SAKATA Yoshiyuki 坂田義行

Researcher Number	10034927
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Affiliation (based on the past Project Information) *help	2007 – 2008: 山口大学, 大学院・医学系研究科, 講師 2007: Yamaguchi University, 大学医学系研究科, 講師 2006: Yamaguchi University, Graduate School of Medicine, Assistant Professor, 大学院医学系研究科, 講師 1995 – 2005: Dept.Physiol., Yamaguchi Univ.Sch.Med., Lecturer, 医学部, 講師 1986 – 1994: Yamaguchi Univ. School of Medicine, 医学部, 助手
Review Section/Research Field	Principal Investigator Embryonic/Neonatal medicine / Embryonic/Neonatal medicine / 環境生理学(含体力医学･栄養生理学) Except Principal Investigator Obstetrics and gynecology / 環境生理学(含体力医学･栄養生理学) / Embryonic/Neonatal medicine / Environmental physiology (including Physical medicine and Nutritional physiology) / 神経・脳内生理学 / Neuroscience in general / Embryonic/Neonatal medicine / Obstetrics and gynecology
Keywords	Principal Investigator 胎仔脳 / 低酸素症 / 保護機構 / 光学的イメージング / hypoxia / アポトーシス / OVLT / ACTH / CRF / non-NMDA … More / NMDA / in vivo / fetal brain / optical imaging / カスパーゼー3 / SOD / caspase-3 / Bcl-2 / Bax / siRNA / 胎仔ニューロン活動 / 低酸素負荷 / 脳血流量 / 低酸素分圧 / 胎仔低酸素症モデル / 臍帯結紮 / パパベリン / マイクロRNA / カスパーゼ3 / アポトーシア / 神経細胞新生 / インターロイキン-1 / 発熱 / 下垂体-副腎系 / プロスタグランジン / ストレス / テレメトリーシステム / インドメタシン / 精神性ストレス / カテコールアミン / 脳波 / 発熱反応 / 循環系活動 / in situ hybridization / α-hCRF / cRNA / サイトカイン / インタ-ロイキン1 / interleukin-1 / IL-1 / hybridization / hyperthermia / hypertension / グルタミン酸受容体 / Caイオン / イメージング法 / NMOA / 細胞内Ca濃度 / NMDA受容体 / AP-5 / CNQX / glutamate receptor / Ca^<2+> / シクロスポリン-A / チトクロームC / 上丘 / in vivo光学的イメージング / 発達脳 / アポトーシス誘導因子 / チトクロームc / in vivo光単的イメージング / 細胞内Caイオン / fetus / in vivo optical recordings / superior colliculus / caspase-3 inhibitor / cyclosporin-A / カスパーゼー3活性 / ROS / apoptosis / 内因性発熱物質 / 血液・脳関門 / 2相性発熱 / モノクロナール抗体 / アッセイ系 / ポリクローナル抗体 / リコンビナントIL-1α / リコンビナントIL-1β / Fever / Interleukin-1 / Monoclonal antibody / Blood-brain barrier / endogenous pyrogen / blood-brain barrier / biphasic fever / monoclonal antibody / assay system / polyclonal antibody / recombinant IL-1<alpha> … More Except Principal Investigator 胎仔脳 / GABA / 胎仔 / 上丘 / fetal brain / superior colliculus / 子宮 / 陣痛 / 出産 / 視床下部 / 発達 / 胎児脳 / 活動電位 / development / ストレス / in situ hybridization / LPS / OVLT / immunohistochemistry / in vivo / 臍帯結紮 / 低酸素 / umbilical cord occlusion / NO / プロスタグランディン / Fever / Hybridization / 下垂体 / 副腎皮質 / 液性因子 / 出産のタイミング / オキシトシン / バゾトシン / オキシトシン受容体 / 視床下部室傍核 / バソトシン / 脳神経 / 発生分化 / 発生・分化 / 脳・神経 / 膜興奮性 / 母体-胎児相関 / 長期変化 / ホールセルレコーディング / 妊娠ラット / 母体-胎児相間 / membrane excitability / hypothalamus / mother-fetus interaction / action potential / membrane potential / インターロイキン 1 / 細菌性内毒素 / 発熱耐性 / 終板器官 / 免疫組織化学的手法 / インターロイキン1 / Interleukin-1beta / Febrile tolerance / Organum vasculosum laminae terminalis / 視覚系 / 膜電位光学測定 / シナプス電位 / グルタミン酸 / 電位感受性色素 / 光学的記録法 / TTX / visual system / optical imaging / synaptic potential / glutamate / 細胞内Clイオン / 光学的測定 / 蛍光色素 / CIイオン / 発達脳 / intracellular Cl^- / optical recording / fluorescent dye / hypoxia / 脳発達 / DNAチップ / 記憶 / 学習 / 胎仔期のストレス / 神経栄養性 / 神経毒性 / アルツハイマー病 / 海馬 / 胎生期 / brain development / DNA tip / memory / learning / prenatal stress / neurotrophic / neurotoxic / Alzheirmer disease / 仮死 / スーパーオキサイドディスミュテース / 虚血 / 酸素 / 低酸素症 / 胎児 / 脳幹 / 臍帯 / 脳血流 / 活性酸素 / 酸化還元酵素 / zinc diethyldithiocarbamate / 脳性麻痺 / asphyxia / superoxide dismutase / delivery / ischemia / oxygen / 脳薄切標本 / 内因性発熱物質 / 視束前野 / 温度受容細胞 / 視床中継核ニューロン / 2相性発熱 / [【^(14)C】]デオキシグルコース法 / Host defence / Prostaglandin / Acute phase response / Blood-brain barrier / Slice experiment / Rat / 発熱反応 / 発熱物質 / 非特異的生体防御反応 / 無麻酔発熱実験 / 電気生理学的実験 / 発熱発現機序 / 無拘束動物 / Telemetory system / ストレス性高体温 / プロスタグランジン / ACTH / CRF / ノルアドレナリン / 急性相反応 / インタ-ロイキン1 / 家兎 / ラット / 長期運動鍛練 / Interleukinー1 / 発熱 / 腫瘍壊死因子 / インターフェロン / Interleukin-l / EP / サイトカイン / 神経系 / 免疫系 / 下垂体・副腎系 / Pyrogen / Non-specific host defense / Unanesthetized animal / Electrophysiological experiment / Pathogenesis of fever Less

