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IWAMOTO Itsuo  岩本 逸夫

ORCIDConnect your ORCID iD *help
Researcher Number 10111436
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2001 – 2004: 千葉大学, 大学院・医学研究院, 助教授
1996 – 2000: Chiba University School of Medicine, Associate Professor, 医学部, 助教授
1995: 千葉大学, 医学部, 講師
1989 – 1991: 千葉大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine / Respiratory organ internal medicine / 内科学一般
Except Principal Investigator
Respiratory organ internal medicine / Biological Sciences / 内科学一般 / 膠原病・アレルギー・感染症内科学
Keywords
Principal Investigator
気管支喘息 / Eosinophils / 好酸球 / IL-25 / IL-5 / Stat 5 / RDA / アレルギー性炎症 / Th2 cells / Asthma … More / IL-17 / Mast cells / Th2細胞 / アレルギー性気道炎症 / 肥満細胞 / transcription factor / bronchial asthma / retrovirus-mediated expression cloning / One hybrid screening / IL-5 receptor α chain / レトロウイルス / one-hybridスクリーニング / 発現制御 / プロモーター / IL-5レセプター / 転写因子 / レトロウイルス発現クローニング / one hybrid法 / IL-5Rα鎖 / Knockout mouse / Allergic intlammation / DNAマイクロアレイ / SAGE / Stat5 / 遺伝子欠損マウス / IFN-gamma / NK T cells / Valpha24JalphaQ TCR / 免疫制御 / TCR / Th2タイプ免疫応答 / IFN-γ / T細胞レセプター / NK T細胞 / Vα24JαQ T細胞 / Antigen stimulation / Nonatopic asthma / TCR Vbeta gene / T cell receptor / Bronchial asthma / 核酸塩基配列 / T細胞活性化 / T細胞抗原レセプター遺伝子 / 抗原刺激 / 非アトピー型喘息 / TCR Vβ遺伝子 / T細胞レセプター(TCR) / インタ-ロイキン5 / サイトカイン / T細胞クロ-ン / アレルゲン … More
Except Principal Investigator
気管支喘息 / Stat6 / アレルギー性炎症 / レトロウイルス / elastase / Stat5 / DNA vaccination / サイトカイン / 核局在 / 蛋白分解酵素 / 肥満細胞 / 組織好酸球浸潤 / Th2細胞 / Stat5a / mast cells / ONO-5046 / protease / 核内蛋白 / エラスターゼ / Pulmonary Artery Smooth Muscle Cells / Autoantibodies / BMP receptor / BMP (bone morphogenetic protein) / Collagen-Vascular disease / Pulmonary Hypertension / 肺動脈平滑筋 / 自己抗体 / BMPレセプター / BMP / 膠原病 / 肺高血圧症 / ICAM-1 / interferon-gamma / cytokines / immunologicam mechanism / Polymyositis / 接着分子 / 副刺激 / Interferen-γ / Interferon-γ / サイトカイソ / 免疫機構 / 多発筋炎 / Eosinophilia / Substance P / Cytokine / Anti-eosinophil antibody / Eosinophil / Bronchial asthma / 抗好酸球抗体 / 低親和性IgEレセプタ- / ヒト好酸球 / 神経ペプチド / 抗アレルギ-薬 / 化学伝達物質 / ロイコトリエン / 好酸球増多症 / サブスタンスP / 抗好酸球モノクロ-ナル抗体 / 好酸球 / 樹状細胞 / Th2バランス / Th1 / T-bet / 抗原特異的T細胞 / 気道好酸球浸潤 / レトロウイルス発現法 / IL-13E13K / II型IL-4レセプター / 細胞死抑制 / 蛋白分解 / Stat5切断酵素 / セリンプロテアーゼ / 65kDa Stat6 / Stat6切断酵素 / CD25陽性免疫制御性細胞 / レトロウイルス発現クローニング / CD25陽性免疫制御性T細胞 / Th2細胞分化 / IL-5 Less
  • Research Projects

