Hirama Masahiro 平間正博

… Alternative Names

HIRAMA Masahirohi 平間正博

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Researcher Number	10142077
Affiliation (Current)	2025: 大阪公立大学, 大学院理学研究科 , 客員教授
Affiliation (based on the past Project Information) *help	2012 – 2013: 東北大学, 理学(系)研究科(研究院), 名誉教授 2008 – 2011: Tohoku University, 大学院・理学研究科, 教授 2010: 東北大学, 大学院・理研究科, 教授
Review Section/Research Field	Principal Investigator Living organism molecular science / Chemistry / Science and Engineering
Keywords	Principal Investigator ナトリウムチャネル / イムノアッセイ / 抗体 / シガテラ / シガトキシン / 全合成 / 毒素 / 化学合成 / 中毒予防 / アトロプ異性 … More / 還元的脱離反応 / 51-HydroxyCTX3C / カリブ海産シガトキシンC-CTX / サマリウムアイオダイド / C-1027クロモフォア / マデュロペプチン / ケダルシジン / ELISAキット / ヒト型抗体 / ハプテン / 抗シガトキシン抗体 / シガトキシンCTX1B / エンジイン抗生物質 / チャネル結合部位 / Naチャネル / クロモフォア / C1027 / エンジイン / チャネル / ELISA / モノクローナル抗体 Less

TOTAL SYNTHESES AND BASIC RESEARCHES OF CIGUATOXIN CONGENERS, AND THEIR APPLICATIONSPrincipal Investigator
- Principal Investigator
  
  HIRAMA MASAHIRO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Tohoku University
Chemical Syntheses of Natural and Designed Molecules : Innovative Research on Their New Functions, Antibodies and ReceptorsPrincipal Investigator
- Principal Investigator
  
  HIRAMA Masahirohi, 平間正博
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
  Chemistry
- Research Institution
  Tohoku University

All 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book Patent

[Book] 天然物合成で活躍した反応-実験のコツとポイント2011
- Author(s)
  山下修治, 平間正博, 化学同人
- Publisher
  有機合成化学協会編
- Data Source
  KAKENHI-PROJECT-23310146
[Book] 天然物合成で活躍した反応-実験のコツとポイント、Ni触媒を用いたクロスカップリング、有機合成化学協会編2011
- Author(s)
  山下修治、平間正博
- Total Pages
  4
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23310146
[Book] Ni触媒を用いたクロスカップリング、Ireland-Claisen転移,天然物合成で活躍した反応-実験のコツとポイント(有機合成化学協会編)2011
- Author(s)
  山下修治, 平間正博
- Total Pages
  4
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 東北大学理学研究科附属巨大分子解析研究センター年報「(-)-マデュロペプチンクロモフォアの全合成と構造改訂」2010
- Author(s)
  駒野和雄、島村賢、法月祐太朗、趙冬林、甲千寿子、佐藤格、平間正博
- Publisher
  東北大学理学研究科附属巨大分子解析研究センター
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 20周年記念万有福岡シンポジウム要旨集「シガテラ中毒への化学の挑戦」2010
- Author(s)
  平間正博
- Publisher
  万有福岡シンポジウム組織委員会
- Data Source
  KAKENHI-PROJECT-19001003
[Book] Ni触媒を用いたクロスカップリング、Ireland-Claisen転移2010
- Author(s)
  山下修治、平間正博
- Publisher
  天然物合成で活躍した反応-実験のコツとポイント、有機合成化学協会編、化学同人
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 天然物の全合成2000-2008(日本)2009
- Author(s)
  平間正博
- Total Pages
  10
- Publisher
  化学同人(2009)
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 天然物全合成の最新動向2009
- Author(s)
  井上将行、佐藤隆章、平間正博
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19001003
[Book] シガトキシン、ピナトキシン、マデュロペプチンクロモフォアアグリコンの全合成天然物の全合成,2000-2008(日本)(有機合成化学協会編)2009
- Author(s)
  平間正博
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 東北大学理学部研究科附属巨大分子解析研究センター年報2008
- Author(s)
  佐藤格、法月祐太朗、駒野和雄平間正博
- Total Pages
  3
- Publisher
  巨大分子解析研究センター
- Data Source
  KAKENHI-PROJECT-19001003
[Book] SORSTジョイントシンポジウム(8)要旨集2008
- Author(s)
  平間正博
- Total Pages
  3
- Publisher
  JST
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Solvent-mediated Tuning of the Regioselectivity of Intramolecular Diaryl Ether Formation : Total Synthesis of (+)-Aspercyclide C2014
- Author(s)
  吉野達也, 山下修治,佐藤格, 林雄二郎, 平間正博
- Journal Title
  
  Chem. Lett
  
  Volume: 43巻 Issue: 3 Pages: 349-351
- DOI
  10.1246/cl.131045
- NAID
  130004868021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146, KAKENHI-PROJECT-24590003
[Journal Article] Preparation of Anti-Ciguatoxin Monoclonal Antibodies Using Synthetic Haptens : Sandwich ELISA Detection of Ciguatoxins2014
- Author(s)
  円谷健, 藤井郁雄, 平間正博
- Journal Title
  
  Journal of AOAC International
  
  Volume: 97巻 Issue: 2 Pages: 373-379
- DOI
  10.5740/jaoacint.sgetsumuraya
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23310146, KAKENHI-PROJECT-23550196, KAKENHI-PROJECT-25242068, KAKENHI-PROJECT-26410184
[Journal Article] Concise Synthesis of the Tetracyclic Framework of Azadiradione: Tandem Radical Cyclization Route2013
- Author(s)
  山下修治, 成子朗人, 林雄二郎, 平間正博
- Journal Title
  
  Chem. Lett.
  
