TSUDA Yuko 津田裕子

… Alternative Names

津田裕子ツダユウコ

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Researcher Number	10098478
Other IDs
External Links
Affiliation (Current)	2025: 神戸学院大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2007 – 2020: Kobe Gakuin University, 薬学部, 教授 1999 – 2001: 神戸学院大学, 薬学部, 講師 1996 – 1997: 神戸学院大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Drug development chemistry / 医薬分子機能学 Except Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Drug development chemistry / 医薬分子機能学
Keywords	Principal Investigator P1’ 残基 / 炎症性疾患治療薬 / 活性部位指向型 / 阻害剤 / プラスミン / 分子設計 / 臨床応用 / プラスミン阻害剤 / 活性中心指向型 / fibrinolysis … More / coagulation / bifunctional inhibitor / 線溶系 / 凝固系 / 二機能性阻害剤 / 酵素選択性 / P2残基 / DNA polymerase阻害 / DNA polymerase 阻害 / ソマトスタチン配列 / 疎水性 / 抗腫瘍活性 / コンフォメーション解析 / 酵素安定性 / オピオイド受容体 / エンドモルフィン … More Except Principal Investigator HIVプロテアーゼ / アミロイドベータ / トリプシン / ストレプトアビジン / ビオチン / リムーバブル阻害剤 / 酵素活性 / プロテアーゼ / 有機化学 / 脳・神経 / 薬学 / 肥満 / CD / 二次構造 / ステープルヘリックス / リラキシンスーパーファミリー / PPI / モダリティー / ペプチド固相合成 / アンタゴニスト / アゴニスト / リラキシン / ペプチド合成 / 神経ペプチド / ヘリックス / ステープルペプチド / GPCR / インスリンファミリー / ペプチドアナログ / μ-opioid receptor agoniat / dimethyltyrosine / diamine derivartives / endomorphine derivatives / pyrazinone derivatives / opioid mimetics / 二機能性リガンド / δ-オピオイドレセプターアンタゴニスト / エンドモルーフィン誘導体 / オピオイドミナティクス / 皮下投与 / 鎮痛薬 / μ-オピオイドレセプターアゴニスト / ジメチルチロシン / ジアミン誘導体 / エンドモルフィン誘導体 / ピラジノン誘導体 / オピオイドミメティクス Less

Discovery of removable inhibitors targeting proteases
- Principal Investigator
  
  Hidaka Koushi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kobe Gakuin University
Discovery of INSL7 analogue with agonistic activity for RXFP3 in the brai
- Principal Investigator
  
  Hojo Keiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Design of the active site-directed plasmin inhibitor oriented to the clinical applicationsPrincipal Investigator
- Principal Investigator
  
  Tsuda Yuko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Studies on the active site-directed plasmin inhibitor: It may control plasmin having multifunctional propertiesPrincipal Investigator
- Principal Investigator
  
  TSUDA YUKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Search for the anti-tumor derivatives containing the somatostatin sequence focusing on the hydrophobic indexPrincipal Investigator
- Principal Investigator
  
  TSUDA Yuko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Design of agonists and antagonists for opioid receptors based on the structures of endomorphinsPrincipal Investigator
- Principal Investigator
  
  TSUDA Yuko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Design and synthesis of μ-selective opioidomimetic peptides
- Principal Investigator
  
  OKADA Yoshio
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kobe Gakuin University
Design of Bifunctional Inhibitors for Enzymes in Coagulation-Fibrinolytic SystemPrincipal Investigator
- Principal Investigator
  
  TSUDA Yuko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kobe Gakuin University

[Book] オピオイド:アゴニスト,アンアゴニストの医薬品開発に向けた戦略遺伝子医学MOOK21号2012
- Author(s)
  岡田芳男,津田裕子.
- Data Source
  KAKENHI-PROJECT-22590111
[Book] 最新ペプチド合成技術とその創薬研究への応用2012
- Author(s)
  津田裕子
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-22590111
[Book] Amino Acids, Peptides and Proteins in Organic Chemistry. Vol. 3 -Building Blocks,Catalysis and Coupling Chemistry;Solution;Phase Peptide Synthesis, Edited by Andre B. Hughes2011
- Author(s)
  Tsuda Y., Okada Y.
- Publisher
  Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- Data Source
  KAKENHI-PROJECT-22590111
[Book] Amino Acids, Peptides and Proteins in Organic Chemistry. Vol. 3-Building Blocks, Catalysis and Coupling Chemistry ; Solution-Phase Peptide Synthesis2010
- Author(s)
  Yuko Tsuda
- Publisher
  Wiley-VCH Verlag GmbH & Co.
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] OFF-to-ON control of trypsin activity and target protein degradation using ISAAC.2020
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Journal Title
  
  Peptide Science 2019
  
  Volume: - Pages: 125-126
- Data Source
  KAKENHI-PROJECT-18K05344
[Journal Article] Acquired Removability of Aspartic Protease Inhibitors by Direct Biotinylation2019
- Author(s)
  Hidaka Koushi、Adachi Motoyasu、Tsuda Yuko
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 30 Issue: 7 Pages: 1979-1985
- DOI
  10.1021/acs.bioconjchem.9b00195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05344
[Journal Article] ON/OFF repetitive control of protease activity using peptidemimetic ligands through biotin-streptavidin affinity.2019
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Journal Title
  
  Proceedings of 35th European Peptide Symposium
  
  Volume: - Pages: 173-174
- DOI
  10.17952/35eps.2018.173
- Data Source
  KAKENHI-PROJECT-18K05344
[Journal Article] Exploration of active site-directed plasmin inhibitors2019
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Journal Title
  
  Peptide Science
  
  Volume: 2018 Pages: 97-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Removable peptidomimetic inhibitors for controlling activity of proteases.2019
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Journal Title
  
