Nakano Masaki 中野将希

Researcher Number	00823890
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 神経難病研究センター, 助教
Affiliation (based on the past Project Information) *help	2020 – 2025: 滋賀医科大学, 神経難病研究センター, 助教 2019: 滋賀医科大学, 神経難病研究センター, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator アミロイドβ / 老化 / アルツハイマー病 / 並体結合 / 液性因子 / Amyloid-β / 転写 / 加齢性分子 Except Principal Investigator アミロイドβ / アルツハイマー病 … More / 老化 / 先制医療 / 予防的介入 / 遺伝子発現制御 / APP / FAM3C / ゲノム編集 / リスク遺伝子 Less

新規加齢性分子の発現変化に伴うアミロイドβ代謝制御機構の解明Principal Investigator
- Principal Investigator
  
  中野将希
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
老化関連因子が脳Aβ蓄積を促進する分子メカニズムの解析
- Principal Investigator
  
  西村正樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
全身性循環因子からの加齢依存的Aβ蓄積制御機構の解明Principal Investigator
- Principal Investigator
  
  中野将希
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
The search identification and functional analysis of the systemic humoral factor controlling Abeta accumulation in the brainPrincipal Investigator
- Principal Investigator
  
  Nakano Masaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Development of preventive therapy for Alzheimer's disease by modification in expressional levels of the risk genes
- Principal Investigator
  
  Nishimura Masaki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Reduction of amyloid-β production without inhibiting secretase activity by MS-2752024
- Author(s)
  Yachiyo Mitsuishi, Masaki Nakano, Hirotatsu Kojima, Takayoshi Okabe, Masaki Nishimura
- Journal Title
  
  ACS chemical neuroscience
  
  Volume: 15 Issue: 6 Pages: 1234-1241
- DOI
  10.1021/acschemneuro.3c00848
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15639
[Journal Article] Nicotinic acetylcholine receptor activation induces BACE1 transcription via the phosphorylation and stabilization of nuclear SP12023
- Author(s)
  Masaki Nakano*, Tomohiro Tsuchida, Yachiyo Mitsuishi, Masaki Nishimura*.
- Journal Title
  
  Neuroscience Research
  
  Volume: in press Pages: 28-41
- DOI
  10.1016/j.neures.2023.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15639
[Journal Article] Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70.4 loss-of-function mutants.2022
- Author(s)
  Nakano M, Imamura R, Sugi T, Nishimura M.
- Journal Title
  
  PNAS Nexus
  
  Volume: 1 Issue: 5 Pages: 1-11
- DOI
  10.1093/pnasnexus/pgac242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03546
[Journal Article] Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70.4 loss-of-function mutants.2022
- Author(s)
  Masaki Nakano, Ryuki Imamura, Takuma Sugi, Masaki Nishimura.
- Journal Title
  
  PNAS Nexus
  
  Volume: 1 Pages: 242-242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15639
[Journal Article] Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain.2022
- Author(s)
  Watanabe N, Nakano M, Mitsuishi Y, Hara N, Mano T, Iwata A, Murayama S, Suzuki T, Ikeuchi T, Nishimura M
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 31 Issue: 1 Pages: 122-132
- DOI
  10.1093/hmg/ddab226
- NAID
  120007186913
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-20H03587, KAKENHI-PROJECT-20K16491, KAKENHI-PROJECT-16H06277
[Journal Article] Extracellular release of ILEI/FAM3C and amyloid-β is associated with the activation of distinct synapse subpopulations.2021
- Author(s)
  Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido C T, Murayama S, Kasuga K, Ikeuchi K, Suzuki T, Nishimura M
- Journal Title
  
  Journal of Alzheimer’s disease
  
  Volume: 80 Issue: 1 Pages: 159-174
- DOI
  10.3233/jad-201174
- NAID
  120007019774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-20K16491, KAKENHI-PROJECT-18H02566, KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546
[Journal Article] A Potential Defense Mechanism Against Amyloid Deposition in Cerebellum2021
- Author(s)
  Shahnur Alam, Masaki Nakano, Seiko Ishihara, Nobuto Kakuda, Tomohiro Miyasaka, Hina Uchiyama, Yuuna Shirai, Mohammad Moniruzzaman, Takashi Saito, Takaomi C. Saido, Masaki Nishimura, Satoru Funamoto
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 535 Pages: 25-32
- DOI
  10.1016/j.bbrc.2020.12.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546
[Journal Article] FAM3C in Alzheimer’s disease. A risk-related molecule and potential therapeutic target.2020
- Author(s)
  Nishimura M, Watanabe N, Hibino E, Nakano M, Mitsuishi Y, Liu L, Sugi T
- Journal Title
  
