Hasuzawa Nao 蓮澤奈央

Researcher Number	00837908
Other IDs
Affiliation (Current)	2025: 久留米大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 久留米大学, 医学部, 講師 2023: 久留米大学, 医学部, 講師 2020 – 2022: 久留米大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator 脂肪肝炎 / プリンシグナル / HepG2 / Quinacrine / 脂質代謝 / VLDL分泌 / purinergic signaling / extracellular ATP / NASH / EPA … More / メタボリックシンドローム / VNUT / ATP / VLDL / MASH / MASLD … More Except Principal Investigator NASH / VNUT / ATPトランスポーター / クロドロン酸 / プリンシグナル / 新生児外科 / IFALD / 小児外科 / 短腸症候群 / inflammation / Purine signal / 慢性炎症 / プリン受容体シグナル / ミトコンドリアダイナミクス / Autophagy / Mitochondrial fission / Purinergic signal / DRP1 / Mitochondrial dynamics / ATP Less

肝細胞-肝星細胞のATP細胞間シグナルに着目したMASLDの病態解明Principal Investigator
- Principal Investigator
  
  蓮澤奈央
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kurume University
プリンシグナル制御による代謝・炎症を標的とした多元的IFALD治療法の創出
- Principal Investigator
  
  町頭成郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kagoshima University
Molecular mechanisms underlying hepatic VLDL secretion induced by extracellular ATP.Principal Investigator
- Principal Investigator
  
  Hasuzawa Nao
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kurume University
ATP signaling controlled by mitochondrial dynamics
- Principal Investigator
  
  NOMURA Masatoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kurume University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Reduced Number of Remaining or Healthy Teeth in Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study Assessed by Dentists or Dental Hygienists in Japan2023
- Author(s)
  Kurinami Noboru、Ashida Kenji、Sugiyama Seigo、Morito Yoko、Hasuzawa Nao、Yoshida Akira、Morita Ayami、Hieshima Kunio、Miyamoto Fumio、Kajiwara Keizo、Jinnouchi Katsunori、Jinnouchi Tomio、Jinnouchi Hideaki、Nomura Masatoshi
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 7 Pages: 987-993
- DOI
  10.2169/internalmedicine.9773-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-04-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17653, KAKENHI-PROJECT-20K08921
[Journal Article] Is the vesicular nucleotide transporter a molecular target of eicosapentaenoic acid?2022
- Author(s)
  Moriyama Yoshinori、Hasuzawa Nao、Nomura Masatoshi
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 13 Pages: 01-09
- DOI
  10.3389/fphar.2022.1080189
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17653
[Journal Article] Effects of Elobixibat, an Inhibitor of Ileal Bile Acid Transporter, on Glucose and Lipid Metabolism: A Single-arm Pilot Study in Patients with T2DM2022
- Author(s)
  Yoshinobu Satoko、Hasuzawa Nao、Nagayama Ayako、Iwata Shimpei、Yasuda Junichi、Tokubuchi Rie、Kabashima Masaharu、Gobaru Mizuki、Hara Kento、Murotani Kenta、Moriyama Yoshinori、Ashida Kenji、Nomura Masatoshi
- Journal Title
  
  Clinical Therapeutics
  
  Volume: 44 Issue: 10 Pages: 1418-1426
- DOI
  10.1016/j.clinthera.2022.08.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17653, KAKENHI-PROJECT-20K08921
[Journal Article] A simplified prediction model for end-stage kidney disease in patients with diabetes2022
- Author(s)
  Inoguchi Toyoshi、Okui Tasuku、Nojiri Chinatsu、Eto Erina、Hasuzawa Nao、Inoguchi Yukihiro、Ochi Kentaro、Takashi Yuichi、Hiyama Fujiyo、Nishida Daisuke、Umeda Fumio、Yamauchi Teruaki、Kawanami Daiji、Kobayashi Kunihisa、Nomura Masatoshi、Nakashima Naoki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 12482-12482
- DOI
  10.1038/s41598-022-16451-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08347, KAKENHI-PROJECT-21K17653, KAKENHI-PROJECT-20K08921
[Journal Article] Maria Teresa Miras Portugal: a pioneer for vesicular nucleotide storage2022
- Author(s)
  Moriyama Yoshinori、Hasuzawa Nao、Nomura Masatoshi
- Journal Title
  