    (15 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (7 People)
  •  アレルギー性炎症監視機構におけるT‐betの役割の解明

    • Principal Investigator
      中島 裕史
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  Role of IL/25 in the regulation of allergic airway inflammationPrincipal Investigator

    • Principal Investigator
      IWAMOTO Itsuo
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      CHIBA UNIVERSITY
  •  Characterization of Stat6 protease and Stat5 protease

    • Principal Investigator
      NAKAJIMA Hiroshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Chiba University
  •  レトロウイルス発現法を用いたアレルギー性気道炎症の抗原特異的制御

    • Principal Investigator
      中川 典明
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Chiba University
  •  Role of anti-BMP receptor antibodies in the development of pulmonary hypertension

    • Principal Investigator
      KURASAWA Kazuhiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Chiba University
  •  Stat5aにより発現誘導されるTh2細胞分化誘導因子の単離

    • Principal Investigator
      中島 裕史
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  肥満細胞特異的Stat6アイソフォームの発現制御機構とその機能解析

    • Principal Investigator
      中島 裕史
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      内科学一般
    • Research Institution
      Chiba University
  •  Molecular Mechanism underlying Eosinophil Differentiation in Bronchial AsthmaPrincipal Investigator

    • Principal Investigator
      IWAMOTO Itsuo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Chiba University
  •  Th2細胞分化におけるStat5aの役割

    • Principal Investigator
      NAKAJIMA Hiroshi
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  Identification and characterization of activated genes of eosinophils in asthmaPrincipal Investigator

    • Principal Investigator
      IWAMOTO Itsuo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Chiba University
  •  Role of interferon-gamma in development of myositis : generation and analysis of murine myositis by DNA vaccination

    • Principal Investigator
      KURASAWA Kazuhiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Chiba University
  •  Role of Valpha24JalphaQ TCR T Cells in the Pathogenesis of AsthmaPrincipal Investigator

    • Principal Investigator
      IWAMOTO Itsuo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Chiba University Scool of Medicine
  •  Mechanism of T cell activation in the airways of asthmaPrincipal Investigator

    • Principal Investigator
      IWAMOTO Itsuo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Chiba University
  •  アレルゲン特異的CD4陽性T細胞クロ-ンの選択的サイトカイン産生Principal Investigator

    • Principal Investigator
      岩本 逸夫
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Chiba University
  •  Activation and differentiation of eosinophils in asthmaPrincipal Investigator

    • Principal Investigator
      KOIKE Takao, 岩本 逸夫, TOMIOKA Hisao
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Chiba University

All 2005 2004 2003 2002 Other

All Journal Article

  • [Journal Article] Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.2005

    • Author(s)
      Nakajima H, Takatori H, Kubo M, Yoshimura A, Iwamoto I.
    • Journal Title

      J.Immunol (In press)

    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.2005

    • Author(s)
      Nakajima H, Takatori H, Kagami S-i, Hirose K, Suto A, Suzuki K, Kubo M, Yoshimura A, Saito Y, Iwamoto I.
    • Journal Title

      J.Immunol. 174

      Pages: 4105-4112

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Stat5 inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.2005

    • Author(s)
      Nakajima H, Takatori H, Kubo M, Yoshimura A, Iwamoto I.
    • Journal Title

      J.Immunol (In press)

    • Data Source
      KAKENHI-PROJECT-16043212
  • [Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005

    • Author(s)
      Takatori H, Nakajima H, Suto A, Saito Y, Iwamoto I. et al.
    • Journal Title

      J.Immunol. (In press)

    • Data Source
      KAKENHI-PROJECT-16043212
  • [Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005

    • Author(s)
      Takatori H, Nakajima H, Suto A, Saito Y, Iwamoto I.
    • Journal Title

      J.Immunol. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.2005

    • Author(s)
      Nakajima H, Takatori H, Kubo M, Yoshimura A, Iwamoto I.
    • Journal Title

