FUKAMI HIROTAKA 深水大天

… Alternative Names

Fukami Hirotaka 深水大天

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Researcher Number	00908006
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 熊本大学, 大学院生命科学研究部(医), 特任助教 2021 – 2022: 熊本大学, 病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / 0904:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator ペプチドワクチン / ANGPTL3 / ワクチン / 家族性高コレステロール血症 / 脂質異常症 / 脂質代謝 / 動脈硬化 / NASH / NAFLD / 治療ワクチン / 動脈硬化性疾患

ANGPTL3を標的とした脂質異常症治療ワクチンの作用メカニズム解明と最適化研究Principal Investigator
- Principal Investigator
  
  深水大天
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
Fundamental research to expand indications for dyslipidemia vaccinePrincipal Investigator
- Principal Investigator
  
  Fukami Hirotaka
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
Development of a therapeutic vaccine for dyslipidemiaPrincipal Investigator
- Principal Investigator
  
  Fukami Hirotaka
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0904:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kumamoto University

All 2023 2022 2021

All Journal Article Presentation Patent

[Journal Article] Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine2023
- Author(s)
  Fukami Hirotaka、Morinaga Jun、Nakagami Hironori、Hayashi Hiroki、Okadome Yusuke、Matsunaga Eiji、Kadomatsu Tsuyoshi、Horiguchi Haruki、Sato Michio、Sugizaki Taichi、Miyata Keishi、Torigoe Daisuke、Mukoyama Masashi、Morishita Ryuichi、Oike Yuichi
- Journal Title
  
  npj Vaccines
  
  Volume: 8 Issue: 1 Pages: 168-168
- DOI
  10.1038/s41541-023-00770-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18291, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-22K11727, KAKENHI-PROJECT-23K07511, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-22K16429, KAKENHI-PROJECT-21H04825, KAKENHI-PROJECT-21H02827
[Journal Article] Plasma ANGPTL8 Levels and Risk for Secondary Cardiovascular Events in Japanese Patients With Stable Coronary Artery Disease Receiving Statin Therapy2023
- Author(s)
  Morinaga Jun、Mukoyama Masashi、Oike Yuichi、et al.
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 43 Issue: 8 Pages: 1549-1559
- DOI
  10.1161/atvbaha.122.318880
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18291, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-22K11727, KAKENHI-PROJECT-23K07511, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-22K16429, KAKENHI-PROJECT-21H04825
[Journal Article] Increased numbers of pre-operative circulating monocytes predict risk of developing cardiac surgery-associated acute kidney injury in conditions requiring cardio pulmonary bypass.2023
- Author(s)
  Okadome Y, Morinaga J, Yamanouchi Y, Matsunaga E, Fukami H, Kadomatsu T, Horiguchi H, Sato M, Sugizaki T, Hayata M, Sakaguchi T, Hirayama R, Ishimura T, Kuwabara T, Usuku K, Yamamoto T,Mukoyama M, Suzuki R, Fukui T, and Oike Y
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 27 Issue: 4 Pages: 329-339
- DOI
  10.1007/s10157-022-02313-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-22K08357, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-22K16429, KAKENHI-PROJECT-21K16061, KAKENHI-PROJECT-21K20935, KAKENHI-PROJECT-23K18291
[Journal Article] Hyperglycemia and Thrombocytopenia　― Combinatorially Increase the Risk of Mortality in Patients With Acute Myocardial Infarction Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation ―2021
- Author(s)
  Okadome Yusuke、Morinaga Jun、Fukami Hirotaka、Hori Kota、Ito Teruhiko、Sato Michio、Miyata Keishi、Kuwabara Takashige、Mukoyama Masashi、Suzuki Ryusuke、Tsunoda Ryusuke、Oike Yuichi
- Journal Title
  
  Circulation Reports
  
  Volume: 3 Issue: 12 Pages: 707-715
- DOI
  10.1253/circrep.CR-21-0043
- NAID
  130008128243
- ISSN
  2434-0790
- Year and Date
  2021-12-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08560, KAKENHI-PROJECT-19K08728, KAKENHI-PROJECT-20K17288, KAKENHI-PROJECT-21H04825, KAKENHI-PROJECT-21K16061, KAKENHI-PROJECT-21K20935
[Journal Article] Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia2021
- Author(s)
  Fukami Hirotaka、Morinaga Jun、Nakagami Hironori、Hayashi Hiroki、Okadome Yusuke、Matsunaga Eiji、Kadomatsu Tsuyoshi、Horiguchi Haruki、Sato Michio、Sugizaki Taichi、Kuwabara Takashige、Miyata Keishi、Mukoyama Masashi、Morishita Ryuichi、Oike Yuichi
- Journal Title
  
