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ONJI Morikazu  恩地 森一

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OHJI Morikazu  恩地 森一

ONJI MORIKAZU  恩地 森一

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Researcher Number 10112260
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2006: Ehime University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授
2006: 愛媛大学, 大学院医学系研究科, 教授
2003 – 2005: 愛媛大学, 医学部, 教授
1998 – 2001: 愛媛大学, 医学部, 教授
1999: Third Department of Internal Medicine School of Medicine, Ehime University, Professor, 医学部・第三内科, 教授 … More
1994 – 1996: Ehime University, the department of Medicine, professor, 医学部, 教授
1990 – 1993: 愛媛大学, 医学部・附属病院, 講師
1992: Ehime Univ. University Hospital, Assistant Professor., 医学部附属病院, 講師
1989: 愛媛大学, 医学部付属病院, 講師
1988 – 1989: 愛媛大学, 医学部附属病院, 講師
1988: 愛媛大学, 医学部, 講師
1986: EHIME UNIVERSITY, LECTURER, 医学部附属病院, 講師 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology
Except Principal Investigator
Gastroenterology
Keywords
Principal Investigator
樹状細胞 / B型肝炎ウイルス / MHC class II / B型肝炎ウィルス / BAFF / H-2K / I-A / allogenic MLR / HCV / リンパ性樹状細胞 … More / トランスジェニックマウス / トランスフェクション / インターフェロン感受性 / Humoral immunity / Antigen-pulsed DC / Antibody to HBsAg / Hepatitis B surface antigen / Dendritic cells / ウイルス / 免疫学 / 液性免疫 / 抗原パルスDC / HBs抗体 / HBs抗原 / Dendritic cell / Vaccine / Hepatitis B Virus / ワクチン / B型肝炎 / immune therapy / dendritic cells / hepatocellular carcinoma / CTL / 免疫療法 / 肝細胞癌 / Hepatitis B virus / Transgenic mice / Vaccine therapy / Dendric cells / ワクチン治療 / ワクチン療法 / Adenovirus vector / Lymphoid dendritic cells / Lac Z遺伝子 / C型肝炎 ウイルス / アデノウイルスベクター / r-IFN / Transgenic mouse / dendritic cell / HBV / γ-IFN / primary biliary cirrhosis / CD8 positive cell / senescent mice / 胆管障害機構 / 原発性胆汁性肝硬変モデル・動物 / 原発性胆汁性肝硬変 / CD8陽性細胞 / 老化マウス / 慢性肝炎 / 免疫異常 / 細胞障害性T細胞 / HBc抗原 / B型慢性肝炎 … More
Except Principal Investigator
Mutation / HBVDNA / B型慢性肝炎 / PGR(Polymerase chain reaction) / PCR法 / mutation / PCR / PCR(Polymerase chain reaction) / Chronic Hepatitis Type B / Prednisolone / Hepatitis B Virus DNA / HBV-DNAの肝細胞核内への組込み / ステロイド / B型肝炎ウイルスDNA / ウイルス変異 / 肝炎 Less
  • Research Projects

    (13 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (7 People)
  •  Characteristics features of immune producing dendritic cells : cross talk between dendritic cells. and B cellsPrincipal Investigator

    • Principal Investigator
      ONJI Morikazu
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  Study about mechanism of action of vaccine therapy and their antiviral potential: development of more potent and new regimen of vaccine therapyPrincipal Investigator

    • Principal Investigator
      ONJI Morikazu
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  Immunotherapy by dendritic cells against hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      ONJI Morikazu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  Role of dendritic cells during vaccine therapy in hepatitis B virus carriers.Principal Investigator

    • Principal Investigator
      OHJI Morikazu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  The Role of Lymphoid Dendritic Cells in Persistent Infection with HCVPrincipal Investigator

    • Principal Investigator
      ONJI Morikazu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The Third Department of Internal Medicine, Ehime University School of Medicine
  •  Analysis of mechanism on the suppression of the exprssion of MHC class III antigen in dendritic cells in HBV infection.Principal Investigator

    • Principal Investigator
      ONJI Morikazu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  亜小葉性肝壊死の発現機構に関する分子生物学的研究-C型とB型慢性肝炎の比較

    • Principal Investigator
      OHTA YASUYUKI
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  Mechanism of bile duct injury in autoimmune cholangitis in senescent micePrincipal Investigator

