10072-021-05737-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-20H03588, KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-16H06277
[Journal Article] Ropinirole hydrochloride for amyotrophic lateral sclerosis: A single-center, randomized feasibility, double-blind, placebo-controlled trial2021
- Author(s)
  Morimoto Satoru、Takahashi Shinichi、Ito Daisuke、Date Yugaku、Okada Kensuke、Chyi Chai Muh、Nishiyama Ayumi、Suzuki Naoki、Fujimori Koki、Takao Masaki、Hirai Miwa、Kabe Yasuaki、Suematsu Makoto、Jinzaki Masahiro、Aoki Masashi、Fujiki Yuto、Sato Yasunori、Suzuki Norihiro、Nakahara Jin、Okano Hideyuki
- Journal Title
  
  medRxiv
  
  Volume: 2021(Dec)
- DOI
  10.1101/2021.12.05.21267266
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Brain transcriptome analysis links deficiencies of stress-responsive proteins to the pathomechanism of Kii ALS/PDC2020
- Author(s)
  Satoru Morimoto, Mitsuru Ishikawa, Hirotaka Watanabe, Miho Isoda, Masaki Takao, Shiho Nakamura, Fumiko Ozawa, Yoshifumi Hirokawa, Shigeki Kuzuhara, Hideyuki Okano, Yasumasa Kokubo
- Journal Title
  
  Antioxidants
  
  Volume: 9 Issue: 5 Pages: 423-423
- DOI
  10.3390/antiox9050423
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18K07514, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-19K17002, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17H01689
[Journal Article] iPS細胞技術が切り拓く精神・神経疾患創薬の未来2020
- Author(s)
  森本　悟、髙橋愼一、岡野栄之
- Journal Title
  
  東京都病院薬剤師会雑誌
  
  Volume: 69（1） Pages: 1-15
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Generation of an ALS human iPSC line KEIOi001-A from peripheral blood of a Charcot disease-affected patient carrying TARDBP p.N345K heterozygous SNP mutation2020
- Author(s)
  Leventoux Nicolas、Morimoto Satoru、Hara Kenju、Nakamura Shiho、Ozawa Fumiko、Mitsuzawa Shio、Akiyama Tetsuya、Nishiyama Ayumi、Suzuki Naoki、Warita Hitoshi、Aoki Masashi、Okano Hideyuki
- Journal Title
  
  Stem Cell Research
  
  Volume: 47 Pages: 101896-101896
- DOI
  10.1016/j.scr.2020.101896
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07519, KAKENHI-PROJECT-19K17002, KAKENHI-PROJECT-20K07897
[Journal Article] Human Astrocytes Model Derived from Induced Pluripotent Stem Cells2020
- Author(s)
  Leventoux Nicolas、Morimoto Satoru、Imaizumi Kent、Sato Yuta、Takahashi Shinichi、Mashima Kyoko、Ishikawa Mitsuru、Sonn Iki、Kondo Takahiro、Watanabe Hirotaka、Okano Hideyuki
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 12 Pages: 2680-2680
- DOI
  10.3390/cells9122680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08002, KAKENHI-PROJECT-20K16502, KAKENHI-PROJECT-19K16927
[Journal Article] iPS細胞を用いた神経難病治療開発．BIO Clinica「神経難病の治療開発update」2020
- Author(s)
  髙橋愼一、森本　悟、岡野英之
- Journal Title
  
