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HIGASHI Hideho
東 英穂
Connect your ORCID iD
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Researcher Number
10098907
External Links
Affiliation (based on the past Project Information)
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1994 – 2006: Kurume University School of Medicine Professor, 医学部, 教授
2001: Kurume Univ. Sch. of Med. Professor, 医学部, 講師
1986 – 1993: 久留米大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies
/
Neurochemistry/Neuropharmacology
/
General physiology
/
General physiology
/
Neurophysiology and muscle physiology
Except Principal Investigator
Neurophysiology and muscle physiology
/
Biological Sciences
/
麻酔学
/
神経・脳内生理学
/
Neurochemistry/Neuropharmacology
…
More
/
Neurochemistry/Neuropharmacology
/
Anesthesiology/Resuscitation studies
/
生理学一般
/
General physiology
Less
Keywords
Principal Investigator
海馬錐体細胞 / 脳虚血 / ATP依存性Kチャネル / 細胞内Ca濃度 / Hippocampal CA 1 neurons / Necrosis / Ca依存性Kチャネル / 細胞内情報伝達系 / 急峻脱分極電位 / Brain ischemia
…
More
/ Rapid depolarization / 海馬 / EPSP / IPSP / NMDA受容体 / 低酸素負荷 / Catmodulin kinaseII / C-kinase / 低酸素誘起過分極電位 / 海馬錘体細胞 / Diazoxide / Nicorandil / Glybenclamide / Tolbutamide / Calmoduline Kinase II / Ckinase / Fura-2 / Anoxic hyperpolarization / Ca^<2+> -dependent K^+ channels / ATP-sensitive K^+ channels / Signal transduction system / Internal Ca^<2+> concentration / Calmodulin Kinase II / C kinase / Calmodulin kinase II / Glutamate antagonist / Terminal deporarizaiton / 興奮性アミノ酸受容体 / GABA受容体 / East EPSP / Fast IPSP / Slow IPSP / Muscimol / Baclofen / 興奮性アミノ酸 / Glutamate拮抗薬 / Initial hyperpolarization / Slow depolarization / Electrogenic Na^+ pump / ATP-sensitive K^+ channel / ネクローシス / シナプス応答 / 細胞内Ca^<2+>蓄積 / Ca^<2+>拮抗薬 / NO synthase阻害薬 / small blebs / CA^<2+>蓄積 / 細胞膨化 / biocytin / 低温環境 / NO / NO scavengers / superoxide dismutase / glutamate / Small blebs / Cell swelling / Ca^<2+> antagonists / Synaptic responses / てんかん様発作放電 / 神経回路網 / リドカイン / アデノシン / A_1受容体 / てんかん様放電 / 局麻薬 / 海馬CA1領域 / GABA_A受容体 / イオン透過型グルタミン酸受容体 / 興奮性シナプス後電位 / 抑制性シナプス後電位 / 海馬歯状回 / 海馬CA3領域 / アデノシン1受容体 / neural network / hippocampus / epilepsy / lidocaine / A_1 receptor / adenosine / アストロサイト / プロテオグリカン / 細胞外K^+濃度 / 細胞質Ca^<2+>濃度 / ヘパラン硫酸 / コンドロイチン硫酸 / 虚血 / 中枢神経系 / CA1錐体細胞 / グリア / 細胞内Ca^<2+>濃度 / 細胞構築 / Astrocyte / Proteoglycan / Hippocampus / Extracellular K^+ concentration / Cytoplasmic Ca^<2+> concentration / Heparan sulfate / Chondroitin sulfate / Ischemia / 低酸素症(ハイポキシア) / 細胞死 / Ca誘起性Ca遊離 / 有機性Ca拮抵薬 / 脳保護薬 / Ca誘起生Ca遊離 / 誘起Ca拮抗薬 / 無酸素状態(アノキシア) / 無グルコース液潅流 / 膜電位 / Naポンプ / Caポンプ / Na@Ca交換機構 / 細胞内自由Ca濃度 / CNS neurones / Cell death / Hippocampal neurones / Intracellular Ca / Intracellular ATP / Ca antagonists / NMDA antagonists / Non-NMDA antagonists
…
More
Except Principal Investigator
