HASEGAWA Hiroyuki 長谷川宏幸

… Alternative Names

長谷川宏幸ハセガワヒロユキ

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Researcher Number	10092983
Affiliation (based on the past Project Information) *help	2010: 帝京科学大学, 理工学部, 教授 2000 – 2008: 帝京科学大学, 理工学部, 教授 2007: Teikyo University of Science & Technology, Biosciences, Professor 1999: 帝京科学大学, 理工部, 教授 1998: 帝京科学大学, 理工学部, 教授 1991: 西東京科学大学, バイオサイエンス学科, 教授
Review Section/Research Field	Principal Investigator Functional basic dentistry / General medical chemistry Except Principal Investigator Functional basic dentistry / 動物生理・代謝 / Functional basic dentistry
Keywords	Principal Investigator RBL2H3 / Site-directed mutagenesis / Proteasomes / Ubiquitination / Enzyme regulation by phosphorylation / Serotonin biosynthesis / Tryptopha hydroxylase / 部位特異的突然変異 / トリプトファン水酸化酵素抗体 / 部位特異的点変異 … More / プロテアソーム / ユビキチン化 / リン酸化による活性調節 / セロトニン生合成 / トリプトファン水酸化酵素 / 2,4ージアミノー4ーヒドロキシピリミジン / パラクロロフェニルアラニン / 十二指腸 / セロトニン / テトラヒドロビオプテリン / グルコ-ス吸収 … More Except Principal Investigator nitric oxide synthase / tetrahydrobiopterin / vesicular monoamine transporter / cyclic GMP / cyclic AMP / dopamine / serotonin / neurotransmitter / GFP / ion transporter / serotonine / proteolysis / adrenal cortex / gene expression / protease / mitochondria / 活性酸素 / チオレドキシン / ATP依存性プロテアーゼ / タンパク分解 / 副腎皮質 / 遺伝子発現 / プロテアーゼ / ミトコンドリア / multidrug resistance / toxin extruding antiporter / vesicular monoamine transport / membrane transport / nitric oxide / vascular monoamine transporter / nitric ocide synthase / RNA editing / GTP cyclohydrolase I / transcriptional regulation / 転写 / RNA干渉 / アンチセンスRNA / post-transcriptional regulation / microRNA / transcriptome / RNA interference / GTP cyclohydrolase 1 / natural antisense RNA / トランスクリプトーム / 神経伝達物質 / 一酸化窒素 / テトラヒドロビオプテリン / 遺伝子発現調節 / GTPシクロヒドロラーゼ / 内在性アンチセンスRNA Less

Natural antisense of GTP cyclohydrolase 1 : physiological functions and expression mechanisms of the antisense RNA
- Principal Investigator
  
  NAKANISHI Nobuo
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
On the Possible Control of Allergic Inflammation based on Molecular Mechanism of Serotonin Synthesizing EnzymePrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hiroyuki
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Teikyo University of Science & Technology
Regulation of tetrahydrobiopterin and monoamine transport by cyclic GMP
- Principal Investigator
  
  NAKANISHI Nobuo
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
ATP-dependent proteolysis in mitochondria
- Principal Investigator
  
  WATABE Shoji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  動物生理・代謝
- Research Institution
  Yamaguchi University
Tetrahydrobiopterin transport through plasma membranes and regulation of nitric oxide- and monoamine-dependent signaling.
- Principal Investigator
  
  NAKANISHI Nobuo
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
テトラヒドロビオプテリンの実験的枯渇による腸管のグルコ-ス吸収能消失の機構についてPrincipal Investigator
- Principal Investigator
  
  長谷川宏幸
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Teikyo University of Science & Technology

All 2008 2007 2006 2005 2003 2002 Other

All Journal Article Presentation Book

[Book] Recent studies on sepiapterin and biopterin transport in mammalian cells: Chemistry and Biology of Pteridines and Folates(Blau, N. and Thony, B. eds.,)2007
- Author(s)
  Hasegawa H, Sawabe K, Sugawara Y, Maruyama S, Matsuoka H, Nakanishi N, Wakasugi K O
- Publisher
  SPS Verlagsgesellschaft mbH
- Data Source
  KAKENHI-PROJECT-19592157
[Book] Proceedings of 13th International Symposium on Chemistry & Biology of Pteridines & Folates2007
- Author(s)
  Hasegawa, H., et. al.
- Publisher
  SPS Publication,Germany
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Book] Recent studies on sepiapterin and biopterin transport in mammalian cells: Chemistry and Biology of Pteridines and Folates(Blau, N. and Thony, B. eds.)Heibronn, Germany2007
- Author(s)
  Hasegawa H, Sawabe K, Sugawara Y, Maruyama S, Matsuoka H, Nakanishi N, Wakasugi KO
- Publisher
  SPS Verlagsgesellschaft mbH
- Data Source
  KAKENHI-PROJECT-19592157
[Journal Article] Role of a Serotonin Precursor in Development of Gut Microvilli.2008
- Author(s)
  Nakamura, K., T. Sato, A. Ohashi, H. Tsurui, H. Hasegawa
- Journal Title
  
  Am J Pathol 172(2)
  