  BIO Clinica
  
  Volume: 35(8): Pages: 702-706
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] ニューロサイエンスの最新情報「ロピニロールの運動ニューロン細胞死抑制効果」2020
- Author(s)
  髙橋愼一、森本　悟、岡野英之
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 38(4) Pages: 507-509
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Expression of mutant ubiquitin and proteostasis impairment in Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex brains2020
- Author(s)
  Bert M. Verheijen, Satoru Morimoto, Ryogen Sasaki, Kiyomitsu Oyanagi, Yasumasa Kokubo, Shigeki Kuzuhara, Fred W. van Leeuwen
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 79 Issue: 8 Pages: 902-907
- DOI
  10.1093/jnen/nlaa056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18K07514, KAKENHI-PROJECT-19K07820, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-17H01689
[Journal Article] Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial) -.2019
- Author(s)
  .Satoru Morimoto, Shinichi Takahashi, Komei Fukushima, Hideyuki Saya, Norihiro Suzuki, Masashi Aoki, Hideyuki Okano, Jin Nakahara
- Journal Title
  
  Regen Ther
  
  Volume: 11 Pages: 143-166
- DOI
  10.1016/j.reth.2019.07.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Ropinirole, a new ALS drug candidate developed using iPSCs.2019
- Author(s)
  Hideyuki Okano, Daisuke Yasuda, Koki Fujimori, Satoru Morimoto, Shinichi Takahashi
- Journal Title
  
  Trends Pharmacol Sci
  
  Volume: 41(2) Issue: 2 Pages: 99-109
- DOI
  10.1016/j.tips.2019.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] 特集神経疾患のドラッグ･リポジショニング-新時代へ ALS治療薬候補としてのロピニロール塩酸塩2019
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Hideyuki Okanao
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 71 Issue: 9 Pages: 943-952
- DOI
  10.11477/mf.1416201386
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2019-09-01
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] 増大特集 ALS2019 ロピニロール塩酸塩-iPS細胞創薬2019
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Komei Fukushima, Jin Nakahara, Hideyuki Okano
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 71 Issue: 11 Pages: 1279-1288
- DOI
  10.11477/mf.1416201438
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2019-11-01
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Optineurin pathology in the spinal cord of amyotrophic lateral sclerosis/parkinsonism-dementia complex patients in Kii Peninsula, Japan2018
- Author(s)
  Morimoto Satoru、Hatsuta Hiroyuki、Motoyama Rie、Kokubo Yasumasa、Ishiura Hiroyuki、Tsuji Shoji、Kuzuhara Shigeki、Murayama Shigeo
- Journal Title
  
  Brain Pathology
  
  Volume: 28 Issue: 3 Pages: 422-426
- DOI
  10.1111/bpa.12558
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09364, KAKENHI-PROJECT-25305030, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-15J03921
[Journal Article] Nitrative Stress and Tau Accumulation in Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) in the Kii Peninsula, Japan2018
- Author(s)
  Hata Yukiko、Ma Ning、Yoneda Misao、Morimoto Satoru、Okano Hideyuki、Murayama Shigeo、Kawanishi Shosuke、Kuzuhara Shigeki、Kokubo Yasumasa
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 11 Pages: 751-751
- DOI
  10.3389/fnins.2017.00751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09364, KAKENHI-PROJECT-17K09168, KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-17H04654, KAKENHI-PROJECT-15K08787, KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-15J03921
[Journal Article] Unusual tau pathology of the cerebellum in patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex from the kii peninsula, Japan.2017
- Author(s)
  Morimoto S, Hatsuta H, Kokubo Y, Nakano Y, Hasegawa M, Yoneda M, Hirokawa Y, Kuzuhara S, Shiraishi T, Murayama S.
- Journal Title
  
  Brain Pathol.
  
