Hirai Yukihiko 平井幸彦

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HIRAI Yukihiko 平井幸彦

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Researcher Number	10089617
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 特任研究員
Affiliation (based on the past Project Information) *help	2018: 日本医科大学, 大学院医学研究科, 研究生 2017: 日本医科大学, 医学部, 研究生 2013 – 2016: 日本医科大学, 医学部, 講師 2002 – 2005: 日本医科大学, 医学部, 講師 1992 – 1999: 日本医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Human genetics / Human genetics Except Principal Investigator Circulatory organs internal medicine / Pediatrics / 応用微生物学・発酵学
Keywords	Principal Investigator AAVベクター / Adeno-associated virus / Gene therapy / アデノ随伴ウイルス / 遺伝子治療 / AAV vector plasmid / Protein delivery / Rep 78 / Site-specific integration / 部位特異的挿入 … More / アデノ隨伴ウイルス / 組換えウイルス / xeno-free system / AAVベクター作成 / AAV ベクター / 分析用超遠心機 / ハイブリッドベクター / 分析用超遠心 / 簡易精製法 / 適正製造規範 / HVJ-virosome / Repタンパク質 / 非ウイルスベクター / 遺伝子導入 / 組換ウイルスベクター / 組換えウイルスベクター / Affinity chromatography / Packaging cell-line / AAV vector / Recombinant virus / 抗ウイルス外殻タンパク抗血清 / 抗ウイルス外殻タンパク抗体 / パッケイジング細胞 / パッケージング細胞 / down-steam processing / rAAV 9 vector / 遺伝子細胞治療 / AAVベクター精製法 / AAV type 9 vector / AAV type 1 vector / down-stream processing / 適正製造規範準拠 / AAV ベクター精製法 … More Except Principal Investigator 遺伝子治療 / heart failure / ongoing myocardial damage / H-FABP / troponin T / cardiac hypertrophy / gene transfer therapy / Fabry disease / HIVベクター / デコイ / AAVベクター / エイズ / NT-pro BNP / N-terminal pro-brain natriuretic peptide / adeno-associated virus / α-galactosidase / enzyme replacement therapy / myocardial damage / heart-type fatty acid binding protein / apoptosis / Fas Ligand system / Fas / cardiac hypertriphy / adriamycin cardiomyopathy / BNP / renal failure / atrial-ventricular block / NT-proBNP / AAV vector / neural stem cells / stem cells / lysosomal disorders / cell therapy / gene therapy / 多能性骨髄幹細胞 / 異染性白質ジストロフィー / 脂肪組織由来幹細胞 / 多能性幹細胞 / アリルサルファターゼ / 異染性ロイコジストロフィー / 神経幹細胞 / 幹細胞 / リソゾーム病 / 細胞治療 / Intracellular hydrophobicity / Alcohol metabolism / Activity regulation / Solution hydrophobicity / Class III ADH / Class I ADH / Alcohol dehydrogenase / Mouse / マイクロダイアリシス法 / 疎水物質 / ClassIおよびIIIADH / 細胞内疎水性 / アルコール代謝 / 活性調節 / 溶液疎水性 / Class III / Class I / アルコール脱水素酵素 / マウス / 自殺遺伝子 Less

Purification of rAAV with ultracentrifugation-free technique towards GMP prodction Part 2Principal Investigator
- Principal Investigator
  
  Hirai Yukihiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Nippon Medical School
Purification of rAAV-1 and -9 with ultracentrifugation-free technique towards GMP production.Principal Investigator
- Principal Investigator
  
  Hirai Yukihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Nippon Medical School
Effects of novel adeno-associated virus-mediated muscle-directed gene transfer therapy in Fabry mouse : especially regarding cardiovascular systems
- Principal Investigator
  
  SEINO Yoshuhiko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nippon Medical School
Therapeutic strategies for inherited neurodegerative disorders using gene transfer and stem-cell transplantation technologies
- Principal Investigator
  
  SHIMADA Takashi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School
DEVELOPMENT OF THE SITE-SPECIFIC INTEGRATION OF THE PLASMID BY THE DIRECT PROTEIN DELIVERYPrincipal Investigator
- Principal Investigator
  
  HIRAI Yukihiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  NIPPON MEDICAL SCHOOL
Mechanism of the site-specific integration of Adeno-Associated Virus vector.Principal Investigator
- Principal Investigator
  
  HIRAI Yukihiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Nippon Medical School
AIDS遺伝子治療のためのベクターの開発
- Principal Investigator
  