  Pages: 333-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Developmental role of tryptophan hydroxylase in the nervous system.2007
- Author(s)
  Nakamura, K., H. Hasegawa
- Journal Title
  
  Mol Neurobiol 35(1)
  
  Pages: 45-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats.2007
- Author(s)
  Hong, K. W., Y. Sugawara, H. Hasegawa, I. Hayasaka, R. Hashimoto, S. Ito, M. Inoue-Murayama
- Journal Title
  
  Neurosci Lett 412(3)
  
  Pages: 195-200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Recent Studies on Sepiapterin and Biopterin Transport in Mammalian Cells2007
- Author(s)
  H. Hasegawa
- Journal Title
  
  Proceedings of 13th International Symposium on Chemistry & Biology of Pteridines & Folates
  
  Pages: 259-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating.2006
- Author(s)
  Nakamura, K., Y. Koyama, K. Takahashi, H. Tsurui, Y. Xiu, M. Ohtsuji, Q. S. Lin, Y. Sugawara, K. Sawabe, A. Ohashi, T. Ohnuma, H. Arai, H. Nishimura, H. Hasegawa, S. Hirose
- Journal Title
  
  J Mol Biol 363(2)
  
  Pages: 345-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.2006
- Author(s)
  Nakamura, K., Y. Sugawara, K. Sawabe, A. Ohashi, H. Tsurui, Y. Xiu, M. Ohtsuji, Q. S. Lin, H. Nishimura, H. Hasegawa, S. Hirose
- Journal Title
  
  J Neurosci 26(2)
  
  Pages: 530-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes ; direct uptake and indirect uptake mediated by a methotrexate-sensitive process.2005
- Author(s)
  Sawabe, K., Suetake, Y., Nakanishi, N., Wakasugi, K.O., Hasegawa, H.
- Journal Title
  
  Mol.Genet.Metab. 86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571774
[Journal Article] Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs : role of salvage pathway and uptake of its precursor in effective elevation of tissue BH42005
- Author(s)
  Hasegawa Hiroyuki
- Journal Title
  
  Mol Genet Metab 86・S1
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Distinctive iron requirement of tryptophan 5-monooxygenase : TPH1 requires dissociable ferrous iron.2005
- Author(s)
  Hasegawa, H., A. Ichiyama
- Journal Title
  
  Biochem Biophys Res Commun 338(1)
  
  Pages: 277-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Increase in tetrahydrobiopterin release from PC12 cells under hypotonic culture conditions is inhibited by HgCl_2.2005
- Author(s)
  Nakanishi, N., Kurihara, K., Tomomura, A., Tonosaki, K., Hattori, Y., Oguro, K., Hasegawa, H
- Journal Title
  
  Pteridines 16
  
  Pages: 1-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571774
[Journal Article] Delivery of exogenous tetrahydrobiopterin(BH_4)to cells of target organs : Role of salvage pathway and uptake of its precursor in effective elevation of tissue BH_42005
- Author(s)
  Hasegawa, H.
- Journal Title
  
  Molecular Genetics and Metabolism 86
- Data Source
  KAKENHI-PROJECT-14571774
[Journal Article] Delivery of tetrahydrobiopterin (BH_4) to cells of target organs : Role of salvage pathway and uptake of its precursor in effective elevation of tissue BH_4.2005
- Author(s)
  Hasegawa, H., Sawaba, K., Nakanishi, N., Wakasugi, O.K.
- Journal Title
  
  Mol.Genet.Metab.[Review] 86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571774
[Journal Article] Distinctive iron requirement of tryptophan 5-monooxygenase:TPH1 requires dissociable ferrous iron2005
- Author(s)
  Hasegawa, H., et. al.
- Journal Title
  
  Biochem Biophys Res Commun 338
  
  Pages: 277-84
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Distinctive iron requirement of tryptophan 5-monooxygenase : TPH1 requires dissociable ferrous iron2005
- Author(s)
  Hasegawa Hiroyuki
- Journal Title
  
  Biochem Biophys Res Commun 338・1
  
  Pages: 277-284
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Delivery of tetrahydrobiopterin (BH_4) to cells of target organs : Role of salvage pathway and uptake of its precursor in effective elevation of tissue BH_<4-> [Review]2005
- Author(s)
  Hasegawa, H.
- Journal Title
  
  Mol. Genet. Metab. 86
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571774
[Journal Article] Regulatory effect of cyclic AMP on transport of biogenic amines and of inorganic ions.2003
- Author(s)
  Kurihara, K., Hasegawa, H., Nakanishi, N.
- Journal Title
  
  In : Recent Research Developments in Biochemistry, Research Signpost, Kerala, India.[Book] Vol.4
  
  Pages: 303-334
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571774
[Journal Article] Increase in the biopterin pool after tetrahydrobiopterin administration is due to uptake of an oxidation product dihydrobiopterin and its conversion to the reduced state.2003
- Author(s)
  Sawabe, K., Yamamoto, K., Matsuhashi, Y., Miura, H., Wakasugi, K.O., Nakanishi, N., Hasegawa, H.
- Journal Title
  