  Volume: - Issue: 2 Pages: 287-291
- DOI
  10.1111/bpa.12500
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25257507, KAKENHI-PROJECT-15J03921, KAKENHI-PROJECT-15K09364, KAKENHI-PROJECT-25305030, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239
[Presentation] 筋萎縮性側索硬化症に対するiPS細胞創薬～Physician-scientistによるTR/rTRの実践～2024
- Author(s)
  森本悟
- Organizer
  Online Young Investigators Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] 筋萎縮性側索硬化症に対するiPS細胞創薬～Physician-scientistによるTR/rTRの実践～2024
- Author(s)
  森本悟
- Organizer
  第3回ニューロン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] 筋萎縮性側索硬化症に対するiPS細胞創薬～Physician-scientistによるTR/rTRの実践～2024
- Author(s)
  森本悟
- Organizer
  聖マリア病院/聖マリア研究センター講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] 牟婁病（Kii ALS/PDC）－300年の謎に挑む－2024
- Author(s)
  森本悟
- Organizer
  東京大学医科学研究所学友会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] ALS患者体液由来細胞外小胞におけるmiRNAプロファイルの特徴と経時的変化2023
- Author(s)
  森本悟、加藤玖里純、髙橋愼一、中村志穂、小澤史子、伊東大介、伊達悠岳、岡田健佑、中原仁、岡野栄之
- Organizer
  第64回日本神経学会学術大会（口演）
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] Ropinirole hydrochloride suppresses cholesterol synthetic pathway in ALS spinal motor neurons2023
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Chris Kato, Shiho Nakamura, Fumiko Ozawa, Daisuke Ito, Yugaku Date, Kensuke Okada, Jin Nakahara, Hideyuki Okano
- Organizer
  Society for Neuroscience 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] Ropinirole hydrochloride suppresses cholesterol synthetic pathway in ALS spinal motor neurons2023
- Author(s)
  髙橋愼一、森本悟、加藤玖里純、中村志穂、小澤史子、伊東大介、伊達悠岳、岡田健佑、中原仁、岡野栄之
- Organizer
  第66回日本脳循環代謝学会学術集会（口演）
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] ロピニロール塩酸塩はALS脊髄運動ニューロンのコレステロール合成経路を抑制する2023
- Author(s)
  髙橋愼一、森本悟、加藤玖里純、中村志穂、小澤史子、伊東大介、伊達悠岳、岡田健佑、中原仁、岡野栄之
- Organizer
  第64回日本神経学会学術大会（口演）
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] ALS患者体液由来細胞外小胞におけるmiRNAプロファイルの特徴と経時的変化2023
- Author(s)
  森本悟、加藤玖里純、髙橋愼一、中村志穂、小澤史子、伊東大介、伊達悠岳、岡田健佑、中原仁、岡野栄之
- Organizer
  第41回日本神経治療学会学術集会（医師優秀口演）
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] iPSCs-based disease modeling, drug screening, clinical trials, and reverse translational research for ALS2023
- Author(s)
  森本悟
- Organizer
  第76回日本薬理学会西南部会（次世代薬理学セミナー 2023 in 沖縄）
- Invited
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] iPS細胞を用いたドラッグ・リポジショニングによるALS治療薬の探索2023
- Author(s)
  髙橋愼一、森本悟、中原仁、岡野栄之
- Organizer
  第56回日本成人病（生活習慣病）学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] ALS患者体液由来細胞外小胞におけるプロテオームの特徴と経時的変化2023
- Author(s)
  加藤玖里純、植田幸嗣、森本悟、髙橋愼一、中村志穂、小澤史子、伊東大介、伊達悠岳、岡田健佑、中原仁、岡野栄之
- Organizer
  第41回日本神経治療学会学術集会（口演）
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] ALS患者体液由来細胞外小胞におけるmiRNAプロファイルと経時的変化2023
- Author(s)
  森本悟, 加藤玖里純, 髙橋愼一, 中村志穂, 小澤史子, 伊東大介, 伊達悠岳, 岡田健佑, 中原仁, 岡野栄之
- Organizer
  第64回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] 紀伊半島におけるALS/PDCを中心とするタウオパチーのヒト死後脳研究2023
- Author(s)
  森本悟
- Organizer
  第64回日本神経学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] 筋萎縮性側索硬化症患者体液由来細胞外小胞におけるmiRNAプロファイルの特徴と経時的変化2023
- Author(s)
  森本悟, 加藤玖里純, 髙橋愼一, 中村志穂, 小澤史子, 伊東大介, 伊達悠岳, 岡田健佑, 中原仁, 岡野栄之
- Organizer
  第41回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] ALS患者体液由来細胞外小胞におけるプロテオームの特徴と経時的変化2023
- Author(s)
  加藤玖里純、植田幸嗣、森本悟、髙橋愼一、中村志穂、小澤史子、伊東大介、伊達悠岳、岡田健佑、中原仁、岡野栄之
- Organizer
  第64回日本神経学会学術大会（口演）
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] ロピニロール塩酸塩によるALS脊髄運動ニューロンのコレステロール合成抑制と病態修飾2023
- Author(s)
  髙橋愼一、森本悟、加藤玖里純、中村志穂、小澤史子、伊東大介、伊達悠岳、岡田健佑、中原仁、岡野栄之
- Organizer
  第41回日本神経治療学会学術集会（医師優秀口演）
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] Mechanism of therapeutic action of ropinirole in spinal motor neurons derived from ALS patients2023
- Author(s)
  Satoru Morimoto
- Organizer