  Peptide Science 2018
  
  Volume: - Pages: 96-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05344
[Journal Article] Design and synthesis of hydrocarbon stapling peptide antagonist for relaxin family peptide receptor 3 (RXFP3)2018
- Author(s)
  Keiko Hojo, Mika Izutsu, Ross A. D. Bathgate, K Johan Rosengern, Koushi Hidaka, Yuko Tsuda, Mohammad Akhter Hossain, John D. Wade
- Journal Title
  
  Peptide Science
  
  Volume: 54
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] Design and synthesis of hydrocarbon stapling peptide antagonist for relaxin family peptide receptor 3 (RXFP3)2018
- Author(s)
  Keiko Hojo, Mika Izutsu, Ross A. D. Bathgate, K Johan Rosengern, Koushi Hidaka, Yuko Tsuda, Mohammad Akhter Hossain, John D. Wade
- Journal Title
  
  Peptide Science 2017
  
  Volume: 54 Pages: 148-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] Design of plasmin inhibitors with targeting the S2’ subsite2018
- Author(s)
  Seika Sugiura, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Journal Title
  
  Peptide Science
  
  Volume: 54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] Design of new cyclic plasmin inhibitors2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Journal Title
  
  Proceedings of 35th European Peptide Symposium
  
  Volume: 2017 Pages: 171-172
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Identification of dipeptidic inhibitors targeting DPP7 derived from multiple drug resistant bacteria Stenotrophomonas maltophilia2018
- Author(s)
  Yuki Sakurai, Koushi Hidaka, Anna Miyazaki, Keiko Hojo, Saori Roppongi, Yasumitsu Sakamoto, Yasuhiro Ito, Yoshiyuki Suzuki, Wataru Ogasawara, Nobutada Tanaka, Yuko Tsuda
- Journal Title
  
  Peptide Science
  
  Volume: 54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] The role of plasmin in the pathogenesis of murine multiple myeloma2017
- Author(s)
  Eiamboonsert S, Salama Y, Watarai H, Dhahri D, Tsuda Y, Okada Y, Hattori K, Heissig B.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 488 Issue: 2 Pages: 387-392
- DOI
  10.1016/j.bbrc.2017.05.062
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333, KAKENHI-PROJECT-16K09821, KAKENHI-PROJECT-16K09866, KAKENHI-PROJECT-17K09941, KAKENHI-PROJECT-16K14591
[Journal Article] Keiko Hojo, Hossain A. Hossain, K. Johan Rosengren, Sheri Ma, Andrew. L. Gundlach, Yuko Tsuda, Koushi Hidaka, R. A. D. Bathgate, John D. Wade. Design, synthesis and biological activity of hydrocarbon stapled single-chain relaxin-3 analogue.2017
- Author(s)
  Keiko Hojo, Hossain A. Hossain, K. Johan Rosengren, Sheri Ma, Andrew. L. Gundlach, Yuko Tsuda, Koushi Hidaka, R. A. D. Bathgate, John D. Wade
- Journal Title
  
  Peptides
  
  Volume: 34 Pages: 148-149
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] Pharmacological targeting of plasmin prevents lethality and tissue damage in a murine model of macrophage activation syndrome2017
- Author(s)
  1.Shimazu H, Munakata S, Tashiro Y, Salama Y, Eiamboonser S, Ohta Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B and Hattori K
- Journal Title
  
  Blood
  
  Volume: 印刷中 Issue: 1 Pages: 59-72
- DOI
  10.1182/blood-2016-09-738096
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461415, KAKENHI-PROJECT-16K09821, KAKENHI-PROJECT-16K19956, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08333, KAKENHI-PROJECT-16K09866, KAKENHI-PROJECT-17K09941, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-15K21373
[Journal Article] X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.2017
- Author(s)
  Law RHP, Wu G, Leung EWW, Hidaka K, Quek AJ, Caradoc-Davies TT, Jeevarajah D, Conroy PJ, Kirby NM, Norton RS, Tsuda Y, Whisstock JC.
- Journal Title
  
  Blood Adv.
  
  Volume: 1 Issue: 12 Pages: 766-771
- DOI
  10.1182/bloodadvances.2016004150
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Structure-based design of plasmin inhibitors with novel P1’moiety2017
- Author(s)
  Takashi Masuda, Mototsugu Kuno, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Journal Title
  
  Peptide Science 2016
  
  Volume: - Pages: 89-90
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Design of plasmin inhibitors targeting the S1’subsite.2016
- Author(s)
  M. Kusano, K. Hidaka, K. Gohda, N. Teno, K. Wanaka, Y. Tsuda
- Journal Title
  
  Peptide Science 2015
  
  Volume: 2015 Pages: 143-144
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460164
[Journal Article] Active site-directed plasmin inhibitors: Extension on the P2 residue.2016
- Author(s)
  K. Hidaka, K. Gohda, N. Teno, K. Wanaka, Y. Tsuda.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Pages: 545-553
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460164
[Journal Article] Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity2016
- Author(s)
  Naoki Teno, Keigo Gohda, Yukoko Yamashita, Tadamune Otsubo, Masafumi Yamaguchi, Keiko Wanaka, Yuko Tsuda
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 26 Issue: 9 Pages: 2259-2261
- DOI
  10.1016/j.bmcl.2016.03.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Novel type of plasmin inhibitors: Providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine.2015
- Author(s)
  N. Teno, K, Gohda, K. Wanaka, Y. Tsuda, M. Akagawa, E. Akiduki, M. Araki, Masuda A. Masuda, T. Otsubo, Y. Yamashita.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 13 Pages: 3696-3704
- DOI
  10.1016/j.bmc.2015.04.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460164
[Journal Article] Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking.2015
- Author(s)
  A Sato, C Nishida, K Sato-Kusubata, M Ishihara, Y Tashiro, I Gritli, H Shimazu, S Munakata, H Yagita, K Okumura, Y Tsuda, Y Okada, A Tojo, H Nakauchi, S Takahashi, B Heissig and K Hattori
- Journal Title
  
