Maeda Keiko 前田啓子

Researcher Number	00830291
Other IDs	https://orcid.org/0000-0001-6477-1865
Affiliation (Current)	2026: 名古屋大学, 医学部附属病院, 病院講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 名古屋大学, 医学部附属病院, 助教 2019 – 2021: 名古屋大学, 医学部附属病院, 病院助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 炎症性腸疾患 / インターロイキン18 / インフラマソーム / 抗体治療 / エンドサイトーシス / バリア機構 / 防御機構 / 腸管上皮細胞 Except Principal Investigator 神経伝達物質 / 粘液 / ソマトスタチン / 潰瘍性大腸炎

新たな炎症性腸疾患動物モデルの解析による、その病態解明と治療法の開発Principal Investigator
- Principal Investigator
  
  前田啓子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya University
Role of somatostatin as a neurotransmitter in the regulation of mucosal inflammation in ulcerative colitis.
- Principal Investigator
  
  中村正直
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya University
Novel Inflammasome-Targeted Therapies for Diverse Inflammatory Bowel DiseasesPrincipal Investigator
- Principal Investigator
  
  MAEDA Keiko
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya University
Elucidation of a novel defense mechanism mediated by PARD6B and its therapeutic application to inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  Maeda Keiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya University

All 2025 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Predictors of the efficacy of vedolizumab in patients with ulcerative colitis2024
- Author(s)
  Kajikawa G, Sawada T, Nakamura M, Yamamura T, Maeda K, Ishikawa E, Uetsuki K, Hirose T, Iida T, Mizutani Y, Yamao K, Ishikawa T, Furukawa K, Kawashima H.
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 86 Issue: 3 Pages: 407-421
- DOI
  10.18999/nagjms.86.3.407
- ISSN
  0027-7622
- URL
  https://nagoya.repo.nii.ac.jp/records/2011493
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07801, KAKENHI-PROJECT-24K11149
[Journal Article] Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function2024
- Author(s)
  Mu Jingxi、Maeda Keiko、Ohashi Ayako、Urano Takeshi、Nariai Yuko、Kamino Hiroki、Nakamura Masanao、Yamamura Takeshi、Sawada Tsunaki、Ishikawa Eri、Murate Kentaro、Yamamoto Kenta、Hirose Takashi、Furukawa Kazuhiro、Fujishiro Mitsuhiro、Kawashima Hiroki
- Journal Title
  
  Digestive Diseases and Sciences
  
  Volume: - Issue: 7 Pages: 2573-2585
- DOI
  10.1007/s10620-024-08453-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08438, KAKENHI-PROJECT-21K08753, KAKENHI-PROJECT-21K15920
[Journal Article] Monoclonal Antibody Against Mature Interleukin-18 Ameliorates Colitis in Mice and Improves Epithelial Barrier Function2023
- Author(s)
  Ikegami Shuji、Maeda Keiko、Urano Takeshi、Mu Jingxi、Nakamura Masanao、Yamamura Takeshi、Sawada Tsunaki、Ishikawa Eri、Yamamoto Kenta、Muto Hisanori、Oishi Akina、Iida Tadashi、Mizutani Yasuyuki、Ishikawa Takuya、Kakushima Naomi、Furukawa Kazuhiro、Ohno Eizaburo、Honda Takashi、Ishigami Masatoshi、Kawashima Hiroki
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: - Issue: 8 Pages: 1353-1366
- DOI
  10.1093/ibd/izad292
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08438, KAKENHI-PROJECT-21K08753, KAKENHI-PROJECT-21K15920
[Journal Article] Gelsolin as a Potential Biomarker for Endoscopic Activity and Mucosal Healing in Ulcerative Colitis2022
- Author(s)
  Maeda K, Nakamura M, Yamamura T, Sawada T, Ishikawa E, Oishi A, Ikegami S, Kakushima N, Furukawa K, Iida T, Mizutani Y, Ishikawa T, Ohno E, Honda T, Ishigami M, Kawashima H
- Journal Title
  