  Hybrid Satellite Symposium at the 2023 Annual Meeting of the Society for Neuroscience (SfN)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] 神経変性疾患における真のDMTを実現するための“iPS細胞"の役割（シンポジウム: 精神神経医療における「聖杯」とは：Disease-Modifying Therapyの現在地と可能性）2022
- Author(s)
  森本悟
- Organizer
  第118回日本精神神経学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] 大規模レジストリーデータベース（PRO-ACT）を活用したALSに対するロピニロール塩酸塩の有効性の検証2022
- Author(s)
  髙橋愼一、森本　悟、伊東大介、伊達悠岳、岡田健佑、Chai Muh Chyi、西山亜由美、鈴木直輝、平井美和、加部泰明、末松誠、陣崎雅弘、青木正志、佐藤泰憲、中原仁、鈴木則宏、岡野栄之
- Organizer
  第65回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] APOE alleles with tau and Aβ pathology in patients with ALS/PDC in Kii peninsula2022
- Author(s)
  Satoru Morimoto, Ryogen Sasaki, Fumiko Ozawa, Hideyuki Okano, Mari Yoshida, Hiroyuki Ishiura, Shoji Tsuji, Shigeki Kuzuhara, Yasumasa Kokubo
- Organizer
  第41回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Kii ALS/PDC患者iPS細胞由来グリアモデルを用いた、エクソソーム中網羅的タンパク質プロファイリング2022
- Author(s)
  小林博也, 森本　悟, 植田幸嗣, 小久保康昌, 岡野栄之
- Organizer
  第63回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] 大規模レジストリデータベースを活用したALS治験（ROPALS試験）におけるロピニロール塩酸塩の有効性の検証2022
- Author(s)
  髙橋愼一，森本悟，伊東大介，伊達悠岳，岡田健佑，Muh Chyi Chai，西山亜由美，鈴木直輝，平井美和，加部泰明，末松誠，陣崎雅弘，青木正志，佐藤泰憲，中原仁，鈴木則宏，岡野栄之
- Organizer
  第65回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合患者のAPOEε2対立遺伝子はタウ病理と関連する2022
- Author(s)
  森本悟, 佐々木良元,小澤史子, 岡野栄之, 吉田眞理, 石浦浩之, 辻省次, 葛原茂樹, 小久保康昌
- Organizer
  第65回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] iPS細胞由来孤発性疾患モデルを用いたDisease Modifying Therapyの開発（シンポジウム: てんかんの Disease Modifying Therapy ～現在地と将来性を考える～）2022
- Author(s)
  森本悟
- Organizer
  第55回日本てんかん学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] PRACTICAL INDUCTION AND EVALUATION METHOD OF HUMAN MOTOR NEURONS TARGETED AT DRUG SCREENING FOR ALS.2022
- Author(s)
  Setsu S, Morimoto S, Nakamura S, Ozawa F, Takahashi S, Okano H.
- Organizer
  The International Society for Stem Cell Research (ISSCR) annual meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] APOE alleles with tau and Aβ pathology in patients with ALS/PDC in Kii peninsula2022
- Author(s)
  Satoru Morimoto, Ryogen Sasaki, Fumiko Ozawa, Hideyuki Okano, Mari Yoshida, Hiroyuki Ishiura, Shoji Tsuji, Shigeki Kuzuhara, Yasumasa Kokubo
- Organizer
  第41回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] A Practical Induction And Evaluation Method Of Human Spinal Motor Neurons To Accelerate Drug Screening For ALS2022
- Author(s)
  Selena Setsu, Satoru Morimoto, Shiho Nakamura, Fumiko Ozawa, Shinichi Takahashi, Hideyuki Okano
- Organizer
  ISSCR 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] 大規模レジストリーデータベース（PRO-ACT）を活用したALSに対するロピニロール塩酸塩の有効性の検証2022
- Author(s)
  森本　悟、髙橋愼一、伊東大介、伊達悠岳、岡田健佑、Chai Muh Chyi、西山亜由美、鈴木直輝、平井美和、加部泰明、末松誠、陣崎雅弘、青木正志、佐藤泰憲、中原仁、鈴木則宏、岡野栄之
- Organizer
  第40回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] Kii ALS/PDC患者iPS細胞由来グリアモデルを用いた、エクソソーム中網羅的タンパク質プロファイリング2022
- Author(s)
  小林博也, 森本　悟, 植田幸嗣, 小久保康昌, 岡野栄之
- Organizer
  第63回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合患者のAPOEε2対立遺伝子はタウ病理と関連する2022
- Author(s)
  森本悟, 佐々木良元,小澤史子, 岡野栄之, 吉田眞理, 石浦浩之, 辻省次, 葛原茂樹, 小久保康昌
- Organizer
  第65回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] 大規模レジストリーデータベース（PRO-ACT）を活用したALSに対するロピニロール塩酸塩の有効性の検証2022
- Author(s)
  森本悟，髙橋愼一，伊東大介，伊達悠岳，岡田健佑，Muh Chyi Chai，西山亜由美，鈴木直輝，平井美和，加部泰明，末松誠，陣崎雅弘，青木正志，佐藤泰憲，中原仁，鈴木則宏，岡野栄之
- Organizer
  第40回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15736
[Presentation] Kii ALS/PDCアストロサイト由来エクソソーム中タンパク質の特異性2022
- Author(s)
  小林博也, 森本　悟, 植田幸嗣, 小久保康昌, 岡野栄之
- Organizer
  第41回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] Kii ALS/PDCアストロサイト由来エクソソーム中タンパク質の特異性2022
- Author(s)
  小林博也, 森本　悟, 植田幸嗣, 小久保康昌, 岡野栄之
- Organizer
