HARA Kenji 原研治

… Alternative Names

原研治ハラケンジ

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Researcher Number	10039737
External Links
Affiliation (based on the past Project Information) *help	2013 – 2015: 長崎大学, 水産・環境科学総合研究科(水産), 教授 2011 – 2012: 長崎大学, 水産・環境科学総合研究科, 教授 2006 – 2010: 長崎大学, 水産学部, 教授 1997 – 2003: Nagasaki University Faculty of Fisheries Professor, 水産学部, 教授 1993 – 1996: 長崎大学, 水産学部, 助教授 1989: 長崎大学, 水産学部, 助教授
Review Section/Research Field	Principal Investigator Fisheries chemistry / Fisheries chemistry Except Principal Investigator General fisheries / Fisheries chemistry / Fisheries chemistry / Pathological medical chemistry / Aquatic life science
Keywords	Principal Investigator 筋原線維タンパク質 / プロテアーゼ / Serine proteinase inhibitor / Modori / Trypsin type protease / Lizard fish / Carp / Amino acid sequence / Molecular cloning / Myofibril-bound serine protease … More / プローブ / 精製 / 火戻り / N末端アミノ酸配列 / 筋原繊維結合型セリンプロテアーゼ / mRNA発現 / セリン型酵素インヒビター / 戻り / トリプシン型酵素 / エソ / コイ / 一次構造 / 遺伝子クローニング / 筋原線維結合型セリンプロテアーゼ / Protease Inhibitor / Myofibrillar Proteins / Protease / Autolysis / Red sea bream Muscle / 筋原繊維タンパク質 / プロテアーゼインヒビター / 自己消化 / マダイ筋肉 / Pulse-chase experiment / Macrophage / Processing / Biosynthesis / Fish Cathepsins / パルス-チェイス実験 / マクロファージ / プロセッシング / 魚類カテプシン / ATPase / 組織化学 / 養殖ブリ / 肉質低下 / カテプシン / ヤケ肉 / やけ肉 … More Except Principal Investigator 酸化ストレス / lymphocytes / リンパ球 / β-カロチン / 細胞培養系 / 魚病細菌 / 抗酸化酵素 / SOD / ウイルス感染 / マダイ / Japanese parrotfish / beta-carotene / 幼若化 / イシダイ / 干潟生物 / ワムシ / プロモーター / クローニング / Oxidative stress / Bacterial infection / Fish disease / Cloning / Purification / Fish / Superoxide dismutase / スーパーオキシドジムターゼ / 細菌感染症 / 魚病 / 精製 / 魚類 / スーパーオキシドジスムターゼ / PRC-RFLP analysis / low saliinity tolerance / ecological growth / morphological growth / early life history / reproduction / growth / yoshinogochi / magochi / DNA / 浸透圧調節 / 初期生活史 / 有明海 / コチ属 / 初期生体 / 低塩分耐性 / 形態発達 / 初期生態 / 種判別 / 成熟 / 成長 / ヨシノゴチ / マゴチ / cultivation without medication / antibacterial agent / tiger puffer / red sea bream / yellowtail / astraxanthin / β-carotene / 抗生物質 / アスキタサンチン / 無投薬 / 抗菌剤 / トラフグ / ブリ / アスタキサンチン / virus infection / larvae / rotifer / Spotted parrotfish / Red sea bream / 稚魚 / 脾臓リンパ球 / 種苗 / イシガキダイ / Tidal flat organisms / Biological Processes / Coastal Wetlands / 干潟動物 / 生物生産過程 / 海浜湿地帯 / macrophages / IFN_<gamma>. / 免疫防御機能 / γ-IFN / インターフェロン / ウイルス / mφ(アクロファージ) / γ-INF / adaptive radiation / phylogeny / Periophthalmus / Boleophthalmus / air breathing fish / animal on mud flat / 適応放散 / 系統発生 / トビハゼ / ムツゴロウ / 空気呼吸魚 / Atherinids / Mudskippers / Rotifers / Benthos / Feeding habits / Bioloical production / Tidal flats / Estuary / イカ類 / 干湾 / 免疫学 / シオミズツボワムシ / ベントス / トウゴロウイワシ類 / ムツゴロウ類 / 底生生物 / 食性 / 生物生産 / 干潟 / 河口域 / Cathepsin L / CA-074 / Selective inhibitor of cathepsin B / Cathepsin B / E-64a / Cysteine proteinase inhibitor / Cysteine proteinase / Lysosome / Eー64誘導体 / アレルギ- / IgE / 骨粗鬆症 / シスタチン / カテプシンL / カテプシンB特異的阻害剤 / CAー074 / カテプシンB / Eー64a / システインプロテア-ゼ阻害剤 / システインプロテア-ゼ / リソゾ-ム / flagellin / 遺伝子構造 / 培養細胞系 / 活性酸素 / ピンク筋 / 筋タイプ / 死後硬直 Less

