Hosaka Takashi 保坂孝史

… Alternative Names

Takashi Hosaka 保坂孝史

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Researcher Number	00847890
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 特任講師
Affiliation (based on the past Project Information) *help	2019 – 2022: 筑波大学, 医学医療系, 講師
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / 0902:General internal medicine and related fields
Keywords	Principal Investigator バイオマーカー / RNA編集 / 筋萎縮性側索硬化症 / GluA2 / biomarker / GluA2 mRNA Q/R部位 / ALS / 細胞外RNA / ADAR2

Research Projects
(2 results)
Research Products
(12 results)

筋萎縮性側索硬化症の治療開発に向けたRNA編集異常を標的とする診断マーカーの開発Principal Investigator
- Principal Investigator
  
  保坂孝史
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Tsukuba
The Develpment of biomarker for amyotrophic lateral sclerosis by measuring editing efficiency on extracellular RNAPrincipal Investigator
- Principal Investigator
  
  Takashi Hosaka
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  University of Tsukuba

All 2023 2021 2020 2019

All Journal Article Presentation Book

[Book] 遺伝子治療開発ハンドブック第2版2023
- Author(s)
  保坂孝史、郭伸
- Total Pages
  772
- Publisher
  (株)エヌ・ティー・エス
- ISBN
  9784860438401
- Data Source
  KAKENHI-PROJECT-21K15178
[Book] 筋萎縮性側索硬化症―RNAメタポリズムの観点からみたバイオマーカーおよび治療の開発2020
- Author(s)
  保坂孝史, 郭伸
- Total Pages
  7
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19K23957
[Journal Article] Tracheoarterial fistula in a patient with amyotrophic lateral sclerosis successfully managed by overinflation of the tracheostomy tube cuff alone: a case report2023
- Author(s)
  Takashi Hosaka, Shintaro Furuno, Makoto Terada, Yumiko Hamano, Kenichi Komatsu, Katsuichiro Okubo, Yasuaki Koyama, Tetsu Suzuki, Hiroshi Tsuji, Akira Tamaoka, Taro Mizutani
- Journal Title
  
  J Med Case Rep
  
  Volume: 17(1) Issue: 1 Pages: 65-65
- DOI
  10.1186/s13256-023-03799-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15178
[Journal Article] Glutamine/arginine site-unedited GluA2 mRNA in cerebrospinal fluid as a biomarker for amyotrophic lateral sclerosis2023
- Author(s)
  Takashi Hosaka, Hiroshi Tsuji, Makoto Terada, Yasushi Tomidokoro, Akiko Ishii, Kiyotaka Nakamagoe, Kazuhiro Ishii, Hiroo Terashi, Hitoshi Aizawa, Akira Tamaoka, Shin Kwak
- Journal Title
  
  J Neurol Neurosurg Psychiatry .
  
  Volume: in press Issue: 10 Pages: 876-878
- DOI
  10.1136/jnnp-2023-331164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15178, KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-22H04923
[Journal Article] RNA Editing: A New Therapeutic Target in Amyotrophic Lateral Sclerosis and Other Neurological Diseases2021
- Author(s)
  Hosaka Takashi、Tsuji Hiroshi、Kwak Shin
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 20 Pages: 10958-10958
- DOI
  10.3390/ijms222010958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15178
[Journal Article] Biomolecular Modifications Linked to Oxidative Stress in Amyotrophic Lateral Sclerosis: Determining Promising Biomarkers Related to Oxidative Stress2021
- Author(s)
  Hosaka Takashi、Tsuji Hiroshi、Tamaoka Akira
- Journal Title
  
  Processes
  
  Volume: 9 Issue: 9 Pages: 1667-1667
- DOI
  10.3390/pr9091667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15178
[Journal Article] 筋萎縮性側索硬化症――RNAメタボリズムの観点からみたバイオマーカーおよび治療の開発2020
- Author(s)
  保坂孝史, 郭伸
- Journal Title
  
