Mukudai Shigeyuki 椋代茂之

Researcher Number	00821860
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator TGF-β/SMAD signaling / 声帯瘢痕 / タモキシフェン / 選択的エストロゲン受容体修飾薬 / TGF-β1/Smad signaling / ステロイドホルモン / GPR30 / ERα / 声帯線維芽細胞 / エストロゲン受容体 / TGF-β/Smad signaling / エストロゲン … More Except Principal Investigator … More 声帯瘢痕 / 再生医療 / 増殖因子治療 / 細胞治療 / 羊膜 / 声帯再生 / サルコペニア / 凍結標本 / 頭頚部外科手術 / 嚥下筋 / 筋病理 / PRP / 細胞増殖因子 / 幹細胞 / 声帯溝症 / 分化誘導 / 線維芽細胞 / 間葉系幹細胞 Less

Hybrid strategy for regenerative treatment of severe vocal fold scar
- Principal Investigator
  
  平野滋
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto Prefectural University of Medicine
ヒト嚥下筋の組織学的検討―多施設共同研究によるサルコペニアの嚥下障害の病態解明
- Principal Investigator
  
  巨島文子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Aichi Medical University
Mechanical analysis and novel therapies development of selective estrogen receptor modulators (SERMs) for vocal fold scarsPrincipal Investigator
- Principal Investigator
  
  椋代茂之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Regeneration for vocal fold sulcus with amniotic membrane
- Principal Investigator
  
  Hirano Shigeru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto Prefectural University of Medicine
Development of novel estrogen treatment for vocal fold scarPrincipal Investigator
- Principal Investigator
  
  Mukudai Shigeyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Basic research for development of regenerative medicine for stiffened vocal folds according to severity
- Principal Investigator
  
  Hirano Shigeru
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto Prefectural University of Medicine

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Tamoxifen Alters <scp>TGF</scp> ‐β1/Smad Signaling in Vocal Fold Injury2022
- Author(s)
  Matsushita Hiroki、Mukudai Shigeyuki、Ozawa Satomi、Kinoshita Shota、Hashimoto Keiko、Kaneko Mami、Sugiyama Yoichiro、Branski Ryan C.、Hirano Shigeru
- Journal Title
  
  The Laryngoscope
  
  Volume: - Issue: 9 Pages: 2248-2254
- DOI
  10.1002/lary.30448
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09671, KAKENHI-PROJECT-19H03805, KAKENHI-PROJECT-22K16902
[Journal Article] 声帯瘢痕・溝症に対する再生医療の現状と羊膜の応用．2022
- Author(s)
  小川真智子、椋代茂之、中西庸介、吉崎智一、平野　滋．
- Journal Title
  
  喉頭
  
  Volume: 34 Pages: 144-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03805
[Journal Article] Effects of Repeated Intracordal Glucocorticoid Injection on the Histology and Gene Expression of Rat Vocal Folds.2021
- Author(s)
  Hashimoto K, Kaneko M, Kinoshita S, Ozawa S, Mukudai S, Sugiyama Y, Hirano S. Effects of Repeated Intracordal Glucocorticoid Injection on the Histology and Gene Expression of Rat Vocal Folds. J Voice. 2021 Jul 17:S0892-1997(21)00199-5. doi: 10.1016/j.jvoice.2021.06.013. Online ahead of print.
- Journal Title
  
  J Voice.
  
  Volume: E-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03805
[Journal Article] Anti-inflammatory and Antioxidant Effects of Japanese Herbal Medicine Kyoseihatekigan on Vocal Fold Wound Healing.2021
- Author(s)
  Ozawa S, Mukudai S, Kaneko M, Kinoshita S, Hashimoto K, Sugiyama Y, Hashimoto S, Akaki J, Hirano S.
- Journal Title
  
  J Voice
  
  Volume: E-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03805
[Journal Article] Physiological Effects of Voice Therapy for Aged Vocal Fold Atrophy Revealed by EMG Study.2021
- Author(s)
  Kaneko M, Sugiyama Y, Fuse S, Mukudai S, Hirano S.
- Journal Title
  
  J Voice.
  
  Volume: E-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03805
[Journal Article] The Effects of Amniotic Membrane Transplantation on Vocal Fold Regeneration.2021
- Author(s)
  Ogawa M, Mukudai S, Sugiyama Y, Matsushita H, Kinoshita S, Ozawa S, Hashimoto K, Fuse S, Kaneko M, Nakanishi Y, Yoshizaki T, Sotozono C, Hirano S
- Journal Title
  
  Laryngoscope
  
  Volume: - Issue: 10 Pages: 2017-2025
- DOI
  10.1002/lary.29997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22691, KAKENHI-PROJECT-19H03805
[Journal Article] 細胞増殖因子による声帯の再生医療up to date.2020
- Author(s)
  平野　滋、杉山庸一郎、椋代茂之、橋本慶子、布施慎也、木下翔太、金子真美．
- Journal Title
  