  島田隆
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nippon Medical School
AIDS遺伝子治療のための基礎的研究
- Principal Investigator
  
  SHIMADA Takashi
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nippon Medical School
DEVELOPMENT OF IN VITRO PACKAGING SYSTEM FOR ADENO-ASSOCIATED VIRUS VECTOR.Principal Investigator
- Principal Investigator
  
  HIRAI Yukihiko
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  NIPPON MEDICAL SCHOOL
CONTRIBUTION OF ACIDIC ADH(CLASS III) TO ALCHOL METABOLISM
- Principal Investigator
  
  HASEBA Takeshi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用微生物学・発酵学
- Research Institution
  NIPPON MEDICAL SCHOOL

All 2018 2017 2016 2015 2014 2013 2005 2004 2002 Other

All Journal Article Presentation Patent

[Journal Article] Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 92018
- Author(s)
  Tomono Ｔ, Hirai Y, Okada H, Miyagawa Y, Adachi 1, Sakamoto S, Kawano Y, Chono H, Mineno J, Ishii A, Shimada T, Onodera M, Tamaoka A, Okada T.
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: １１ Pages: 180-190
- DOI
  10.1016/j.omtm.2018.10.015
- NAID
  120007128300
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07081, KAKENHI-PROJECT-16K08644, KAKENHI-PROJECT-16K09964, KAKENHI-PROJECT-16K15093, KAKENHI-PROJECT-26293328
[Journal Article] Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector.2016
- Author(s)
  Nakamura-Takahashi,A., Miyake,K., Watanabe, A., Hirai, Y., Iijima, O., Miyake, N., Adachi K.,, Nitahara-Kasahara, Y., Kinoshita, H., Noguchi, T., Abe, S., Narisawa, S., Millán, J. L., Shimada, T.,Okada, T.
- Journal Title
  
  Molecular Therapy- Methods & Clinical Development
  
  Volume: 3 Pages: 15059-15059
- DOI
  10.1038/mtm.2015.59
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-25461564, KAKENHI-PROJECT-26293328
[Journal Article] Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1).2016
- Author(s)
  Taro Tomono, Yukihiko Hirai, Hironori Okada, Kumi Adachi, Akiko Ishii, Takashi Shimada, Masafumi Onodera, Akira Tamaoka, and Takashi Okada
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 3 Pages: 15058-15058
- DOI
  10.1038/mtm.2015.58
- NAID
  120007128523
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430102, KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-16K07081, KAKENHI-PROJECT-16K08644
[Journal Article] Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation.2016
- Author(s)
  Igarashi, T., Miyake, K., Kobayashi, M., Kameya, S., Fujimoto, C., Nakamoto, K., Takahashi, H., Igarashi, T., Miyake, N., Iijima, O., Hirai,Y., Shimada, T., Okada, T., Takahashi, H.
- Journal Title
  
  Molecular Vision
  
  Volume: 22 Pages: 816-826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08644
[Journal Article] Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of self-complementary AAV1 vector.2015
- Author(s)
  Hironaka K, Yamazaki Y, Hirai Y, Yamamoto M, Miyake N, Miyake K, Okada T, Morita A, Shimada T.
- Journal Title
  
  Sci Rep.
  
  Volume: 18 Issue: 1 Pages: 1-12
- DOI
  10.1038/srep13104
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-26461596, KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-26293328
[Journal Article] Targeted gene transfer into ependymal cells through intraventricular injection of AAV1 vector and long-term enzyme replacement via the CSF.2014
- Author(s)
  Yamazaki Y, Hirai Y, Miyake K, Shimada T.
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 5506-5506
- DOI
  10.1038/srep05506
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-26461596
[Journal Article] Intrathecal AAV Serotype 9-mediated Delivery of shRNA Against TRPV1 Attenuates Thermal Hyperalgesia in a Mouse Model of Peripheral Nerve Injury.2014
- Author(s)
  Hirai T, Enomoto M, Kaburagi H, Sotome S, Yoshida-Tanaka K, Ukegawa M, Kuwahara H, Yamamoto M, Tajiri M, Miyata H, Hirai Y, Tominaga M, Shinomiya K, Mizusawa H, Okawa A, Yokota T
- Journal Title
  
  Mol Ther
  
  Volume: 22 Issue: 2 Pages: 409-19
- DOI
  10.1038/mt.2013.247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592188, KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-26282136
[Journal Article] Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice.2013
- Author(s)
  Akira Machida, Hiroya Kuwahara, Azat Mayra, Takayuki Kubodera, Takashi Hirai, Fumiko Sunaga, Mio Tajiri, Yukihiko Hirai, Takashi Shimada, Hidehiro Mizusawa, Takanori Yokota.
- Journal Title
  
  Mol Pain.
  
