Ishimura Ryosuke 石村亮輔

Researcher Number	00816960
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2023: 順天堂大学, 医学部, 助教 2018: 新潟大学, 医歯学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related
Keywords	Principal Investigator CYB5R3 / UFM1 / ER-phagy / 小胞体選択的オートファジー / ユビキチン様タンパク質 / UBA5 / Ufmylation / Alphafold / E3 / 小頭症 … More / ユビキチン様修飾 / ユビキチン用修飾システム / 発達障害 / ユビキチン様修飾システム Less

UFM1修飾を介した小胞体選択的オートファジーの解明Principal Investigator
- Principal Investigator
  
  石村亮輔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
Regulation of CYB5R3 function by UfmylationPrincipal Investigator
- Principal Investigator
  
  Ishimura Ryosuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
The mechanism of severe developmental disorders caused by abnormalities in UFM1 systemPrincipal Investigator
- Principal Investigator
  
  Ishimura Ryosuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
  Niigata University

All 2023 2022 2021 2020 2018

All Journal Article Presentation

[Journal Article] Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control2023
- Author(s)
  Ishimura Ryosuke、Ito Sota、Mao Gaoxin、Komatsu-Hirota Satoko、Inada Toshifumi、Noda Nobuo N.、Komatsu Masaaki
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 33
- DOI
  10.1126/sciadv.adh3635
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06931, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-WRAPUP-23H05424, KAKENHI-PLANNED-21H05277, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-22H00401
[Journal Article] Loss of <i>Atg2b</i> and <i>Gskip</i> Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size2022
- Author(s)
  Sakai Shun-suke、Hasegawa Atsushi、Ishimura Ryosuke、Tamura Naoki、Kageyama Shun、Komatsu-Hirota Satoko、Abe Manabu、Ling Yiwei、Okuda Shujiro、Funayama Manabu、Kikkawa Mika、Miura Yoshiki、Sakimura Kenji、Narita Ichiei、Waguri Satoshi、Shimizu Ritsuko、Komatsu Masaaki
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 42 Issue: 1 Pages: 1-17
- DOI
  10.1128/mcb.00024-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01972, KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K16478, KAKENHI-PROJECT-20K16161, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-19H03555, KAKENHI-PROJECT-20H03415, KAKENHI-PROJECT-21H04163, KAKENHI-PROJECT-18KK0458, KAKENHI-PROJECT-21K17850
[Journal Article] The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.2022
- Author(s)
  Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M.
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 7857-7857
- DOI
  10.1038/s41467-022-35501-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07104, KAKENHI-PROJECT-22K06931, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-20H03415, KAKENHI-PROJECT-22H04360, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707
[Journal Article] A Description of Novel Variants and Review of Phenotypic Spectrum in UBA5-related Early Epileptic Encephalopathy2021
- Author(s)
  Briere LC, Walker MA, High FA, Rogers CA, Callahan C, Cooper C, Ishimura R, Ichimura Y, Caruso PA, Sharma N, Brokamp E, Koziura ME, Mohammad SS, Dale RC, Riley LG, Network UD, Phillips JA, Komatsu M, Sweetser DA.
- Journal Title
  
  Cold Spring Harb Mol Case Stud.
  
  Volume: mcs Issue: 3 Pages: a005827-a005827
- DOI
  10.1101/mcs.a005827
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-20K16161, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-16H06276
[Journal Article] A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy2020
- Author(s)
  Cabrera-Serrano Macarena、Coote David Joseph、Azmanov Dimitar、Goullee Hayley、Andersen Erik、McLean Catriona、Davis Mark、Ishimura Ryosuke、Stark Zornitza、Vallat Jean-Michel、Komatsu Masaaki、Kornberg Andrew、Ryan Monique、Laing Nigel G、Ravenscroft Gina
- Journal Title
  
  Journal of Medical Genetics
  
  Volume: - Issue: 12 Pages: 835-842
- DOI
  10.1136/jmedgenet-2019-106496
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18K15061, KAKENHI-PROJECT-20K16161
[Journal Article] Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.2018
- Author(s)
  Nahorski MS, Maddirevula S, Ishimura R, Alsahli S, Brady AF, Begemann A, Mizushima T, Guzman-Vega FJ, Obata M, Ichimura Y, Alsaif HS, Anazi S, Ibrahim N, Abdulwahab F, Hashem M, Monies D, Abouelhoda M, Meyer BF, Alfadhel M, Eyaid W, Zweier M, Steindl K, Rauch A, Arold ST, Woods CG, Komatsu M, Alkuraya FS.
- Journal Title
  