    • Principal Investigator
      ONJI Morikazu
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  樹状細胞の抗原呈示機能に及ぼすB型肝炎ウィルスの直接作用Principal Investigator

    • Principal Investigator
      恩地 森一
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  細胞障害性T細胞が認識するHBc抗原エピト-プの同定Principal Investigator

    • Principal Investigator
      恩地 森一
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  THE MOLECULAR BIOLOGICAL STUDY OF THE RELATIONSHIP BETWEEN THE ACTIVE STAGE OF CHRONIC HEPATITIS B AND THE MUTATION OF THE HEPATITIS B VIRUS

    • Principal Investigator
      OHTA Yasuyuki
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  感染細胞のインターフェロン感受性を抑制するB型肝炎ウイルス遺伝子亜領域の同定Principal Investigator

    • Principal Investigator
      恩地 森一
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Ehime University
  •  RELATIONSHIP BETWEEN PREDNISOLONE THERAPY AND OCCURRENCE OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC ACTIVE HEPATITIS TYPE B

    • Principal Investigator
      OHTA YASUYUKI
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      EHIME UNIVERSITY

All 2007 2006 2005 2004 Other

All Journal Article Book Patent

  • [Book] Dendritic Cells in Clinics2004

    • Author(s)
      Onji M
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Impaired dendritic cell function resulting from chronic undernutrition disrupt the antigen-specific immune response in mice.2007

    • Author(s)
      Niiya T, Akbar SM, Yoshida O, Miyake T, Matsuura B Murakami H, Abe M, Hiasa Y, Onji M.
    • Journal Title

      Journal of Nutrition 137

      Pages: 671-675

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Immune therapy including dendritic cell-based therapy in chronic hepatitis B virus infection.2006

    • Author(s)
      Akbar SM, Horiike N, Onji M
    • Journal Title

      World Journal of Gastroenterology 12

      Pages: 2876-2883

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Impaired dendritic cell function resulting from chronic undernutrition disrupts the antigen-specific immune response in mice.2006

    • Author(s)
      Niiya T, Akbar SM, Yoshida O, Miyake T, Matsuura B, Murakami H, Abe M, Hiasa Y, Onji M
    • Journal Title

      Journal of Nutrition 137

      Pages: 671-675

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Rationale for designing of antigen-specific immune therapy including dendritic cell-based therapy in patients with chronic hepatitis B virus infection.2006

    • Author(s)
      Akbar SM, Murakami H, Horiike N, Onji M.
    • Journal Title

      Anti-infective agents in Medicinal Chemistry 5

      Pages: 75-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Immune therapy including dendritic cell-based therapy in chronic hepatitis B virus infection.2006

    • Author(s)
      Akbar SM, Horiike N, Onji M.
    • Journal Title

      World Journal of Gastroenterology 12

      Pages: 2876-2883

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Dendritic cell-based therapy as a multidisciplinary approach to cancer treatment : present limitations and future scopes.2006

    • Author(s)
      Akbar SM, Abe M, Yoshida M, Murakami H, Onji M
    • Journal Title

      Current Medicinal Chemistry 13

      Pages: 3113-3119

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Zinc and hepatitis B virus vaccination.2006

    • Author(s)
      Abe M, Akbar SM, Onji M.
    • Journal Title

      Journal of Gastroenterology 35

      Pages: 1-2

    • NAID

      10020329491

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Rationale for Designing of Antigen-Specific Immune Therapy Including Dendritic Cell-Based Therapy in Patients with Chronic Hepatitis B Venus Infection.2006

    • Author(s)
      Akbar SMF, Murakami H, Horiike N, Onji M
    • Journal Title

      Anti-Infective Agents in Medicinal Chemistry 5

      Pages: 75-84

    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Zinc and hepatitis B virus vaccination.2006

    • Author(s)
      Abe M, Akbar SM, Onji M
    • Journal Title

      Journal of Gastroenterology 35

      Pages: 1-2

    • NAID

      10020329491

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Rationale for designing of antigen-specific immune therapy including dendritic cell-based therapy in patients with chronic hepatitis B virus infection.2006

    • Author(s)
      Akbar SM, Murakami H, Horiike N, Onji M
    • Journal Title

      Anti-infective agents in Medicinal Chemistry 5

      Pages: 75-86

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Dendritic cell-based therapy as a multidisciplinary : approach to cancer treatment : present limitation and future scopes.2006