  In : Pterines, Folates and Neurotransmitters in Molecular Medicine.(Blau, N. and Thony, B. eds.) (SPS Publications, Heilbronn, Germany) [Book]
  
  Pages: 41-47
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571774
[Journal Article] Proteasome driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line.2002
- Author(s)
  Iida, Y., Sawaba, K., Oguro, K., Nakanishi, N., Hasegawa, H.
- Journal Title
  
  Eur.J.Biochem. 269 (19)
  
  Pages: 4780-4788
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571774
[Journal Article] Recent Studies on Sepiapterin and Biopterin Transport in Mammalian Cells
- Author(s)
  Hasegawa, H.
- Journal Title
  
  The proceedings of 13th International Symposium on Chemistry ＆ Biology of Pteridines ＆ Folates (印刷中)
- Data Source
  KAKENHI-PROJECT-16591872
[Presentation] Immunohistochemical and enzymological detection of tryptophan hydroxylase in villus epithelium of intestinal mucosa.2007
- Author(s)
  Ohashi, A., K. Nakamura, T. Sato, H. Hasegawa.
- Organizer
  26th International winter-workshop clinical, chemical, & biochemical aspects of pteridines
- Place of Presentation
  St. Christoph/Arlberg, Austria
- Year and Date
  2007-03-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Presentation] 神経成長因子はLPS/NFFαによるPC12細胞iNOS 発現誘導を抑制する2007
- Author(s)
  栗原琴二, 外崎肇一, 長谷川宏幸, 服部良之, 中西信夫
- Organizer
  第3回JPC/JCNRA合同プテリジン研究会
- Place of Presentation
  東京(帝京大学医学部)
- Data Source
  KAKENHI-PROJECT-19592157
[Presentation] Non-reduced Biopterin is a potential replacement of(6R)tetrahydrobiopterin for BH4-supplementation2007
- Author(s)
  長谷川宏幸
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2007-03-19
- Data Source
  KAKENHI-PROJECT-16591872
[Presentation] 神経成長因子はLPS/NFFαによるPC12細胞iNOS発現誘導を抑制する2007
- Author(s)
  栗原琴二, 外崎肇一, 長谷川宏幸, 服部良之, 中西信夫
- Organizer
  第3回JPC/JCNRA合同プテリジン研究会
- Place of Presentation
  東京(帝京大学医学部)
- Data Source
  KAKENHI-PROJECT-19592157
[Presentation] 神経成長因子はLPS/TNFαによるPC12細胞iNOS発現誘導を抑制する2007
- Author(s)
  栗原琴二, 外崎肇一, 長谷川宏幸, 服部良之, 中西信夫
- Organizer
  第3回JPC/JCNRA合同プテリジン研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19592157
[Presentation] PC12細胞のBH4レベルに対するLPS/TNFαと神経成長因子の作用2007
- Author(s)
  中西信夫, 栗原琴二, 外崎肇一, 服部良之, 長谷川宏幸
- Organizer
  第3回JPC/JCNRA合同プテリジン研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19592157

1. NAKANISHI Nobuo (20118574)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
2. KURIHARA Kinji (10170086)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. OGURO Kazuya (00233081)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. WATABE Shoji (30113020)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMASHIRO Yasuhiro (50243671)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YAMAMOTO Yoshimi (40115514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAHASHI Susumu (90022665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAWABE Keiko (10399008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

HASEGAWA Hiroyuki 長谷川 宏幸

長谷川 宏幸 ハセガワ ヒロユキ

Research Projects

Research Products

Co-Researchers

Natural antisense of GTP cyclohydrolase 1 : physiological functions and expression mechanisms of the antisense RNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

On the Possible Control of Allergic Inflammation based on Molecular Mechanism of Serotonin Synthesizing EnzymePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of tetrahydrobiopterin and monoamine transport by cyclic GMP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ATP-dependent proteolysis in mitochondria

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tetrahydrobiopterin transport through plasma membranes and regulation of nitric oxide- and monoamine-dependent signaling.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

テトラヒドロビオプテリンの実験的枯渇による腸管のグルコ-ス吸収能消失の機構についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Recent studies on sepiapterin and biopterin transport in mammalian cells: Chemistry and Biology of Pteridines and Folates(Blau, N. and Thony, B. eds.,)2007

Author(s)

Publisher

Data Source

[Book] Proceedings of 13th International Symposium on Chemistry & Biology of Pteridines & Folates2007

Author(s)

Publisher

Description

Data Source

[Book] Recent studies on sepiapterin and biopterin transport in mammalian cells: Chemistry and Biology of Pteridines and Folates(Blau, N. and Thony, B. eds.)Heibronn, Germany2007

Author(s)

Publisher

Data Source

[Journal Article] Role of a Serotonin Precursor in Development of Gut Microvilli.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Developmental role of tryptophan hydroxylase in the nervous system.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Recent Studies on Sepiapterin and Biopterin Transport in Mammalian Cells2007

Author(s)

Journal Title

Data Source

[Journal Article] Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.2006

Author(s)

HASEGAWA Hiroyuki 長谷川宏幸

長谷川宏幸ハセガワヒロユキ