  Biomedicines
  
  Volume: 10(4) Issue: 4 Pages: 867-872
- DOI
  10.3390/biomedicines10040872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17486, KAKENHI-PROJECT-21K15920
[Journal Article] Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces2022
- Author(s)
  Maeda K, Zachos NC, Orzalli MH, Schmieder SS, Chang D, Bugda Gwilt K, Doucet M, Baetz NW, Lee S, Crawford SE, Estes MK, Kagan JC, Turner JR, Lencer WI
- Journal Title
  
  Cell Host Microbe.
  
  Volume: 30 (2) Issue: 2 Pages: 216-231
- DOI
  10.1016/j.chom.2021.12.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17486
[Journal Article] Accuracy of Serum Leucine-Rich Alpha-2 Glycoprotein in Evaluating Endoscopic Disease Activity in Crohn's Disease2022
- Author(s)
  Kawamura T, Yamamura T, Nakamura M, Maeda K, Sawada T, Ishikawa E, Iida T, Mizutani Y, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: - Issue: 2 Pages: 245-253
- DOI
  10.1093/ibd/izac076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17486
[Journal Article] Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients2022
- Author(s)
  Nakamura M, Maeda K, Yamamoto K, Yamamura T, Sawada T, Ishikawa E, Kakushima N, Furukawa K, Iida T, Mizutani Y, Ishikawa T, Ohno E, Honda T, Ishigami M, Kawashima H.
- Journal Title
  
  Digestion
  
  Volume: 103 (3) Issue: 3 Pages: 232-243
- DOI
  10.1159/000521929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17486, KAKENHI-PROJECT-19H04042, KAKENHI-PROJECT-20K07801, KAKENHI-PROJECT-21K15920, KAKENHI-PROJECT-20K08382
[Journal Article] Detection of colorectal neoplasms using linked color imaging: A prospective, randomized, tandem colonoscopy trial2021
- Author(s)
  Hasegawa Issei、Yamamura Takeshi、Suzuki Hiroto、Maeda Keiko、Sawada Tsunaki、Mizutani Yasuyuki、Ishikawa Eri、Ishikawa Takuya、Kakushima Naomi、Furukawa Kazuhiro、Ohno Eizaburo、Kawashima Hiroki、Nakamura Masanao、Fujishiro Mitsuhiro
- Journal Title
  
  Clinical Gastroenterology and Hepatology
  
  Volume: ー Issue: 8 Pages: 1708-1716.e4
- DOI
  10.1016/j.cgh.2021.04.004
- NAID
  120007190667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17486
[Journal Article] Diagnostic yield of colon capsule endoscopy for Crohn’s disease lesions in the whole gastrointestinal tract2021
- Author(s)
  Yamada Keisaku、Nakamura Masanao、Yamamura Takeshi、Maeda Keiko、Sawada Tsunaki、Mizutani Yasuyuki、Ishikawa Eri、Ishikawa Takuya、Kakushima Naomi、Furukawa Kazuhiro、Ohno Eizaburo、Kawashima Hiroki、Honda Takashi、Ishigami Masatoshi、Fujishiro Mitsuhiro
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21 Issue: 1
- DOI
  10.1186/s12876-021-01657-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17486
[Journal Article] Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn’s Disease Patients2020
- Author(s)
  Murate Kentaro、Maeda Keiko、Nakamura Masanao、Sugiyama Daisuke、Wada Hirotaka、Yamamura Takeshi、Sawada Tsunaki、Mizutani Yasuyuki、Ishikawa Takuya、Furukawa Kazuhiro、Ohno Eizaburo、Honda Takashi、Kawashima Hiroki、Miyahara Ryoji、Ishigami Masatoshi、Nishikawa Hiroyoshi、Fujishiro Mitsuhiro
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 26 Issue: 11 Pages: 1669-1681
- DOI
  10.1093/ibd/izaa086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07801, KAKENHI-PROJECT-19K17486, KAKENHI-PROJECT-17H06162
[Journal Article] Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice2020
- Author(s)
  Nishikawa Takahiro、Maeda Keiko、Nakamura Masanao、Yamamura Takeshi、Sawada Tsunaki、Mizutani Yasuyuki、Ito Takanori、Ishikawa Takuya、Furukawa Kazuhiro、Ohno Eizaburo、Miyahara Ryoji、Kawashima Hiroki、Honda Takashi、Ishigami Masatoshi、Yamamoto Tokunori、Matsumoto Seiji、Hotta Yuji、Fujishiro Mitsuhiro
- Journal Title
  
