Fujii Masayuki 藤井正幸

Researcher Number	00867575
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2025: 慶應義塾大学, 医学部(信濃町), 准教授 2020 – 2024: 慶應義塾大学, 医学部(信濃町), 講師
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator オルガノイド / シングルセル解析 / 大腸がん / 転移 / がん / 細胞個性 / エピゲノム / がん進化 / 異種移植 / 大腸癌 … More / 遺伝子編集 / 発がん / 遺伝子変異 / 異種移植モデル / 再発 / 遺伝子スクリーニング / 浸潤 … More Except Principal Investigator オルガノイド / 肺癌 Less

治療抵抗性肺癌オルガノイドライブラリーを用いた獲得耐性機構の本態解明
- Principal Investigator
  
  安田浩之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
Re-defining human tumor evolution based on cellular identity plasticity and its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  藤井正幸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Keio University
Multi-layered decoding and therapeutic co-option of the metastatic checkpoint in human colorectal cancerPrincipal Investigator
- Principal Investigator
  
  藤井正幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Keio University
Deep phenotyping of human colorectal cancer evolution using adult stem cell organoids and CRISPR-Cas9 technologyPrincipal Investigator
- Principal Investigator
  
  Fujii Masayuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Decoding the basis of histological variation in human cancer2023
- Author(s)
  Fujii Masayuki、Sekine Shigeki、Sato Toshiro
- Journal Title
  
  Nature Reviews Cancer
  
  Volume: 24 Issue: 2 Pages: 141-158
- DOI
  10.1038/s41568-023-00648-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04995, KAKENHI-PROJECT-23K27677
[Journal Article] Cell-matrix interface regulates dormancy in human colon cancer stem cells2022
- Author(s)
  Ohta Yuki、Fujii Masayuki、Takahashi Sirirat、Takano Ai、Nanki Kosaku、Matano Mami、Hanyu Hikaru、Saito Megumu、Shimokawa Mariko、Nishikori Shingo、Hatano Yoshiko、Ishii Ryota、Sawada Kazuaki、Machinaga Akihito、Ikeda Wataru、Imamura Takeshi、Sato Toshiro
- Journal Title
  
  Nature
  
  Volume: 608 Issue: 7924 Pages: 784-794
- DOI
  10.1038/s41586-022-05043-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04995, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-22KJ2666, KAKENHI-PROJECT-20K08340
[Journal Article] Identification of Quiescent LGR5+ Stem Cells in the Human Colon2022
- Author(s)
  Ishikawa K, Sugimoto S, Oda M, Fujii M, Toshimitsu K, Sawada K, Shimokawa M, Saito M, Kawasaki K, Ishii R, Taniguchi K, Sato T.
- Journal Title
  
  Gastroenterology.
  
  Volume: 163 Issue: 5 Pages: 1391-1406
- DOI
  10.1053/j.gastro.2022.07.081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-22H04995, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-22KJ2666, KAKENHI-PROJECT-20K08340, KAKENHI-PROJECT-21K19540, KAKENHI-PROJECT-15K21775, KAKENHI-PROJECT-20H03758
[Journal Article] Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer2022
- Author(s)
  Toshimitsu Kohta、Takano Ai、Fujii Masayuki、Togasaki Kazuhiro、Matano Mami、Takahashi Sirirat、Kanai Takanori、Sato Toshiro
- Journal Title
  
  Nature Chemical Biology
  
  Volume: - Issue: 6 Pages: 605-614
- DOI
  10.1038/s41589-022-00984-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20J12287, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-20K08340
[Journal Article] Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening2021
- Author(s)
  Ebisudani Toshiki、Sugimoto Shinya、Haga Kei、Mitsuishi Akifumi、Takai-Todaka Reiko、Fujii Masayuki、Toshimitsu Kohta、Hamamoto Junko、Sugihara Kai、Hishida Tomoyuki、Asamura Hisao、Fukunaga Koichi、Yasuda Hiroyuki、Katayama Kazuhiko、Sato Toshiro
- Journal Title
  
  Cell Reports
  
  Volume: 35 Issue: 10 Pages: 109218-109218
- DOI
  10.1016/j.celrep.2021.109218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08610, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-21K08496, KAKENHI-PROJECT-20H03746
[Journal Article] An organoid-based organ-repurposing approach to treat short bowel syndrome2021
- Author(s)
  Sugimoto S, Kobayashi E, Fujii M, Ohta Y, Arai K, Matano M, Ishikawa K, Miyamoto K, Toshimitsu K, Takahashi S, Nanki K, Hakamata Y, Kanai T, Sato T.
- Journal Title
  