  Volume: 42 Issue: 3 Pages: 220-221
- DOI
  10.1246/cl.2013.220
- NAID
  10031155758
- ISSN
  0366-7022, 1348-0715
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146, KAKENHI-PROJECT-24590003
[Journal Article] コルチスタチンの全合成2013
- Author(s)
  山下修治, 平間正博
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 71巻 Pages: 768-778
- NAID
  10031191014
- URL
  http://www.ssocj.jp/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] Stereoselective Synthesis of Zoanthenol ABC-ring by Radical Strategy2013
- Author(s)
  山下修治, 須田直樹, 林雄二郎, 平間正博
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 54巻 Issue: 11 Pages: 1389-1391
- DOI
  10.1016/j.tetlet.2012.12.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146, KAKENHI-PROJECT-24590003
[Journal Article] コルチスタチンの全合成2013
- Author(s)
  山下修治、平間正博
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 71 Pages: 768-778
- NAID
  10031191014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] Remote C-H Bond Functionalization of Androstane C-Ring : C12-Amination2013
- Author(s)
  Shuji Yamashita, masafumi Himuro, Yujiro Hayashi, Masahiro Hirama
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 54 Issue: 10 Pages: 1307-1308
- DOI
  10.1016/j.tetlet.2012.12.103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02256, KAKENHI-PROJECT-23310146, KAKENHI-PROJECT-24590003
[Journal Article] Total Syntheses of Complanadines A and B2013
- Author(s)
  Le Zhao, 塚野千尋,Eunsang Kwon, 竹本佳司, 平間正博
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 52巻 Issue: 6 Pages: 1722-1725
- DOI
  10.1002/anie.201208297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146, KAKENHI-PROJECT-24790010, KAKENHI-PUBLICLY-23105522
[Journal Article] Development of Monoclonal Antibody Against the Left Wing of Ciguatoxin CTX1B : Thiol Strategy and Sandwich ELISA Detection2012
- Author(s)
  円谷健, 竹内勝俊, 山下修治, 平間正博, 藤井郁雄
- Journal Title
  
  Toxicon
  
  Volume: 60巻 Issue: 3 Pages: 348-357
- DOI
  10.1016/j.toxicon.2012.04.347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146, KAKENHI-PROJECT-23550196, KAKENHI-PROJECT-23655161, KAKENHI-PROJECT-24590003
[Journal Article] Total Synthesis of Aspercyclides A and B via Intramolecular Oxidative Diaryl Ether Formation2012
- Author(s)
  吉野達也, 佐藤格, 平間正博
- Journal Title
  
  Org. Lett
  
  Volume: 14巻 Issue: 16 Pages: 4290-4292
- DOI
  10.1021/ol3019727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] Development of Monoclonal Antibody Against the Left Wing of Ciguatoxin CTX1B : Thiol Strategy and Sandwich ELISA Detection2012
- Author(s)
  T.Tsumuraya, K.Takeuchi, S.Yamashita, M.Hirama, I.Fujii
- Journal Title
  
  Toxicon
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Copper(II) Catalyzed O-Arylation of Tertiary Alcohols with Arylbismuth(III) Reagents : A Convenient System for Aryl Transfer2012
- Author(s)
  S.Harada, D.Hayashi, I.Sato, M.Hirama
- Journal Title
  
  Synlett
  
  Volume: 23 Pages: 405-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] The First Total Synthesis of Gravicycle2012
- Author(s)
  K.Ueda, I.Sato, M.Hirama
- Journal Title
  
  Chem.Lett.
  
  Volume: 41 Pages: 87-89
- NAID
  10030222646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Development of Monoclonal Antibody Against the Left Wing of Ciguatoxin CTX1B : Thiol Strategy and Sandwich ELISA Detection2012
- Author(s)
  T.Tsumuraya, K.Takeuchi, S.Yamashita, M.Hirama, I.Fujii
- Journal Title
  
  Toxicon
  
  Volume: 60(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] Copper (II) Catalyzed O-Arylation of Tertiary Alcohols with Arylbismuth (III) Reagents : A Vnvenient System for Aryl Transfer2012
- Author(s)
  原田修治, 林大輔, 佐藤格, 平間正博
- Journal Title
  
  Synlett
  
  Volume: 23巻 Issue: 03 Pages: 405-408
- DOI
  10.1055/s-0031-1290205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] The First Total Synthesis of Gravicycle2012
- Author(s)
  K.Ueda, I.Sato, M.Hirama
- Journal Title
  
  Chem.Lett.
  
  Volume: 41 Pages: 87-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] Copper(II) Catalyzed O-Arylation of Tertiary Alcohols with Arylbismuth(III) Reagents : A Convenient System for Aryl Transfer2012
- Author(s)
  S.Harada, D.Hayashi, I.Sato, M.Hirama
- Journal Title
  
  Synlett
  
  Volume: 23 Pages: 405-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] The First Total Synthesis of Gravicycle2012
- Author(s)
  上田克明, 佐藤格, 平間正博
- Journal Title
  
  Chem. Lett.
  
  Volume: 41 Issue: 1 Pages: 87-89
- DOI
  10.1246/cl.2012.87
- NAID
  10030222646
- ISSN
  0366-7022, 1348-0715
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] Stereoselective 6-exo Radical Cyclization Using cis-Vinyl Sulfoxide: Practical Total Synthesis of CTX3C2011
- Author(s)
  S. Yamashita, Y. Ishihara, H. Morita, J. Uchiyama, K. Takeuchi, M. Inoue, and M. Hirama
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 74 Pages: 357-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga2011
- Author(s)
  K. Yogi, N. Oshiro, Y. Inafuku, M. Hirama, and T. Yasumoto
- Journal Title
  
  Anal. Chem.
  
  Volume: 83 Pages: 8886-8891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Comparative Study of the Effect of Ciguatoxins on Voltage-dependent Na+ and K+ Channels in Cerebellar Neurons2011
- Author(s)
  S.Perez, C.Vale, E.Alonso, C.Alfonso, P.Rodriguez, P.Otero, A.Alfonso, P.Vale, M.Hirama, M.R.Vieytes, L.M.Botana
- Journal Title
  
  Chem.Res.Toxicol.
  