  Leukemia
  
  Volume: 29 Issue: 1 Pages: 145-56
- DOI
  10.1038/leu.2014.151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112007, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24591382, KAKENHI-PROJECT-25460164, KAKENHI-PROJECT-25861215
[Journal Article] Inhibition of Plasmin Protects Against Colitis in Mice by Suppressing Matrix Metalloproteinase 9-Mediated Cytokine Release From Myeloid Cells.2015
- Author(s)
  Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonsert S, Takeda K, Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, Hattori K.
- Journal Title
  
  Gastroenterology
  
  Volume: 148 Issue: 3 Pages: 565-78
- DOI
  10.1053/j.gastro.2014.12.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112007, KAKENHI-PROJECT-24591382, KAKENHI-PROJECT-25460164, KAKENHI-PROJECT-25461961, KAKENHI-PROJECT-25861215, KAKENHI-PROJECT-26461415, KAKENHI-PROJECT-26462025, KAKENHI-PROJECT-26462136, KAKENHI-PROJECT-25462068
[Journal Article] Study on the plasmin inhibitors: Replacement of the P2 and P1’ residues2015
- Author(s)
  Suzuki A, Hidaka K, Gohda K, Teno N, Wanaka K, Tsuda Y.
- Journal Title
  
  Peptide Science 2014
  
  Volume: 2015 Pages: 209-210
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460164
[Journal Article] Pyrrolpyridine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin.2014
- Author(s)
  Teno N, Gohda K, Wanaka K, Tsuda Y, Sueda T, Yamashita Y, Otsubo T.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Pages: 2339-2352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460164
[Journal Article] Synthetic substrates specific to activated plasmin can monitor the enzymatic functional status in situ in breast cancer cells2014
- Author(s)
  Gohda, K., Fujimori, K., Teno, N., Wanaka, K., and Tsuda, Y.
- Journal Title
  
  Chem. Biol. Drug Des.
  
  Volume: 83 Issue: 1 Pages: 52-57
- DOI
  10.1111/cbdd.12232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460079, KAKENHI-PROJECT-25460164
[Journal Article] Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase. Bioorg.2013
- Author(s)
  Kuriyama I., Miyazaki A., Tsuda Y., Yoshida H., Mizushina Y.
- Journal Title
  
  Med. Chem.
  
  Volume: 21 Issue: 2 Pages: 408-411
- DOI
  10.1016/j.bmc.2012.11.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] Mechanismof the experimental antithromboticeffect of some apple varieties involves enhanced endogenous thrombolytic activity.2012
- Author(s)
  Morishita M., Naemura A., Tamura Y., Yamaya H., Tsuda Y., Okada Y., Okada K., Matsuo O., Yamamoto J.
- Journal Title
  
  Interventional Med. & applied Sci.
  
  Volume: 4 Pages: 115-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] Synthesis and anticancer activities of lipophilic somatostatin derivatives. Peptide2012; Proceedings of the 32nd European Peptide Symposium, Edited by Kokotos2012
- Author(s)
  Imazumi H., Suyama T., Takami D., Hidaka K., Miyazaki A., Yokoi T., Kuriyama I., Yoshida H., Mizushina Y., Tsuda Y.
- Journal Title
  
  G., et al.
  
  Pages: 666-667
- URL
  http://www.eurpepsoc.com/symposis.proceedigs
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] Plasmin inhibitor reduces lymphoid tumor growth by suppressing matrixmetallproteinase-9 dependent CD11b+/F4/80+ myeloid cell recruitment2012
- Author(s)
  Ishihara M, Heissig B, Nishida C, Rosenkvist J, Tashiro Y, Ohki M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Hattori K
- Journal Title
  
  Leukemia
  
  Volume: 26 Issue: 2 Pages: 332-339
- DOI
  10.1038/leu.2011.203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00480, KAKENHI-PROJECT-21249059, KAKENHI-PROJECT-21591193, KAKENHI-PROJECT-21591234, KAKENHI-PUBLICLY-22019006, KAKENHI-PUBLICLY-22021013, KAKENHI-PLANNED-22112007, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590111, KAKENHI-PUBLICLY-23013009, KAKENHI-PROJECT-23591371, KAKENHI-PROJECT-23701090, KAKENHI-PUBLICLY-22117506
[Journal Article] Predicting subsite interactions of plasmin with substrates and inhibitors through computational docking analysis.2012
- Author(s)
  Gohda K., Teno N., Wanaka K., Tsuda Y.
- Journal Title
  
  J. Enzyme Inhib. Med. Chem.
  
  Volume: 27 Issue: 4 Pages: 571-577
- DOI
  10.3109/14756366.2011.603129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] Relationship between structure and P-glycoprotein inhibitory activity of dimeric peptides related to the Dmt-Tic pharmacophore. Bioorg.2012
- Author(s)
  Ambo A., Ohkatsu H., Minamizawa M.,Watanabe H., Sugawara S., Nitta K., Tsuda Y., Okada Y., Sasaki Y.
- Journal Title
  
  Med.Chem. Lett.
  
  Volume: 22 Issue: 6 Pages: 192-194
- DOI
  10.1016/j.bmcl.2012.01.107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] Developmental Potential for endomorphin opioidmimetic drugs.2012
- Author(s)
  Okada Y. , Tsuda Y., Salvadori S., Lazarus L. H.
- Journal Title
  
  Int. J. Med. Chem.
  
  Volume: 715123 Pages: 10-10
- DOI
  10.1155/2012/715123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] Identification of novel plasmin inhibitors possessing nitril moiety as warhead. Bioorg. Med.2011
- Author(s)
  Teno N., Gohda K., Wanaka K., Sueda T., Tsuda Y.
- Journal Title
  
  Chem. Lett.
  