  Brain
  
  Volume: 141 Issue: 7 Pages: 1934-1945
- DOI
  10.1093/brain/awy135
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15061, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-16H06276
[Presentation] UFM1化と翻訳品質管理機構におけるUFM1 E3複合体の役割2023
- Author(s)
  石村亮輔, 伊藤壮太, Mao Gaoxin, 小松聡子, 稲田利文, 野田展生, 小松雅明
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06931
[Presentation] UFM1システムはCYB5R3のUfmylationを介してER-phagyを制御する2023
- Author(s)
  石村亮輔, 能代大輔, 植村武文, 和栗聡, 野田展生, 小松雅明
- Organizer
  第75回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-22K06931
[Presentation] UFM1化と翻訳品質管理機構におけるUFM1 E3複合体の役割2023
- Author(s)
  石村亮輔, 伊藤壮太, Mao Gaoxin, 小松聡子, 稲田利文, 野田展生, 小松雅明
- Organizer
  第5 回「マルチモードオートファジー」班会議・第15 回オートファジー研究会
- Data Source
  KAKENHI-PROJECT-22K06931
[Presentation] UFM1 E3リガーゼ複合体によるufmylationと翻訳品質管理機構の制御メカニズムの解明2023
- Author(s)
  石村亮輔, 伊藤壮太, Mao Gaoxin, 小松聡子, 稲田利文, 野田展生, 小松雅明
- Organizer
  2023年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-22K06931
[Presentation] Alphafold2構造予測からわかったUFM1システムの作動原理2022
- Author(s)
  石村亮輔, 野田展生, 小松雅明
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06931
[Presentation] UFM1システム：Alphafold2構造予測からわかったUFM1システムの作動原理2022
- Author(s)
  石村亮輔, 能代大輔, 植村武文, 和栗聡, 野田展生, 小松雅明
- Organizer
  第30回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06931
[Presentation] UFM1システムはCYB5R3のUFM1化を介してER-phagyを制御する2022
- Author(s)
  石村亮輔, 能代大輔, 植村武文, 和栗聡, 野田展生, 小松雅明
- Organizer
  日本顕微鏡学会第78回学術講演会
- Data Source
  KAKENHI-PROJECT-22K06931
[Presentation] UFM1システムによるER&-phagy制御ーその異常と遺伝性脳症ー2022
- Author(s)
  石村亮輔
- Organizer
  第64回日本小児神経学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K06931
[Presentation] E3-ligase for the UFM1-system acts as an adaptor for ER-phagy2020
- Author(s)
  Ishimura R, El-Gowily A. H., Noda NN, Komatsu M
- Organizer
  KEYSTONE SYMPOSIA Autophagy: Mechanisms and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16161

1. ICHIMURA Yoshinobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. UEMURA Takefumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 阿部学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小松雅明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 李賢哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishimura Ryosuke 石村 亮輔

Research Projects

Research Products

Co-Researchers

UFM1修飾を介した小胞体選択的オートファジーの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of CYB5R3 function by UfmylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of severe developmental disorders caused by abnormalities in UFM1 systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of <i>Atg2b</i> and <i>Gskip</i> Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Description of Novel Variants and Review of Phenotypic Spectrum in UBA5-related Early Epileptic Encephalopathy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] UFM1化と翻訳品質管理機構におけるUFM1 E3複合体の役割2023

Author(s)

Organizer

Data Source

[Presentation] UFM1システムはCYB5R3のUfmylationを介してER-phagyを制御する2023

Author(s)

Organizer

Data Source

[Presentation] UFM1化と翻訳品質管理機構におけるUFM1 E3複合体の役割2023

Author(s)

Organizer

Data Source

[Presentation] UFM1 E3リガーゼ複合体によるufmylationと翻訳品質管理機構の制御メカニズムの解明2023

Author(s)

Organizer

Data Source

[Presentation] Alphafold2構造予測からわかったUFM1システムの作動原理2022

Author(s)

Organizer

Data Source

[Presentation] UFM1システム：Alphafold2構造予測からわかったUFM1システムの作動原理2022

Author(s)

Organizer

Data Source

[Presentation] UFM1システムはCYB5R3のUFM1化を介してER-phagyを制御する2022

Author(s)

Organizer

Data Source

Ishimura Ryosuke 石村亮輔