IWAMOTO Itsuo 岩本逸夫

Researcher Number	10111436
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2001 – 2004: 千葉大学, 大学院・医学研究院, 助教授 1996 – 2000: Chiba University School of Medicine, Associate Professor, 医学部, 助教授 1995: 千葉大学, 医学部, 講師 1989 – 1991: 千葉大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / 内科学一般 / Respiratory organ internal medicine Except Principal Investigator Biological Sciences / Respiratory organ internal medicine / 内科学一般 / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 気管支喘息 / 好酸球 / Eosinophils / Asthma / Th2 cells / アレルギー性炎症 / RDA / Stat 5 / IL-5 / IL-25 … More Except Principal Investigator アレルギー性炎症 / Stat6 / 気管支喘息 / レトロウイルス / Stat5a / Th2細胞 / 組織好酸球浸潤 / 肥満細胞 / 蛋白分解酵素 / 核局在 / サイトカイン / DNA vaccination / Stat5 / elastase / IL-5 / Th2細胞分化 / CD25陽性免疫制御性T細胞 / レトロウイルス発現クローニング / CD25陽性免疫制御性細胞 / Stat6切断酵素 / 65kDa Stat6 / セリンプロテアーゼ / Stat5切断酵素 / 蛋白分解 / 細胞死抑制 / II型IL-4レセプター / IL-13E13K / レトロウイルス発現法 / 気道好酸球浸潤 / 抗原特異的T細胞 / T-bet / Th1 / Th2バランス / 樹状細胞 / 好酸球 / 抗好酸球モノクロ-ナル抗体 / サブスタンスP / 好酸球増多症 / ロイコトリエン / 化学伝達物質 / 抗アレルギ-薬 / 神経ペプチド / ヒト好酸球 / 低親和性IgEレセプタ- / 抗好酸球抗体 / Bronchial asthma / Eosinophil / Anti-eosinophil antibody / Cytokine / Substance P / Eosinophilia / 多発筋炎 / 免疫機構 / サイトカイソ / Interferon-γ / Interferen-γ / 副刺激 / 接着分子 / Polymyositis / immunologicam mechanism / cytokines / interferon-gamma / ICAM-1 / 肺高血圧症 / 膠原病 / BMP / BMPレセプター / 自己抗体 / 肺動脈平滑筋 / Pulmonary Hypertension / Collagen-Vascular disease / BMP (bone morphogenetic protein) / BMP receptor / Autoantibodies / Pulmonary Artery Smooth Muscle Cells / エラスターゼ / 核内蛋白 / protease / ONO-5046 / mast cells Less

アレルギー性炎症監視機構におけるT‐betの役割の解明
- Principal Investigator
  
  中島裕史
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Role of IL/25 in the regulation of allergic airway inflammationPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Itsuo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  CHIBA UNIVERSITY
Characterization of Stat6 protease and Stat5 protease
- Principal Investigator
  
  NAKAJIMA Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Chiba University
レトロウイルス発現法を用いたアレルギー性気道炎症の抗原特異的制御
- Principal Investigator
  
  中川典明
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba University
Role of anti-BMP receptor antibodies in the development of pulmonary hypertension
- Principal Investigator
  
  KURASAWA Kazuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba University
Stat5aにより発現誘導されるTh2細胞分化誘導因子の単離
- Principal Investigator
  
  中島裕史
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
肥満細胞特異的Stat6アイソフォームの発現制御機構とその機能解析
- Principal Investigator
  
  中島裕史
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  内科学一般
- Research Institution
  Chiba University
Molecular Mechanism underlying Eosinophil Differentiation in Bronchial AsthmaPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Itsuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba University
Th2細胞分化におけるStat5aの役割
- Principal Investigator
  
  NAKAJIMA Hiroshi
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Identification and characterization of activated genes of eosinophils in asthmaPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Itsuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba University
Role of interferon-gamma in development of myositis : generation and analysis of murine myositis by DNA vaccination
- Principal Investigator
  
  KURASAWA Kazuhiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Chiba University
Role of Valpha24JalphaQ TCR T Cells in the Pathogenesis of AsthmaPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Itsuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba University Scool of Medicine
Mechanism of T cell activation in the airways of asthmaPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Itsuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba University
アレルゲン特異的CD4陽性T細胞クロ-ンの選択的サイトカイン産生Principal Investigator
- Principal Investigator
  
  岩本逸夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Chiba University
Activation and differentiation of eosinophils in asthmaPrincipal Investigator
- Principal Investigator
  
  KOIKE Takao, 岩本逸夫, TOMIOKA Hisao
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba University

All 2005 2004 2003 2002 Other

All Journal Article

[Journal Article] Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.2005
- Author(s)
  Nakajima H, Takatori H, Kubo M, Yoshimura A, Iwamoto I.
- Journal Title
  