  Volume: 21 Issue: 21 Pages: 6305-6309
- DOI
  10.1016/j.bmcl.2011.08.121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] A new class of somatostatin analogues with antiproliferative activity in human cancer cells. Peptides 2010; Proceedings of the 31th European Peptide Symposium, Edited by Lebl, M. et al.2010
- Author(s)
  Tsuda Y., Miyazaki A., Otkuno E., Kuriyama I., Mizushina Y., Yoshida H
- Journal Title
  
  Prompt Scientific Publishing, San Diego, U.S.A.
  
  Pages: 468-469
- URL
  http://www.eurpepsoc.com/symposis.proceedigs
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] A new class of somatostatin analogues with antiproliferative activity in human cancer cells.2010
- Author(s)
  Tsuda Yuko
- Journal Title
  
  Peptides 2010
  
  Volume: Vol.31 Pages: 468-469
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] Inhibitory effect of somatostatin peptide analogues on DNA polymerase activity and human cancer cell proliferation.2010
- Author(s)
  Kuriyama I., Miyazaki A., Tsuda Y., Yokoi T., Okada Y., Takeuchi T., Sugawara F., Yoshida H., Mizushina Y.
- Journal Title
  
  Anticancer Res.
  
  Volume: 30 Pages: 4841-4850
- URL
  http://ar.iiarjournals.org/contact/by/year
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] Lipkowski A. PK20 a new opiod-neurotensin hybrid peptides that exhibits central and peripheral antinociceptive effects.2010
- Author(s)
  Kleczkowska P., Kosson P., Ballet S., Van den Eynde I., Tsuda Y., Tourwe D.
- Journal Title
  
  MolecularPain.
  
  Volume: 6 Pages: 86-86
- URL
  http://www.molecularpain.com/content/6/1/86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] New cyclic somatostatin analogues containing a pyrazinone ring: Importance of Tyr for antiproliferative activity2008
- Author(s)
  Miyazaki, A., Tsuda, Y., Fukushima, S., Yokoi, T., Vantus, T., Bokonyi, G., Szabo, E., Horvath, A., Keri, G., Okada Y
- Journal Title
  
  Bioorg. Med. Chem. Lett 18
  
  Pages: 6199-6201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties2008
- Author(s)
  Miyazaki, A., Tsuda, Y., Fukushima, S., Yokoi, T., Vantus, T., Bokonyi, G., Szabo, E., Horvath, A., Keri, G., Okada Y
- Journal Title
  
  J. Med. Chem 51
  
  Pages: 5121-5124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis of endomorphin-2 analogues containing piperidinecarboxylic acid (Pip) and 2-azetidinecarboxylic acid (Aze)2008
- Author(s)
  Tsuda, Y., Miyazaki, A., Yamada, T., Isozaki, K., Shimohigashi, Y., Ambo, A., Sasaki, Y., Okada, Y
- Journal Title
  
  Peptide Science 2007
  
  Pages: 267-268
- NAID
  10021906993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Structural studies of [2, 6-dimethyl-L-tyrosine1] endomorphin-2 analogues containing proline mimics2008
- Author(s)
  Tsuda, Y., Miyazaki, A., Yamada, T., Isozaki, K., Shimohigashi, Y., Ambo, A., Sasaki, Y., Minoura, K., In, Y., Ishida, T., Okada, Y
- Journal Title
  
  Peptide Science 2008
  
  Pages: 227-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH2)(m)]-6-[H-Dmt-NH(CH2)(n)]-2(1H)-pyrazinon es, and studies on structure-activity relationships2007
- Author(s)
  Shiotani, K., Miyazaki A., Li, T., Tsuda, Y., Yokoi, T., Ambo, A., Sasaki, Y., Bryant, S.D., Jinsmaa, Y., Lazarus, L.H., Okada, Y
- Journal Title
  
  Med. Chem 3
  
  Pages: 583-598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Bifunctional [2', 6'-dimethyl-Ltyrosine1] endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/deltaantagonist and dual mu-agonist/ delta-agonist opioid ligands2007
- Author(s)
  Li, T., Shiotani, K., Miyazaki, A., Tsuda, Y., Ambo, A., Sasaki, Y., Jinsmaa, Y., Marczak, E., Bryant, S.D., Lazarus, L.H., Okada, Y
- Journal Title
  
  J. Med. Chem 50
  
  Pages: 2753-2766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] [N-Allyl-Dmt1] Endomorphins are {micro}-opioid receptor antagonists lacking inverse agonist properties2007
- Author(s)
  Marczak, E.D., Jinsmaa, Y., Li, T., Bryant, S.D., Tsuda, Y., Okada, Y., Lazarus, L. H
- Journal Title
  
  J. Pharmacol. Exp. Ther 323
  
  Pages: 374-380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Design and synthesis of opioidmimetics containing 2', 6'-dimethyl-L-tyrosine and a pyrazinone-ring platform2007
- Author(s)
  Shiotani, K., Li, T., Miyazaki, A., Tsuda, Y., Yokoi, T., Ambo, A., Sasaki, Y., Bryant, S.D., Lazarus, L.H., Okada, Y
- Journal Title
  
  Chem. Lett 17
  
  Pages: 5768-5771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis and binding activities for the opioid receptors of endomorphin and morphiceptin analogs containing conformationally constrained 1-aminocyclolakane-1-carboxylic acids2007
- Author(s)
  Yamada, T., Hakogi, S., Iino, M., Murashima, T., Miyazawa, T., Tsuda, Y., Kawakami, T., Okada, Y., Isozaki, K., Shimohigashi, T
- Journal Title
  