      J.Immunol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005

    • Author(s)
      Takatori H, Nakajima H, Hirose K, Kagami S-i, Tamachi T, Suto A, Suzuki K, Saito Y, Iwamoto I.
    • Journal Title

      J.Immunol. 174

      Pages: 3734-3740

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005

    • Author(s)
      Takatori H, Nakajima H, Suto A, Saito Y, Iwamoto I.
    • Journal Title

      J.Immunol (In press)

    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Stat5a inhibits IL-12-induced cell differentiation through the induction of SOCS3 expression.2005

    • Author(s)
      Nakajima H, Takatori H, Kubo M, Yoshimura A, Iwamoto I.
    • Journal Title

      J.Immunol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.2005

    • Author(s)
      Takatori H, Nakajima H, Suto A, Saito Y, Iwamoto I.
    • Journal Title

      J.Immunol. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Tyk2 is essential for IFN-α-induced gene expression in mast cells.2004

    • Author(s)
      Mori Y, Hirose K, Nakajima H, Iwamoto I, et al.
    • Journal Title

      Int.Arch.Allergy Immunol. 134

      Pages: 25-29

    • Data Source
      KAKENHI-PROJECT-16043212
  • [Journal Article] Tyk2 is essential for IFN-α-induced gene expression in mast cells.2004

    • Author(s)
      Mori Y, Hirose K, Suzuki K, Nakajima H, Seto Y, Ikeda K, Shimoda K, Nakayama K, Saito Y, Iwamoto I.
    • Journal Title

      Int.Arch.Allergy Immunol. 134

      Pages: 25-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways.2004

    • Author(s)
      Maezawa Y, Nakajima H, Seto Y, Suto A, Iwamoto I.
    • Journal Title

      Clin.Exp.Immunol. 135

      Pages: 12-18

    • Data Source
      KAKENHI-PROJECT-16043212
  • [Journal Article] IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways2004

    • Author(s)
      Maezawa Y, Nakajima H, Seto Y, Suto A, Kumano K, Kubo S, Karasuyama H, Saito Y, Iwamoto I.
    • Journal Title

      Clin.Exp.Immunol. 135

      Pages: 12-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-α production in mast cells.2003

    • Author(s)
      Suzuki K, Nakajima H, Ikeda K, Maezawa Y, Suto A, Takatori H, Saito Y, Iwamoto I.
    • Journal Title

      J.Exp.Med. 198

      Pages: 1717-1727

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] A lineage-specific negative regulation of STAT-mediated signaling by proteolytic processing.2003

    • Author(s)
      Nakajima H, Suzuki K, Iwamoto I.
    • Journal Title

      Cytokine Growth Factor Rev. 14

      Pages: 375-380

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor, ONO-5046.2003

    • Author(s)
      Suzuki K, Nakajima H, Ikeda K, Tamachi T, Hiwasa T, Saito Y, Iwamoto I.
    • Journal Title

      Biochem.Biophys.Res.Commun. 309

      Pages: 768-773

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Mast cells produce Interleukin-25 upon FcεRI-mediated activation.2003

    • Author(s)
      Ikeda K, Nakajima H, Suzuki K, Kagami S-i, Hirose K, Suto A, Saito Y, Iwamoto I.
    • Journal Title

      Blood 101

      Pages: 3594-3596

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] IL-4-Stat6 signaling induces trsitetraprolin expression and inhibits TNF-α production in mast cells.2003

    • Author(s)
      Suzuki K, Nakajima H, Takatori H, Saito Y, Iwamoto I.
    • Journal Title

      J.Exp.Med. 198

      Pages: 1717-1727

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Stat6-protease but not Stat5-protease is inhibited by an elastate inhibitor, ONO-5046.2003

    • Author(s)
      Suzuki K, Nakajima H, Saito Y, Iwamoto I.
    • Journal Title

      Biochem.Biophys.Res.Commun. 309

      Pages: 768-773

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-α production in mast cells.2003