Protection mechanism of fetal brain against severe hypxia : analysis of micro RNA using with in vivo optical imagingPrincipal Investigator
- Principal Investigator
  
  SAKATA Yoshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Yamaguchi University
Distinguishing the effects of maternal environment on the development of fetal brains
- Principal Investigator
  
  FUJIOKA Takashi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Yamaguchi University
The role of Bcl-2 and Bax in hypoxia-induced caspase-3 activation in the fetal superior colliculus: in vivo opticalPrincipal Investigator
- Principal Investigator
  
  SAKATA Yoshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Yamaguchi University
Studies on the protective mechanism of the fetal brain against hypoxic-ischemic insult during delivery
- Principal Investigator
  
  NAKAMURA Shoji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamaguchi University
Effects of hypoxia on caspase-3 activity in fetal superior colliculus : in vivo optical imagingsPrincipal Investigator
- Principal Investigator
  
  SAKATA Yoshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Yamaguchi University
胎仔脳はオキシトシンを分泌して出産を誘発するか?
- Principal Investigator
  
  中村彰治
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamaguchi University
Development of drugs for facilitating brain development and memory/learning
- Principal Investigator
  
  NAKAMURA Shoji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Yamaguchi University
Protective mechanism of fetal brain against hypoxia: in vivo optical recordingsPrincipal Investigator
- Principal Investigator
  