  Peptides 2006
  
  Pages: 668-669
- Data Source
  KAKENHI-PROJECT-19590112
[Patent] 新規ソマトスタチン由来ペプチド化合物並びに該化合物を含むＤＮＡポリメラーゼ阻害剤、抗癌剤及びアポトーシス誘導剤2012
- Inventor(s)
  水品善之、津田裕子、宮崎杏奈、栗山磯子、吉田弘美
- Industrial Property Rights Holder
  学校法人神戸学院
- Industrial Property Rights Type
  特許
- Filing Date
  2012-11-06
- Data Source
  KAKENHI-PROJECT-22590111
[Patent] 新規ソマトスタチン由来ペプチド化合物並びに該化合物を含む DNA ポリメラーゼ阻害剤,抗癌剤及びアポトーシス誘導剤2012
- Inventor(s)
  水品善之,津田裕子,宮崎杏奈,栗山磯子,吉田弘美
- Industrial Property Rights Holder
  学校法人神戸学院
- Industrial Property Number
  2012-244575
- Filing Date
  2012-11-06
- Data Source
  KAKENHI-PROJECT-22590111
[Patent] 新規なオピオイド誘導体2010
- Inventor(s)
  岡田芳男, 津田裕子, 横井利夫
- Industrial Property Rights Holder
  帝国製薬株式会社
- Acquisition Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] ISAACを利用する病原タンパク質の分解2020
- Author(s)
  日高興士、北條恵子、津田裕子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] ビオチン結合型トリプシン阻害剤の設計とヒトトリプシン2の酵素活性調節2019
- Author(s)
  日高興士、北條恵子、津田裕子
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] トリプシンを標的とするリームバブル阻害剤の設計と酵素活性のOFF to ON制御2019
- Author(s)
  日高興士、北條恵子、津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] ヒトトリプシンを標的とするリムーバブル阻害剤の設計と酵素活性の制御2019
- Author(s)
  日高興士、北條恵子、津田裕子
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] Relaxin-2 B鎖のステープルアナログの設計と合成2019
- Author(s)
  福本哲也、北條恵子、日高興士、屋山勝俊、津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] ベンズイミダゾール骨格を有するプラスミン阻害剤の設計と活性の検討2019
- Author(s)
  川神千昂, 日高興士, 北條恵子, 合田圭吾, 手納直規, 和中敬子, 津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] OFF-to-ON control of trypsin activity using directly biotin conjugated inhibitors2019
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Organizer
  The 11th General Meeting of International Proteolysis Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] 活性中心指向型プラスミン阻害剤のヒト結腸癌細胞(HCT116)への影響2019
- Author(s)
  後藤光香子, 日高興士, 北條恵子, 合田圭吾, 手納直規, 和中敬子, 津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] OFF-to-ON control of trypsin activity and target protein degradation using ISAAC2019
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Organizer
  The 56th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] 直接的ビオチン化阻害剤を利用するHIVプロテアーゼの薬剤感受性評価2019
- Author(s)
  日高興士、安達基泰、北條恵子、津田裕子
- Organizer
  第33回近畿エイズ研究会学術集会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] リムーバブル阻害剤を用いる病態プロテアーゼの薬剤感受性の検討2018
- Author(s)
  日高興士、安達基泰、北條恵子、津田裕子
- Organizer
  第13回日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] Relaxin-3アゴニストの合成とアゴニストの一過性脳虚血モデルにおける脳保護作用2018
- Author(s)
  相坂洋平、北條恵子、原田慎一、日高興士、徳山尚吾、津田裕子
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] ON/OFF repetitive control of protease activity using peptidemimetic ligands through biotin-streptavidin affinity2018
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Organizer
  The 35th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] リムーバブル阻害剤を利用するプロテアーゼ活性のON/OFF繰り返し制御2018
- Author(s)
  日高興士、安達基泰、北條恵子、津田裕子
- Organizer
  第23回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] New plasmin inhibitors targeting interactions at the S2’ subsite2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Yoshio Okada
- Organizer
  The 17th Akabori Conference, September 1st -5th, 2018, Konstanz & Lindau
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] リムーバブル阻害剤の薬剤感受性試験への新規利用法2018
- Author(s)
  日高興士、安達基泰、北條恵子、津田裕子
- Organizer
  第32回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] X-線結晶構造に基づく多剤耐性菌由来DPP-7阻害剤の設計と評価―国際宇宙ステーションで抗菌薬を開発する2018
- Author(s)
  関拓海、奥野優香、櫻井有紀、日高興士、宮崎杏奈、北條恵子、六本木沙織、阪本康広、鈴木義之、小笠原渉、田中信忠、木平清人、山田貢、吉崎泉、田仲広明、伊中浩治、津田裕子
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] Removable peptidomimetic inhibitors for controlling activity of proteases2018
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Organizer
  The 10th International Peptide Symposium/The 55th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] Design of new cyclic plasmin inhibitors2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Organizer
  The 35th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] S2’サブサイトを標的としたプラスミン阻害剤の設計と活性の検討2018
- Author(s)
  杉浦成香、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] S1ポケットにおける相互作用を標的としたプラスミン阻害剤の分子設計2018
- Author(s)
  津田裕子, 児嶋基樹, 近藤めぐみ, 日高興士, 北條恵子, 合田圭吾, 手納直規, 和中敬子
- Organizer
  第23回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Exploration of Active site-directed plasmin inhibitors2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Organizer
  The 10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] X線構造解析に基づくプラスミン阻害剤の設計2017
- Author(s)
  桝田昂志、久野元嗣、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第67回日本薬学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Identification of dipeptidic inhibitors targeting DPP7 derived from multiple drug resistant bacteria Stenotrophomonas maltophilia2017
- Author(s)
  Yuki Sakurai, Koushi Hidaka, Anna Miyazaki, Keiko Hojo, Saori Roppongi, Yasumitsu Sakamoto, Yasuhiro Ito, Yoshiyuki Suzuki, Wataru Ogasawara, Nobutada Tanaka, Yuko Tsuda
- Organizer
  The 54th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] Design of plasmin inhibitors with targeting the S2’ subsite2017
- Author(s)
  Seika Sugiura, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  The 54th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Design and synthesis of hydrocarbon stapling peptide antagonist for relaxin family peptide receptor 3 (RXFP3)2017
- Author(s)
  Keiko Hojo, Mika Izutsu, Ross A. D. Bathgate, K Johan Rosengern, Koushi Hidaka, Yuko Tsuda, Mohammad Akhter Hossain, John D. Wade
- Organizer
  The 54th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] P1残基を修飾したプラスミン阻害剤の分子設計2017
- Author(s)
  園田浩士、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第22回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Design of plasmin inhibitors with targeting the S2’ subsite2017
- Author(s)
  Seika Sugiura, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  The 54th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] S1サブサイトを標的としたプラスミン阻害剤の探索2016
- Author(s)
