Tenshin Hirofumi 天眞寛文

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TENSHIN Hirofumi 天眞寛文

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Researcher Number	00829187
Other IDs
Affiliation (Current)	2025: 徳島大学, 病院, 助教
Affiliation (based on the past Project Information) *help	2024: 徳島大学, 病院, 助教 2019 – 2021: 徳島大学, 病院, 助教 2018: 徳島大学, 大学院医歯薬学研究部(歯学域), 特任助教
Review Section/Research Field	Principal Investigator 0907:Oral science and related fields / Basic Section 57070:Developmental dentistry-related
Keywords	Principal Investigator 炎症 / NLRP3インフラマソーム / 関節リウマチ / 破骨細胞 / TAK1 / 加齢性変化 / 歯槽骨 / 骨細胞 / マクロファージ / 滑膜線維芽細胞 … More / 関節破壊 / 自己免疫性疾患 / インフラマソーム形成 / TAK1阻害 / 骨破壊 / 炎症性疾患 Less

加齢性歯槽骨吸収における骨細胞の役割の解明Principal Investigator
- Principal Investigator
  
  天眞寛文
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  The University of Tokushima
Investigation of the role of TAK1-NLRP3 inflammasome axis in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  TENSHIN Hirofumi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  The University of Tokushima
The novel therapeutic roles of TAK1 inhibition in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  TENSHIN Hirofumi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  The University of Tokushima

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] TGF‐β‐activated kinase‐1 inhibitor LL‐Z1640‐2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF‐α and RANKL expression2022
- Author(s)
  Tenshin H, Teramachi J, Ashtar M, Hiasa M, Inoue Y, Oda A, Tanimoto K, Shimizu S, Higa Yi, Harada T, Oura M, Sogabe K, Hara T, Sumitani R, Maruhashi T, Sebe M, Tsutsumi R, Sakaue H, Endo I, Matsumoto T, Tanaka E, Abe M
- Journal Title
  
  Clinical & Translational Immunology
  
  Volume: 11 Issue: 1
- DOI
  10.1002/cti2.1371
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22719, KAKENHI-PROJECT-20K18784, KAKENHI-PROJECT-17KK0169, KAKENHI-PROJECT-19H04055, KAKENHI-PROJECT-22K19626, KAKENHI-PROJECT-23K21485, KAKENHI-PROJECT-23K24792
[Journal Article] Mechanical unloading aggravates bone destruction and tumor expansion in myeloma2022
- Author(s)
  Tanimoto K, Hiasa M, Tenshin H, Teramachi J, Oda A, Harada T, Higa Y, Sogabe K, Oura M, Sumitani R, Hara T, Endo I, Matsumoto T, Tanaka E, Abe M
- Journal Title
  
  Haematologica
  
  Volume: 107 Issue: 3 Pages: 744-749
- DOI
  10.3324/haematol.2021.278295
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08329, KAKENHI-PROJECT-19K22719, KAKENHI-PROJECT-20K18784, KAKENHI-PROJECT-17KK0169, KAKENHI-PROJECT-21K21016
[Journal Article] The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat.2020
- Author(s)
  1. Ashtar M, Tenshin H, Teramachi J, Bat-Erdene A, Hiasa M, Oda A, Tanimoto K, Shimizu S, Higa Y, Harada T, Oura M, Sogabe K, Nakamura S, Fujii S, Sumitani R, Miki H, Udaka K, Takahashi M, Kagawa K, Endo I, Tanaka E, Matsumoto T, Abe M.
- Journal Title
  
  Cancers (Basel)
  
  Volume: 12 Issue: 4 Pages: 929-929
- DOI
  10.3390/cancers12040929
- NAID
  120006894611
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17858, KAKENHI-PROJECT-17KK0169, KAKENHI-PROJECT-16K11504, KAKENHI-PROJECT-18K08329, KAKENHI-PROJECT-19K22719, KAKENHI-PROJECT-20K18784, KAKENHI-PROJECT-17H05104
[Journal Article] Persistent activation of calcium-sensing receptor suppresses bone turnover, increases microcracks and decreases bone strength2019
- Author(s)
  Bingzi Dong, Itsuro Endo, Yukiyo Ohnishi, Yukari Mitsui, Kiyoe Kurahashi, Mai Kanai, Masahiro Hiasa, Jumpei Teramachi, Hirofumi Tenshin, Seiji Fukumoto, Masahiro Abe, Toshio Matsumoto.
- Journal Title
  
  JBMR Plus
  
  Volume: inpress Issue: 7
- DOI
  10.1002/jbm4.10182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05327, KAKENHI-PROJECT-17H05104, KAKENHI-PROJECT-17KK0169, KAKENHI-PROJECT-16K11504, KAKENHI-PROJECT-19K21382
[Journal Article] PD-L1 upregulation in myeloma cells by panobinostat in combination with interferon-γ.2019
- Author(s)
  Iwasa Masami、Harada Takeshi、Oda Asuka、Bat-Erdene Ariunzaya、Teramachi Jumpei、Tenshin Hirofumi、Ashtar Mohannad、Oura Masahiro、Sogabe Kimiko、Udaka Kengo、Fujii Shiro、Nakamura Shingen、Miki Hirokazu、Kagawa Kumiko、Ozaki Shuji、Abe Masahiro
- Journal Title
  