  Volume: 24 Pages: 587-596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of Cortistatins A and J2011
- Author(s)
  S.Yamashita, K.Iso, K.Kitajima, M.Himuro, M.Hirama
- Journal Title
  
  J.Org.Chem.(Featured Article)
  
  Volume: 76 Pages: 2408-2425
- NAID
  10031191014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] The First Total Synthesis of Gravicycle2011
- Author(s)
  K. Ueda, I. Sato, and M. Hirama
- Journal Title
  
  Chem. Lett.
  
  Volume: 41 Pages: 87-89
- NAID
  10030222646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga from the Pacific2011
- Author(s)
  K. Yogi, N. Oshiro, Y. Inafuku, M. Hirama, and T. Yasumoto
- Journal Title
  
  Anal. Chem.
  
  Volume: 83 Pages: 8886-8891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective 6-exo Radical Cyclization Using cis-Vinyl Sulfoxide : Practical Total Synthesis of CTX3C2011
- Author(s)
  S.Yamashita, Y.Ishihara, H.Morita, J.Uchiyama, K.Takeuchi, M.Inoue, M.Hirama
- Journal Title
  
  J.Nat.Prod.
  
  Volume: 74 Pages: 357-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A study on mechanisms of toxic actions of ciguatoxins : existence of functional relationship between CTX3C and charged residues of voltage sensors in Na_v1.4 sodium channel2011
- Author(s)
  K.Yamaoka, M.Inoue, M.Hirama
- Journal Title
  
  Forensic Toxicology
  
  Volume: 29 Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Copper(II) Catalyzed O-Arylation of Tertiary Alcohols with Arylbismuth(III) Reagents: A Convenient System for Aryl Transfer2011
- Author(s)
  S. Harada, D. Hayashi, I. Sato, and M. Hirama
- Journal Title
  
  Synlett
  
  Volume: 23 Pages: 405-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective Synthesis of the Left Wing of Caribbean Ciguatoxin2011
- Author(s)
  山下修治, 上松亮平, 平間正博
- Journal Title
  
  Tetrahedron
  
  Volume: 67巻 Issue: 35 Pages: 6616-6626
- DOI
  10.1016/j.tet.2011.05.080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga from the Pacific2011
- Author(s)
  K.Yogi, N.Oshiro, Y.Inafuku, M.Hirama, T.Yasumoto
- Journal Title
  
  Anal.Chem.
  
  Volume: 83 Pages: 8886-8891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Development of Monoclonal Antibody Against the Left Wing of Ciguatoxin CTX1B: Thiol Strategy and Sandwich ELISA Detection2011
- Author(s)
  T. Tsumuraya, K. Takeuchi, S. Yamashita, M. Hirama, and I. Fujii
- Journal Title
  
  Toxicon.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective Synthesis of the Left Wing of Caribbean Ciguatoxin2011
- Author(s)
  S. Yamashita, R. Uematsu, and M. Hirama
- Journal Title
  
  Tetrahedron.
  
  Volume: 67 Pages: 6616-6626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective Synthesis of the Left Wing of Caribbean Ciguatoxin2011
- Author(s)
  S.Yamashita, R.Uematsu, M.Hirama
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Pages: 6616-6626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] Total Synthesis of Cortistatins A and J2011
- Author(s)
  S. Yamashita, K. Iso, K. Kitajima, M. Himuro, and M. Hirama
- Journal Title
  
  J. Org. Chem.
  
  Volume: 76 Pages: 2408-2425
- NAID
  10031191014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective Synthesis of the Left Wing of Caribbean Ciguatoxin2011
- Author(s)
  S.Yamashita, R.Uematsu, M.Hirama
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Pages: 6616-6626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] First Toxin Profile of Ciguateric Fish in Madeira Arquipelago (Europe)2011
- Author(s)
  P. Otero, M. Hirama, L. M. Botana, 他10名
- Journal Title
  
  Anal. Chem.
  
  Volume: 82 Pages: 6032-6032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga from the Pacific2011
- Author(s)
  與儀健太郎, 大城直雅, 稲福康夫, 平間正博, 安元健
- Journal Title
  
  Anal. Chem
  
  Volume: 83巻 Issue: 23 Pages: 8886-8891
- DOI
  10.1021/ac200799j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga from the Pacific2011
- Author(s)
  K.Yogi, N.Oshiro, Y.Inafuku, M.Hirama, T.Yasumoto
- Journal Title
  
  Anal.Chem.
  
  Volume: 83 Pages: 8886-8891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310146
[Journal Article] A study on mechanisms of toxic actions of ciguatoxins: existence of functional relationship between CTX3C and charged residues of voltage sensors in Na_v1.4 sodium channel2011
- Author(s)
  K. Yamaoka, M. Inoue, and M. Hirama
- Journal Title
  
  Forensic Toxicol.
  
  Volume: 29 Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Comparative Study of the Effect of Ciguatoxins on Voltage-dependent Na+ and K+ Channels in Cerebellar Neurons2011
- Author(s)
  S. Perez, M. Hirama, and L. M. Botana, 他12名
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 24 Pages: 587-596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] シガトキシンの全合成を中心とする生理活性天然物の研究2010
- Author(s)
  平間正博
- Journal Title
  
  科研費NEWS
  
  Volume: 2 Pages: 18-18
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Ciguatera Incidence and Fish Toxicity in Okinawa, Japan2010
- Author(s)
  N. Oshiro, K. Yogi, S. Asato, T. Sasaki, K. Tamanaha, M. Hirama, T. Yasumoto, and Y. Inafuku
- Journal Title
  
  Toxicon
  
  Volume: 56 Pages: 656-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Production of Monoclonal Antibodies for Sandwich Immunoassay Detection of Pacific Ciguatoxins2010
- Author(s)
  T. Tsumuraya, I. Fujii, and M. Hirama
- Journal Title
  
  Toxicon
  
  Volume: 56 Pages: 797-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective Synthesis of Caribbean Ciguatoxin M-Ring Using [2+2] Photocyclization2010
- Author(s)
  S. Yamashita, N. Iijima, T. Shida, and M. Hirama
- Journal Title
  
  Heterocycles
  
  Volume: 82 Pages: 761-774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Practical Synthesis of the C-1027 Aminosugar Moiety2010
- Author(s)
  K.Hirai, Y.Tamura, I.Sato, M.Hirama
- Journal Title
  
  Synlett
  
  Volume: 14 Pages: 2156-2158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] The First F-ring Modified Ciguatoxin Analogue Showing Significant Toxicity2010
- Author(s)
  Y.Ishihara, N.Lee, N.Oshiro, S.Matsuoka, S.Yamashita.M.Inoue, M.Hirama
- Journal Title
  
  Chem.Commun.
  