  村本凌太郎、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  日本薬学会135年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] S1ポケットにおける相互作用を利用したプラスミン阻害剤の分子設計2016
- Author(s)
  園田浩士、桝田昂志、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第21回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  吹田
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Exploration of plasmin inhibitors targeting an S2 subsite2016
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Yoshio Okada
- Organizer
  The 16th Akabiori Conference
- Place of Presentation
  Ｋｏｂｅ
- Year and Date
  2016-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Development of a single chain peptide agonist of relaxin-3 receptor: optimization of stapling strategies2016
- Author(s)
  Keiko Hojo, Ross A. D. Bathgate, K Johan Rosengern, Andrew L Gundlach, Koushi Hidaka, Yuko Tsuda, Mohammed A. Hossain, John D. Wade
- Organizer
  The 53rd Japanese Peptide Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2016-10-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] Plasmin specific inhibitors: Optimization of the P2 and P1’ residues2016
- Author(s)
  Naomichi Iwasa, Takashi Masuda, Mototsugu Kuno, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  34th European Peptide Symposium
- Place of Presentation
  ライプツィッヒ、ドイツ
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] 疎水性アミノ酸をリンカーとして導入した新規プラスミン阻害剤の合成と構造活性相関の検討2016
- Author(s)
  山下ユキコ、手納直規、合田圭吾、大坪忠宗、山口雅史、和中敬子、津田裕子
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Structure-based design of plasmin inhibitors with novel P1’ moiety2016
- Author(s)
  Takashi Masuda, Mototsugu Kuno, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  The 53rd Japanese Peptide Symposium
- Place of Presentation
  Ｋｙｏｔｏ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Design, synthesis and biological activity of hydrocarbon stapled single-chain relaxin-3 analogue2016
- Author(s)
  Keiko Hojo, Mohammed A. Hossain, K. Johan Rosengren, Sheri Ma, Andrew. L. Gundlach, Yuko Tsuda, Koushi Hidaka, R. A. D. Bathgate, John D. Wade
- Organizer
  34th European Peptide Symposium
- Place of Presentation
  Leipzig
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] Structural studies on plasminogen activation and plasmin inhibition.2015
- Author(s)
  R.H.P. Law, A.J. Quek, G. Wu, P.J. Conroy, K Hidaka, T. T. Caradoc-Davies, Y Tsuda, J. C. Whisstock
- Organizer
  The 9th General Meeting of International Proteolysis Society
- Place of Presentation
  Peneng, Malysia
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] The x-ray crystal structure of microplasmin with a small-molecular active site inhibitor PSI-112.2015
- Author(s)
  G. Wu, K. Hidaka, D. Jeevarajah, Y. Tsuda, J. C Whisstock, R.H.P. Law
- Organizer
  The 9th General Meeting of International Proteolysis Society
- Place of Presentation
  Peneng, Malysia
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] Design of plasmin inhibitors targeting the S1’subsite2015
- Author(s)
  M. Kusano, K. Hidaka, K. Gohda, N. Teno, K. Wanaka, Y. Tsuda
- Organizer
  The 52nd Japanese Peptide Symposium
- Place of Presentation
  Hiratsuka
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] Active site directed plasmin inhibitors: modification on P1’ residue2015
- Author(s)
  M. Kusano, A. Suzuki, K. Hidaka, K. Gohda, N. Teno, K. Wanaka, Y. Tsuda
- Organizer
  7th International peptide symposium 2015
- Place of Presentation
  Singapore
- Year and Date
  2015-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] 新規プラスミン阻害剤への展開：pyrrolopyrimidine scaffoldからbenzimidazole scaffoldへの変換2015
- Author(s)
  山下ユキコ, 合田圭吾, 大坪忠宗, 和中敬子, 津田裕子，手納直規
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] 活性中心指向型プラスミン阻害剤の長鎖P1'残基導入による構造活性相関2015
- Author(s)
  草野真衣、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第20回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] P2残基置換によるプラスミン阻害剤の構造活性相関2014
- Author(s)
  渥美沙紀、松井千紗、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本、熊本市総合体育館その他
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] プラスミン(PL)選択的阻害剤を目指して～結合ポケットの比較からデザインする2013
- Author(s)
  岡部未奈子、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  吹田、千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] Search for plasmin specific inhibitors: Extension on the P2 residue2013
- Author(s)
  Atsumi S, Hidaka K, Gohda K, Teno N, Wanaka K, Tsuda Y
- Organizer
  4th Asia-Pacific International Peptide Symposium/50th Japanese Peptide Symposium
- Place of Presentation
  吹田、ホテル阪急エキスポパーク
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] DNAポリメラーゼ・選択的阻害活性を有する小分子ペプチドミメティクスの構造活性相関研究.2013
- Author(s)
  宮崎杏奈,伊藤梨紗,榎本章,津田裕子,栗山磯子,吉田弘美,水品善之.
- Organizer
  日本薬学会133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] 新規ソマトスタチン由来ペプチドのDNAポリメラーゼ・特異的阻害活性に基づくヒトがん細胞増殖抑制とアポトーシス誘導.2013
- Author(s)
  栗山磯子,宮崎杏奈,津田裕子,吉田弘美,水品善之.
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] 活性中心志向型プラスミン阻害剤の探索2013
- Author(s)
  津田裕子
- Organizer
  生命分子機能研究会２０１３学術集会
- Place of Presentation
  長浜、長浜バイオ大学
- Invited
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] 脂溶性に富むソマトスタチン誘導体の合成と抗腫瘍活性2012
- Author(s)
  津田裕子
- Organizer
  第49回ペプチド討論会
- Place of Presentation
  鹿児島県民交流センター（鹿児島）
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] 疎水性を指標としたソマトスタチン誘導体の合成と生物活性2012
- Author(s)
  津田裕子
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] Synthesis and anticancer activities of lipophilic somatostatin derivatives.2012
- Author(s)
  Inazumi H., Suyama T., Takami D., Hidaka K., Miyazaki A., Yokoi T., Kuriyama I., Yoshida H., Mizushina Y., Tsuda Y.
- Organizer
  The 32nd European Peptide Symposium
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] 疎水性を指標としたソマトスタチン誘導体の合成と生物活性.2012
- Author(s)
  越智文也、北岡健二、宮崎杏奈、横井利夫、日高興士、栗山磯子、吉田弘美、水品善之、津田裕子.
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] 脂溶性に富むソマトスタチン誘導体の合成と抗腫瘍活性.2012
- Author(s)
  陶山泰治郎,稲住瞳,高見大介,日高興士,宮崎杏奈,横井利夫,栗山磯子,吉田弘美,水品善之,津田裕子.
- Organizer
  第49回ペプチド討論会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] ナフチル基を有するペプチドミメティックのDNAポリメラーゼ・阻害活性.2012
- Author(s)
  宮崎杏奈,伊藤梨紗,榎本章,津田裕子,栗山磯子,吉田弘美,水品善之.
- Organizer