  The Neuroscience of Dementia
  
  Volume: 2 Pages: 293-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16912
[Journal Article] Emodin, as a mitochondrial uncoupler, induces strong decreases in ATP levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.2019
- Author(s)
  Sugiyama, U., Shudo, T., Hosokawa, S., Watanabe, A., Nakano, M., Kakizuka, A.
- Journal Title
  
  Genes to Cells
  
  Volume: 8 Issue: 8 Pages: 569-584
- DOI
  10.1111/gtc.12712
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-19H03435
[Presentation] ILEI/FAM3Cのストレスにおける新規機能解析2024
- Author(s)
  中野将希
- Organizer
  同志社大学神経病理学研究室／神経変性疾患研究センター共催セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] Nicotinic ACh receptor activation induces BACE1 transcription via MEK/ERK-SP1 signaling pathway2023
- Author(s)
  Masaki Nakano, Yachiyo Mitsuishi, Takashi Saito, Takaomi C Saido, Masaki Nishimura
- Organizer
  AAIC2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] ニコチン性アセチルコリン受容体活性化はMEK/ERK-SP1経路を介してBACE1の転写を誘導する2023
- Author(s)
  中野将希, 三ツ石弥千代, 西村正樹
- Organizer
  第96回日本生化学大会
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] Alzheimer病の新たなバイオマーカーの開発に向けて2023
- Author(s)
  中野将希
- Organizer
  滋賀医科大学 2022年度SUMSグランド・ラウンド（第11回）重点研究領域発表会
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] ニコチン性アセチルコリン受容体活性化によるBACE1の転写メカニズム2023
- Author(s)
  中野将希, 三ツ石弥千代, 西村正樹
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70.4 loss-of-function mutants2023
- Author(s)
  Masaki Nakano, Ryuki Imamura, Takuma Sugi, Masaki Nishimura
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] PresenilinによるAβ産生のデュアル制御メカニズム2022
- Author(s)
  西村正樹,渡邊直希,中野将希
- Organizer
  第41回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] ニコチン受容体活性化のAPP代謝に与える影響2022
- Author(s)
  中野将希、三ツ石弥千代、斉藤貴志、西道隆臣、西村正樹
- Organizer
  第41回日本認知症学会学術集会第37回日本老年精神医学会合同開催
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] ニコチン受容体活性化のAPP代謝に与える影響2022
- Author(s)
  中野将希、三ツ石弥千代、斉藤貴志、西道隆臣、西村正樹
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Aβ代謝に与えるニコチン性アセチルコリン受容体活性化の影響2022
- Author(s)
  中野将希、斉藤貴志、西道隆臣、西村正樹
- Organizer
  第95回日本生化学大会
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] 新規Aβ産生抑制分子ILEIの発現低下によるアルツハイマー病リスクの検証2022
- Author(s)
  渡邊直希、中野将希、西村正樹
- Organizer
  第41回日本認知症学会学術集会第37回日本老年精神医学会合同開催
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] 全身性老化からみたアルツハイマー病発症リスクの解析2022
- Author(s)
  中野将希
- Organizer
  滋賀医科大学第7回SUMSグランド・ラウンド
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] Aβ代謝に与えるニコチン性アセチルコリン受容体活性化の影響2022
- Author(s)
  中野将希,斉藤貴志,西道隆臣,西村正樹
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] 新規Aβ産生抑制分子ILEIの発現低下によるアルツハイマー病リスクの検証2022
- Author(s)
  渡邊直希,中野将希.西村正樹
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] PresenilinによるAβ産生のデュアル制御メカニズム2022
- Author(s)
  西村正樹、渡邊直希、中野将希
- Organizer
  第41回日本認知症学会学術集会第37回日本老年精神医学会合同開催
- Data Source
  KAKENHI-PROJECT-22K15639
[Presentation] ニコチン性アセチルコリン受容体刺激がAβ産生に与える影響2021
- Author(s)
  中野将希、斉藤貴志、西道隆臣、西村正樹．
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation.2021
- Author(s)
  Nakano M, Mitsuishi Y, Liu L, Watanabe N, Saito T, Saido TC, Suzuki T, Nishimura M
- Organizer
  AAIC 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] ニコチン性アセチルコリン受容体刺激がAβ産生に与える影響2021
- Author(s)
  中野将希、斉藤貴志、西道隆臣、西村正樹
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16912
[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation2021
- Author(s)
  Masaki Nakano, Yachiyo Mitsuishi, Lei Liu, Naoki Watanabe, Takashi Saito, Takaomi C Saido, Toshiharu Suzuki, Masaki Nishimura
- Organizer
  AAIC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16912
[Presentation] なぜAβ沈着は大脳で多く小脳で少ないのか？―小脳からの盛んなAβ排出ー2020
- Author(s)
  Alam Shahnur、中野将希、石原聖子、宮坂知宏、角田伸人、斉藤貴志、西道隆臣、舟本聡
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16912
[Presentation] Aβ産生を抑制するILEI/FAM3Cの転写制御メカニズム解析2020
- Author(s)
  渡邊直希、中野将希、西村正樹
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Aβ産生を抑制するFAM3C/ILEIは線虫において記憶学習に関連する2020
- Author(s)
  中野将希、杉琢磨、西村正樹
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16912
[Presentation] Activation of distinct synaptic populations regulates extracellular release of ILEI/FAM3C and Aβ2020
- Author(s)
  中野将希、三ツ石弥千代、渡邊直樹、日比野絵美、斉藤貴志、西道隆臣、鈴木利治、西村正樹
- Organizer
  AAIC2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16912
[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation.2020
- Author(s)
  Nakano M, Mitsuishi Y, Watanabe N, Saito T, Saido TC, Suzuki T, Nishimura M
- Organizer
  AAIC 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Aβ産生を抑制するFAM3C/ILEIは線虫において記憶学習に関連する2020
- Author(s)
  中野将希、杉拓磨、西村正樹
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] なぜAβ沈着は大脳で多く小脳で少ないのか？―小脳からの盛んなAβ排出ー2020
- Author(s)
  Alam Shahnur、中野将希、石原聖子、宮坂知宏、角田伸人、斉藤貴志、西道隆臣、西村正樹、舟本　聡
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Synaptic activity-dependent release of presynaptic ilei/FAM3C.2019
- Author(s)
  中野将希、三ツ石弥千代、渡邊直希、日比野絵美、斉藤貴志、西道隆臣、鈴木利治、西村正樹.
- Organizer
  AAIC 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16912
[Presentation] Presynaptic ILEI/FAM3C is released in an activity-dependent manner like Aβ exocytosis2019
- Author(s)
  中野将希、三ツ石弥千代、渡邊直希、日比野絵美、杉拓磨、斉藤貴志、西道隆臣、鈴木利治、西村正樹
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Synaptic activity-dependent release of presynaptic ILEI/FAM3C2019
- Author(s)
  Nakano M, Mitsuishi Y, Watanabe N, Hibino E, Saito T, Saido TC, Suzuki T, Nishimura M.
- Organizer
  AAIC 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] 大脳皮質におけるILEI/FAM3CおよびAβの間質液への分泌様式に関する比較検討2019
- Author(s)
  中野将希, 三ツ石弥千代, 渡邊直希, 日比野絵美, 斉藤貴志, 西道隆臣, 鈴木利治, 西村正樹
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] 大脳皮質におけるILEI/FAM3CおよびAβの間質液への分泌様式に関する比較検討2019
- Author(s)
  中野将希、三ツ石弥千代、渡邊直希、日比野絵美、斉藤貴志、西道隆臣、鈴木利治、西村正樹
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16912
[Presentation] Presynaptic ILEI/FAM3C is released in an activity-dependent manner like Aβ exocytosis.2019
- Author(s)
  中野将希、三ツ石弥千代、渡邊直希、日比野絵美、杉拓磨、斉藤貴志、西道隆臣、鈴木利治、西村正樹.
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-19K16912