  Volume: 46 Pages: 2968-2970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Recent Advances in the Synthetic Studies of Nine-membered Enediyne Antitumor　Antibiotics2010
- Author(s)
  I. Sato and M. Hirama
- Journal Title
  
  J. Syn. Org. Chem.
  
  Volume: 68 Pages: 1123-1131
- NAID
  10027371615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] First Toxin Profile of Ciguateric Fish in Madeira Arquipelago (Europe)2010
- Author(s)
  P.Otero, S.Perez, A.Alfonso, C.Vale, P.Rodriguez, N.N.Gouveia, N.Gouveia, J.Delgado, P.Vale, M.Hirama, Y.Ishihara, J.Molgo, Luis M.Botana
- Journal Title
  
  Anal.Chem.
  
  Volume: 82 Pages: 6032-6039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Concise Total Synthesis of (±)-Lycodine2010
- Author(s)
  C.Tsukano, L.Zhao, Y.Takemoto, M.Hirama
- Journal Title
  
  Eur.J.Org.Chem.
  
  Volume: 22 Pages: 4198-4200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Recent Advances in the Synthetic Studies of Nine-membered Enediyne Antitumor Antibiotics2010
- Author(s)
  I.Sato, M.Hirama
- Journal Title
  
  J.Syn.Org.Chem.(有機合成化学協会誌、英文版)
  
  Volume: 68 Pages: 1123-1131
- NAID
  10027371615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] 巻頭言「地の利、人の和、そして始めに天然物ありき」2010
- Author(s)
  M.Hirama
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 68 Pages: 801-801
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] シガトキシンCTX3Cの全合成2010
- Author(s)
  平間正博、山下修治
- Journal Title
  
  和光純薬時報
  
  Volume: 78 Pages: 7-9
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] The First F-ring Modified Ciguatoxin Analogue Showing Significant Toxicity2010
- Author(s)
  Y. Ishihara, N. Lee, N. Oshiro, S. Matsuoka, S. Yamashita, M. Inoue, and M. Hirama
- Journal Title
  
  Chem. Commun.
  
  Volume: 46 Pages: 2968-2970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Practical Synthesis of C-1027 Aminosugar Moiety2010
- Author(s)
  K. Hirai, Y. Tamura, I. Sato, and M. Hirama
- Journal Title
  
  Synlett
  
  Volume: 14 Pages: 2156-2158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Route to the C_2-Symmetric Tricyclic Skeleton of Ryanodine2009
- Author(s)
  K.Hagiwara, M.Himuro, M.Hirama, M.Inoue
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 1035-1037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Design and Synthesis of a Conformationally Restricted Analogue of the EFGH-Ring System of Ciguatoxin2009
- Author(s)
  N. Lee, M. Inoue, and M. Hirama
- Journal Title
  
  Heterocycles
  
  Volume: 79 Pages: 325-330
- NAID
  40016543064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Remarkable Selectivity in Derivatization and Protection of Hydroxy Groups of 51-hydroxyCTX3C : Chemoselective Synthesis of tin-conjugated Ciguatoxin Derivatives2009
- Author(s)
  Y.Ishihara, K.Miyazaki, S.Yamashita, M.Hirama
- Journal Title
  
  Chemistry Lett. 38
  
  Pages: 886-887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Remarkable Selectivity in Derivatization and Protection of hydrocy Groups of 51-hydroxyCTX3C: Chemoselective Synthesis of Biotin-conjugated Ciguatoxin Derivatives2009
- Author(s)
  Y. Ishihara, K. Miyazaki, S. Yamashita, and M. Hirama
- Journal Title
  
  Chemistry Lett.
  
  Volume: 38 Pages: 886-887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Design and Synthesis of a Conformationally Restricted Analogue of the EFGH-Ring System of Ciguatoxin2009
- Author(s)
  N.Lee, M.Inoue, M.Hirama
- Journal Title
  
  Heterocycles 79
  
  Pages: 325-330
- NAID
  40016543064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Efficient and Stereoselective Installation of Isoquinoline : Formal Total Synthesis of Cortistatin A2009
- Author(s)
  S.Yamashita, K.Kitajima, K.Iso, M.Hirama
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 3277-3279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Use of Monoclonal Antibodies as an Effective Strategy for Treatment of Ciguatera Poisoning2009
- Author(s)
  M.Inoue, N.Lee, T.Tsumuraya, I.Fujii, M.Hirama
- Journal Title
  
  Toxicon 53
  
  Pages: 802-805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Seyama, Synthetic Ciguatoxins Selectively Activate Nav1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells2009
- Author(s)
  K. Yamaoka, M. Inoue, K. Miyazaki, M. Hirama, C. Kondo, E. Kinoshita, H. Miyoshi, and I.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 284 Pages: 7597-7605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Route to the C_2-Symmetric Tricyclic Skeleton of Ryanodine2009
- Author(s)
  K. Hagiwara, M. Himuro, M. Hirama, and M. Inoue
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 50 Pages: 1035-1037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of Protected Aglycon of Kedarcidin Chromophore2009
- Author(s)
  K.Ogawa, Y.Koyama, I.Ohashi, I.Sato, M.Hirama
- Journal Title
  
