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Ishimoto Takahiro  石本 尚大

ORCIDConnect your ORCID iD *help
Researcher Number 00843062
Other IDs
Affiliation (Current) 2025: 金沢大学, 附属病院, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 金沢大学, 薬学系, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / 0801:Pharmaceutical sciences and related fields
Keywords
Principal Investigator
バイオマーカー / 記憶学習 / 神経系の可塑性 / 細胞外小胞 / 記憶学習能力 / 神経新生 / RNA-seq解析 / 海馬 / 神経突起伸長 / 海馬歯状回特異的遺伝子発現抑制 / 網羅的トランスクリプトーム解析 / 脳部位特異的遺伝子発現制御 / 脳由来エクソソーム
  • Research Projects

    (3 results)
  • Research Products

    (48 results)
  • Co-Researchers

    (2 People)
  •  Evaluation of neuroplasticity-related molecules in the serum brain-derived extracellular vesicles reflecting the cognitive functionPrincipal Investigator

    • Principal Investigator
      石本 尚大
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Kanazawa University
  •  RNA-seq based transcriptome analysis on novel mechanism(s) of learning and memoryPrincipal Investigator

    • Principal Investigator
      Ishimoto Takahiro
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Kanazawa University
  •  Analysis on novel mechanism(s) of learning and memory and evaluation of cognitive function using brain-derived exosomes in plasmaPrincipal Investigator

    • Principal Investigator
      Ishimoto Takahiro
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0801:Pharmaceutical sciences and related fields
    • Research Institution
      Kanazawa University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Ergothioneine promotes longevity and healthy aging in male mice2024

    • Author(s)
      Katsube Makoto、Ishimoto Takahiro、Fukushima Yutaro、Kagami Asuka、Shuto Tsuyoshi、Kato Yukio
    • Journal Title

      GeroScience

      Volume: . Issue: 4 Pages: 3889-3909

    • DOI

      10.1007/s11357-024-01111-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K15991, KAKENHI-PLANNED-20H05811
  • [Journal Article] TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans2024

    • Author(s)
      Ishimoto Takahiro、Yamashita Reiya、Matsumoto Ruri、Matsumoto Satoshi、Matsuo Yusuke、Nakao Shunsuke、Masuo Yusuke、Suzuki Makoto、Kato Yukio
    • Journal Title

      npj Science of Food

      Volume: 8 Issue: 1 Pages: 11-11

    • DOI

      10.1038/s41538-024-00250-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K15991, KAKENHI-PROJECT-23K24044
  • [Journal Article] Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice.2023

    • Author(s)
      Al-Shammari AH, Masuo Y, Yoshino S, Yamashita R, Ishimoto T, Fujita K, Kato Y.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 49 Pages: 100483-100483

    • DOI

      10.1016/j.dmpk.2022.100483

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06688, KAKENHI-PROJECT-19K07204, KAKENHI-PROJECT-23K24044, KAKENHI-PROJECT-20K15991
  • [Journal Article] Ergothioneine in the brain2022

    • Author(s)
      Ishimoto Takahiro、Kato Yukio
    • Journal Title

      FEBS Letters

      Volume: 596 Issue: 10 Pages: 1290-1298

    • DOI

      10.1002/1873-3468.14271

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K15991, KAKENHI-PROJECT-23K24044
  • [Journal Article] Food-derived antioxidant ergothioneine improves sleep difficulties in humans2022

    • Author(s)
      Katsube Makoto、Watanabe Hiroshi、Suzuki Kosuke、Ishimoto Takahiro、Tatebayashi Yoshitaka、Kato Yukio、Murayama Norihito
    • Journal Title

      Journal of Functional Foods

      Volume: 95 Pages: 105165-105165

    • DOI

      10.1016/j.jff.2022.105165

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K15991, KAKENHI-PROJECT-23K24044
  • [Journal Article] Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications2021

    • Author(s)
      Ishimoto Takahiro、Kato Yukio
    • Journal Title

      Handbook of Experimental Pharmacology

      Volume: - Pages: 281-300

    • DOI

      10.1007/164_2021_445

    • ISBN
      9783030829834, 9783030829841
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23797, KAKENHI-PROJECT-20K15991
  • [Journal Article] Identification of Food-Derived Isoflavone Sulfates as Inhibition Markers for Intestinal Breast Cancer Resistance Proteins.2021