  Purinergic Signalling
  
  Volume: Epub ahead of print Issue: 2 Pages: 93-98
- DOI
  10.1007/s11302-022-09912-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K17653
[Journal Article] Eruptive xanthomas as a marker for metabolic disorders: A specific form of xanthoma that reflects hypertriglyceridemia2022
- Author(s)
  Ohtaki Sohichiroh、Ashida Kenji、Matsuo Yuko、Moritaka Kanoko、Iwata Shimpei、Nagayama Ayako、Kawaguchi Aya、Koga Hiroshi、Yoshinobu Satoko、Hasuzawa Nao、Motomura Seiichi、Akiba Jun、Nakama Takekuni、Nomura Masatoshi
- Journal Title
  
  Clinical Case Reports
  
  Volume: 10 Issue: 4 Pages: 5671-5676
- DOI
  10.1002/ccr3.5671
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17653
[Journal Article] An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing’s Syndrome and Autonomous Cortisol Secretion2021
- Author(s)
  Oda Satoko、Ashida Kenji、Uchiyama Makiko、Sakamoto Shohei、Hasuzawa Nao、Nagayama Ayako、Wang Lixiang、Nagata Hiromi、Sakamoto Ryuichi、Kishimoto Junji、Todaka Koji、Ogawa Yoshihiro、Nakanishi Yoichi、Nomura Masatoshi
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 106 Issue: 10 Pages: e3865-e3880
- DOI
  10.1210/clinem/dgab450
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08921, KAKENHI-PROJECT-20K11617
[Journal Article] Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice2021
- Author(s)
  Wang L, Li X, Hanada Y, Hasuzawa N, Moriyama Y, Nomura M, Yamamoto K
- Journal Title
  
  Commun Biol
  
  Volume: 4 Issue: 1 Pages: 894-894
- DOI
  10.1038/s42003-021-02413-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08520, KAKENHI-PROJECT-20K08921, KAKENHI-PROJECT-21K17653
[Journal Article] VNUT Is a Therapeutic Target for Type 2 Diabetes and NASH2021
- Author(s)
  Hasuzawa Nao、Tatsushima Keita、Tokubuchi Rie、Kabashima Masaharu、Nomura Masatoshi
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 4 Pages: 517-526
- DOI
  10.1248/yakushi.20-00204-4
- NAID
  130008013898
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-04-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08921, KAKENHI-PROJECT-21K17653
[Journal Article] Vesicular ATP release from hepatocytes plays a role in the progression of nonalcoholic steatohepatitis2021
- Author(s)
  Tatsushima Keita、Hasuzawa Nao、Wang Lixiang、Hiasa Miki、Sakamoto Shohei、Ashida Kenji、Sudo Nobuyuki、Moriyama Yoshinori、Nomura Masatoshi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1867 Issue: 3 Pages: 166013-166013
- DOI
  10.1016/j.bbadis.2020.166013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08921, KAKENHI-PROJECT-18H02407, KAKENHI-PROJECT-19K17988, KAKENHI-PROJECT-20H04106
[Journal Article] Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury2021
- Author(s)
  Hasuzawa Nao、Tatsushima Keita、Wang Lixiang、Kabashima Masaharu、Tokubuchi Rie、Nagayama Ayako、Ashida Kenji、Ogawa Yoshihiro、Moriyama Yoshinori、Nomura Masatoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 5192-5192
- DOI
  10.1038/s41598-021-83144-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08921, KAKENHI-PROJECT-18H02407
[Journal Article] Quinacrine is not a vital fluorescent probe for vesicular ATP storage2021
- Author(s)
  Hasuzawa Nao、Moriyama Sawako、Wang Lixiang、Nagayama Ayako、Ashida Kenji、Moriyama Yoshinori、Nomura Masatoshi
- Journal Title
  