  Nature
  
  Volume: 592 Pages: 99-104
- DOI
  10.1038/s41586-021-03247-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-23K20316
[Journal Article] Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases2021
- Author(s)
  Fujii M, Sato T.
- Journal Title
  
  Nat Mater
  
  Volume: 20 Issue: 2 Pages: 156-169
- DOI
  10.1038/s41563-020-0754-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20H03757
[Journal Article] Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer2021
- Author(s)
  Togasaki K, Sugimoto S, Ohta Y, Nanki K, Matano M, Takahashi S, Fujii M, Kanai T, Sato T.
- Journal Title
  
  Gastroenterology
  
  Volume: 160 Issue: 3 Pages: 823-830
- DOI
  10.1053/j.gastro.2020.10.047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08340, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-20J12287, KAKENHI-PROJECT-23K20316
[Journal Article] Organoid Derivation and Orthotopic Xenotransplantation for Studying Human Intestinal Stem Cell Dynamics2020
- Author(s)
  Shinya Sugimoto, Masayuki Fujii, Toshiro Sato
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2171 Pages: 303-320
- DOI
  10.1007/978-1-0716-0747-3_21
- ISBN
  9781071607466, 9781071607473
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757
[Journal Article] Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages2020
- Author(s)
  Sato T, Ishikawa S, Asano J, Yamamoto H, Fujii M, Sato T, Yamamoto K, Kitagaki K, Akashi T, Okamoto R, Ohteki T.
- Journal Title
  
  Nat Cell Biol
  
  Volume: 22 Issue: 8 Pages: 919-926
- DOI
  10.1038/s41556-020-0545-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-18K07062
[Journal Article] Linking human intestinal scaffolds and organoids to combat intestinal failure2020
- Author(s)
  Masayuki Fujii, Shinya Sugimoto, Toshiro Sato
- Journal Title
  
  Nature Medicine
  
  Volume: 26 Issue: 10 Pages: 1517-1518
- DOI
  10.1038/s41591-020-1096-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757
[Journal Article] An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping2020
- Author(s)
  Kawasaki K、Toshimitsu K、Matano M、Fujita M、Kudo Atsushi、Kitagawa Y、Kanai T、Nakagawa H、Sato T, et.al.
- Journal Title
  
  Cell
  
  Volume: 183 Issue: 5 Pages: 1420-1435
- DOI
  10.1016/j.cell.2020.10.023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09041, KAKENHI-PROJECT-20K08340, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-20H03533, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-18J21346, KAKENHI-PROJECT-20J12287, KAKENHI-PROJECT-23K20316
[Presentation] ヒト膵癌における系譜進化2024
- Author(s)
  藤井正幸
- Organizer
  第113回日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27677
[Presentation] Understanding principles of cancer metastasis using patient-derived organoids2023
- Author(s)
  Masayuki Fujii
- Organizer
  第82回日本癌学会総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27677
[Presentation] Organoid technology in the era of precision medicine2023
- Author(s)
  藤井正幸
- Organizer
  第62回日本癌治療学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27677
[Presentation] Lessons from patient-derived organoid biobanks2023
- Author(s)
  Masayuki Fujii
- Organizer
  Sapporo International Symposium and Ohno Moonshot International Cancer Symposium, Cancer Organoid Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27677
[Presentation] Tumor environment drives epigenetic reprogramming of human pancreatic cancer2022
- Author(s)
  Masayuki Fujii
- Organizer
  The 81st Annual Meeting of the Japanese Cancer Association
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03757
[Presentation] Microenvironmental regulation of somatic evolution and tumorigenesis2020
- Author(s)
  藤井正幸，佐藤俊朗
- Organizer
  第79回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03757

1. 安田浩之 (70365261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 浜本純子 (40570239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. MATANO Mami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 佐藤俊朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
5. 杉本真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 伊川正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 工藤篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 南木康作

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujii Masayuki 藤井 正幸

Research Projects

Research Products

Co-Researchers

治療抵抗性肺癌オルガノイドライブラリーを用いた獲得耐性機構の本態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Re-defining human tumor evolution based on cellular identity plasticity and its therapeutic applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multi-layered decoding and therapeutic co-option of the metastatic checkpoint in human colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deep phenotyping of human colorectal cancer evolution using adult stem cell organoids and CRISPR-Cas9 technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Decoding the basis of histological variation in human cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell-matrix interface regulates dormancy in human colon cancer stem cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Quiescent LGR5+ Stem Cells in the Human Colon2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An organoid-based organ-repurposing approach to treat short bowel syndrome2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Organoid Derivation and Orthotopic Xenotransplantation for Studying Human Intestinal Stem Cell Dynamics2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Linking human intestinal scaffolds and organoids to combat intestinal failure2020

Fujii Masayuki 藤井正幸