  J.Immunol (In press)
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.2005
- Author(s)
  Nakajima H, Takatori H, Kagami S-i, Hirose K, Suto A, Suzuki K, Kubo M, Yoshimura A, Saito Y, Iwamoto I.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 4105-4112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Stat5 inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.2005
- Author(s)
  Nakajima H, Takatori H, Kubo M, Yoshimura A, Iwamoto I.
- Journal Title
  
  J.Immunol (In press)
- Data Source
  KAKENHI-PROJECT-16043212
[Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005
- Author(s)
  Takatori H, Nakajima H, Suto A, Saito Y, Iwamoto I. et al.
- Journal Title
  
  J.Immunol. (In press)
- Data Source
  KAKENHI-PROJECT-16043212
[Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005
- Author(s)
  Takatori H, Nakajima H, Suto A, Saito Y, Iwamoto I.
- Journal Title
  
  J.Immunol. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.2005
- Author(s)
  Nakajima H, Takatori H, Kubo M, Yoshimura A, Iwamoto I.
- Journal Title
  
  J.Immunol (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005
- Author(s)
  Takatori H, Nakajima H, Hirose K, Kagami S-i, Tamachi T, Suto A, Suzuki K, Saito Y, Iwamoto I.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 3734-3740
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005
- Author(s)
  Takatori H, Nakajima H, Suto A, Saito Y, Iwamoto I.
- Journal Title
  
  J.Immunol (In press)
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Stat5a inhibits IL-12-induced cell differentiation through the induction of SOCS3 expression.2005
- Author(s)
  Nakajima H, Takatori H, Kubo M, Yoshimura A, Iwamoto I.
- Journal Title
  
  J.Immunol (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005
- Author(s)
  Takatori H, Nakajima H, Suto A, Saito Y, Iwamoto I.
- Journal Title
  
  J.Immunol. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Tyk2 is essential for IFN-α-induced gene expression in mast cells.2004
- Author(s)
  Mori Y, Hirose K, Nakajima H, Iwamoto I, et al.
- Journal Title
  
  Int.Arch.Allergy Immunol. 134
  
  Pages: 25-29
- Data Source
  KAKENHI-PROJECT-16043212
[Journal Article] Tyk2 is essential for IFN-α-induced gene expression in mast cells.2004
- Author(s)
  Mori Y, Hirose K, Suzuki K, Nakajima H, Seto Y, Ikeda K, Shimoda K, Nakayama K, Saito Y, Iwamoto I.
- Journal Title
  
  Int.Arch.Allergy Immunol. 134
  
  Pages: 25-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways.2004
- Author(s)
  Maezawa Y, Nakajima H, Seto Y, Suto A, Iwamoto I.
- Journal Title
  
  Clin.Exp.Immunol. 135
  
  Pages: 12-18
- Data Source
  KAKENHI-PROJECT-16043212
[Journal Article] IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways2004
- Author(s)
  Maezawa Y, Nakajima H, Seto Y, Suto A, Kumano K, Kubo S, Karasuyama H, Saito Y, Iwamoto I.
- Journal Title
  
  Clin.Exp.Immunol. 135
  
  Pages: 12-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-α production in mast cells.2003
- Author(s)
  Suzuki K, Nakajima H, Ikeda K, Maezawa Y, Suto A, Takatori H, Saito Y, Iwamoto I.
- Journal Title
  
  J.Exp.Med. 198
  
  Pages: 1717-1727
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] A lineage-specific negative regulation of STAT-mediated signaling by proteolytic processing.2003
- Author(s)
  Nakajima H, Suzuki K, Iwamoto I.
- Journal Title
  
  Cytokine Growth Factor Rev. 14
  
  Pages: 375-380
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor, ONO-5046.2003
- Author(s)
  Suzuki K, Nakajima H, Ikeda K, Tamachi T, Hiwasa T, Saito Y, Iwamoto I.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 309
  
  Pages: 768-773
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Mast cells produce Interleukin-25 upon FcεRI-mediated activation.2003
- Author(s)
  Ikeda K, Nakajima H, Suzuki K, Kagami S-i, Hirose K, Suto A, Saito Y, Iwamoto I.
- Journal Title
  
  Blood 101
  
  Pages: 3594-3596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] IL-4-Stat6 signaling induces trsitetraprolin expression and inhibits TNF-α production in mast cells.2003
- Author(s)
  Suzuki K, Nakajima H, Takatori H, Saito Y, Iwamoto I.
- Journal Title
  
  J.Exp.Med. 198
  
  Pages: 1717-1727
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Stat6-protease but not Stat5-protease is inhibited by an elastate inhibitor, ONO-5046.2003
- Author(s)
  Suzuki K, Nakajima H, Saito Y, Iwamoto I.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 309
  