  日気食
  
  Volume: 71 Pages: 167-168
- NAID
  130007835755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03805
[Journal Article] Mechanisms Underlying the Antifibrotic Potential of Estradiol for Vocal Fold Fibrosis2020
- Author(s)
  Ozawa Satomi、Mukudai Shigeyuki、Sugiyama Yoichiro、Branski Ryan C.、Hirano Shigeru
- Journal Title
  
  The Laryngoscope
  
  Volume: - Issue: 10 Pages: 2285-2291
- DOI
  10.1002/lary.29355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18813, KAKENHI-PROJECT-19H03805
[Journal Article] Complex fibroblast response to glucocorticoids may underlie variability of clinical efficacy in the vocal folds2020
- Author(s)
  Nakamura Ryosuke、Mukudai Shigeyuki、Bing Renjie、Garabedian Michael J.、Branski Ryan C.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1
- DOI
  10.1038/s41598-020-77445-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18813
[Journal Article] Intracordal Injection of Basic Fibroblast Growth Factor in 100 Cases of Vocal Fold Atrophy and Scar2020
- Author(s)
  Hirano Shigeru、Sugiyama Yoichiro、Kaneko Mami、Mukudai Shigeyuki、Fuse Shinya、Hashimoto Keiko
- Journal Title
  
  The Laryngoscope
  
  Volume: - Issue: 9 Pages: 2059-2064
- DOI
  10.1002/lary.29200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09353, KAKENHI-PROJECT-19K22691, KAKENHI-PROJECT-19H03805
[Journal Article] Implementing Efficient Peptoid‐Mediated Delivery of RNA‐Based Therapeutics to the Vocal Folds2019
- Author(s)
  Mukudai Shigeyuki、Kraja Iv、Bing Renjie、Nalband Danielle M.、Tatikola Mallika、Hiwatashi Nao、Kirshenbaum Kent、Branski Ryan C.
- Journal Title
  
  Laryngoscope Investigative Otolaryngology
  
  Volume: 4 Issue: 6 Pages: 640-644
- DOI
  10.1002/lio2.310
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18813
[Journal Article] Quantifying vocal fold wound‐healing biomechanical property changes2019
- Author(s)
  Dion Gregory R.、Guda Teja、Mukudai Shigeyuki、Bing Renjie、Lavoie Jean‐Francois、Branski Ryan C.
- Journal Title
  