Molecular mechanism of the defense systems against host immunity by causative bacillus of Edwardsiellosis in fishes - Cell biological approach -
- Principal Investigator
  
  OSATOMI Kiyoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Aquatic life science
- Research Institution
  Nagasaki University
Mechanism of gene expression regulation of anti-oxidant enzymeswith oxidative stress in fishes - Molecular cell biological approach -
- Principal Investigator
  
  OSATOMI Kiyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Nagasaki University
Response mechanism of anti-oxidant enzymes with bacterial infection in fishes-Cell biological approach -
- Principal Investigator
  
  OSATOMI Kiyoshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Nagasaki University
Studies on mechanism of burnt meat caused by seawater warming in cultured yellowtail (Seriola quinqueradita)-enzymatic approachPrincipal Investigator
- Principal Investigator
  
  HARA Kenji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Nagasaki University
Study on structure and function of myofibril-bound serine proteinase (MBP) using molecular cloningPrincipal Investigator
- Principal Investigator
  
  HARA Kenji
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Nagasaki University
Studies on the early life history of two Platycephalus fishes distributed in Ariake Sound
- Principal Investigator
  
  TAKITA Toru
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General fisheries
- Research Institution
  Nagasaki University
Studies on superoxide dismutase and oxidative stress response in fishes
- Principal Investigator
  
  OSATOMI Kiyoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Nagasaki University
Study of fish cultivation using carotenoids supplemented diets without medication
- Principal Investigator
  
  TACHIBANA Katsuyasu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General fisheries
- Research Institution
  Nagasaki University
Proteolytic degradation of muscllarr proteins of red sea bream by using immuno-electron mycroscope and immunoblot analysisPrincipal Investigator
- Principal Investigator
  
  HARA Kenji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Nagasaki University
Studies onBiological Processes Coastal Wet Lands
- Principal Investigator
  
  TAKITA Toru
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General fisheries
- Research Institution
  Nagasaki University
Effects of feeding of beta-carotene supplemented rotifers on anti viral activity of fish larva
- Principal Investigator
  
  TACHIBANA Katsuyasu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General fisheries
- Research Institution
  Nagasaki University
魚類の筋タイプと死後硬直進行に関する研究
- Principal Investigator
  
  TSUCHIMOTO Mutsuyoshi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Nagasaki University
Adaptive radiation and phylogeny of the mudskippers
- Principal Investigator
  
  NATSUKARI Yutaka
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Nagasaki University
Effects of large dosage of beta-carotene on anti viral immune function in Japanese parrotfish (Oplegnathus fasciatus)
- Principal Investigator
  
  TACHIBANA Katsuyasu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General fisheries
- Research Institution
  Nagasaki University
A Study on biological processes in estuaries
- Principal Investigator
  
  TAKITA Toru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Nagasaki University
Biosynthesis and processing of cathepsins B,H and L in carp macrophagesPrincipal Investigator
- Principal Investigator
  
  HARA Kenji
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Nagasaki University
Involvement of Cathepsins in Osteoporosis and Allergy and Cathepsin Inhibitors as the New Therapeutic Drugs
- Principal Investigator
  
  KATUNUMA Nobuhiko
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima

All 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Purification molecular cloning, and some properties of a manganese-containing superoxide dismutase from Japanese flounder (Paralichthys olivaceus)2011
- Author(s)
  Y. Wang, K. Osatomi, Y. Nagatomo, A. Yoshida, K. Hara.
- Journal Title
  
  Comparative Biochemistry and Physiology Part B
  
  Volume: 158 Pages: 289-96
- NAID
  120006984788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580224
[Journal Article] Extracellular products from virulent strain of Edwardsiella tarda stimulate mouse macrophages (RAW264.7) to produce nitric oxide (NO) and tumor necrosis factor (TNF)-α.2010
- Author(s)
  Y. Wang, K. Osatomi, A. Yoshida, X. Liang, K. Kanai, T. Oda, K. Hara
- Journal Title
  
  Fish&Shellfish Immunology
  
  Volume: 29 Pages: 778-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580224
[Journal Article] Comparative analysis of the production of nitric oxide (NO) and tumor necrosis factor-α(TNF-α) from macrophages exposed to high virulent and low virulent strains of Edwardsiella tarda.2009
- Author(s)
  K. Ishibe, T. Yamanishi, Y. Wang, K. Osatomi, K. Hara, K. Kanai, K. Yamaguchi, T. Oda
- Journal Title
  
  Fish&Shellfish Immunology Vol.27
  
  Pages: 386-389
- NAID
  120006984058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580236
[Journal Article] Comparison of the responses of peritoneal macrophages from Japanese flounder (Paralichthys olivaceus) against high virulent and low virulent strains of Edwardsiella tarda.2008
- Author(s)
  K. Ishibe, K. Osatomi, K. Hara, K. Kanai, K. Yamaguchi, T. Oda
- Journal Title
  