  Digestive Diseases and Sciences
  
  Volume: 66 Issue: 4 Pages: 1034-1044
- DOI
  10.1007/s10620-020-06359-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17486
[Journal Article] Ustekinumab is effective against small bowel lesions in Crohn’s disease: two case reports2020
- Author(s)
  Murate Kentaro、Nakamura Masanao、Yamamura Takeshi、Maeda Keiko、Sawada Tsunaki、Mizutani Yasuyuki、Ishikawa Eri、Kakushima Naomi、Furukawa Kazuhiro、Ohno Eizaburo、Honda Takashi、Kawashima Hiroki、Ishigami Masatoshi、Fujishiro Mitsuhiro
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 1 Pages: 129-135
- DOI
  10.1007/s12328-020-01242-0
- Data Source
  KAKENHI-PROJECT-19K17486
[Journal Article] Clinical Factors Associated With Missing Colorectal Polyp on Colon Capsule Endoscopy2019
- Author(s)
  Keisaku Yamada 1, Masanao Nakamura 2, Takeshi Yamamura 3, Keiko Maeda 3, Tsunaki Sawada 3, Yasuyuki Mizutani 1, Takuya Ishikawa 1, Kazuhiro Furukawa 1, Eizaburo Ohno 1, Ryoji Miyahara 1, Hiroki Kawashima 1, Naoki Hotta 4, Yoshiki Hirooka 3
- Journal Title
  
  Digestion
  
  Volume: 5 Issue: 3 Pages: 1-7
- DOI
  10.1159/000498942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17486
[Journal Article] Lewis Score on Capsule Endoscopy as a Predictor of the Risk for Crohn's Disease-Related Emergency Hospitalization and Clinical Relapse in Patients With Small Bowel Crohn's Disease2019
- Author(s)
  Nishikawa T, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Miyahara R, Kawashima H, Hirooka Y
- Journal Title
  