    • Author(s)
      Akbar SM, Abe M, Yoshida M, Murakami H, Onji
    • Journal Title

      Current Medicinal Chemistry 13

      Pages: 3113-3119

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Administration of dendritic cells in cancer nodules in hepatocellular carcinoma.2005

    • Author(s)
      Kumagai T, SMF Akbar, Horiike N, Kurose K, Hirooka M, Hiraoka A, Hiasa Y, Michitaka K, Onji M
    • Journal Title

      Oncology Reports 14

      Pages: 969-973

    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Impaired functional capacities of liver dendritic cells from murine hepatitis B virus (HBV) carriers : relevance to low HBV-specific immune responses2005

    • Author(s)
      Hasebe A, Akbar SM, Furukawa S, Horiike N, Onji M.
    • Journal Title

      Clinical & Experimental Immunology 139(1)

      Pages: 35-42

    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Impaired functional capacities of liver dendritic cells from murine hepatitis B virus (HBV) carriers : relevance to low HBV-specific immune responses.2005

    • Author(s)
      Hasebe A, Akbar SM, Furukawa S, Horiike N, Onji M.
    • Journal Title

      Clinical & Experimental Immunology 139(1)

      Pages: 35-42

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] In vivo immunization by vaccine therapy following virus suppression by lamivudine : anovel approach for treating patients with chronic hepatitis B.2005

    • Author(s)
      Horiike N, Akbar SMF, Michitaka K, Joukou K, Yamamoto K, Kojima N, Hiasa Y, Abe M, Onji M
    • Journal Title

      Journal of Clinical Virology 32

      Pages: 156-161

    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Impaired functional capacities of liver dendritic cells from murine hepatitis B virus (HBV) carriers : relevance to low HBV-specific immune responses.2005

    • Author(s)
      Hasebe A, Akbar SM Furukawa S, Horiike N, Onji M
    • Journal Title

      Clinical Experimental of Immunology 139

      Pages: 35-42

    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Therapeutic efficacy of decreased nitrite production by bezafibrate in patients with primary biliary cirrhosis.2005

    • Author(s)
      Akbar SMF, Furukawa S, Nakanishi S, Abe M, Horiike N, Onji M
    • Journal Title

      Journal of Gastroenterology 40

      Pages: 157-163

    • NAID

      10014513631

    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] On dendritic cell-based therapy for cancers.2005

    • Author(s)
      Onji M, Akbar SMF
    • Journal Title

      Journal of Zhejiang University Science 68

      Pages: 1-3

    • Data Source
      KAKENHI-PROJECT-17590652
  • [Journal Article] Impaired functional capacities of liver dendritic cells from murine hepatitis B virus (HBV) carriers: relevance to low HBV-specific immune responses2005

    • Author(s)
      Hasebe A, Akbar SM, Furukawa S, Horiike N, Onji M
    • Journal Title

      Clin Exp Inmunol. 139 (1)

      Pages: 35-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Vaccine therapy for Hepatitis B virus carrier.2004

    • Author(s)
      Akbar SMF, Furukawa S, Horiike N, Onji M.
    • Journal Title

      Current rug Targets-Infectious Disorders. 4

      Pages: 93-101

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Safety and efficacy of hepatitis B surface antigen-pulsed dendritic cells in human volunteers2004

    • Author(s)
      Fazle Akbar SM, Furukawa S, Onji M
    • Journal Title

      Hepatology research 29(3)

      Pages: 136-141

    • NAID

      10018024509

    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Vaccine therapy for Hepatitis B virus carrier.2004

    • Author(s)
      Akbar SMF, Furukawa S, Horiike N, Onji M.
    • Journal Title

      Current rug Targets-Infectious Disorders, 4

      Pages: 93-101

    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Production of Hepatitis B surface antigen-pulsed dendritic cells for immunosuppressed murine hepatitis B virus carrier ; evaluation of immunogenicity of antigen-pulsed dendritic cells in vivo2004

    • Author(s)
      Furukawa S, Akbar SMF, Hasebe A, Horiike N, Onji M
    • Journal Title

      Immunobiology 209

      Pages: 551-557

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Induction and maintenance of anti-HBs in immunosuppressed murine hepatitis B virus carrier by a novel vaccination approach : implication during liver transplantation in hepatitis B virus-infected subjects2004