  第49回ペプチド討論会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] Synthesis and anticancer activities of lipophilic somatostatin derivatives2012
- Author(s)
  Tsuda Yuko
- Organizer
  The 32nd European Peptide Symposium
- Place of Presentation
  アテネ、ギリシャ
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] ソマトスタチン関連抗腫瘍性ペプチドの膜透過性.2011
- Author(s)
  堀麻衣,宮崎杏奈,坂遼,津田裕子,岡田芳男,岸本修一,福島昭二.
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] Somatostatin derivatives that exhibit inhibitory effects on DNA polymerae and human cancer cell proliferation2011
- Author(s)
  Yuko Tsuda
- Organizer
  14th Peptide forum
- Place of Presentation
  鹿児島大学
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] Somatostatin derivatives that exhibit inhibitory effects on DNA polymerae and human cancer cell proliferation.2011
- Author(s)
  Ochi F., Kitaoka K., Miyazaki A., Yokoi T., Hidaka K., Kuriyama I., Yoshida H, Mizushina Y., Tsuda Y.
- Organizer
  14th Peptide Forum
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] DNAポリメラーゼ分子種選択的阻害剤の開発研究.2011
- Author(s)
  宮崎杏奈,栗山磯子,水品善之,吉田弘美,津田裕子.
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] A new class of somatostatin analogues with antiproliferative activity in human cancer cells2010
- Author(s)
  Tsuda Yuko
- Organizer
  第31回ヨーロッパペプチドシンポジウム
- Place of Presentation
  ベラセンター(デンマーク、コペンハーゲン)
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] ソマトスタチン関連抗腫瘍性ペプチドの膜透過性.2010
- Author(s)
  堀麻衣,宮崎杏奈,坂遼,津田裕子,岡田芳男,岸本修一,福島昭二.
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  摂南大学
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] A new class of somatostatin analogues with antiproliferative activity.2010
- Author(s)
  Tsuda Y., Miyazaki A., Okuno E., Kuriyama I., Mizushina Y., Yoshida H.
- Organizer
  The31th European Peptide Symposium
- Place of Presentation
  Copenhagen
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] プロリンミミックを含む[2', 6'-dimethyl-L-tyrosine1] endomorphin 2類似体の酵素安定性とコンフォメーションの検討2010
- Author(s)
  津田裕子, 安保明博, 佐々木友亮, 箕浦克彦, 尹康子, 石田寿昌, 岡田芳男
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] ソマトスタチン由来ペプチドによるDNA合成酵素阻害活性とヒト由来癌細胞増殖抑制活性への影響.2010
- Author(s)
  栗山磯子,宮崎杏奈,津田裕子,吉田弘美,坂口謙吾,水品善之.
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] プロリンミミックを含む[2',6'-dimethl-L-tyrosine^1]endomorphin 2類似体の酵素安定性とコンフォメーションの検討2010
- Author(s)
  津田裕子
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] The considerable effects on anti-tumor activity and cell permeability of small peptides containing adamantly group.2010
- Author(s)
  Miyazaki A., Hori M., Saka R., Kishimoto S., Fukushima S., Tsuda Y.
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] μ-オピオイド拮抗剤はアルコールで誘導された抑制性シナプス後電流の振動数の増加を減弱させる2009
- Author(s)
  津田裕子
- Organizer
  第12回ペプチドフォーラム
- Place of Presentation
  九州工業大学、北九州市
- Year and Date
  2009-01-23
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] [N-allyl-Dmt^1]endomorphinの合成とそれによるアルコール依存性の改善2009
- Author(s)
  津田裕子
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] Synthesis and biological activities of endomorphin-2 analogues containing proline mimics2008
- Author(s)
  津田裕子
- Organizer
  II Workshop "From Endogenous Systems to Medi cines"
- Place of Presentation
  ワルシャワ
- Year and Date
  2008-09-06
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] プロリンミミックを含む[2', 6'-dimethy1-L-tyrosine^1]endomorphin-2類似体のコンフォメーシヨン解析2008
- Author(s)
  津田裕子
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] Synthesis and biological activities of endomorphin-2 analogues containing proline mimics2008
- Author(s)
  津田裕子
- Organizer
  II Workshop“From Endogenous Systems to Medicines"
- Place of Presentation
  Warsaw, Poland
- Year and Date
  2008-09-06
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] Synthesis and biological activities of endomorphin analogues containing Pro mimics2008
- Author(s)
  津田裕子
- Organizer
  第30回ヨーロッパペプチドシンポジウム
- Place of Presentation
  ヘルシンキ
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] ynthesis and biological activities of endomorphin-2 analogues containing Pro mimics2008
- Author(s)
  津田裕子, 宮崎杏奈, 山田隆巳, 磯崎要, 下東康幸, 安保明博, 佐々木有亮, 箕浦克彦, 尹康子、石田寿昌、岡田芳男
- Organizer
  第30回European Peptide Symposium
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] プロリンミミックを含む[2', 6'-dimethyl-L-tyrosine1] endomorphin-2類似体のコンフォメーション解析2008
- Author(s)
  津田裕子, 宮崎杏奈, 山田隆巳, 磯崎要, 下東康幸, 安保明博, 佐々木有亮, 箕浦克彦, 尹康子, 石田寿昌、岡田芳男
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] 芳男:ピペリジンカルボン酸またはアゼチジンカルボン酸を含むエンドモルフィンー2類似体の合成2007
- Author(s)
  津田裕子, 宮崎杏奈, 山田隆巳, 磯崎要, 下東康幸, 安保明博, 佐々木有亮, 岡田芳男
- Organizer
  第44回ペプチド討論会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] Synthesis and biological activity of endomorphin-2 analogues containing Promimcs2007
- Author(s)
  津田裕子
- Organizer
  The 6th Symposium on frontiers in Protein Chemistry and Biotechnology
- Place of Presentation
  Chang Chun,China
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] Development of active center-directed plasmin inhibitors
- Author(s)
  Yoshio Okada, Keiko Wanaka, Yuko Tsuda
- Organizer
  15th Akabori Conference/Japanese-German Symposium on Peptide Science
- Place of Presentation
  Boppard, Germany
- Year and Date
  2014-09-07 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] プラスミン(PL)選択的阻害剤を目指して～P1’残基の構造変換
- Author(s)
  前原いつか、松井千紗、村上弥生、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第19回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  吹田、千里ライフサイエンスセンター
- Year and Date
  2014-08-08 – 2014-08-09
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] Study on the plasmin inhibitors: Replacement of the P2 and P1’ residues
- Author(s)
  Ayako Suzuki, Koushi Hidaka, Keigo Gohda, Naoki Teno, Keiko Wanaka and Yuko Tsuda
- Organizer
  The 51st Japanese Peptide Symposium
- Place of Presentation
  徳島
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] Plasmin specific inhibitors: Additional interaction at the S2/S3 and S’1 sites
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Organizer
  33rd European Peptide Symposium
- Place of Presentation
  Sofia, Bulgaria
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25460164

