YOTSUMOTO KAREN 四本かれん

… Alternative Names

Yotsumoto Karen 四本かれん

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Researcher Number	00898322
Affiliation (Current)	2025: 九州大学, 歯学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2023: 九州大学, 歯学研究院, 共同研究員 2021 – 2022: 九州大学, 歯学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related
Keywords	Principal Investigator ヒストン修飾 / 免疫抑制 / アメロジェニン / エピジェネティック制御 / マクロファージ / 皮膚移植 / 創傷治癒

Elucidation of immunosuppressive mechanism by amelogenin and development of novel Th1-type disease therapeutic agents.Principal Investigator
- Principal Investigator
  
  四本かれん
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
Elucidation of Epigenetic Control mechanisms by amelogenin and challenge for refractory diseasesPrincipal Investigator
- Principal Investigator
  
  Yotsumoto Karen
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University

All 2022 2021

All Journal Article Presentation

[Journal Article] miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.2022
- Author(s)
  Hayashi C, Fukuda T, Kawakami K, Toyoda M, Nakao Y, Watanabe Y, Shinjo T, Sano T, Iwashita M, Yotsumoto K, Shida M, Taketomi T, Sanui T, Uchiumi T, Kanematsu T, Nishimura F.
- Journal Title
  
  Front Cell Dev Biol
  
  Volume: 10 Pages: 1061216-1061216
- DOI
  10.3389/fcell.2022.1061216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-21K09817, KAKENHI-PROJECT-20K18512, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-21K16972, KAKENHI-PROJECT-22K21041, KAKENHI-PROJECT-20H03865, KAKENHI-PROJECT-21K21017
[Journal Article] Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression.2022
- Author(s)
  Watanabe Y, Fukuda T, Hayashi C, Nakao Y, Toyoda M, Kawakami K, Shinjo T, Iwashita M, Yamato H, Yotsumoto K, Taketomi T, Uchiumi T, Sanui T, Nishimura F.
- Journal Title
  
  Sci Rep
  
  Volume: 12(1) Issue: 1 Pages: 13344-13344
- DOI
  10.1038/s41598-022-17692-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-21K16972, KAKENHI-PROJECT-22K21041, KAKENHI-PROJECT-20H03865, KAKENHI-PROJECT-21K21017, KAKENHI-PROJECT-21K21089
[Journal Article] Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells.2021
- Author(s)
  Yamato H, Sanui T, Yotsumoto K, Nakao Y, Watanabe Y, Hayashi C, Aihara R, Iwashita M, Tanaka U, Taketomi T, Fukuda T, Nishimura F
- Journal Title
  