  Angew.Chem.Int.Ed.(HIP) 48
  
  Pages: 1110-1113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Use of Monoclonal Antibodies as an Effective Strategy for Treatment of Ciguatera Poisoning2009
- Author(s)
  M. Inoue, N. Lee, T. Tsumuraya, I. Fujii, and M. Hirama
- Journal Title
  
  Toxicon
  
  Volume: 53 Pages: 802-805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis and Structure Revision of the(-)-Maduropeptin Chromophore2009
- Author(s)
  K.Komano, S.Shimamura, Y.Norizuki, D.Zhao, C.Kabuto, I.Sato, M.Hirama
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 12072-12073
- NAID
  110009757642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthetic Ciguatoxins Selectively Activate Na_v1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells2009
- Author(s)
  K.Yamaoka, M.Inoue, K.Miyazaki, M.Hirama, C.Kondo, E.Kinoshita, H.Miyoshi, I.Seyama
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 7597-7605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis and Structure Revision of the (-)-Maduropeptin Chromophore2009
- Author(s)
  K. Komano, I. Sato, and M. Hirama, 他3名
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 131 Pages: 12072-12073
- NAID
  110009757642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Efficient and Stereoselective Installation of Isoquinoline: Formal Total Synthesis of Cortistatin A2009
- Author(s)
  S. Yamashita, K. Kitajima, K. Iso, and M. Hirama
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 50 Pages: 3277-3279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of Protected Aglycon of Kedarcidin Chromophore2009
- Author(s)
  K. Ogawa, Y. Koyama, I. Ohashi, I. Sato, and M. Hirama
- Journal Title
  
  Angew. Chem. Int. Ed. (HIP)
  
  Volume: 48 Pages: 1110-1113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] How Protein Recognizes Ladder-like Polycyclic Ethers : Interactions between Ciguatoxin (CTX3C) Fragments and Its Specific Antibody 10C92008
- Author(s)
  M. Ui, Y. Tanaka, T. Tsumuraya, I. Fujii, M. Inoue, M. Hirama, and K. Tsumoto
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 19440-19447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Critical Contribution of Aromatic Rings to Specific Recognition of Polyether Rings : The Case of Ciguatoxin CTX3C-ABC and Its Specific Antibody 1C492008
- Author(s)
  K.Tsumoto, A.Yokota, Y.Tanaka, M.Ui, T.Tsumuraya, I.Fujii, I. Kumagai, Y. Nagumo, H.Oguri, M. Inoue, and M. Hirama
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 12259-12266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of the C-1027 Chromophore Core. Extremely Facile Enediyne Formation via SmI_2-Mediated 1,2-Elimination2008
- Author(s)
  M. Inoue, I. Ohasi, T. Kawaguchi, and M. Hirama
- Journal Title
  
  Angew. Chem. Int. Ed
  
  Volume: 47 Pages: 1777-1779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] 高反応性エンジイン系抗腫瘍性物質の機能と合成2008
- Author(s)
  井上将行、平間正博
- Journal Title
  
  ファルマシア 44(2)
  
  Pages: 130-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Enantioselective Synthesis of the Fully Functionalized ABC-Ring of Zoanthenol2008
- Author(s)
  N. Sugano, Y. Koizumi, G. Hirai, H. Oguri, S. Kobayashi, S. Yamashita, and M. Hirama
- Journal Title
  
  Chem. Asian J.
  
  Volume: 3 Pages: 1549-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Enantioselective Synthesis of the Fully Functionalized ABC-Ring of Zoanthenol2008
- Author(s)
  N. Sugano, Y. Koizumi, G. Hirai, H.Oguri, S.Kobayashi, S.Yamashita, and M. Hirama
- Journal Title
  
  Chem. Asian J 3
  
  Pages: 1549-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Critical Importance of the 9-Membered F-Ring of Ciguatoxin for Potent Bioactivity : Total Synthesis and Biological Evaluation of F-Ring Modified Analogs.2008
- Author(s)
  M. Inoue, N. Lee, K. Miyazaki, T.Usuki, S. Matsuoka, and M.Hirama
- Journal Title
  
  Angew. Chem. Mt. Ed.(VIP) 47
  
  Pages: 8611-8614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Secure Route to The Epoxybicyclo[7.3.0]dodecadienediyne Core of Kedarcidin Chromophore2008
- Author(s)
  K. Ogawa, Y. Koyama, I. Ohashi, I. Sato, and M. Hirama
- Journal Title
  
  Chem. Commun
  
  Pages: 6327-6329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Critical Importance of the 9-Membered F-Ring of Ciguatoxin for Potent Bioactivity: Total Synthesis and Biological Evaluation of F-Ring Modified Analogs2008
- Author(s)
  M. Inoue, N. Lee, K. Miyazaki, T. Usuki, S. Matsuoka, and M. Hirama
- Journal Title
  
  Angew. Chetn. Int. Ed. (VIP)
  
  Volume: 47 Pages: 8611-8614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Bicyclo[7.3.0]dodecadiyne Core of the Maduropeptin Chromophore.2008
- Author(s)
  K. Iso, M. Inoue, N. Kato, and M. Hirama
- Journal Title
  
  Chem. Asian J. 3
  
  Pages: 447-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Internal Amide-Triggered Cycloaromatization of Maduropeptin-Like Nine-Membered Enediyne2008
- Author(s)
  Y. Norizuki, K. Komano, I. Sato, and M. Hirama
- Journal Title
  
  Chem Commun.
  
  Pages: 5372-5374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Bicyclo[7.3.0]dodecadiyne Core of the Maduropeptin Chromophore2008
- Author(s)
  K. I so, M. Inoue, N. Kato, and M. Hirama
- Journal Title
  
  Chew. Asian J.
  
  Volume: 3 Pages: 447-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Secure Route to The Epoxybicyclo[7.3.0]dodecadienediyne Core of Kedarcidin Chromophore2008
- Author(s)
  K. Ogawa, Y. Koyama, I. Ohashi, I. Sato, and M. Hirama
- Journal Title
  
  Chetn. Commun.
  