1. HIDAKA KOUSHI (30445960)

# of Collaborated Projects: 4 results

# of Collaborated Products: 62 results
2. YUKOI Toshio (50122255)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. OKADA Yoshio (60068236)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
4. Hojo Keiko (20289028)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
5. MIZUSHINA Yoshiyuki (20307705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
6. MIYAZAKI Anna (00340919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
7. YAMAMOTO Junichiro (60068252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TENO naoki (00535586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
9. HATTORI kouichi (10360116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. GOHDA keigo

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
11. WANAKA keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
12. LAW ruby

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. FUJIMORI Ko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. HEISSIG Beate

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TSUDA Yuko 津田 裕子

津田 裕子 ツダ ユウコ

Research Projects

Research Products

Co-Researchers

Discovery of removable inhibitors targeting proteases

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Discovery of INSL7 analogue with agonistic activity for RXFP3 in the brai

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Design of the active site-directed plasmin inhibitor oriented to the clinical applicationsPrincipal Investigator

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Studies on the active site-directed plasmin inhibitor: It may control plasmin having multifunctional propertiesPrincipal Investigator

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Search for the anti-tumor derivatives containing the somatostatin sequence focusing on the hydrophobic indexPrincipal Investigator

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Design of agonists and antagonists for opioid receptors based on the structures of endomorphinsPrincipal Investigator

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Design and synthesis of μ-selective opioidomimetic peptides

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Design of Bifunctional Inhibitors for Enzymes in Coagulation-Fibrinolytic SystemPrincipal Investigator

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[Book] オピオイド:アゴニスト,アンアゴニストの医薬品開発に向けた戦略 遺伝子医学MOOK21号2012

Author(s)

Data Source

[Book] 最新ペプチド合成技術とその創薬研究への応用2012

Author(s)

Publisher

Data Source

[Book] Amino Acids, Peptides and Proteins in Organic Chemistry. Vol. 3 -Building Blocks,Catalysis and Coupling Chemistry;Solution;Phase Peptide Synthesis, Edited by Andre B. Hughes2011

Author(s)

Publisher

Data Source

[Book] Amino Acids, Peptides and Proteins in Organic Chemistry. Vol. 3-Building Blocks, Catalysis and Coupling Chemistry ; Solution-Phase Peptide Synthesis2010

Author(s)

Publisher

Data Source

[Journal Article] OFF-to-ON control of trypsin activity and target protein degradation using ISAAC.2020

Author(s)

Journal Title

Data Source

[Journal Article] Acquired Removability of Aspartic Protease Inhibitors by Direct Biotinylation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ON/OFF repetitive control of protease activity using peptidemimetic ligands through biotin-streptavidin affinity.2019

Author(s)

Journal Title

TSUDA Yuko 津田裕子

津田裕子ツダユウコ

[Book] オピオイド:アゴニスト,アンアゴニストの医薬品開発に向けた戦略遺伝子医学MOOK21号2012