  医学のあゆみ
  
  Volume: 273 Pages: 50-56
- Data Source
  KAKENHI-PROJECT-19K23957
[Journal Article] Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases.2019
- Author(s)
  Hosaka T, Yamashita T, Tamaoka A, Kwak S.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 13 Pages: 3148-3148
- DOI
  10.3390/ijms20133148
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23957, KAKENHI-PROJECT-16K09666, KAKENHI-PROJECT-16H06277
[Presentation] Q/R site-unedited GluA2 mRNA in cerebrospinal fluid; A promising biomarker for sporadic ALS2023
- Author(s)
  Takashi Hosaka, Hiroshi Tsuji, Makoto Terada, Yasushi Tomidokoro, Akiko Ishii, Kiyotaka Nakamagoe, Kazuhiro Ishii, Akira Tamaoka, Shin Kwak
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K15178
[Presentation] Total extracellular RNA levels in cerebrospinal fluid derived from amyotrophic lateral sclerosis2021
- Author(s)
  Takashi Hosaka, Hiroshi Tsuji, Makoto Terada, Takenari Yamashita, Sayaka Teramoto, Yasushi Tomidokoro, Akiko Ishii, Kiyotaka Nakamagoe, Kazuhiro Ishii, Akira Tamaoka, Shin Kwak
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K15178
[Presentation] ADAR2 downregulation is a cause of death not only in ALS motor neurons but also in cultured cells2020
- Author(s)
  保坂孝史，山下雄也，寺本さやか，玉岡晃，郭伸
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K23957
[Presentation] ADAR2 downregulation is a cause of death not only in ALS motor neurons but also in cultured cells2020
- Author(s)
  Takashi Hosaka, Takenari Yamashita, Sayaka Teramoto, Akira Tamaoka, Shin Kwak
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K23957

Hosaka Takashi 保坂 孝史

Takashi Hosaka 保坂 孝史

Research Projects

Research Products

筋萎縮性側索硬化症の治療開発に向けたRNA編集異常を標的とする診断マーカーの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Develpment of biomarker for amyotrophic lateral sclerosis by measuring editing efficiency on extracellular RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 遺伝子治療開発ハンドブック 第2版2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 筋萎縮性側索硬化症―RNAメタポリズムの観点からみたバイオマーカーおよび治療の開発2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Tracheoarterial fistula in a patient with amyotrophic lateral sclerosis successfully managed by overinflation of the tracheostomy tube cuff alone: a case report2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glutamine/arginine site-unedited GluA2 mRNA in cerebrospinal fluid as a biomarker for amyotrophic lateral sclerosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA Editing: A New Therapeutic Target in Amyotrophic Lateral Sclerosis and Other Neurological Diseases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biomolecular Modifications Linked to Oxidative Stress in Amyotrophic Lateral Sclerosis: Determining Promising Biomarkers Related to Oxidative Stress2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 筋萎縮性側索硬化症――RNAメタボリズムの観点からみたバイオマーカーおよび治療の開発2020

Author(s)

Journal Title

Data Source

[Journal Article] Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Q/R site-unedited GluA2 mRNA in cerebrospinal fluid; A promising biomarker for sporadic ALS2023

Author(s)

Organizer

Data Source

[Presentation] Total extracellular RNA levels in cerebrospinal fluid derived from amyotrophic lateral sclerosis2021

Author(s)

Organizer

Data Source

[Presentation] ADAR2 downregulation is a cause of death not only in ALS motor neurons but also in cultured cells2020

Author(s)

Organizer

Data Source

[Presentation] ADAR2 downregulation is a cause of death not only in ALS motor neurons but also in cultured cells2020

Author(s)

Organizer

Data Source

Hosaka Takashi 保坂孝史

Takashi Hosaka 保坂孝史

[Book] 遺伝子治療開発ハンドブック第2版2023