  Pages: 6327-6329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Bicyclo[7.3.0] dodecadiyne Core of the Maduropeptin Chromophore2008
- Author(s)
  K. Iso, M. Inoue, N. Kato, and M. Hirama
- Journal Title
  
  Chem. Asian J 3
  
  Pages: 447-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Synthesis of the Pentacyclic Framework of Cortistatins2008
- Author(s)
  S. Yamashita, K. I so, and M. Hirama
- Journal Title
  
  Org. Lett.
  
  Volume: 10 Pages: 3413-3415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] 高反応性エンジン系抗腫瘍性物質の機能と合成2008
- Author(s)
  井上将行、平間正博
- Journal Title
  
  ファルマシア
  
  Volume: 44(2) Pages: 130-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] How Protein Recognizes Ladder-like Polycyclic Ethers: Interactions between Ciguatoxin (CTX3C) Fragments and Its Specific Antibody 10C92008
- Author(s)
  M. Ui, Y. Tanaka, T. Tsumuraya, I. Fujii, M. Inoue, M. Hirama, and K. Tsumoto
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 283 Pages: 19440-19447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of the C-1027 Chromophore Core. Extremely Facile Enediyne Formation via SmI2-Mediated 1, 2-Elimination2008
- Author(s)
  M. Inoue, I. Ohasi, T.Kawaguchi, and M. Hirama
- Journal Title
  
  Angew. Chem. Int. Ed 47
  
  Pages: 1777-1779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Internal Amide-Triggered Cycloaromatization of Maduropeptin-Like Nine-Membered Enediyne2008
- Author(s)
  Y. Norizuki, K. Komano, I. Sato, and M. Hirama
- Journal Title
  
  Chem. Commun
  
  Pages: 5372-5374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of the C-1027 Chromophore Core. Extremely Facile Enediyne Formation via SmI_2-Mediated 1,2-Elimination.2008
- Author(s)
  M. Inoue, I. Ohasi, T. Kawaguchi, and M. Hirama
- Journal Title
  
  Angew. Chem. Int. Ed. 47
  
  Pages: 1777-1779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Synthesis of the Pentacyclic Framework of Cortistatins2008
- Author(s)
  S. Yamashita, K. Iso, and M. Hirama
- Journal Title
  
  Organic Lett 10
  
  Pages: 3413-3415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of Trans-fused Tetrahydrooxepins : Stereoselective Allylation of Sulfur or Fluoro-substituted Terahvdrooxepins2008
- Author(s)
  S. Kobayashi, M. Hori, and M. Hirama
- Journal Title
  
  Carbohydrate Res 343
  
  Pages: 443-452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Critical Contribution of Aromatic Rings to Specific Recognition of Polyether Rings:The Case of Ciguatoxin CTX3C-ABC and Its Specific Antibody 1C492008
- Author(s)
  K. Tsumoto, A. Yokota, Y. Tanaka, M. Ui, T. Tsumuraya, I. Fujii, I. Kumagai, Y. Nagumo, H. Oguri, M. Inoue, and M. Hirama
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 283 Pages: 12259-12266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Entire Carbon Framework of the Kedarcidin Chromophore Aglycon2007
- Author(s)
  F. Yoshimura, M. J. Lear, I. Ohashi, Y. Koyama, and M. Hirama
- Journal Title
  
  Chew. Cowwun.
  
  Pages: 3057-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the LMN-Ring Fragment of Caribbean Ciguatoxin2007
- Author(s)
  K. Yoshikawa, M. Inoue, M. Hirama
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 48 Pages: 2177-2180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of the Maduropeptin Chromophore Aglycon2007
- Author(s)
  K. Komano, S. Shimamura, M. Inoue, and M. Hirama
- Journal Title
  
  J. Aw. Chew. Soc.
  
  Volume: 129 Pages: 14184-14186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis and Bioactivity of an Unnatural Enantiomer of Merrilactone A: Development of an Enantioselective Desymmetrization Strategy.2007
- Author(s)
  M. Inoue, N. Lee, S. Kasuya, T. Sato, M. Hirama, M. Moriyama, and Y. Fukuyama
- Journal Title
  
  J. Org. Chem. 72
  
  Pages: 3065-3075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Entire Carbon Framework of the Kedarcidin Chromophore Aglycon.2007
- Author(s)
  F. Yoshimura, M.J. Lear, I. Ohashi, Y. Koyama, and M. Hirama
- Journal Title
  
  Chem. Commun.
  
  Pages: 3057-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the LMN-Ring Fragment of Caribbean Ciguatoxin.2007
- Author(s)
  K. Yoshikawa, M. Inoue, M. Hirama
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 2177-2180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of the Maduropeptin Chromophore Aglycon.2007
- Author(s)
  K. Komano, S. Shimamura, M. Inoue, and M. Hirama
- Journal Title
  
  J. Am. Chem. Soc. 129
  
  Pages: 14184-14186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Route to Two Distinct E-Ring Structures of Ciguatoxins.2007
- Author(s)
  M. Inoue, M. Iwatsu, S. Yamashita, M. Hirama
- Journal Title
  
  Heterocycles 72
  
  Pages: 327-338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Convergent Synthesis of the ABCDE-Ring Fragment of the Caribbean Ciguatoxin C-CTX-12007
- Author(s)
  M. Inoue, F. Saito, M. Iwatsu, Y. Ishihara, M. Hirama
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 48 Pages: 2171-2175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Route to Two Distinct E-Ring Structures of Ciguatoxins2007
- Author(s)
  M. Inoue, M. Iwatsu, S, Yamashita, M. Hirama
- Journal Title
  