    • Author(s)
      Agustina R, Masuo Y, Kido Y, Shinoda K, Ishimoto T, Kato Y
    • Journal Title

      Drug Metab Dispos

      Volume: 49 Issue: 11 Pages: 972-984

    • DOI

      10.1124/dmd.121.000534

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06688, KAKENHI-PROJECT-20K15991
  • [Journal Article] Oral Administration of the Food Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice2020

    • Author(s)
      Nakamichi N, Nakao S, Nishiyama M, Takeda Y, Ishimoto T, Masuo Y, Matsumoto S, Suzuki M, Kato Y.
    • Journal Title

      Curr Mol Pharmacol

      Volume: - Issue: 2 Pages: 220-233

    • DOI

      10.2174/1874467213666200212102710

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06745, KAKENHI-PROJECT-19K23797, KAKENHI-PROJECT-19K07126, KAKENHI-PROJECT-20K15991
  • [Journal Article] Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice2020

    • Author(s)
      Nishiyama Misa、Nakamichi Noritaka、Yoshimura Tomoyuki、Masuo Yusuke、Komori Tomoe、Ishimoto Takahiro、Matsuo Jun-ichi、Kato Yukio
    • Journal Title

      Neurochemical Research

      Volume: 45 Issue: 11 Pages: 2664-2678

    • DOI

      10.1007/s11064-020-03118-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07126, KAKENHI-PROJECT-20K15991, KAKENHI-PROJECT-18H02584, KAKENHI-PROJECT-18K06745, KAKENHI-PROJECT-19K23797
  • [Journal Article] Maturational Characterization of Mouse Cortical Neurons Three-Dimensionally Cultured in Functional Polymer FP001-Containing Medium2019

    • Author(s)
      Nakamichi N, Matsumoto Y, Kawanishi T, Ishimoto T, Masuo Y, Horikawa M, Kato Y
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 9 Pages: 1545-1553

    • DOI

      10.1248/bpb.b19-00307

    • NAID

      130007700083

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-09-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06745, KAKENHI-PROJECT-19K07126, KAKENHI-PROJECT-19K23797, KAKENHI-PROJECT-18H02584
  • [Presentation] 記憶学習能力を向上させるトリデオキシシチジンのphosphorothioate化による生体内安定性の改善2024

    • Author(s)
      藤原里帆 、石本尚大 、林芙優、藤田美華 、増尾友佑 、須藤慶太、加藤将夫
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] 食物由来含硫アミノ酸ergothioneineはヒスタミン代謝阻害と脳免疫細胞ミクログリアの活性化抑制を示す2024

    • Author(s)
      石本尚大、加藤将夫
    • Organizer
      第24回日本ヒスタミン学会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Antidepressant-like activity by TrkB overexpression using brain-directed adeno-associated virus2023

    • Author(s)
      Reiya Yamashita, Takahiro Ishimoto, Yusuke Masuo, and Yukio Kato
    • Organizer
      第97回日本薬理学会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Involvement of xenobiotics efflux transporter MRP5/ABCC5 in transport of a neurotransmitter and neurotoxicity2023

    • Author(s)
      Shoma Yamada, Takahiro Ishimoto, Maki Watanabe, Yusuke Masuo, and Yukio Kato
    • Organizer
      第97回日本薬理学会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Effect of Inhibition of Xenobiotic Transporter MRP5/ABCC5 on Neurite Elongation: Screening for MRP5 Inhibitors among Clinically Used Drugs2023

    • Author(s)
      Ishimoto Takahiro, Yagi Hirofumi, Masuo Yusuke, and Kato Yukio
    • Organizer
      ASPET 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] 食物由来アミノ酸ergothioneineの体内濃度を記述するPBPKモデル2023

    • Author(s)
      蘭雄大、石本尚大、松本聡、鈴木真、加藤将夫
    • Organizer
      CBI学会2023年大会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] TrkB-containing serum extracellular vesicles as a potential biomarker for cognitive improvement2023

    • Author(s)
      Reiya Yamashita, Takahiro Ishimoto, Satoshi Matsumoto, Yusuke Masuo, Makoto Suzuki, and Yukio Kato
    • Organizer
      ASPET 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Protective effect of novel strain of Pleurotus sp. mushroom on UVB-induced skin damage: Involvement of antioxidant ergothioneine and its transporter SLC22A42023