  Volume: 9 Pages: 36-45
- DOI
  10.1186/1744-8069-9-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460407
[Journal Article] Co-expression of FGE is essential for synthesis and secretion of functional arylsulfatase A in a mouse model of metachromatic leukodystrophy.2005
- Author(s)
  Takakusaki, Y., Hisayasu, S., Hirai, Y., Shimada, T.
- Journal Title
  
  Hum.Gene Ther. 16
  
  Pages: 1-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Cardiovascular manifestations of Fabry disease and the novel therapeutic strategies2005
- Author(s)
  Seino Y, Takahashi H, Fukumoto H, Utsumi K, Hirai Y
- Journal Title
  
  J Nippon Med Sch 72 (5)
  
  Pages: 254-261
- NAID
  130004146803
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590774
[Journal Article] Cardiovascular manifestations of Fabry disease and the novel therapeutic strategies2005
- Author(s)
  Seino Y, Takahashi H, Fukumoto H, Utsumi K, Hirai Y
- Journal Title
  
  J Nippon Med Sch 72(5)
  
  Pages: 254-261
- NAID
  130004146803
- Data Source
  KAKENHI-PROJECT-15590774
[Journal Article] HGF receptor is a coreceptor for adeno-associated virus type 2 (AAV2) infection.2004
- Author(s)
  Kashiwakura, Y., Tamayose, K., Iwabuti, K., Hirai, Y., Shimada, T., Matsumoto, K., Nakamura, T., Oshimi, K., Daiwa, H.
- Journal Title
  
  J.Viol. 79
  
  Pages: 609-614
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer.2002
- Author(s)
  Takahashi H, Hirai Y, Seino Y, et al.
- Journal Title
  
  ProNAS 99
  
  Pages: 13777-13782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590774
[Journal Article] Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer.2002
- Author(s)
  Takahashi, H., Hirai, Y., et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 99
  
  Pages: 13777-13782
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer.2002
- Author(s)
  Takahashi, H., Hirai, Y., Migita, M., Seino, Y., Fukuda, Y., Sakuraba, H., Kase, R., Kobayashi, T., Hashimoto, Y., Shimada, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 99
  
  Pages: 13777-13782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Long-term systemic therapy of Fabry didease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer.2002
- Author(s)
  Takahashi H, Hirai Y, Seino Y, et al.
- Journal Title
  