  Cell Reports Medicine
  
  Volume: 2 Issue: 11 Pages: 100446-100446
- DOI
  10.1016/j.xcrm.2021.100446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08560, KAKENHI-PROJECT-19K08728, KAKENHI-PROJECT-20K17288, KAKENHI-PROJECT-21H04825, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-21K15508, KAKENHI-PROJECT-21K16061, KAKENHI-PROJECT-21K20935
[Patent] 脂質異常関連疾患治療薬2022
- Inventor(s)
  尾池雄一、森永潤、深水大天
- Industrial Property Rights Holder
  尾池雄一、森永潤、深水大天
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21K20935
[Patent] 脂質異常関連疾患治療薬2022
- Inventor(s)
  尾池雄一、森永潤、深水大天
- Industrial Property Rights Holder
  尾池雄一、森永潤、深水大天
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-22K16429
[Patent] 脂質異常関連疾患治療薬2021
- Inventor(s)
  尾池　雄一、森永　潤、深水　大天
- Industrial Property Rights Holder
  尾池　雄一、森永　潤、深水　大天
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K20935
[Presentation] The 88th Annual Scientific Meeting of the Japanese Circulation Society, Symposium Session2023
- Author(s)
  Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Masashi Mukoyama, Yuichi Oike
- Organizer
  Development of Vaccine Therapeutics Targeting ANGPTL3 for Dyslipidemia and Atherosclerotic Disease.
- Invited
- Data Source
  KAKENHI-PROJECT-22K16429
[Presentation] 健康長寿を阻害する動脈硬化関連疾患へのワクチン治療薬開発2023
- Author(s)
  深水大天、森永潤、中神啓徳、森下竜一、向山政志、尾池雄一
- Organizer
  第13回日本脳血管・認知症学会総会, シンポジウムセッション
- Invited
- Data Source
  KAKENHI-PROJECT-22K16429
[Presentation] アンジオポエチン様因子3（ANGPTL3）を標的とした脂質異常症および関連疾患治療ワクチンの開発2022
- Author(s)
  深水大天、森永潤、中神啓徳、森下竜一、桒原孝成、尾池雄一、向山政志
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K16429
[Presentation] 臨床研究に基づく治療候補選定及びangiopoietin様蛋白3（ANGPTL3）を標的とした脂質異常症ワクチンの開発2022
- Author(s)
  深水大天、森永潤、中神啓徳、森下竜一、桒原孝成、尾池雄一、向山政志
- Organizer
  第119回日本内科学会総会・講演会
- Data Source
  KAKENHI-PROJECT-21K20935
[Presentation] 健康長寿を阻害する動脈硬化関連疾患へのワクチン治療薬開発2022
- Author(s)
  深水大天、森永潤、中神啓徳、桒原孝成、向山政志、尾池雄一
- Organizer
  第54回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K20935
[Presentation] 臨床研究に基づく治療候補選定及びangiopoietin様蛋白3（ANGPTL3）を標的とした脂質異常症ワクチンの開発2022
- Author(s)
  深水大天、森永潤、中神啓徳、森下竜一、桒原孝成、尾池雄一、向山政志
- Organizer
  第119回日本内科学会総会・講演会
- Data Source
  KAKENHI-PROJECT-22K16429
[Presentation] Development of a therapeutic vaccine for dyslipidemia and related diseases targeting angiopoietin-like protein 3 (ANGPTL3).2022
- Author(s)
  深水大天、森永潤、中神啓徳、桒原孝成、森下竜一、尾池雄一、向山政志
- Organizer
  第29回国際高血圧学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16429
[Presentation] 健康長寿を阻害する動脈硬化関連疾患へのワクチン治療薬開発2022
- Author(s)
  深水大天、森永潤、中神啓徳、森下竜一、向山政志、尾池雄一
- Organizer
  第18回脳心血管抗加齢研究会学術大会
- Data Source
  KAKENHI-PROJECT-22K16429
[Presentation] アンジオポエチン様因子(ANGPTL3)を標的とした脂質異常症および関連疾患治療ワクチンの開発2022
- Author(s)
  深水大天、森永潤、中神啓徳、森下竜一、桒原孝成、尾池雄一、向山政志
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K20935
[Presentation] 健康長寿を阻害する動脈硬化関連疾患へのワクチン治療薬開発2022
- Author(s)
  深水大天、森永潤、中神啓徳、森下竜一、向山政志、尾池雄一
- Organizer
  第18回脳心血管抗加齢研究会学術大会
- Data Source
  KAKENHI-PROJECT-21K20935
[Presentation] アンジオポエチン様因子(ANGPTL3)を標的とした脂質異常症および関連疾患治療ワクチンの開発2022
- Author(s)
  深水大天、森永潤、松永　英士、中神啓徳、森下竜一、桒原孝成、尾池雄一、向山政志
- Organizer
  Science Pioneers Consortium 2022
- Data Source
  KAKENHI-PROJECT-21K20935
[Presentation] アンジオポエチン様因子3（ANGPTL3）を標的とした脂質異常症および関連疾患治療ワクチンの開発2022
- Author(s)
  深水大天、森永潤、松永　英士、中神啓徳、森下竜一、桒原孝成、尾池雄一、向山政志
- Organizer
  Science Pioneers Consortium 2022
- Data Source
  KAKENHI-PROJECT-22K16429
[Presentation] Development of a therapeutic vaccine for dyslipidemia and related diseases targeting angiopoietin-like protein (ANGPTL3)2022
- Author(s)
  深水大天、森永潤、中神啓徳、桒原孝成、森下竜一、尾池雄一、向山政志
- Organizer
  第29回国際高血圧学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20935
[Presentation] アンジオポエチン様因子3（ANGPTL3）を標的とした新規脂質異常症治療ワクチンの開発2021
- Author(s)
  深水大天、森永潤、中神啓徳、尾池雄一、向山政志
- Organizer
  日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-21K20935