  第41回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Phase 1/2a, Double-blind, Placebo-controlled Study of Ropinirole Hydrochloride (ROPALS trial) based on the iPSC drug repositioning.2021
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Date, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  American Academy of Neurology 73rd Annual Meeting
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] iPS細胞創薬に基づいた筋萎縮性側索硬化症（ALS）に対するロピニロール塩酸塩の医師主導治験（ROPALS試験）．2021
- Author(s)
  森本　悟、髙橋愼一、伊東大介、伊達悠岳、岡田健佑、Chai Muh Chyi、西山亜由美、鈴木直輝、平井美和、加部泰明、末松誠、陣崎雅弘、青木正志、佐藤泰憲、中原仁、鈴木則宏、岡野栄之
- Organizer
  第39回日本神経治療学会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Ropinirole hydrochloride identified by iPSC drug discovery for amyotrophic lateral sclerosis: a randomised, double-blind , placebo-controlled phase 1/2Atrial.2021
- Author(s)
  Satoru Morimoto, Shinichi Takahashi, Daisuke Ito, Yugaku Date, Kensuke Okada, Muh Chyi Chai, Ayumi Nishiyama, Naoki Suzuki, Miwa Hirai, Yasuaki Kabe, Makoto Suematsu, Masahiro Jinzaki, Masashi Aoki, Yasunori Sato, Jin Nakahara, Norihiro Suzuki, Hideyuki Okano
- Organizer
  ISSCR in Tokyo
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Results Of A Randomized Clinical Trial of Ropinirole Hydrochloride For ALS (ROPALS) Based On iPS Cell Drug Discovery.2021
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Daisuke Ito, Yugaku Date, Kensuke Okada, Chai Muh Chyi, Ayumi Nishiyama, Naoki Suzuki, Miwa Hirai, Yasuaki Kabe, Makoto Suematsu, Masahiro Jinzaki, Masashi Aoki, Yasunori Sato, Jin Nakahara, Norihiro Suzuki, Hideyuki Okano
- Organizer
  第62回日本神経学会学術大会、Late Breakingセッション
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Results Of A Randomized Clinical Trial of Ropinirole Hydrochloride For ALS (ROPALS)．2021
- Author(s)
  髙橋愼一、森本　悟、伊東大介、伊達悠岳、岡田健佑、Chai（姓） Muh Chyi（名）、西山亜由美、鈴木直輝、平井美和、加部泰明、末松　誠、陣崎雅弘、青木正志、佐藤泰憲、中原　仁、鈴木則宏、岡野栄之
- Organizer
  第64回日本脳循環代謝学会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Phase 1/2a, Double-blind, Placebo-controlled Study of Ropinirole Hydrochloride (ROPALS).2021
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Date, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] ROPALS trial: phase 1/2a, double-blind, placebo-controlled study of ropinirole hydrochloride for ALS patients based on the iPSC drug repositioning.2021
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Date, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  International Society for Stem Cell Research　(ISSCR) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] ROPALS trial: phase 1/2a, double-blind, placebo-controlled study of ropinirole hydrochloride for ALS patients based on the iPSC drug repositioning.2021
- Author(s)
  Satoru Morimoto, Shinichi Takahashi, Kensuke Okada, Yugaku Date, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  The 44th Annual Meeting of the Japanese Neuroscience Society
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] ROPALS trial based on the iPSC drug repositioning for ALS: baseline profiles of trial participants.2020
- Author(s)
  高橋愼一，森本悟, 岡田健佑，伊達悠岳，伊東大介，中原仁，岡野栄之
- Organizer
  第63回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Medical manual for Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan2020
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, K Kanai, K Okamoto, T Kihira, S. Kuzuhara
- Organizer
  第61回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] ROPALS trial based on the iPSC drug repositioning for ALS: baseline profiles of trial participants.2020
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Daté, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Expression of mutant ubiquitin and proteostasis impairment in Kii ALS/PDC2020
- Author(s)