  J Cell Biochem
  
  Volume: 122(7) Issue: 7 Pages: 716-730
- DOI
  10.1002/jcb.29903
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-21K16972, KAKENHI-PROJECT-21K21089
[Journal Article] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss2021
- Author(s)
  Nakao Yuki、Fukuda Takao、Zhang Qunzhou、Sanui Terukazu、Shinjo Takanori、Kou Xiaoxing、Chen Chider、Liu Dawei、Watanabe Yukari、Hayashi Chikako、Yamato Hiroaki、Yotsumoto Karen、Tanaka Urara、Taketomi Takaharu、Uchiumi Takeshi、Le Anh D.、Shi Songtao、Nishimura Fusanori
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 122 Pages: 306-324
- DOI
  10.1016/j.actbio.2020.12.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-20H03865, KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-21K16972, KAKENHI-PROJECT-21K21089
[Presentation] Fabrication of stem cell-based scaffold-free bone-like 3D structures.2022
- Author(s)
  Toyoda M, Kajioka S, Fujimoto R, Hayashi C, Kawakami K, Watanabe Y, Nakao Y, Yotsumoto K, Sanui T, Fukuda T, Nakayama K, Nishimura. F.
- Organizer
  The 108th Annual Meeting of the American Academy of Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] バイオ３Dプリンターを用いた、間葉系幹細胞からの骨様立法構造物作製への挑戦2022
- Author(s)
  豊田真顕、梶岡俊一、川上賢太郎、林千華子、渡邊ゆかり、中尾雄紀、四本かれん、讃井彰一、福田隆男、西村英紀
- Organizer
  令和4年度日本歯周病学会九州五大学日本臨床歯周病学会九州支部合同研究会
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] TNF-a/IFN-a共刺激した歯肉幹細胞由来エクソソームはCD73とCD5Lを介して抗炎症性M2マクロファージを誘導する2022
- Author(s)
  渡邊ゆかり、林千華子、川上賢太郎、豊田真顕、中尾雄紀、大和寛明、四本かれん、新城尊徳、岩下未咲、讃井彰一、福田隆男、西村英紀
- Organizer
  第156回日本歯科保存学会2022年度春季学術大会
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] miR-1260b inhibits periodontal bone loss by targeting ATF6β.2022
- Author(s)
  Hayashi C, Kawakami K, Toyoda M, Watanabe Y, Nakao Y, Yotsumoto K, Yamato H, Shinjo T, Sanui T, Fukuda T, Nishimura F.
- Organizer
  The 108th Annual Meeting of the American Academy of Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯周炎骨吸収抑制効果2022
- Author(s)
  林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀
- Organizer
  第65回日本歯周病学会春季学術大会
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] バイオ3Dプリンターを用いた、間葉系幹細胞からの骨様立法構造物作製への挑戦2022
- Author(s)
  豊田真顕、梶岡俊一、福田隆男、渡辺ゆかり、林千華子、川上賢太郎、中尾雄紀、四本かれん、大和寛明、讃井彰一、西村英紀
- Organizer
  第65回日本歯周病学会春季学術大会
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯槽骨吸収抑制作用2021
- Author(s)
  林千華子, 福田隆男, 渡邊ゆかり, 川上賢太郎, 豊田真顕, 中尾雄紀, 四本かれん，大和寛明，新城尊徳，讃井彰一，西村英紀
- Organizer
  2021年度日本歯科保存学会秋季学術大会(第155回)
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss.2021
- Author(s)
  Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Hiroaki Yamato, Karen Yotsumoto, Terukazu Sanui, Takanori Shinjo, Takao Fukuda, Fusanori Nishimura.
- Organizer
  Kyudai Oral Bioscience & OBT Research Center 5th Joint International Symposium（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] ゲラニルゲラニルアセトンとアメロジェニンの歯周組織再生への複合的効果2021
- Author(s)
  大和寛明、讃井彰一、四本かれん、中尾雄紀、渡邊ゆかり、林千華子、相原良亮、岩下未咲、田中麗、福田隆男、西村英紀
- Organizer
  2021年度日本歯科保存学会春季学術大会(第154回)
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] Chikako Hayashi, Takao Fukuda, Yukari Watanabe, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Terukazu Sanui, Fusanori Nishimura2021
- Author(s)
  Chikako Hayashi, Takao Fukuda, Yukari Watanabe, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Terukazu Sanui, Fusanori Nishimura
- Organizer
  Kyudai Oral Bioscience & OBT Research Center 5th Joint International Symposium（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16972
[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した抗炎症作用.2021
- Author(s)
  林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀.
- Organizer
  第64回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-21K16972

1. SANUI Terukazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. FUKUDA Takao

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. TAKETOMI Takaharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 新城尊徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOTSUMOTO KAREN 四本 かれん

Yotsumoto Karen 四本 かれん

Research Projects

Research Products

Co-Researchers

Elucidation of immunosuppressive mechanism by amelogenin and development of novel Th1-type disease therapeutic agents.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Epigenetic Control mechanisms by amelogenin and challenge for refractory diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Fabrication of stem cell-based scaffold-free bone-like 3D structures.2022

Author(s)

Organizer

Data Source

[Presentation] バイオ３Dプリンターを用いた、間葉系幹細胞からの骨様立法構造物作製への挑戦2022

Author(s)

Organizer

Data Source

[Presentation] TNF-a/IFN-a共刺激した歯肉幹細胞由来エクソソームはCD73とCD5Lを介して抗炎症性M2マクロファージを誘導する2022

Author(s)

Organizer

Data Source

[Presentation] miR-1260b inhibits periodontal bone loss by targeting ATF6β.2022

Author(s)

Organizer

Data Source

[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯周炎骨吸収抑制効果2022

Author(s)

Organizer

Data Source

[Presentation] バイオ3Dプリンターを用いた、間葉系幹細胞からの骨様立法構造物作製への挑戦2022

Author(s)

Organizer

Data Source

[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯槽骨吸収抑制作用2021

Author(s)

Organizer

Data Source

[Presentation] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss.2021

Author(s)

Organizer

Data Source

[Presentation] ゲラニルゲラニルアセトンとアメロジェニンの歯周組織再生への複合的効果2021

Author(s)

Organizer

Data Source

[Presentation] Chikako Hayashi, Takao Fukuda, Yukari Watanabe, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Terukazu Sanui, Fusanori Nishimura2021

Author(s)

Organizer

Data Source

[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した抗炎症作用.2021

Author(s)

Organizer

YOTSUMOTO KAREN 四本かれん

Yotsumoto Karen 四本かれん