  Oncotarget
  
  Volume: 10 Issue: 20 Pages: 1903-1917
- DOI
  10.18632/oncotarget.26726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KK0169, KAKENHI-PROJECT-16K11504, KAKENHI-PROJECT-17K09956, KAKENHI-PROJECT-18K16118, KAKENHI-PROJECT-19K21382
[Presentation] Targeting SLAMF7 to disrupt myeloma-osteoclast interaction: elotuzumab’s ADCC activity with Th1-like γδT cells towards osteoclasts and myeloma cells.2022
- Author(s)
  Hirofumi Tenshin, Takeshi Harada, Yusuke Inoue, Jumpei Teramachi, Masahiro Hiasa, Kotaro Tanimoto, So Shimizu, Yoshiki Higa, Emiko Nakaue, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe
- Organizer
  Cancer and bone society young investigator symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18784
[Presentation] The anti-SLAMF7 elotuzumab enhances ADCC activity with Th1-like γδT cells towards osteoclasts and myeloma cells.2021
- Author(s)
  Hirofumi Tenshin, Takeshi Harada, Yusuke Inoue, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Kotaro Tanimoto, So Shimizu, Yoshiki Higa, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Tomoko Maruhashi, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe
- Organizer
  The European Calcified Tissue Society 2021 Digital Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18784
[Presentation] The novel therapeutic approaches with TAK1 inhibition against the aberrant NLRP3 inflammasome activation in rheumatoid arthritis2020
- Author(s)
  Hirofumi Tenshin, Mohannad Ashtar, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Kotaro Tanimoto, So Shimizu, Yoshiki Higa, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe
- Organizer
  ヨーロッパ骨代謝学会（ECTS）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18784
[Presentation] TAK1 inhibition effectively alleviates joint inflammation as well as bone destruction in rheumatoid arthritis: Suppression of NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption.2019
- Author(s)
  Tenshin H, Teramachi J, Hiasa M, Oda A, Mohannad A, Tanimoto K, Iwasa M, Ariunzaya E, Harada T, Endo I, Tanaka E, Matsumoto T, Abe M.
- Organizer
  ASBMR 2019 Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21382
[Presentation] NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption in rheumatoid arthritis: the therapeutic roles of TAK1 inhibition.2019
- Author(s)
  Tenshin H, Teramachi J, Hiasa M, Oda A, Tanimoto K, Shimizu S, Mohannad A, Harada T, Tanaka E, Matsumoto T, Abe M
- Organizer
  16th Meeting of Bone Biology Forum
- Data Source
  KAKENHI-PROJECT-19K21382
[Presentation] Effective suppression of inflammasome-mediated joints destruction by TAK1 inhibition.2019
- Author(s)
  Tenshin H, Teramachi J, Hiasa M, Abe M, Tanaka
- Organizer
  97th IADR general session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21382
[Presentation] The role of NLRP3 inflammasome activation in joint inflammation and destruction in rheumatoid arthritis: novel therapeutic approaches with TAK1 inhibition.2019
- Author(s)
  Tenshin H, Teramachi J, Hiasa M, Oda A, Mohannad A, Tanimoto K, Shimizu S, Harada T, Oura M, Sogabe K, Endo I, Tanaka E, Matsumoto T, Abe M
- Organizer
  29th ANZBMS Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21382

1. TERAMACHI Jyumpei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. HIASA Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 松本俊夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 福本誠二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 藤井志朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 安部正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tenshin Hirofumi 天眞 寛文

TENSHIN Hirofumi 天眞 寛文

Research Projects

Research Products

Co-Researchers

加齢性歯槽骨吸収における骨細胞の役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the role of TAK1-NLRP3 inflammasome axis in rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The novel therapeutic roles of TAK1 inhibition in rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] TGF‐β‐activated kinase‐1 inhibitor LL‐Z1640‐2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF‐α and RANKL expression2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanical unloading aggravates bone destruction and tumor expansion in myeloma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Persistent activation of calcium-sensing receptor suppresses bone turnover, increases microcracks and decreases bone strength2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-L1 upregulation in myeloma cells by panobinostat in combination with interferon-γ.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Targeting SLAMF7 to disrupt myeloma-osteoclast interaction: elotuzumab’s ADCC activity with Th1-like γδT cells towards osteoclasts and myeloma cells.2022

Author(s)

Organizer

Data Source

[Presentation] The anti-SLAMF7 elotuzumab enhances ADCC activity with Th1-like γδT cells towards osteoclasts and myeloma cells.2021

Author(s)

Organizer

Data Source

[Presentation] The novel therapeutic approaches with TAK1 inhibition against the aberrant NLRP3 inflammasome activation in rheumatoid arthritis2020

Author(s)

Organizer

Data Source

[Presentation] TAK1 inhibition effectively alleviates joint inflammation as well as bone destruction in rheumatoid arthritis: Suppression of NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption.2019

Author(s)

Organizer

Data Source

[Presentation] NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption in rheumatoid arthritis: the therapeutic roles of TAK1 inhibition.2019

Author(s)

Organizer

Data Source

[Presentation] Effective suppression of inflammasome-mediated joints destruction by TAK1 inhibition.2019

Author(s)

Organizer

Data Source

[Presentation] The role of NLRP3 inflammasome activation in joint inflammation and destruction in rheumatoid arthritis: novel therapeutic approaches with TAK1 inhibition.2019

Author(s)

Organizer

Data Source

Tenshin Hirofumi 天眞寛文

TENSHIN Hirofumi 天眞寛文