1. KADOMATSU Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 向山政志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 宮田敬士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUKAMI HIROTAKA 深水 大天

Fukami Hirotaka 深水 大天

Research Projects

Research Products

Co-Researchers

ANGPTL3を標的とした脂質異常症治療ワクチンの作用メカニズム解明と最適化研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fundamental research to expand indications for dyslipidemia vaccinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a therapeutic vaccine for dyslipidemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasma ANGPTL8 Levels and Risk for Secondary Cardiovascular Events in Japanese Patients With Stable Coronary Artery Disease Receiving Statin Therapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased numbers of pre-operative circulating monocytes predict risk of developing cardiac surgery-associated acute kidney injury in conditions requiring cardio pulmonary bypass.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hyperglycemia and Thrombocytopenia ― Combinatorially Increase the Risk of Mortality in Patients With Acute Myocardial Infarction Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation ―2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia2021

Author(s)

Journal Title

DOI

Data Source

[Patent] 脂質異常関連疾患治療薬2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 脂質異常関連疾患治療薬2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 脂質異常関連疾患治療薬2021

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] The 88th Annual Scientific Meeting of the Japanese Circulation Society, Symposium Session2023

Author(s)

Organizer

Data Source

[Presentation] 健康長寿を阻害する動脈硬化関連疾患へのワクチン治療薬開発2023

Author(s)

Organizer

Data Source

[Presentation] アンジオポエチン様因子3（ANGPTL3）を標的とした脂質異常症および関連疾患治療ワクチンの開発2022

Author(s)

FUKAMI HIROTAKA 深水大天

Fukami Hirotaka 深水大天

[Journal Article] Hyperglycemia and Thrombocytopenia　― Combinatorially Increase the Risk of Mortality in Patients With Acute Myocardial Infarction Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation ―2021

[Presentation] 臨床研究に基づく治療候補選定及びangiopoietin様蛋白3（ANGPTL3）を標的とした脂質異常症ワクチンの開発2022

[Presentation] 臨床研究に基づく治療候補選定及びangiopoietin様蛋白3（ANGPTL3）を標的とした脂質異常症ワクチンの開発2022