    • Author(s)
      Akira Moritomo, Takahiro Ishimoto, Motoki Hanayama, Junya Kawai, Koichiro Mori, Yukio Kato
    • Organizer
      第97回日本薬理学会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Involvement of Organic Cation Transporter OCTN1/SLC22A4 in Neurogenesis: a Potential Preventive Target for Neurodegenerative Diseases2023

    • Author(s)
      Ishimoto Takahiro
    • Organizer
      2023 ICCP450/JSSX
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Role of BCRP/ABCG2 in pharmacokinetics and neurotoxicity after intrathecal administration of methotrexate in mice2023

    • Author(s)
      Nguyet Kim Nguyen, Takahiro Ishimoto, Keiko Shintani, Ayuka Itaya, and Yukio Kato
    • Organizer
      2023 ICCP450/JSSX
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Inhibition of amino acid transporter suppresses activation of microglial cell lines2023

    • Author(s)
      石本尚大、岡部将之、増尾友佑、加藤将夫
    • Organizer
      第97回日本薬理学会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Phosphorylation of neurotrophin receptor TrkB in serum extracellular vesicles as potential biomarker of food component ergothioneine-induced cognitive enhancement in humans2023

    • Author(s)
      Reiya Yamashita, Takahiro Ishimoto, Satoshi Matsumoto, Yusuke Masuo, Makoto Suzuki, and Yukio Kato
    • Organizer
      2023 ICCP450/JSSX
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Investigation of mechanisms underlying cognitive enhancement induced by oral ingestion of yeast derived RNA in mice2023

    • Author(s)
      Fuyu Hayashi, Takahiro Ishimoto, Keisuke Kiriyama, Mica Fujita, Yusuke Masuo, Keita Sutoh, and Yukio Kato
    • Organizer
      第97回日本薬理学会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Extracellular vesicles expressing brain-derived TrkB is detectable in serum: Its potential as biomarker for cognitive enhancement2022

    • Author(s)
      Reiya Yamashita, Takahiro Ishimoto, Satoshi Matsumoto, Yusuke Masuo, Makoto Suzuki, and Yukio Kato
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Evaluation of golden oyster mushroom derived ergothioneine-induced cognitive enhancement by amount of phosphorylated TrkB in serum extracellular vesicles.2022

    • Author(s)
      Takahiro Ishimoto, Reiya Yamashita, Satoshi Matsumoto, Yusuke Masuo, Makoto Suzuki, and Yukio Kato
    • Organizer
      BPCNPNPPP
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Food-derived hydrophilic amino acid ergothioneine prevents cognitive decline in Alzheimer’s disease model mice at its clinically relevant plasma concentrations.2022

    • Author(s)
      Yusuke Matsuo, Takahiro Ishimoto, Yusuke Masuo, Hiroki Sasaguri, Takashi Saito, Takaomi Saido, and Yukio Kato
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Food-derived amino acid ergothioneine inhibits histamine metabolizing enzyme and promotes anti-inflammatory M2 microglia polarization2022

    • Author(s)
      Yuka Ueda, Takahiro Ishimoto, Makoto Katsube, Yusuke Masuo, and Yukio Kato
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Involvement of xenobiotic efflux transporter MRP5/ABCC5 in neurite outgrowth2022

    • Author(s)
      Takahiro Ishimoto, Hirofumi Yagi, Yusuke Masuo, and Yukio Kato
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] 神経栄養因子受容体TrkBを脳内で発現するアデノ随伴ウイルスによる神経新生促進と細胞外小胞による評価2022

    • Author(s)
      石本尚大、山下怜矢、加藤将夫
    • Organizer
      第43回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Signaling pathway for proliferation effect of tri-deoxycytidine in neural stem cells.2022

    • Author(s)
      Yuya Yamamoto, Takahiro Ishimoto, Naoto Matsumura, Yusuke Masuo, Keisuke Kiriyama, Keita Sutoh, and Yukio Kato
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Effect of intravenously administered adeno-associated virus encoding TrkB gene on hippocampal neurogenesis.2022

    • Author(s)
      Reiya Yamashita, Takahiro Ishimoto, Yusuke Masuo, and Yukio Kato
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Proteomics analysis of trideoxycytidine-induced proliferation of neural stem cells.2021