  ProNAS 99
  
  Pages: 13777-13782
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590774
[Patent] 筋委縮性側索硬化症を含む神経疾患の予防剤及び／又は治療剤2018
- Inventor(s)
  望月秀樹、長野清一、佐々木勉、鐘其静と、岡田尚巳、平井幸彦
- Industrial Property Rights Holder
  望月秀樹、長野清一、佐々木勉、鐘其静と、岡田尚巳、平井幸彦
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K08644
[Presentation] Refinements of rAAV8 purification protocol with chromatography technology2018
- Author(s)
  3）Taro Tomono, Yukihiko Hirai, Hironori Okada, Yoshitaka Miyagawa, Kumi Adachi, Akiko Ishii, Takashi Shimada, Akira Tamaoka, Takashi Okada.
- Organizer
  The ASGCT 21st annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08644
[Presentation] Ultracentrifugation-free Chromatography-mediated Purification of Recombinant Adeno-Associated Virus Serotype 9 (rAAV9)2017
- Author(s)
  Taro Tomono, Yukihiko Hirai, Hironori Okada, Yoshitaka Miyagawa, Kumi Adachi, Shuhei Sakamoto, Yasuhiro Kawano, Hideto Chono, Junichi Mineno, Akiko Ishii, Takashi Shimada, Masafumi Onodera, Akira Tamaoka, Takashi Okada
- Organizer
  American Society of Gene and Cell Therapy 20th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08644
[Presentation] rAAV-8 production by using HEK293 derivatives, xeno-free media and flow electroporation-based transfection2017
- Author(s)
  Hironori Okada, Taro Tomono,, Kumi Adachi, Yukihiko Hirai, Masaaki Ouchi, Yuko Utsunomiya, Hideto Chono, Junichi Mineno, Takashi Okada
- Organizer
  American Society of Gene and Cell Therapy 20th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08644
[Presentation] Development of flow electroporation-based suspension-adapted HEK293 transfection system toward rAAV production in GMP2017
- Author(s)
  Hironori Okada, Taro Tomono, Kumi Adachi, Yukihiko Hirai, Masaaki Ouchi, Yuko Utsunomiya, Hideto Chono, Junichi Mineno, Takashi Okada
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08644
[Presentation] イオン交換カラムクロマトグラフィー技術による組換え5型アデノ随伴ウイルス精製法の開発2017
- Author(s)
  増田千明、伴野太郎、宮川世志幸、岡田浩典、平井幸彦、岡田尚巳
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08644
[Presentation] クロマトグラフィー技術を用いた8型アデノ随伴ウイルスベクター(rAAV8) の精製2017
- Author(s)
  伴野太郎、増田千明、宮川世志幸、岡田浩典、平井幸彦、石井亜紀子、玉岡晃、岡田尚巳
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08644
[Presentation] Purification of recombinant adeno-associated virus with only chromatography technique2017
- Author(s)
  Taro Tomono, Chiaki Masuda, Yukihiko Hirai, Hironori Okada, Yoshitaka Miyagawa, Kumi Adachi, Shuhei Sakamoto, Yasuhiro Kawano, Hideto Chono, Junichi Mineno, Akiko Ishii, Takashi Shimada, Masafumi Onodera, Akira Tamaoka, Takashi Okada
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08644
[Presentation] Ultracentrifugation-free Chromatography-mediated Large-scale Purification of Recombinant Adeno-Associated Virus Serotype 1 (rAAV1) and rAAV9 from the Serum-free Culture Supernatant2016
- Author(s)
  Tomono, T., Hirai, Y., Okada, H., Adachi、K., Ishii, A., Shimada, T., Onodera, M., Tamaoka, A., Okada T
- Organizer
  The 19th Annual Meeting of the American Society of Gene & Cell Therapy
- Place of Presentation
  Washington, DC, USA.
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] The large-scale purification of rAAV1 from the serum-free cultured medium by ion-exchange and gel-filtration chromatography-steps with ultracentrifugation-free technique.2015
- Author(s)
  Tomono, T., Hirai, Y., Okada, H., Adachi, K., Chiyo, T., Ishii, A., Shimada, T., Onodera, M., Tamaoka, A., Okada T.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Osaka, JAPAN
- Year and Date
  2015-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Efficient Scalable Purification of rAAV1 Using Ion-Exchange and Gel-Filtration Chromatography To Avoid Ultracentrifugation Procedure.2015
- Author(s)
  Tomono, T., Hirai, Y., Okada, H., Chiyo, T., Shimada, T., Onodera, M.., Okada T.
- Organizer
  The 18th Annual Meeting of the American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans, Louisiana, USA.
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Prolonged Survival and Improved Phenotypes of Lethal Hypophosphatasia Model Mice by Adeno-Associated Virus-Mediated Muscle Transduction of Bone-Targeted Alkaline Phosphatase.2015
- Author(s)
  Nakamura-Takahashi,A., Miyake K., Watanabe, A., Hirai, Y., Miyake, N., Iijima, O., Adachi K., Kinoshita, H., Noguchi, T., Abe, S., Shimada, T., Okada, T.
- Organizer
  The 18th Annual Meeting of the American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans, Louisiana, USA.
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Gene therapy to rescue lethal hypophosphatasia model mice by adeno-associated virus-mediated muscle transduction of bone-targeted alkaline phosphatase.2015
- Author(s)
  Nakamura-Takahashi,A., Miyake K., Watanabe, A., Hirai, Y., Miyake, N., Iijima, O., Adachi K., Kinoshita, H., Noguchi, T., Abe, S.,Shimada, T.,Okada, T.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Osaka, JAPAN
- Year and Date
  2015-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Targeted Gene Transfer into the Ependymal Cells and Long－Term Enzyme Replacement in the CSF by Intraventricular Injection of AAV Vector Serotype 12013
- Author(s)
  Yoshiyuki Yamazaki, Kohei Hironaka, Yukihiko Hirai, Koichi Miyake, Takashi Shimada
- Organizer
  The American Society of Gene & Cell Therapy
- Place of Presentation
  Salt Lake City, Utah, USA .
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Production and purification of AAV1 and AAV9 vectors without using ultracentrifugation
- Author(s)
  Tomono T, Hirai Y., Shimada T., Onodera M., Okada T.
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy (JSGT2014)
- Place of Presentation
  Tokyo, JAPAN
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Improvement of hypophosphatasia model mice by muscle specific expression of bone targeted alkaline phosphatase using self-complementary AAV8 vector.
- Author(s)
  Nakarmura A, Iijima 0, Miyake K., Watanabe A., Hirai Y, Kinoshita H, Noguchi T, Abe S., Okada T, Shimada T
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy (JSGT2014)
- Place of Presentation
  Tokyo, JAPAN
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Tyrosine-mutated AAV2 mediated BDNF rescued inner retina in rat retinal ischemic injury mode.
- Author(s)
  Igarash T, Miyake K, Kobayashi M, Miyake N, Iijima O, Nakamoto K, Hirai Y, Shimada T, Okada T, Takahashi T.
- Organizer
  The Association for Research in Vision and Ophthalmology, Inc. (ARVO) Asia-ARVO 2015
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2015-02-16 – 2015-02-19
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Tyrosine-mutated AAV2 mediated BDNF rescued inner retina in rat retinal ischemic injury model
- Author(s)
  Igarashi T, Miyake K., Kobayashi M, Takahashi K., Miyake N., lijima 0., Nakamoto K., Hirai Y, Shimada T, Okada T, Takahashi H
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy (JSGT2014)
- Place of Presentation
  Tokyo, JAPAN
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Long-term enzyme supplementation into the CSF to treat metachromatic leukodystrophy by intraventricular injection of AAV1 vector
- Author(s)
  Yamazaki Y., Hironaka K, Miyake N., Hirai Y., Miyake K., Okada T., Shimada T.
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy (JSGT2014)
- Place of Presentation
  Tokyo, JAPAN
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Rescue of lethal hypophosphatasia model mice by adeno-associated virus mediated muscle specific expression of bone targeted alkaline phosphatase.
- Author(s)
  Nakamura A, Iijima O, Miyake K, Watanabe A, Hirai Y, Kinoshita H, Noguchi T, Abe S, Okada T, Shimada T.
- Organizer
  The 64th Annual Meeting of the American Society of Human Genetics
- Place of Presentation
  San Diego, California,USA
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-25460407
[Presentation] Efficient Protection of Retina By Tyrosine-Mutated Self-Complementary AAV2 Vector Encoding BDNF in a Rat Retinal Ischemic Injury Model
- Author(s)
  Igarashi T, Miyake K, Kobayashi, Takahashi K, Miyake N, Iijima O, Nakamoto K, Hirai Y, Shimada T, Takahashi H.
- Organizer
  The 17th Annual Meeting of the American Society of Gene & Cell Therapy
- Place of Presentation
  Washington, DC、USA
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25460407