DARPP-32 / 線条体 / ドーパミン / リン酸化 / 脳虚血 / fast EPSP / 細胞内情報伝達系 / 細胞内カルシウム / Intracellular calcium / dopamine / phosphorylation / 細胞内情報伝達 / ギャップ結合 / シナプス / グルタミン酸受容体 / NMDA / AMPA / 長期増強 / シグナルトランスダクション / ノルアドレナリン / Ca依存性Kコンダクタンス / 脳損傷 / Brain ischemia / 神経伝達物質 / Glutamate receptors / striatum / Cdk5 / 17β-estradiol / testosterone / fast IPSP / 脊髄側角ニューロン / 脊髄神経節細胞 / whole cell patch recording / Ca電流 / 局所麻酔薬 / 海馬錐体神経細胞 / 細胞内記録 / 伝達物質放出 / cDNAクローニング / 可塑性変化 / CDNAクローニング / グリシン受容体 / 遺伝子クローニング / GABA受容体 / 長期抑圧 / Synapse / Glutamate receptor / Transmitter release / cDNA cloning / Plastic change / 交感性節前ニューロン / シナプス前抑制 / α_1とα_2受容体 / slow EPSPとIPSP / セロトニン / タキキニン / 緩徐シナプス電位 / substance P / alpha_1受容体 / alpha_2受容体 / シグナル・トランスダクション / slow EPSP / slow IPSP / tachykinins / 交感性節前ニュ-ロン / 緩徐シナプス伝達 / P物質 / マイスナ-神経叢細胞 / sympathetic preganglionic neuron / presynaptic inhibition / alpha_1 and alpha_2 receptor / slow EPSP and IPSP / signal transduction / serotonin / tachykinin / レセプター / イオンチャネル / セカンドメッセンジャー / クロストーク / 膜脂質代謝 / 蛋白リン酸化 / mRNA / cDNA / 生体電気シグナル / 神経細胞 / Receptor / Ion Channel / Hydrolysis of membrane lipid / Cross talk / Second messenger / Phosphorilation of protein / カルシウムチャネル / NMDAレセプター / カルシウム結合タンパク / cDNAサブトラクション法 / 一酸化窒素 / NMDAレセプタ / NO / アラキドン酸代謝系 / 海馬スライス / 海馬 / Long term potentiation / Calcium channel / NMDA receptor / Calcium binding protein / cDNA subtraction / Nitric oxide / 細胞内Ca^<2+> / 可塑性 / マスカリン受容体 / シナプス前終末 / 生後発達 / Synapses / Neurotransmitters / Intracellular Ca^<2+> / Plasticity / Muscarinic receptors / Presynaptic terminals / Postnatal development / グリア細胞 / アストロサイト / 培養細胞 / Na,K-pump / パッチクランプ / Glia cell / Astrocytes / Culture cell / Na, K-pump / Patch clamp / プロテインホスファターゼ1 / protein phosphatase-1 / 線条件 / intracclular signaling / グルタミン酸 / ニコチン / glutamate / neostriatum / intracellular signaling / nicotine / ドーパミン作動性神経 / コンロドイチン硫酸プロテオグリカン / 合成糖鎖分子 / 神経突起伸長 / コンドロイチン硫酸ブロテオグリカン / コンドロイチン硫酸プロテオグリカン / dopaminergic neurons / chondroitin sulfate proteoglycan / synthetic oligosaccharide / neurite outgrowth / intracellular signal transduction / 内側扁桃核 / 内側視索前野 / 性差 / 扁桃体 / 内側核ニューロン / アンドロゲン受容体 / 内向き整流 / 後脱分極 / EPSP / IPSP / medial amygdaloid nucleus / medial preoptic area / sexsual specificity / 脊髄側用ニューロン / 辺縁系ニューロン / 側坐核ニューロン / 腸管内在神経叢細胞 / 心臓内神経節細胞 / ドーパミン受容体 / カテコールアミン / 側坐核 / ペプチド作動性ニューロン / 交感性節前線維 / 心壁内神経節細胞 / ノイズ解析 / ニコチン性受容体 / マイスナー神経叢 / ムスカリン性シナプス電位 / Lateral horn cells / limbic neurons / accumbens neurons / enteric submucous neurons / cardiac ganglion cells / 低酸素 / 膜電位 / Kチャンネル / Ca^<2+>流入 / 麻酔薬 / 海馬CA1ニューロン / 脳局所灌流 / Brain slice / Hippocampus / Hypoxia / Membrane potential / Brain injury / Anti-ischemic activity / 脊髄側角細胞 / 速い経過のシナプス電位 / 遅い経過のシナプス電位 / グルタメイト受容体 / カテコ-ルアミン受容体 / プロティンキナ-ゼC / Gタンパク / 脊髄 / 側角細胞 / 興奮性アミノ酸 / 速い経過のシスプス電位 / プロテインキナ-ゼC / 速および緩徐興奮性シナプス電位 / 緩徐抑制性シナプス電位 / アルファ受容体 / 消化管内在神経細胞 / ムスカリン性受容体 / Spinal lateral horn / Fast EPSP / Slow EPSP and IPSP / Adrenoceptors / Signal transduction / Protein kinase C / G protein
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Research Projects
(
23
results)
Co-Researchers
(
52
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Do androgen receptors contribute to the expression of sex differences in the brain?