  Yasumasa Kokubo,Bert M. Verheijen, Satoru Morimoto, Ryogen Sasaki,Kiyomitsu Oyanagi, Shigeki Kuzuhara, Fred W. van Leeuwen
- Organizer
  第61回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Expression of mutant ubiquitin and proteostasis impairment in Kii ALS/PDC2020
- Author(s)
  Yasumasa Kokubo,Bert M. Verheijen, Satoru Morimoto, Ryogen Sasaki,Kiyomitsu Oyanagi, Shigeki Kuzuhara, Fred W. van Leeuwen
- Organizer
  第61回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] Medical manual for Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan2020
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, K Kanai, K Okamoto, T Kihira, S. Kuzuhara
- Organizer
  第61回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Abnormal Accumulation of Citrullinated Proteins of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan.2019
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, S. Kuzuhara, A. Ishigami.
- Organizer
  第13回MDSJ
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] Abnormal Accumulation of Citrullinated Proteins of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan.2019
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, S. Kuzuhara, A. Ishigami.
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] Ropinirole Hydrochloride Remedy for Amyotrophic Lateral Sclerosis2019
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Hideyuki Saya, Hideyuki Okano, Masashi Aoki, Norihiro Suzuki, Jin Nakahara
- Organizer
  AAN 2019 - American Academy of Neurology 71st Annual Meeting
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Phase 1/2a, Double-blind, Placebo-controlled Study with an Open-label Extension of Ropinirole Hydrochloride Extended-Release Tablets (ROPALS trial based on the iPSC drug repositioning)2019
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Daté, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  30th International Symposium on ALS/MND
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Study protocol for a phase Ⅰ/Ⅱa, double-blind, placebo-controlled trial of ropinirole for ALS2019
- Author(s)
  Shinichi Takahashi， Satoru Morimoto， Hideyuki Saya， Hideyuki Okano， Masashi Aoki， Norihiro
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Abnormal Accumulation of Citrullinated Proteins of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan2019
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, S. Kuzuhara, A. Ishigami.
- Organizer
  第60回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] Abnormal Accumulation of Citrullinated Proteins of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan.2019
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, S. Kuzuhara, A. Ishigami.
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Abnormal Accumulation of Citrullinated Proteins of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan.2019
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, S. Kuzuhara, A. Ishigami.
- Organizer
  第13回MDSJ
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Abnormal Accumulation of Citrullinated Proteins of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan2019
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, S. Kuzuhara, A. Ishigami.
- Organizer
  第60回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] A Clinical Manual of Amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan.2018
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, K Kanai, K Okamoto, T Kihira, S. Kuzuhara.
- Organizer
  第59回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18K07368
[Presentation] A Clinical Manual of Amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan.2018
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, K Kanai, K Okamoto, T Kihira, S. Kuzuhara.
- Organizer
  第59回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239