  SAKATA Yoshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Yamaguchi University
胎仔脳が出産のタイミングを決めているか?
- Principal Investigator
  
  NAKAMURA Shoji
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamaguchi University
Is GABA excitatory or inhibitory in the developing brain?
- Principal Investigator
  
  NAKAMURA Shoji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neuroscience in general
- Research Institution
  Yamaguchi University
Development of visual input to superior colliculus in fetal rats : in vivo optical imaging.
- Principal Investigator
  
  NAKAMURA Shoji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Yamaguchi University
in vivo胎仔ニューロン活動に対する低酸素の影響:パッチクランプ法による解析Principal Investigator
- Principal Investigator
  
  坂田義行
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Yamaguchi University
Molecular mechanism of the long-lasting change in the excitability of fetal brain neurons following dam's brain stimulation
- Principal Investigator
  
  NAKAMURA Shoji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamaguchi Univ.
Interleukin-1 production in the brain of febile and stress tolerant rabbits
- Principal Investigator
  
  WATANABE Tatsuo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Yamaguchi Univ.
Physiological role of cytokines on homeostasisPrincipal Investigator
- Principal Investigator
  
  SAKATA Yoshiyuki, MURAKAMI Naotoshi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  Yamaguchi University
Fever and Host Defense
- Principal Investigator
  
  MURAKAMI Naotoshi
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  Yamaguchi University
Production of antiserum against pyrogenic factor and pyrogenic mechanisms using the antiserum.Principal Investigator
- Principal Investigator
  
  SAKATA Yoshiyuki, 森本昭生
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  Yamaguchi University
Pathophysiology of fever
- Principal Investigator
  
  MURAKAMI Naotoshi
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  Yamaguchi University

All 2006

All Journal Article

[Journal Article] In vivo optical recordings of synaptic transmission and intracellular Ca^<2+> and Cl^- in the superior colliculus of fetal rats2006
- Author(s)
  Yoshiyuki Sakata
- Journal Title
  
  Eeuropean Journal of Neuroscience 23・6
  
  Pages: 1406-1416
- Data Source
  KAKENHI-PROJECT-17591143
[Journal Article] In vivo optical recordings of synaptic transmission and intracellular Ca^<2+> and Cl^- in the superior colliculus of fetal rats2006
- Author(s)
  Yoshiyuki Sakata
- Journal Title
  
  European Journal of Neuroscience 23
  
  Pages: 1405-1416
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591143

1. NAKAMURA Shoji (80112051)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. FUJIOKA Takashi (50304473)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. ISHIKAWA Akinori (40363098)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. MORIMOTO Akio (70127794)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. WATANABE Tatsuo (60182929)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. ISHIDA Yoshiyuki (20325210)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. MURAKAMI Naotoshi (90040518)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. KIDA Hiroyuki (70432739)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TSUCHIMOCHI Hirotsugu (60379948)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. IZUMI Tomonori (00261694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MAEKAWA Tsuyoshi (60034972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FUJIOKA Aya (50464334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KOBAYASHI Sei (80225515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. LIU Yin (40335724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OKUYAMA Shigeru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAKATA Yoshiyuki 坂田 義行

Research Projects

Research Products

Co-Researchers

Protection mechanism of fetal brain against severe hypxia : analysis of micro RNA using with in vivo optical imagingPrincipal Investigator

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Research Institution

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The role of Bcl-2 and Bax in hypoxia-induced caspase-3 activation in the fetal superior colliculus: in vivo opticalPrincipal Investigator

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Effects of hypoxia on caspase-3 activity in fetal superior colliculus : in vivo optical imagingsPrincipal Investigator

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Protective mechanism of fetal brain against hypoxia: in vivo optical recordingsPrincipal Investigator

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in vivo胎仔ニューロン活動に対する低酸素の影響:パッチクランプ法による解析Principal Investigator

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Principal Investigator

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Physiological role of cytokines on homeostasisPrincipal Investigator

SAKATA Yoshiyuki 坂田義行