  Heterocycles
  
  Volume: 72 Pages: 327-338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Convergent Synthesis of the ABCDE-Ring Fragment of the Caribbean Ciguatoxin C-CTX-1.2007
- Author(s)
  M. Inoue, S. Yamashita, Y. Ishihara, M. Hirama
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 2171-2175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシン類CTX1Bおよび54-デオキシ-CTX1Bを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット2011
- Inventor(s)
  平間正博、山下修治、藤井郁雄、円谷健
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Number
  2010-226734
- Filing Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシン類を認識するヒト化抗体2011
- Inventor(s)
  藤井郁雄、円谷健、山口亜佐子、平間正博
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Number
  2010-070349
- Filing Date
  2011-03-25
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシン類CTX1Bおよび54-デオキシ-CTX1Bを認識するモノクロナール抗体、並びにそれを用いるシガトキシン類検出キット2011
- Inventor(s)
  藤井郁雄、円谷健、平間正博、山下修治
- Filing Date
  2011-09-16
- Overseas
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシン類CTX1Bおよび54-デオキシ-CTX1Bを認識するモノクローナル抗体、並びにそれを用いるシガトキシン類検出キット2011
- Inventor(s)
  藤井郁雄、円谷健、平間正博、山下修治
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Filing Date
  2011-04-12
- Overseas
- Data Source
  KAKENHI-PROJECT-23310146
[Patent] シガトキシン類を認識するヒト化抗体2010
- Inventor(s)
  藤井郁雄、円谷健、山口亜佐子、平間正博
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Number
  2010-070349
- Filing Date
  2010-03-25
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシン類CTX1Bおよび54-デオキシ-CTX1Bを認識するモノクロナール抗体およびそれを用いるシガトキシン類検出キット2010
- Inventor(s)
  平間正博、山下修治、藤井郁雄、円谷健
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Number
  2010-226734
- Filing Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] CTX3CのA-E環部を持つハプテン部を有するタンパク質コンジュゲートで免疫して得られるシガトキシンCTX3C抗体およびその作製方法2008
- Inventor(s)
  平間正博、大栗博毅、藤井郁雄、円谷健
- Industrial Property Rights Holder
  JST
- Filing Date
  2008-09-01
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシンCTX3Cを検出するサンドイッチ測定キット類2008
- Inventor(s)
  平間正博、大栗博毅、藤井郁雄、円谷健
- Industrial Property Rights Holder
  JST
- Filing Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] p-ベンザインビラジカルのモノクロロ化反応：２面性とシアノスポラサイドＡ，Ｂの合成研究2013
- Author(s)
  山田慧・山下修治・佐藤格・林雄二郎・平間正博
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  草津
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] アンドロスタンＣ環部の遠隔官能基化法の開発2013
- Author(s)
  氷室真史・山下修治・林雄二郎・平間正博
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  草津
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] ウスチロキシンＤの全合成研究2013
- Author(s)
  林大介・原田修治・佐藤格・林雄二郎・平間正博
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  草津
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] アスペルサイクライドＡ，ＢおよびＣの不斉全合成2013
- Author(s)
  吉野達也・佐藤格・林雄二郎・平間正博
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  草津
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] リモニンの全合成研究2013
- Author(s)
  成子朗人・中澤有紀・山下修治・林雄二郎・平間正博
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  草津
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] ケダルシジンクロモフォアの全合成研究2013
- Author(s)
  平井啓一朗・小川幸希・佐藤格・林雄二郎・平間正博
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  草津
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2013
- Author(s)
  平間正博
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] プレスポロライドの合成研究2013
- Author(s)
  寺山香菜江・尾関江理・山下修治・林雄二郎・平間正博
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  草津
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] 天然物合成はシガテラを克服できるか2011
- Author(s)
  平間正博
- Organizer
  有機合成化学協会講習会
- Place of Presentation
  東京
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  大阪府立大学有機化学研究会白鷺セミナー
- Place of Presentation
  堺
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  薬学月例セミナー
- Place of Presentation
  静岡(特別講演)
- Year and Date
  2011-10-17
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] シガテラ中毒への化学の挑戦2011
- Author(s)
  平間正博
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガテラ中毒への化学の挑戦 : 最近の進歩2011
- Author(s)
  平間正博
- Organizer
  理研シンポジウム第6回有機合成化学のフロンティア
- Place of Presentation
  和光
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] 天然物合成はシガテラを克服できるか2011
- Author(s)
  平間正博
- Organizer
  有機合成化学協会講習会
- Place of Presentation
  東京
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  薬学月例セミナー
- Place of Presentation
  静岡
- Year and Date
  2011-10-17
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガテラ中毒への化学の挑戦:最近の進歩2011
- Author(s)
  平間正博
- Organizer
  理研シンポジウム第6回有機合成化学のフロンティア
- Place of Presentation
  和光(特別講演)
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] 天然物合成はシガテラを克服できるか2011
- Author(s)
  平間正博
- Organizer
  有機合成化学協会講習会
- Place of Presentation
  東京(特別講演)(紫綬褒章受章記念講演)
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  東京大学大学院薬学系研究かOrganic Syntheses講演会
- Place of Presentation
  東京
- Year and Date
  2011-10-11
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  大阪府立大学有機化学研究会白鷹セミナー
- Place of Presentation
  堺
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] 最後まで人間味豊かなケミスト西沢麦夫さん-シガトキシン研究-2011
- Author(s)
  平間正博
- Organizer
  西澤麦夫先生追悼講演会
- Place of Presentation
  徳島(招待講演)
- Year and Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] シガテラ中毒への化学の挑戦:最近の進歩2011
- Author(s)
  平間正博
- Organizer
  理研シンポジウム第6回有機合成化学のフロンティア
- Place of Presentation
  和光
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  東京大学大学院薬学系研究科"Organic Syntheses"講演会
- Place of Presentation
  東京(特別講演)
- Year and Date
  2011-10-11
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] シガテラ中毒への化学の挑戦:最近の進歩2011
- Author(s)
  平間正博
- Organizer
  理研シンポジウム第6回有機合成化学のフロンティア
- Place of Presentation
  和光
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  大阪府立大学有機化学研究会白鷺セミナー
- Place of Presentation
  堺(招待講演)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-23310146
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  東京大学大学院薬学系研究科"Organic Syntheses"講演会
- Place of Presentation
  東京
- Year and Date
  2011-10-11
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成はシガテラを克服できるか2010
- Author(s)
  平間正博
- Organizer
  日本化学会東北支部岩手大学学術講演会
- Place of Presentation
  盛岡
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成はシガテラを克服できるか2010
- Author(s)
  平間正博
- Organizer
  日本化学会東北支部「会員増強のための講演会-化学で夢を実現する講演会」
- Place of Presentation
  盛岡
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガテラ中毒への化学の挑戦2010
- Author(s)
  平間正博
- Organizer
  20周年記念万有福岡シンポジウム「最新の有機合成化学が発信する新しい「もの創り」のパラダイム」
- Place of Presentation
  福岡
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成はシガテラを克服できるか2009
- Author(s)
  平間正博
- Organizer
  天然有機化合物討論会50周年記念講演会「これからの天然物化学」
- Place of Presentation
  仙台
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成研究-万有シンポと共に20年2009
- Author(s)
  平間正博
- Organizer
  20周年記念万有仙台シンポジウム「有機化学-その魅力と挑戦」
- Place of Presentation
  仙台
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成研究-万有シンポと共に20年2009
- Author(s)
  平間正博
- Organizer
  第20回万有仙台シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成の進化(特別講演、セッションリマーク)2008
- Author(s)
  平間正博
- Organizer
  第8回SORSTジョイントシンポジウム「有機合成力-そのダイナミズム」
- Place of Presentation
  東京
- Year and Date
  2008-01-30
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] Total Synthesis of Ciguatoxins: A Venture into The Problems of Ciguatera Poisoning2008
- Author(s)
  平間正博
- Organizer
  第一回KMC Frontier Seminar、北里研究所・北里大学北里生命科学研究所
- Place of Presentation
  東京
- Year and Date
  2008-04-23
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 世界最大の海産物食中毒への化学の挑戦2008
- Author(s)
  平間正博
- Organizer
  日本化学会第6回化学イノベーションシンポジウム-明日をひらく化学のとびら
- Place of Presentation
  仙台
- Year and Date
  2008-08-02
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガトキシンの全合成から総合科学へ-君は10年先を視ているか(特別講演)2007
- Author(s)
  平間正博
- Organizer
  正宗悟メモリアルシンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガトキシン全合成--諸科学技術との関わり、人との関わり(特別講演)2007
- Author(s)
  平間正博
- Organizer
  第42回天然物化学談話会
- Place of Presentation
  秋保
- Year and Date
  2007-07-12
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガトキシン全合成-諸科学技術との関わり、人との関わり2007
- Author(s)
  平間正博
- Organizer
  第42回天然物化学談話会
- Place of Presentation
  仙台
- Year and Date
  2007-07-12
- Data Source
  KAKENHI-PROJECT-19001003