1. Nishimura Masaki (40322739)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
2. 渡邊直希 (60769339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results

Nakano Masaki 中野 将希

Research Projects

Research Products

Co-Researchers

新規加齢性分子の発現変化に伴うアミロイドβ代謝制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

老化関連因子が脳Aβ蓄積を促進する分子メカニズムの解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

全身性循環因子からの加齢依存的Aβ蓄積制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The search identification and functional analysis of the systemic humoral factor controlling Abeta accumulation in the brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of preventive therapy for Alzheimer's disease by modification in expressional levels of the risk genes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Reduction of amyloid-β production without inhibiting secretase activity by MS-2752024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nicotinic acetylcholine receptor activation induces BACE1 transcription via the phosphorylation and stabilization of nuclear SP12023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70.4 loss-of-function mutants.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70.4 loss-of-function mutants.2022

Author(s)

Journal Title

Data Source

[Journal Article] Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain.2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Extracellular release of ILEI/FAM3C and amyloid-β is associated with the activation of distinct synapse subpopulations.2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A Potential Defense Mechanism Against Amyloid Deposition in Cerebellum2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FAM3C in Alzheimer’s disease. A risk-related molecule and potential therapeutic target.2020

Author(s)

Journal Title

Data Source

[Journal Article] Emodin, as a mitochondrial uncoupler, induces strong decreases in ATP levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] ILEI/FAM3Cのストレスにおける新規機能解析2024

Nakano Masaki 中野将希