    • Author(s)
      Ishimoto T, Matsumura N, Masuo Y, Kiriyama K, Sutoh K, and Kato Y
    • Organizer
      第64回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Amount of phosphorylated TrkB in serum extracellular vesicles reflect ergothioneine-induced enhancement of cognitive function.2021

    • Author(s)
      Matsumoto R, Ishimoto T, Matsumoto S, Masuo Y, Suzuki M, Kato Y
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Oral administration of food-derived amino acid ergothioneine enhances learning and memory by phosphorylation of TrkB and promotion of neurogenesis in the hippocampal dentate gyrus.2021

    • Author(s)
      Matsuo Y, Ishimoto T, Nakao S, Masuo Y, Matsumoto S, Suzuki M, Kato Y
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] トランスポーターSLC22A4と神経栄養因子受容体TrkB活性化を介したergothioneineによる神経新生促進と記憶学習能力の向上2021

    • Author(s)
      石本尚大、松尾雄介、松本留里、増尾友佑、加藤将夫
    • Organizer
      第42回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Oral administration of food-derived amino acid ergothioneine enhances learning and memory by phosphorylation of TrkB and promotion of neurogenesis in the hippocampal dentate gyrus.2021

    • Author(s)
      Matsuo Y, Ishimoto T, Nakao S, Masuo Y, Matsumoto S, Suzuki M, Kato Y
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Proliferative effect of tri-deoxyribonucleotides on mouse neural stem cells.2021

    • Author(s)
      Ishimoto T, Matsumura N, Masuo Y, Kiriyama K, Sutoh K, Kato Y
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] Amount of phosphorylated TrkB in serum extracellular vesicles reflect ergothioneine-induced enhancement of cognitive function.2021

    • Author(s)
      Matsumoto R, Ishimoto T, Matsumoto S, Masuo Y, Suzuki M, Kato Y
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] Proliferative effect of tri-deoxyribonucleotides on mouse neural stem cells.2021

    • Author(s)
      Ishimoto T, Matsumura N, Masuo Y, Kiriyama K, Sutoh K, Kato Y
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] Functional expression and inhibition by clinically used drugs of efflux transporter MRP5/ABCC5 in neuronal cells.2021

    • Author(s)
      Yagi H, Ishimoto T, Masuo Y, and Kato Y
    • Organizer
      第64回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-20K15991
  • [Presentation] 腎血流速度の評価に応用可能な生体内物質の網羅的探索2020

    • Author(s)
      及川夏月、増尾友佑、石本尚大、加藤将夫
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] マウス神経幹細胞における薬物排出トランスポーターの発現プロファイル2020

    • Author(s)
      高田健矢、石本尚大、増尾友佑、加藤将夫
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] Transporter-mediated Ergothioneine Uptake Promotes Neuronal Differentiation through Activating NT5/TrkB/mTORC1 Signaling in Neural Stem Cells2020

    • Author(s)
      Ishimoto T, Nakamichi N, and Kato Y
    • Organizer
      New Frontier in Neuroscience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] ヒト血液中細胞外膜小胞におけるリン酸化TrkBの測定と食物由来抗酸化物質による変化2020

    • Author(s)
      松本留里、石本尚大、松本聡、増尾友佑、鈴木真、加藤将夫
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] 網羅的メタボロミクス解析による膜輸送体OCTN1脳内基質探索, 第93回日本薬理学会年会2020

    • Author(s)
      西山美沙、吉村智之、増尾友佑、石本尚大、中道範隆、松尾淳一、加藤将夫
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] P-gp及びBcrp阻害剤のマウス神経幹細胞生存率に及ぼす影響2020

    • Author(s)
      石本尚大、高田健矢、増尾友佑、加藤将夫
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] Functional Expression of Xenobiotic Transporters in Neural Stem Cells.2019

    • Author(s)
      Ishimoto T, Masuo Y, and Kato Y
    • Organizer
      The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23797
  • [Presentation] Enhancement of Neurogenesis by OCTN1-mediated Ergothioneine Transport.2019

    • Author(s)
      Ishimoto T
    • Organizer
      APSTJ Global Education Seminar
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23797
  • 1.  増尾 友佑
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 2.  中道 範隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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