Principal Investigator
TANAKA Eiichiro
Project Period (FY)
2006 – 2007
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General physiology
Research Institution
Kurume University
Map of dopamine signaling in the neostriatum
Principal Investigator
NISHI Akinori
Project Period (FY)
2004 – 2005
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Kurume University
Elucidating the structure and function of chondrotin sulfate proteoglycan in differentitation, development and regeneration of dopaminergic neurons
Principal Investigator
SOTOGAKU Naoki
Project Period (FY)
2004 – 2005
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Kurume University
Effects of proteoglycans on the membrane dysfunction produced by in vitro ischemia in the rat hippocampal CA1 neurons.
Principal Investigator
Principal Investigator
HIGASHI Hideho
Project Period (FY)
2004 – 2005
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General physiology
Research Institution
KURUME UNIVERSITY
Epileptic Discharges and the neural network in the hippocampus.
Principal Investigator
Principal Investigator
HIGASHI Hideho
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General physiology
Research Institution
KURUME UNIVERSITY
ドーパミン情報伝達とシグナル統合細胞間分子回路
Principal Investigator
西 昭徳
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Review Section
Biological Sciences
Research Institution
Kurume University
Molecular mechanisms to amplify dopamine signaling in neostriatal neurons
Principal Investigator
NISHI Akinori
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Kurume University Scientifiv Research (C) (2)
線条体神経細胞でのドーパミン情報伝達系、特にD1/D2レセプター相互作用の解析
Principal Investigator
NISHI Akinori
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Review Section
Biological Sciences
Research Institution
Kurume University
Analysis of intracellular signaling cascades mediated by receptor activation and protein phosphorylation in neostriatal
Principal Investigator
NISHI Akinori
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Kurume Unuviersity
Membrane dysfunction induced by in vitro ischemia in rat hippocampal CA1 pyramidal neurons
Principal Investigator
Principal Investigator
HIGASHI Hideho
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Kurume University
Role of glia cell during brain ischemia
Principal Investigator
YAMAMOTO Satoshi
Project Period (FY)
1997 – 1999
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
神経・脳内生理学
Research Institution
Kurume University
Physiological studies on the mechanisms of synaptic transmission.
Principal Investigator
KUBA Kenji
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
神経・脳内生理学
Research Institution
Nagoya University
佐賀医科大学
Experimental Brain Ischemia and Ion Channels
Principal Investigator
Principal Investigator
HIGASHI Hideho
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Kurume University
脊椎麻酔は下行大動脈遮断に伴う脊髄の虚血性障害を緩和できるか
Principal Investigator
杉山 和英
Project Period (FY)
1993
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Kurume University
Mechanisms for hypoxia-induced hyperpolarization in the rat hippocampal CA 1 neurons in vitro.