1. FUJII Ikuo (70189984)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. YAMASHITA Syuuji (50419991)

# of Collaborated Projects: 2 results

# of Collaborated Products: 39 results
3. TSUMURAYA Takeshi (00372855)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. YAMAOKA Kaoru (10200586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. SATO Itaru (80318196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
6. 平間正博 (30165203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hirama Masahiro 平間 正博

HIRAMA Masahirohi 平間 正博

Research Projects

Research Products

Co-Researchers

TOTAL SYNTHESES AND BASIC RESEARCHES OF CIGUATOXIN CONGENERS, AND THEIR APPLICATIONSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical Syntheses of Natural and Designed Molecules : Innovative Research on Their New Functions, Antibodies and ReceptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 天然物合成で活躍した反応-実験のコツとポイント2011

Author(s)

Publisher

Data Source

[Book] 天然物合成で活躍した反応-実験のコツとポイント、Ni触媒を用いたクロスカップリング、有機合成化学協会編2011

Author(s)

Total Pages

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Data Source

[Book] Ni触媒を用いたクロスカップリング、Ireland-Claisen転移,天然物合成で活躍した反応-実験のコツとポイント(有機合成化学協会編)2011

Author(s)

Total Pages

Publisher

Data Source

[Book] 東北大学理学研究科附属巨大分子解析研究センター年報「(-)-マデュロペプチンクロモフォアの全合成と構造改訂」2010

Author(s)

Publisher

Data Source

[Book] 20周年記念万有福岡シンポジウム要旨集「シガテラ中毒への化学の挑戦」2010

Author(s)

Publisher

Data Source

[Book] Ni触媒を用いたクロスカップリング、Ireland-Claisen転移2010

Author(s)

Publisher

Data Source

[Book] 天然物の全合成2000-2008(日本)2009

Author(s)

Total Pages

Publisher

Data Source

[Book] 天然物全合成の最新動向2009

Author(s)

Publisher

Data Source

[Book] シガトキシン、ピナトキシン、マデュロペプチンクロモフォアアグリコンの全合成 天然物の全合成,2000-2008(日本)(有機合成化学協会編)2009

Author(s)

Publisher

Data Source

[Book] 東北大学理学部研究科附属巨大分子解析研究センター年報2008

Author(s)

Total Pages

Publisher

Data Source

[Book] SORSTジョイントシンポジウム(8)要旨集2008

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Solvent-mediated Tuning of the Regioselectivity of Intramolecular Diaryl Ether Formation : Total Synthesis of (+)-Aspercyclide C2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Preparation of Anti-Ciguatoxin Monoclonal Antibodies Using Synthetic Haptens : Sandwich ELISA Detection of Ciguatoxins2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Concise Synthesis of the Tetracyclic Framework of Azadiradione: Tandem Radical Cyclization Route2013

Author(s)

Journal Title

Hirama Masahiro 平間正博

HIRAMA Masahirohi 平間正博

[Book] シガトキシン、ピナトキシン、マデュロペプチンクロモフォアアグリコンの全合成天然物の全合成,2000-2008(日本)(有機合成化学協会編)2009