  Purinergic Signalling
  
  Volume: 17 Issue: 4 Pages: 725-735
- DOI
  10.1007/s11302-021-09820-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08921, KAKENHI-PROJECT-21K17653
[Journal Article] 【経口血糖降下薬の温故知新】イメグリミン　ミトコンドリア機能を改善する経口糖尿病薬2021
- Author(s)
  野村政壽, 蓮澤奈央
- Journal Title
  
  月刊糖尿
  
  Volume: 13 Pages: 60-67
- Data Source
  KAKENHI-PROJECT-21K17653
[Journal Article] Physiopathological roles of vesicular nucleotide transporter (VNUT), an essential component for vesicular ATP release2020
- Author(s)
  Hasuzawa Nao、Moriyama Sawako、Moriyama Yoshinori、Nomura Masatoshi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1862 Issue: 12 Pages: 183408-183408
- DOI
  10.1016/j.bbamem.2020.183408
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08921, KAKENHI-PROJECT-18H02407
[Journal Article] Macrophage Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury2020
- Author(s)
  Umezu Ryuta、Koga Jun-ichiro、Matoba Tetsuya、Katsuki Shunsuke、Wang Lixiang、Hasuzawa Nao、Nomura Masatoshi、Tsutsui Hiroyuki、Egashira Kensuke
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 40 Issue: 7
- DOI
  10.1161/atvbaha.120.314383
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08518, KAKENHI-PROJECT-20K08921
[Presentation] VNUTを介した細胞外ATP分泌と動脈硬化2022
- Author(s)
  蓮澤奈央
- Organizer
  第54回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K17653
[Presentation] VNUT依存性プリンシグナルと生活習慣病2022
- Author(s)
  蓮澤奈央
- Organizer
  第60回日本糖尿病学会九州地方会
- Invited
- Data Source
  KAKENHI-PROJECT-21K17653
[Presentation] ミトコンドリアと疾患・老化　糖尿病の病態形成におけるミトコンドリアダイナミクスの役割2021
- Author(s)
  蓮澤奈央、王麗香、大塚由絵、坂本萌子、喜多村美幸、野村政壽
- Organizer
  第94回　日本内分泌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K17653

1. NOMURA Masatoshi (30315080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 町頭成郎 (80404523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 家入里志 (00363359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大西峻 (10614638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 川野孝文 (40457651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 加治建 (50315420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 杉田光士郎 (50781514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 武藤充 (70404522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 古賀義法 (70569433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 古賀純一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 川浪大治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 高士祐一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山本健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasuzawa Nao 蓮澤 奈央

Research Projects

Research Products

Co-Researchers

肝細胞-肝星細胞のATP細胞間シグナルに着目したMASLDの病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

プリンシグナル制御による代謝・炎症を標的とした多元的IFALD治療法の創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms underlying hepatic VLDL secretion induced by extracellular ATP.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ATP signaling controlled by mitochondrial dynamics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Reduced Number of Remaining or Healthy Teeth in Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study Assessed by Dentists or Dental Hygienists in Japan2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Is the vesicular nucleotide transporter a molecular target of eicosapentaenoic acid?2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Elobixibat, an Inhibitor of Ileal Bile Acid Transporter, on Glucose and Lipid Metabolism: A Single-arm Pilot Study in Patients with T2DM2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A simplified prediction model for end-stage kidney disease in patients with diabetes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Maria Teresa Miras Portugal: a pioneer for vesicular nucleotide storage2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eruptive xanthomas as a marker for metabolic disorders: A specific form of xanthoma that reflects hypertriglyceridemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing’s Syndrome and Autonomous Cortisol Secretion2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VNUT Is a Therapeutic Target for Type 2 Diabetes and NASH2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

Hasuzawa Nao 蓮澤奈央

[Journal Article] 【経口血糖降下薬の温故知新】イメグリミン　ミトコンドリア機能を改善する経口糖尿病薬2021

[Presentation] ミトコンドリアと疾患・老化　糖尿病の病態形成におけるミトコンドリアダイナミクスの役割2021