    • Author(s)
      Furukawa.S, Akbar SMF, Horiike N, Onji M.
    • Journal Title

      Journal of Gastroenterology 39(9)

      Pages: 851-858

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Induction and maintenance of anti-HBs in immunosuppressed murine hepatitis 3 virus carrier by a novel vaccination approach : implication during liver transplantation in hepatitis B virus-infected subjects2004

    • Author(s)
      Futhawa S, Alder SMG, Horiike N, Onji M
    • Journal Title

      Journal of Gastroeterology 39(9)

      Pages: 851-858

    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Safety and efficacy of hepatitis B virus antigen-pulse dendritic cells in human volunteers2004

    • Author(s)
      Akbar SMF, Furukawa S, Onji M, Murata Y, Niya T, Kanno S, Murakami, H, Horiike N
    • Journal Title

      Hepatology Research 29

      Pages: 136-141

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Production and efficacy of a dendritic cell-based therapeutic vaccine for murine hepatitis B virus2004

    • Author(s)
      Akbar SMF, Furukawa S, Hasebe A, Horiike N, Onji M
    • Journal Title

      Current Drug Targets-Inflammation-Allergy 3

      Pages: 305-310

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Dendritic cell-based therapies in the bench and the bedsides.2004

    • Author(s)
      Akbar SM, Murakami H, Horiike N, Onji M
    • Journal Title

      Cur Drug Tagets Intarm Alergy. 3(3)

      Pages: 305-310

    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Dendritic cell-based therapies in the bench and the bed sides2004

    • Author(s)
      Akbar SMF, Murakami H, Horiike N, Onji M
    • Journal Title

      Current Drug Targets-Inflammation-Allergy 3

      Pages: 305-310

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Production of hepatitis B surface antigen-pulsed dendritic cells from immunosuppressed murine hepatitis B virus carrier : evaluation of immunogenicity of antigen-pulsed dendritic cells in vivo2004

    • Author(s)
      Furukawa.S, Akbar SMF, Horiike N, Onji M.
    • Journal Title

      Immunobiology 209(7)

      Pages: 551-557

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Safely and efficacy of hepatitis B surface antigen-pulsed dendritic cells in human volunteers.2004

    • Author(s)
      Fazle Akbar SM, Furukawa S, Onji M
    • Journal Title

      Hepatology research 29(3)

      Pages: 136-141

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Induction and maintenance of anti-HBs in immunosuppressed murine hepatitis B virus carrier by a novel vaccination approach : implication during liver transplantation in hepatitis B virus-infected subjects2004

    • Author(s)
      Furukawa S, Akbar SMF, Hasebe A, Horiike N, Onji M
    • Journal Title

      Journal of Gastroenterology 39

      Pages: 851-858

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Vaccine therapy for Hepatitis B virus carrier2004

    • Author(s)
      Akbar SMF, Furukawa S, Horiike N, Onji M
    • Journal Title

      Current rug Targets-Infectious Disorders 4

      Pages: 93-101

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Journal Article] Induction of anti-HBs in HB vaccine nonresponders in vivo by hepatitis B surface antigen-pulsed blood dendritic cells.

    • Author(s)
      Akbar SM, Furukawa S, Yoshida, Hiasa Y, Horiike N, Onji M
    • Journal Title

      Journal of Hepatology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590652
  • [Patent] 樹状細胞を用いたHBs抗体産生法2004

    • Inventor(s)
      恩地 森一, ファズレ アクバル
    • Industrial Property Rights Holder
      恩地 森一, ファズレ アクバル
    • Filing Date
      2004-04-06
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590655
  • [Patent] 樹状細胞を用いたHBs抗体産生法2004

    • Inventor(s)
      恩地 森一, ファズレアクバル
    • Industrial Property Rights Holder
      恩地 森一, ファズレアクバル
    • Filing Date
      2004-04-06
    • Data Source
      KAKENHI-PROJECT-15590655
  • 1.  OHTA YASUYUKI (40033055)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  HORIIKE NORIO (90173624)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  MASUMOTO Toshikazu (40243779)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  AKBAR S. m. f. (60190633)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  SMF アクバル (90294793)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  HIASA Yoichi (70314961)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MICHITAKA Kojiro (50209798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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