1. 岡野栄之 (60160694)

# of Collaborated Projects: 3 results

# of Collaborated Products: 39 results
2. KOKUBO Yasumasa (60263000)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
3. TAKAHASHI Shinichi (20236285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
4. 葛原茂樹 (70111383)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
5. 馬島恭子 (30812440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 奥宮清人 (20253346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐々木良元 (60303723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. 伊澤良兼 (90468471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 渡部博貴 (30422413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 土井宏 (10326035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田中章景 (30378012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中村治子 (70806223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 國井美紗子 (80725200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 泊幸秀 (90447368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 築地仁美 (40455358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SUZUKI Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 青木正志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 割田仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morimoto Satoru 森本 悟

Research Projects

Research Products

Co-Researchers

新規動物モデル、iPS細胞モデルを用いたCANVASの病態解明

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ALS運動ニューロン標的iPS細胞創薬から同定された薬物のグリア細胞疾患修飾作用

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D2R-mediated Gs/Gi rebalancing in ALS motor neuronsPrincipal Investigator

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Mechanism and application of Hero proteins

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A novel treatment of cerebral infarction with neuroprotective astrocytes induced by inflammatory microglia

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Comprehensive analysis of tau protein phosphorylation in pluripotent stem cells and human brainPrincipal Investigator

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New blood biomarker for Kii ALS/PDC

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ALS/PDC - 世界3大多発地での環境と遺伝子の cross talk -

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[Book] Annual Review 神経20222022

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[Book] Annual Review 神経20212021

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[Journal Article] Questioning the cycad theory of Kii ALS/PDC causation.2024

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[Journal Article] iPS細胞を用いたドラッグ・リポジショニングによるALS治療の探索―ロピニロール塩酸塩の作用とメカニズム―2023

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[Journal Article] Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery2023

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[Journal Article] 精神神経医療におけるDisease-Modifying Therapyの現在地と可能性2023

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Morimoto Satoru 森本悟