Principal Investigator
Principal Investigator
HIGASHI Hideho
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Kurume University
THE CROSS TALK OF SIGNAL TRANSMISSION BETWEEN THE RECEPTOR AND THE CHANNEL
Principal Investigator
AKAIKE Norio
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
生理学一般
Research Institution
KYUSYU UNIVERSITY
Tohoku University
Pathophysiology and treatments of brain ischemia insighted from neuronal function, metabolism and molecular structure
Principal Investigator
SHIMOJI Koki
Project Period (FY)
1992 – 1994
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
麻酔学
Research Institution
Niigata University
Molecular and cellular basis of synaptic function
Principal Investigator
OZAWA Seiji
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Neurophysiology and muscle physiology
Research Institution
Gunma University
Electrophysiological studies of synaptic transmission in the central and peripheral autonomic neurons.
Principal Investigator
NISHI Syogoro
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Neurophysiology and muscle physiology
Research Institution
Kurume University
Synaptic Transmission and Modulation in the Autonomic Nervous System
Principal Investigator
NISHI Syogoro
Project Period (FY)
1988 – 1990
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Neurophysiology and muscle physiology
Research Institution
Kurume University
Effects of deprivation of oxygen and/or glucose on mammalian CNS neurones
Principal Investigator
Principal Investigator
HIGASHI Hideho
Project Period (FY)
1988 – 1989
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Neurophysiology and muscle physiology
Research Institution
Kurume University School of Medicine
The electrical property, chemoreceptivity and synaptic transmission of autonomic neurons
Principal Investigator
NISHI Syogoro
Project Period (FY)
1985 – 1987
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Neurophysiology and muscle physiology
Research Institution
Kurume University
Study on pathophysiology of cerebral hypoxia by means of the brain slice technique and the regional perfusion technique
Principal Investigator
SHIMOJI Koki
Project Period (FY)
1985 – 1987
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
麻酔学
Research Institution
Niigata University
# of Projects (Dsc)
# of Projects (Asc)
1.
NISHI Akinori
(50228144)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
2.
INOKUCHI Hiroe
(10080558)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
3.
TANAKA Eiichiro
(80188284)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
4.
AKAIKE Noriko
(30040182)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
5.
YAMAMOTO Satoshi
(60220464)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
6.
NISHI Syogoro
(00080557)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
7.
YOSHIMURA Megumu
(10140641)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
8.
SOTOGAKU Naoki
(60368884)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
9.
AKASU Takashi
(60113213)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
OZAWA Seiji
(40049044)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
TAKAHASHI Tomoyuki
(40092415)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
MIHARA Satoshi
(40166103)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
KUBA Kenji
(60080561)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
SHIMOJI Koki
(30040158)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
矢野 秀樹
(60210308)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
16.
ONODERA Kayoko
(00053091)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
MISHINA Masayoshi
(80144351)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
KIYOHARA Toshikazu
(50071874)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
KITAZATO Hiroshi
(20079700)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
OKADA Yasunobu
(10025661)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
INOUE Isao
(80001973)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
SATOH Masamichi
(80025709)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
KUMANISHI Toshiro
(40018601)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
ASANO Takao
(70090496)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
TANAKA Masatoshi
(10080954)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
WATANABE Yuka
(80412542)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
NISHI Yoshihiro
(20352122)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
MURAI Yoshinaka
(40322820)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
HOKARI Tamaki
(10173577)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
HASHIBA Masao
(30108047)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
ENDOH Hiroshi
(90168831)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
杉山 和英
(80140721)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
大石 一男
(70203700)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
無敵 剛介
(60080917)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
山岸 俊一
(70014032)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
野間 昭典
(00132738)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
外崎 昭
(90004572)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
富田 忠雄
(50078763)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
39.
高橋 国太郎
(10010034)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
40.
竹中 敏文
(00045999)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
41.
反町 勝
(70036440)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
42.
瀬山 一正
(70034006)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
43.
鈴木 光
(80037548)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
44.
小林 春雄
(20074502)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
45.
崎村 建司
(40162325)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
46.
佐武 明
(70018589)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
47.
平野 丈夫
(50181178)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
48.
木島 博正
(30012397)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
49.
福井 隆一
(00309791)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
50.
聖川 孝介
(20080559)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
51.
丸山 洋一
(00111724)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
52.
MARUYAMA Yoichi
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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