  Gastroenterol Res Pract
  
  Volume: 3 Pages: 425-427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17486
[Patent] MONOCLONAL ANTIBODY AGAINST A NEOEPITOPE OF CASPASE-CLEAVED MATURE INTERLEUKIN-18 AMELIORATES INTESTINAL INFLAMMATION AND FIBROSIS2022
- Inventor(s)
  Keiko Maeda, Takeshi Urano
- Industrial Property Rights Holder
  Keiko Maeda, Takeshi Urano
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21K15920
[Patent] 炎症性腸疾患を治療するための医薬組成物2021
- Inventor(s)
  前田啓子、浦野健
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K15920
[Presentation] 炎症性腸疾患における抗活性型IL-18抗体の抗炎症および抗線維化作用の新展開2025
- Author(s)
  前田啓子、山村健史、川嶋啓揮
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-21K15920
[Presentation] 腸管上皮細胞の腸内細菌叢に対する認識機構の解明と炎症性腸疾患における機能解析2024
- Author(s)
  前田啓子、中村正直、川嶋啓揮
- Organizer
  消化器病学会週間
- Data Source
  KAKENHI-PROJECT-24K11129
[Presentation] Monoclonal antibody against neoepitope of caspase-cleaved mature interleukin-18 ameliorates colitis and improve barrier function2024
- Author(s)
  Keiko Maeda, Masanao Nakamura, Masatoshi Ishigami
- Organizer
  Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15920
[Presentation] 炎症性腸疾患に対する新規インフラマソーム標的治療法の開発2024
- Author(s)
  池上脩二、前田啓子、藤城光弘
- Organizer
  日本消化器病関連学会週間
- Data Source
  KAKENHI-PROJECT-21K15920
[Presentation] Monoclonal antibody against a neoepitope of caspase-cleaved mature interleukin-18 ameliorates intestinal inflammation and fibrosis2023
- Author(s)
  Maeda Keiko, Nakamura　Masanao, Kawashima Hiroki
- Organizer
  ddw
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15920
[Presentation] MONOCLONAL ANTIBODY AGAINST A NEOEPITOPE OF CASPASE-CLEAVED MATURE INTERLEUKIN-18 AMELIORATES INTESTINAL INFLAMMATION AND FIBROSIS2023
- Author(s)
  Maeda Keiko, Nakamura　Masanao, Kawashima Hiroki
- Organizer
  Digestive Disease Week　2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15920
[Presentation] Monoclonal antibody against neoepitope of caspase-cleaved mature interleukin-18 ameliorates colitis and improve barrier function2022
- Author(s)
  Keiko Maeda, Masanao Nakamura, Masatoshi Ishigami,
- Organizer
  Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15920
[Presentation] 炎症性腸疾患に対する新規インフラマソーム標的治療の開発2021
- Author(s)
  池上脩二, 前田啓子, 藤城光弘
- Organizer
  Japan Digestive Disease Week
- Data Source
  KAKENHI-PROJECT-21K15920
[Presentation] PARD6B regulates intestinal barrier function in inflammatory bowel disease2020
- Author(s)
  Keiko Maeda, Masanao Nakamura, Mitsuhiro Fujishiro
- Organizer
  DDW
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17486
[Presentation] PARD6B REGULATES INTESTINAL BARRIER FUNCTION IN INFLAMMATORY BOWEL DISEASE2020
- Author(s)
  前田啓子、中村正直、藤城光弘
- Organizer
  アメリカ消化器病週間
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17486
[Presentation] PARD6Bによる腸管上皮細胞の新たな防御機構の同定2019
- Author(s)
  前田啓子、中村正直、藤城光弘
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-19K17486

1. 川嶋啓揮 (20378045)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 中村正直 (60467321)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 村手健太郎 (50936549)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 山村健史 (10709091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KAMINO Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 藤城光弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 本多隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 浦野健

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Maeda Keiko 前田 啓子

Research Projects

Research Products

Co-Researchers

新たな炎症性腸疾患動物モデルの解析による、その病態解明と治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of somatostatin as a neurotransmitter in the regulation of mucosal inflammation in ulcerative colitis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel Inflammasome-Targeted Therapies for Diverse Inflammatory Bowel DiseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a novel defense mechanism mediated by PARD6B and its therapeutic application to inflammatory bowel diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Predictors of the efficacy of vedolizumab in patients with ulcerative colitis2024

Author(s)

Journal Title

DOI

ISSN

URL

Language

Data Source

[Journal Article] Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Monoclonal Antibody Against Mature Interleukin-18 Ameliorates Colitis in Mice and Improves Epithelial Barrier Function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gelsolin as a Potential Biomarker for Endoscopic Activity and Mucosal Healing in Ulcerative Colitis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accuracy of Serum Leucine-Rich Alpha-2 Glycoprotein in Evaluating Endoscopic Disease Activity in Crohn's Disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of colorectal neoplasms using linked color imaging: A prospective, randomized, tandem colonoscopy trial2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Diagnostic yield of colon capsule endoscopy for Crohn’s disease lesions in the whole gastrointestinal tract2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn’s Disease Patients2020

Author(s)

Journal Title

Maeda Keiko 前田啓子