Sakai Hiroshi 酒井大史

Researcher Number	00820804
Other IDs	https://orcid.org/0000-0001-9456-0911
Affiliation (Current)	2025: 愛媛大学, プロテオサイエンスセンター, 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 愛媛大学, プロテオサイエンスセンター, 助教
Review Section/Research Field	Principal Investigator Basic Section 59020:Sports sciences-related / 0909:Sports sciences, physical education, health sciences, and related fields Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 56020:Orthopedics-related / Basic Section 56030:Urology-related
Keywords	Principal Investigator アンドロゲン / 骨格筋 / 筋肥大 / 男性ホルモン / アンドロゲン受容体 / 骨格筋幹細胞 / 筋再生 / サルコペニア / Pax7 / 性ホルモン … More / PDGFRA / 間葉系前駆細胞 / 幹細胞 / サテライト細胞 / 再生 … More Except Principal Investigator 骨格筋 / 筋萎縮 / 栄養療法 / ICU-AW / PICS / 栄養素 / 筋力低下 / 敗血症 / cecal slurry / 選択的スプライシング / Acin1 / RNA結合タンパク質 / アンドロゲン受容体 / サルコペニア / アンドロゲン / C2C12 / Akt / 上皮成長因子受容体 / androgen receptor / androgen Less

Functional elucidation of Mybph, a novel factor with inhibitory effects on skeletal muscle hypertrophy for the prevention of muscle atrophy.Principal Investigator
- Principal Investigator
  
  酒井大史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Ehime University
敗血症モデルマウスを用いた骨格筋萎縮機序解明と急性期栄養介入法の探索
- Principal Investigator
  
  佐藤格夫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Ehime University
サルコペニア治療標的としてのRNA結合タンパク質Acin1の機能解析
- Principal Investigator
  
  青戸守
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Ehime University
fundamental study for indirect regulattions of skeletal muscle mass by androgen-like action outside of skeletal muscle fibers
- Principal Investigator
  
  Saika Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Ehime University
Elucidation of the molecular mechanism of the effect of androgens on the maintenance and the hypertrophy of skeletal muscle mass.Principal Investigator
- Principal Investigator
  
  Sakai Hiroshi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Ehime University
Elucidation of the mechanism of androgen regulation of skeletal muscle using integrative analysisPrincipal Investigator
- Principal Investigator
  
  Sakai Hiroshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Ehime University
Integrated analysis of androgen signaling in skeletal muscles.Principal Investigator
- Principal Investigator
  
  酒井大史
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0909:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Ehime University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Cell-specific functions of androgen receptor in skeletal muscles2024
- Author(s)
  Sakai Hiroshi, Imai Yuuki.
- Journal Title
  
  Endocrine Journal
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09373
[Journal Article] Uhrf1 governs the proliferation and differentiation of muscle satellite cells.2022
- Author(s)
  Sakai H, Sawada Y, Tokunaga N, Tanaka K, Nakagawa S, Sakakibara I, Ono Y, Fukada SI, Ohkawa Y, Kikugawa T, Saika T, Imai Y.
- Journal Title
  
  iScience.
  
  Volume: 25 Issue: 3 Pages: 103928-103928
- DOI
  10.1016/j.isci.2022.103928
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21398, KAKENHI-PUBLICLY-20H04846, KAKENHI-PUBLICLY-21H00232, KAKENHI-PROJECT-20H00456, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-21K09373, KAKENHI-PROJECT-21K17568, KAKENHI-PROJECT-23K24462
[Journal Article] DNA maintenance methylation enzyme Dnmt1 in satellite cells is essential for muscle regeneration2021
- Author(s)
  Iio Hiroyuki、Kikugawa Tadahiko、Sawada Yuichiro、Sakai Hiroshi、Yoshida Shuhei、Yanagihara Yuta、Ikedo Aoi、Saeki Noritaka、Fukada So-ichiro、Saika Takashi、Imai Yuuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 534 Pages: 79-85
- DOI
  10.1016/j.bbrc.2020.11.116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-19K16015, KAKENHI-PROJECT-19K19947
[Journal Article] Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk42021
- Author(s)
  Iori Sakakibara, Yuta Yanagihara, Koichi Himori, Takashi Yamada, Hiroshi Sakai, Yuichiro Sawada, Hirotaka Takahashi, Noritaka Saeki, Hiroyuki Hirakawa, Atsushi Yokoyama, So-Ichiro Fukada, Tatsuya Sawasaki, Yuuki Imai
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 4 Pages: 102303-102303
- DOI
  10.1016/j.isci.2021.102303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J01754, KAKENHI-PROJECT-19K19947, KAKENHI-PUBLICLY-21H00287, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-21K19230, KAKENHI-PROJECT-21K19723, KAKENHI-PROJECT-21K17568, KAKENHI-PROJECT-23K21587
[Journal Article] Polyamine pathway is associated with muscle anabolic effects by androgen receptor ligand2020
- Author(s)
  Kanou Masanobu、Nakamura Katsuyuki、Horie Kyohei、Sakai Hiroshi、Yanagihara Yuta、Sakakibara Iori、Yamana Kei、Imai Yuuki
- Journal Title
  
  JCSM Rapid Communications
  
  Volume: 4 Issue: 1 Pages: 57-74
- DOI
  10.1002/rco2.28
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-19K19947
[Journal Article] Androgen receptor in satellite cells is not essential for muscle regenerations2020
- Author(s)
  Sakai H, Sato T, Kanagawa M, Fukada S-i, Imai Y
- Journal Title
  