1. SHIMADA Takashi (20125074)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. 新谷英滋 (30206338)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HASEBA Takeshi (50156329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KUROSU Mitsuyasu (70103984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MIGITA Makoto (50256963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. MIYAKE Koichi (90267211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MODHIZUKI Hideki (90230044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NISHI Katsunori (00138257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SEINO Yoshuhiko (10163073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. FUKUMOTO Hiroko (80339423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. TAKANO Teruo (40133441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 鈴木聡 (70246940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Okada Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. SOTOME Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. ENOMOTO Mitsuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 岡田浩典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 石井亜紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 大川淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 三宅紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 岡田尚已

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirai Yukihiko 平井 幸彦

HIRAI Yukihiko 平井 幸彦

Research Projects

Research Products

Co-Researchers

Purification of rAAV with ultracentrifugation-free technique towards GMP prodction Part 2Principal Investigator

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Purification of rAAV-1 and -9 with ultracentrifugation-free technique towards GMP production.Principal Investigator

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Effects of novel adeno-associated virus-mediated muscle-directed gene transfer therapy in Fabry mouse : especially regarding cardiovascular systems

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Therapeutic strategies for inherited neurodegerative disorders using gene transfer and stem-cell transplantation technologies

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DEVELOPMENT OF THE SITE-SPECIFIC INTEGRATION OF THE PLASMID BY THE DIRECT PROTEIN DELIVERYPrincipal Investigator

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Mechanism of the site-specific integration of Adeno-Associated Virus vector.Principal Investigator

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AIDS遺伝子治療のためのベクターの開発

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AIDS遺伝子治療のための基礎的研究

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DEVELOPMENT OF IN VITRO PACKAGING SYSTEM FOR ADENO-ASSOCIATED VIRUS VECTOR.Principal Investigator

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CONTRIBUTION OF ACIDIC ADH(CLASS III) TO ALCHOL METABOLISM

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[Journal Article] Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 92018

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NAID

Data Source

[Journal Article] Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector.2016

Author(s)

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[Journal Article] Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1).2016

Author(s)

Journal Title

DOI

NAID

Data Source

Hirai Yukihiko 平井幸彦

HIRAI Yukihiko 平井幸彦