    • Author(s)
      Suzuki K, Nakajima H, Ikeda K, Maezawa Y, Suto A, Takatori H, Saito Y, Iwamoto I.
    • Journal Title

      J.Exp.Med. 198

      Pages: 1717-1727

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Mast cells produce Interleukin-25 upon FcεRI-mediated activation2003

    • Author(s)
      Ikeda K, Nakajima H, Suzuki K, Suto A, Saito Y, Iwamoto I.
    • Journal Title

      Blood 100

      Pages: 3594-3596

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.2003

    • Author(s)
      Seto Y, Nakajima H, Suto A, Shimoda K, Saito Y, Nakayama KI, Iwamoto I.
    • Journal Title

      J.Immunol. 170

      Pages: 1077-1083

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.2003

    • Author(s)
      Seto Y, Nakajima H, Suto A, Nakayama KI, Iwamoto I.
    • Journal Title

      J.Immunol. 170

      Pages: 1077-1083

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Mast cells produce Interleukin-25 upon FcεRI-mediated activation2003

    • Author(s)
      Ikeda K, Nakajima H, Suzuki K, Suto A, Saito Y, Iwamoto I.
    • Journal Title

      Blood 100

      Pages: 3594-3596

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor, ONO-5046.2003

    • Author(s)
      Suzuki K, Nakajima H, Ikeda K, Tamachi T, Hiwasa T, Saito Y, Iwamoto I.
    • Journal Title

      Biochem.Biophys.Res.Commun. 309

      Pages: 768-773

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] A lineage-specific negative regulation of STAT-mediated signaling by proteolytic processing.2003

    • Author(s)
      Nakajima H, Suzuki K, Iwamoto I.
    • Journal Title

      Cytokine Growth Factor Rev. 14

      Pages: 375-380

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Mast cells produce Interleukin-25 upon FcεRI-mediated activation.2003

    • Author(s)
      Ikeda K, Nakajima H, Suzuki K, Kagami S-i, Hirose K, Suto A, Saito Y, Iwamoto I.
    • Journal Title

      Blood 101

      Pages: 3594-3596

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-α production in mast cells.2003

    • Author(s)
      Suzuki K, Nakajima H, Takatori H, Saito Y, Iwamoto I.
    • Journal Title

      J.Exp.Med. 198

      Pages: 1717-1727

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591046
  • [Journal Article] Role of IgE in Th2 cell-induced allergic inflammation in the airways.2003

    • Author(s)
      Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H, Iwamoto I.
    • Journal Title

      Int.Arch.Allergy Immunol. 131

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Proteolytic processing of Stat6 signaling in mast cells as a negative-regulatory mechanism.2002

    • Author(s)
      Nakajima H, Suzuki K, Kagami S-i, Suto A, Ikeda K, Hirose K, Hiwasa T, Takeda K, Saito Y, Akira S, Iwamoto I.
    • Journal Title

      J.Exp.Med. 196

      Pages: 27-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation.

    • Author(s)
      Takatori H, Nakajima H, Hirose K, Kagami S-i, Tamachi T, Suto A, Suzuki K, Saito Y, Iwamoto I.
    • Journal Title

      J.Immunol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Stat5a is essential for the proliferation and survival of murine mast cells.

    • Author(s)
      Ikeda K., Nakajima H, Suzuki K, Watanabe N, Kagami S-i, Iwamoto I.
    • Journal Title

      Int.Arch.Allergy Immunol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • [Journal Article] Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression.

    • Author(s)
      Nakajima H, Takatori H, Kagami S-i, Hirose K, Suto A, Suzuki K, Kubo M, Yoshimura A, Saito Y, Iwamoto I.
    • Journal Title

      J.Immunol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590797
  • 1.  NAKAJIMA Hiroshi (00322024)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 34 results
  • 2.  KURASAWA Kazuhiro (30282479)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  TOMIOKA Hisao (20009632)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KOIKE Takao (80146795)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TAKABAYASHI Katsumi (90188079)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  縄田 泰史 (60228103)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  中川 典明 (50302542)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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