  The Laryngoscope
  
  Volume: 130 Issue: 2 Pages: 454-459
- DOI
  10.1002/lary.27999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18813
[Presentation] ラット声帯線維芽細胞のTGF-β1/Smad signalingに対するタモキシフェンの抗線維化作用2023
- Author(s)
  椋代茂之　松下大樹　小澤聡美　木下翔太　橋本慶子　金子真美　杉山庸一郎　平野滋
- Organizer
  第35回日本喉頭科学会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K16902
[Presentation] ラット声帯線維芽細胞のTGF-β1/Smad signalingに対するタモキシフェンの抗線維化作用2023
- Author(s)
  椋代茂之，松下大樹，小澤聡美，木下翔太，橋本慶子，金子真美，杉山庸一郎，平野滋
- Organizer
  第35回日本喉頭科学会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K16902
[Presentation] ラット声帯損傷に対するTamoxifenの抗線維化効果2023
- Author(s)
  松下大樹　椋代茂之　小澤聡美　木下翔太　橋本慶子　杉山庸一郎　平野滋
- Organizer
  第124回日本耳鼻咽喉科頭頸部外科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K16902
[Presentation] 声帯瘢痕の基礎と臨床-Scarwars．羊膜移植の声帯再生における効果．2022
- Author(s)
  小川真智子、椋代茂之、杉山庸一郎、中西庸介、吉崎智一、平野　滋
- Organizer
  第35回日本喉頭科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03805
[Presentation] 声帯粘膜再生における羊膜移植の効果．2022
- Author(s)
  小川真智子、椋代茂之、杉山庸一郎、松下大樹、木下翔太、小澤聡美、橋本慶子、布施慎也、金子真美、平野　滋．
- Organizer
  第34回日本喉頭科学会
- Data Source
  KAKENHI-PROJECT-19K22691
[Presentation] The effects of amniotic membrane transplantation on vocal fold regeneration.2022
- Author(s)
  Ogawa M, Mukudai S, Sugiyama Y, Yoshizaki T, Hirano S.
- Organizer
  16th Meeting of International Association of Phonosurgery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03805
[Presentation] ラット培養声帯線維芽細胞に対するエストラジオールの抗線維化作用2021
- Author(s)
  小澤聡美，椋代茂之，木下翔太，布施慎也，橋本慶子，金子真美，杉山庸一郎，平野　滋
- Organizer
  第122回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K18813
[Presentation] The effects of human amniotic membrane transplantation for vocal fold regeneration.2021
- Author(s)
  Ogawa M, Mukudai S, Matsushita H, Kinoshita S, Ozawa S, Hashimoto K, Kaneko M, Nakanishi Y, Sugiyama Y, Yoshikazu T, Hirano S.
- Organizer
  European Laryngoglocial Association,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22691
[Presentation] Anti-inflammatory and Anti-oxidant Effects of Japanese Herbal Medicine Kyoseihatekigan On Vocal Fold Wound Healing2021
- Author(s)
  Mukudai S, Ozawa S, Kaneko M, Sugiyama Y, Hirano S.
- Organizer
  American Bronchoesophagological Association
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03805
[Presentation] SMAD3抑制による声帯瘢痕治療におけるリピトイドの比較検討2020
- Author(s)
  椋代茂之、木下翔太、小澤聡美、布施慎也、橋本慶子、金子真美、杉山庸一郎、平野滋
- Organizer
  第32回日本喉頭科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K18813
[Presentation] SMAD3抑制による声帯瘢痕治療におけるリピトイドの比較検討．2020
- Author(s)
  椋代茂之、木下翔太、小澤聡美、布施慎也、橋本慶子、金子真美、杉山庸一郎、平野　滋．
- Organizer
  第32回日本喉頭科学会
- Data Source
  KAKENHI-PROJECT-19H03805
[Presentation] Estradiol Ameliorates Vocal Fold Fibrosis by Modulation of Estrogen Receptor-Mediated TGF-β1 Signaling2020
- Author(s)
  Satomi Ozawa, MD; Shigeyuki Mukudai, MD, PhD; Yoichiro Sugiyama, MD, PhD; Ryan C. Branski, PhD; Shigeru Hirano, MD, PhD
- Organizer
  ombined Otolaryngology Spring Meetings　2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18813
[Presentation] ラット声帯創傷治癒に対するエストロゲン作用2020
- Author(s)
  小澤聡美、椋代茂之、木下翔太、布施慎也、橋本慶子、金子真美、杉山庸一郎、平野滋
- Organizer
  第32回日本喉頭科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K18813
[Presentation] Estradiol Ameliorates Vocal Fold Fibrosis by Modulation of Estrogen Receptor-Mediated TGFb1 Signaling.2020
- Author(s)
  Ozawa S, Mukudai S, Sugiyama Y, Branski R, Hirano S.
- Organizer
  ALA meeting, 2020, May16-Jun 15, ePoster (Atlanta)
- Data Source
  KAKENHI-PROJECT-19H03805
[Presentation] 声帯線維芽細胞におけるグルココルチコイド受容体のリン酸化とTGFb/SMAD signalingへの関与．2019
- Author(s)
  椋代茂之
- Organizer
  第31回日本喉頭科学会
- Data Source
  KAKENHI-PROJECT-19H03805

1. Hirano Shigeru (10303827)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
2. 杉山庸一郎 (50629566)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. 斉藤敦志 (80573633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 金子真美 (20868591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 巨島文子 (70972785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 久保田暁 (30771589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 清水潤 (40260492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤本保志 (40344337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 國枝顕二郎 (50701885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 平野愛 (60596097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 森健一 (80823666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mukudai Shigeyuki 椋代 茂之

Research Projects

Research Products

Co-Researchers

Hybrid strategy for regenerative treatment of severe vocal fold scar

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト嚥下筋の組織学的検討―多施設共同研究によるサルコペニアの嚥下障害の病態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanical analysis and novel therapies development of selective estrogen receptor modulators (SERMs) for vocal fold scarsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regeneration for vocal fold sulcus with amniotic membrane

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel estrogen treatment for vocal fold scarPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research for development of regenerative medicine for stiffened vocal folds according to severity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Tamoxifen Alters <scp>TGF</scp> ‐β1/Smad Signaling in Vocal Fold Injury2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 声帯瘢痕・溝症に対する再生医療の現状と羊膜の応用．2022

Author(s)

Journal Title

Data Source

[Journal Article] Effects of Repeated Intracordal Glucocorticoid Injection on the Histology and Gene Expression of Rat Vocal Folds.2021

Author(s)

Journal Title

Data Source

[Journal Article] Anti-inflammatory and Antioxidant Effects of Japanese Herbal Medicine Kyoseihatekigan on Vocal Fold Wound Healing.2021

Author(s)

Journal Title

Data Source

[Journal Article] Physiological Effects of Voice Therapy for Aged Vocal Fold Atrophy Revealed by EMG Study.2021

Author(s)

Journal Title

Data Source

[Journal Article] The Effects of Amniotic Membrane Transplantation on Vocal Fold Regeneration.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 細胞増殖因子による声帯の再生医療up to date.2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Mechanisms Underlying the Antifibrotic Potential of Estradiol for Vocal Fold Fibrosis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Complex fibroblast response to glucocorticoids may underlie variability of clinical efficacy in the vocal folds2020

Author(s)

Journal Title

DOI

Mukudai Shigeyuki 椋代茂之