  Experimental Results
  
  Volume: e Pages: 1-9
- DOI
  10.1017/exp.2020.14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K19947, KAKENHI-PROJECT-19H03786
[Presentation] エクソン接合部複合体周辺因子Acin1の骨格筋線維特異的KOマウスの解析2024
- Author(s)
  青戸守、酒井大史、徳永順士、宮崎芽依、今井祐記、満田憲昭
- Organizer
  第101回日本生理学会大会（北九州）
- Data Source
  KAKENHI-PROJECT-22K09425
[Presentation] Androgens and Skeletal Muscle2023
- Author(s)
  Hiroshi Sakai
- Organizer
  HIRAKU-Global International Symposium/Annual Conference FY2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17568
[Presentation] 男性ホルモンによる骨格筋制御2023
- Author(s)
  酒井大史
- Organizer
  第9回骨格筋生物学研究会
- Data Source
  KAKENHI-PROJECT-21K17568
[Presentation] 骨格筋間葉系前駆細胞におけるアンドロゲン受容体の解析2022
- Author(s)
  酒井大史
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-21K17568
[Presentation] Androgen receptor in mesenchymal progenitors of skeletal muscle2022
- Author(s)
  Hiroshi Sakai
- Organizer
  第20回松山国際学術シンポジウム（プロテイン・アイランド・松山2022）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17568
[Presentation] 骨格筋間葉系前駆細胞におけるアンドロゲン受容体の解析2021
- Author(s)
  酒井大史, 今井祐記
- Organizer
  第76回日本体力医学会大会
- Data Source
  KAKENHI-PROJECT-21K17568
[Presentation] Androgen receptor in satellite cells is not essential for muscle regenerations2020
- Author(s)
  Hiroshi Sakai, Takahiko Sato, Motoi Kanagawa, So-ichiro Fukada, Yuuki Imai
- Organizer
  第6回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-19K19947
[Presentation] Muscle regeneration in a muscle stem cell-specific androgen receptor-knockout mice2019
- Author(s)
  Hiroshi Sakai, Yuuki Imai
- Organizer
  第7回骨格筋生物学研究会
- Data Source
  KAKENHI-PROJECT-18H06439
[Presentation] Muscle regeneration in a muscle stem cell-specific androgen receptor-knockout mice2019
- Author(s)
  Hiroshi Sakai, Yuuki Imai
- Organizer
  Protein Island Matsuyama 2019 (PIM2019) International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19947
[Presentation] Muscle regeneration in a muscle stem cell-specific androgen receptor-knockout mice2019
- Author(s)
  Hiroshi Sakai, Takahiko Sato, Yuuki Imai
- Organizer
  第7回若手による骨格筋細胞研究会
- Data Source
  KAKENHI-PROJECT-19K19947
[Presentation] Muscle regeneration in a muscle stem cell-specific androgen receptor-knockout mice2019
- Author(s)
  Hiroshi Sakai
- Organizer
  The 42nd Annual Meeting of the Molecular Biology Society of Japan
- Data Source
  KAKENHI-PROJECT-19K19947
[Presentation] Muscle regeneration in a muscle stem cell-specific androgen receptor-knockout mice2019
- Author(s)
  酒井大史、今井祐記
- Organizer
  日本筋学会第5回学術集会
- Data Source
  KAKENHI-PROJECT-19K19947
[Presentation] Muscle regeneration in a muscle stem cell-specific androgen receptor-knockout mice2019
- Author(s)
  酒井大史
- Organizer
  新学術領域研究「性スペクトラム連続する表現型としての雌雄」第3回領域会議
- Data Source
  KAKENHI-PROJECT-19K19947
[Presentation] Muscle regeneration in Pax7CE/+;ARL2/Y mice2018
- Author(s)
  Hiroshi SAKAI
- Organizer
  Skeletal Science Retreat 2018
- Data Source
  KAKENHI-PROJECT-18H06439

1. 今井祐記 (10423873)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. Saika Takashi (10314676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 菊川忠彦 (70444734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 三浦徳宣 (80554427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 青戸守 (50372727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 佐藤格夫 (30409205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OHKAWA Yasuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakai Hiroshi 酒井 大史

Research Projects

Research Products

Co-Researchers

Functional elucidation of Mybph, a novel factor with inhibitory effects on skeletal muscle hypertrophy for the prevention of muscle atrophy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

敗血症モデルマウスを用いた骨格筋萎縮機序解明と急性期栄養介入法の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

サルコペニア治療標的としてのRNA結合タンパク質Acin1の機能解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

fundamental study for indirect regulattions of skeletal muscle mass by androgen-like action outside of skeletal muscle fibers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism of the effect of androgens on the maintenance and the hypertrophy of skeletal muscle mass.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of androgen regulation of skeletal muscle using integrative analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated analysis of androgen signaling in skeletal muscles.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cell-specific functions of androgen receptor in skeletal muscles2024

Author(s)

Journal Title

Data Source

[Journal Article] Uhrf1 governs the proliferation and differentiation of muscle satellite cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA maintenance methylation enzyme Dnmt1 in satellite cells is essential for muscle regeneration2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk42021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polyamine pathway is associated with muscle anabolic effects by androgen receptor ligand2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Androgen receptor in satellite cells is not essential for muscle regenerations2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] エクソン接合部複合体周辺因子Acin1の骨格筋線維特異的KOマウスの解析2024

Author(s)

Organizer

Data Source

[Presentation] Androgens and Skeletal Muscle2023

Sakai Hiroshi 酒井大史