  Pages: 768-773
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-α production in mast cells.2003
- Author(s)
  Suzuki K, Nakajima H, Ikeda K, Maezawa Y, Suto A, Takatori H, Saito Y, Iwamoto I.
- Journal Title
  
  J.Exp.Med. 198
  
  Pages: 1717-1727
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Mast cells produce Interleukin-25 upon FcεRI-mediated activation2003
- Author(s)
  Ikeda K, Nakajima H, Suzuki K, Suto A, Saito Y, Iwamoto I.
- Journal Title
  
  Blood 100
  
  Pages: 3594-3596
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.2003
- Author(s)
  Seto Y, Nakajima H, Suto A, Shimoda K, Saito Y, Nakayama KI, Iwamoto I.
- Journal Title
  
  J.Immunol. 170
  
  Pages: 1077-1083
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.2003
- Author(s)
  Seto Y, Nakajima H, Suto A, Nakayama KI, Iwamoto I.
- Journal Title
  
  J.Immunol. 170
  
  Pages: 1077-1083
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Mast cells produce Interleukin-25 upon FcεRI-mediated activation2003
- Author(s)
  Ikeda K, Nakajima H, Suzuki K, Suto A, Saito Y, Iwamoto I.
- Journal Title
  
  Blood 100
  
  Pages: 3594-3596
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor, ONO-5046.2003
- Author(s)
  Suzuki K, Nakajima H, Ikeda K, Tamachi T, Hiwasa T, Saito Y, Iwamoto I.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 309
  
  Pages: 768-773
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] A lineage-specific negative regulation of STAT-mediated signaling by proteolytic processing.2003
- Author(s)
  Nakajima H, Suzuki K, Iwamoto I.
- Journal Title
  
  Cytokine Growth Factor Rev. 14
  
  Pages: 375-380
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Mast cells produce Interleukin-25 upon FcεRI-mediated activation.2003
- Author(s)
  Ikeda K, Nakajima H, Suzuki K, Kagami S-i, Hirose K, Suto A, Saito Y, Iwamoto I.
- Journal Title
  
  Blood 101
  
  Pages: 3594-3596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-α production in mast cells.2003
- Author(s)
  Suzuki K, Nakajima H, Takatori H, Saito Y, Iwamoto I.
- Journal Title
  
  J.Exp.Med. 198
  
  Pages: 1717-1727
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591046
[Journal Article] Role of IgE in Th2 cell-induced allergic inflammation in the airways.2003
- Author(s)
  Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H, Iwamoto I.
- Journal Title
  
  Int.Arch.Allergy Immunol. 131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Proteolytic processing of Stat6 signaling in mast cells as a negative-regulatory mechanism.2002
- Author(s)
  Nakajima H, Suzuki K, Kagami S-i, Suto A, Ikeda K, Hirose K, Hiwasa T, Takeda K, Saito Y, Akira S, Iwamoto I.
- Journal Title
  
  J.Exp.Med. 196
  
  Pages: 27-38
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.
- Author(s)
  Takatori H, Nakajima H, Hirose K, Kagami S-i, Tamachi T, Suto A, Suzuki K, Saito Y, Iwamoto I.
- Journal Title
  
  J.Immunol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Stat5a is essential for the proliferation and survival of murine mast cells.
- Author(s)
  Ikeda K., Nakajima H, Suzuki K, Watanabe N, Kagami S-i, Iwamoto I.
- Journal Title
  
  Int.Arch.Allergy Immunol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797
[Journal Article] Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.
- Author(s)
  Nakajima H, Takatori H, Kagami S-i, Hirose K, Suto A, Suzuki K, Kubo M, Yoshimura A, Saito Y, Iwamoto I.
- Journal Title
  
  J.Immunol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590797

1. NAKAJIMA Hiroshi (00322024)

# of Collaborated Projects: 8 results

# of Collaborated Products: 34 results
2. KURASAWA Kazuhiro (30282479)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TOMIOKA Hisao (20009632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KOIKE Takao (80146795)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKABAYASHI Katsumi (90188079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 縄田泰史 (60228103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中川典明 (50302542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IWAMOTO Itsuo 岩本 逸夫

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Role of IL/25 in the regulation of allergic airway inflammationPrincipal Investigator

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Molecular Mechanism underlying Eosinophil Differentiation in Bronchial AsthmaPrincipal Investigator

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Identification and characterization of activated genes of eosinophils in asthmaPrincipal Investigator

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Role of Valpha24JalphaQ TCR T Cells in the Pathogenesis of AsthmaPrincipal Investigator

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Mechanism of T cell activation in the airways of asthmaPrincipal Investigator

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アレルゲン特異的CD4陽性T細胞クロ-ンの選択的サイトカイン産生Principal Investigator

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IWAMOTO Itsuo 岩本逸夫