  Fish&Shellfish Immunology Vol.24
  
  Pages: 243-251
- NAID
  120006983895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580236
[Journal Article] Denaturation of Myofibrillar proteinsin yellowtail (Seriola quinqueradiata)burnt meat
- Author(s)
  Daisy ARROYO MORA, Satishi TAKESHITA, Akira OKAMOTO, Yuki HAMADA, Hirofumi ARAI, Kenji HARA, Katsuyasu Tachibana
- Journal Title
  
  Fishries Science In press
- Data Source
  KAKENHI-PROJECT-18580207
[Presentation] 養殖ハマチやけ肉中のプロテアーゼに関する研究2009
- Author(s)
  梁簾, 吉田朝美, 長富潔, 原研治
- Organizer
  平成21年度日本水産学会
- Place of Presentation
  東京海洋大学
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-18580207
[Presentation] Studies on proteases in cultured yellowtail (Seriola quinqueradiata) burnt meat2009
- Author(s)
  Xiao Liang, Asami Yoshida, Kiyoshi Osatomi, Kenji Hara
- Organizer
  The 10^<th> Joint International Symposium between Pukyong National University and Nagasaki University
- Place of Presentation
  Busan, Korea
- Data Source
  KAKENHI-PROJECT-18580207
[Presentation] 養殖ハマチヤケ肉中のプロテアーゼに関する研究2009
- Author(s)
  梁簫, 吉田朝美, 長富潔, 原研治
- Organizer
  平成21年度日本水産学会春季大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18580207
[Presentation] Studies on proteases in cultured yellowtail (Seriola quinqueradiata) burnt meat2009
- Author(s)
  Xiao Liang, Asami Yoshida, Kiyoshi Osatomi, Kenji Hara
- Organizer
  The 7^<th> International Workshop on the Oceanography and Fisheries Science of the East China Sea
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-18580207

1. TACHIBANA Katsuyasu (20171712)

# of Collaborated Projects: 10 results

# of Collaborated Products: 1 results
2. ISHIHARA Tadashi (40039722)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. OSATOMI Kiyoshi (40253702)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
4. TSUCHIMOTO Mutsuyoshi (20080525)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. TAKITA Toru (30039721)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. ODA Tatsuya (60145307)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
7. KANAI Kinya (40145222)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
8. SOYANO Kiyoshi (80260735)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. HAGIWARA Atsushi (50208419)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. NATSUKARI Yutaka (10039729)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. TAMAKI Akio (40183470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. ISHIMATSU Atsushi (00184565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 平山和次 (80039718)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 多部田修 (50217171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. HAMADA Yuki (90380831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. YOSHIDA Asami (80589870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KATUNUMA Nobuhiko (50035375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TOWATARI Takae (60108876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KITAMUTA Hitoshi (60108347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. IIMA Masafumi (80202836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MARII Hideaki (60039724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. NOZAKI Yukinori (90039727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 瀬口昌洋 (20093974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 白木原國雄 (90196618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. IKE Yoshimasa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. HANADA Kazunori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. LIMBONG Daniel

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. DAHRIL Tenk

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. AHANAD H.muchter

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. HASSAN Anar b

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. AHYAUDIN Ali

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KHOO KHAY Huat

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. ROSHADA Hashim

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. モリーチモシー

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. チマーファウストリチャ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. ウディンサリー

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. スタンシックステファン

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. ディーンジョン

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. MOUSSEAU Timothy a

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. ZIMMER-FAUST Richard k

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. WOODIN Sally ann

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. STANCYK Stephen e

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. DEAN John m

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. フェラーロバート

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. ティモシーモソウ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. リチャード・チマーファウチマーファウスト

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. サリーウディン

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. ロバートフェラー

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. ステファンスタンシック

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. ジョンディーン

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. H.MUCHTAR Ah

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. HUAT Khoo Kh

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. MASHIM Rosha

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. ALI Ahyaudim

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
55. HO Simn Chye

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
56. MASHHOR Mans

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
57. ロシャダハシム

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
58. コウカイファット

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
59. シティアジザ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
60. アヒャユディンアリ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HARA Kenji 原 研治

原 研治 ハラ ケンジ

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Studies on mechanism of burnt meat caused by seawater warming in cultured yellowtail (Seriola quinqueradita)-enzymatic approachPrincipal Investigator

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Study on structure and function of myofibril-bound serine proteinase (MBP) using molecular cloningPrincipal Investigator

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Proteolytic degradation of muscllarr proteins of red sea bream by using immuno-electron mycroscope and immunoblot analysisPrincipal Investigator

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HARA Kenji 原研治

原研治ハラケンジ