MATSUO MASAFUMI 松尾雅文

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MATSUO Masafumi 松尾雅文

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Researcher Number	10157266
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External Links
Affiliation (Current)	2025: 神戸常盤大学, 保健科学部, 特命教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 神戸常盤大学, 保健科学部, 特命教授 2023: 神戸学院大学, 総合リハビリテーション学部, 特命教授 2018 – 2021: 神戸学院大学, 総合リハビリテーション学部, 特命教授 2011 – 2017: 神戸学院大学, 総合リハビリテーション学部, 教授 2013: 神戸学院大学, 大学院総合リハビリテーション学部, 教授 … More 2012: 神戸大学, 医学研究科, 教授 2008 – 2010: Kobe University, 医学研究科, 教授 2008: Kobe University, 大学院医学研究科, 教授 2004 – 2007: 神戸大学, 医学系研究科, 教授 2006: kobe University, Graduate School of Medicine, protessor, 大学院医学系研究科, 教授 2002 – 2005: Kobe University Graduate School of medicine Professor, 大学院・医学系研究科, 教授 1992 – 2003: 神戸大学, 医学部, 教授 1997: 神戸大学, 医学部・付属病院, 教授 1989 – 1990: 神戸大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Human genetics Except Principal Investigator Pediatrics / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Hygiene / Basic Section 53040:Nephrology-related / Medical genome science … More / Rehabilitation science/Welfare engineering / Embryonic/Neonatal medicine / Urology / 応用薬理学・医療系薬学 / Laboratory medicine / Metabolomics / Human genetics / Experimental pathology / Medical sociology / Experimental psychology Less
Keywords	Principal Investigator ジストロフィン / スプライシング / エクソンスキッピング / dystrophin / Duchenne型筋ジストロフィー / exon skipping / エクソン / ジストロフィン遺伝子 / 治療 / クローニング … More / 点突然変異 / 筋ジストロフィー / Duchenne / スキッピング / 分子種 / Duchenne型 / メッセンジャーRNA / 筋芽細胞 / ジストロフィンDp71 / SNPs / デュシェンヌ型筋ジストロフィー / アンチセンス / splicing enhancer sequence / splicing / スプライシング促進配列 / isoform / 心筋 / mRNA / ゲノム / 精神発達遅滞 / アイソフォーム / マイクロサテライト / 遺伝子異常 / がん遺伝子 / 細胞増殖 / CleanCap mRNA / ジストロフィンDp71ab / ミニ遺伝子 / 筋芽細胞増殖因子 / 化合物 / Dp71ab / 衛星細胞 / 衛生細胞 / neonate / E2 gene / maple syrup urine disease / Philippine / 新生児 / E2遺伝子 / メープルシロップ尿症 / フィリピン / antisense / DMD / craniofacial formation / Homeobox genes / 5, 10-methylenetetrahydrofolate reductase / Neural tube defects / Frontoethmoidal encephalocele / Neural tube defect / 頭部形成ホメオボックス遺伝子 / 疾患感受性遺伝子 / 疾患責任遺伝子 / 前頭骨部〓骨部脳瘤 / 頭部形成 / ホメオボックス遺伝子 / メチレンテトラヒドロ葉酸還元酵素 / 神経管欠損 / 前頭骨部篩骨部脳瘤 / molecular therapy / muscular dystrophy / 筋細胞 / 点変異 / DNA / キメラRNA / 分子治療 / antisense oligonucleotide / Duchenne muscular dystrophy / treatment / アンチセンスオリゴオヌクレオチド / Thailand / mesomelic dysplasia / linkage analysis / bone disease / タイ / 責任遺伝子 / mesomedic dysplasia / Mesomelic dysplasia / 連鎖解析 / 骨系統疾患 / dilated cardiomyopathy / exon intron / 拡張型心筋症 / イントロン / heart / alternative splicing / antisenseoligonucleotide / lymphoblastoid cells / dystrophin Kobe / 遺伝子治療 / アンチセンスオリゴヌクレオチド / リンパ芽球 / ジストロフィン神戸 / Indonesia / Deletion mutation / Band 3 protein / Erythrocyte / Ovalocytosis / バンド3蛋白遺伝子 / 遺伝性楕円赤血球症 / インドネシア / 遺伝子欠失 / バンド3蛋白 / 赤血球 / 楕円赤血球症 / 転写産物 / ウェスターンブット / 内在遺伝子 / 脳神経疾患 / 核酸 / 遺伝子 / 低分子 / 炎症 / PGD2 / 筋ジス / 低分子化合物 / 臨床 / 遺伝学 / リボゾーム / 小児神経学 / 逆位 / 新規遺伝子 / 非コード遺伝子 / タンパク / mRNA前駆体 / 核抽出液 / 核タンパク / RNA結合蛋白 / 不安定性 / PCR / がん / 転写 / In vitro翻訳 / 蛋白合成 / 神経線維腫症I型 / Duchenn型筋ジストロフィー / がん抑制遺伝子 / NF1 / 神経線椎腫症1型 / 遺伝子診断 / レトロポゾン / RNA … More Except Principal Investigator スプライシング / 筋ジストロフィー / 遺伝子治療 / splicing / G6PD欠損症 / 遺伝子解析 / 遺伝子異常 / ジストロフィン / アンチセンス核酸 / ミオスタチン / 横紋筋肉腫 / RNAi / childhood leukemia / キメラ遺伝子 / 小児白血病 / C2 / hnRNP C1 / mRNA / MSUD / muscular dystrophy / HPLC / gene therapy / spinal muscular atrophy / 脊髄性筋萎縮症 / スプライシング促進配列 / Philippines / フィリピン / エクソンスキッピング / アンチセンスオリゴヌクレオチド / プロモーター / 生命予後 / 慢性腎臓病 / Myostatin / PAX3-FOXO1 / アポトーシス / AO therapy / Splicing / Intron retention / Dystrophin / tumor suppressor gene, / tumor, / rhabdomyosarcoma, / antisense chemistry, / dystrophin, / intron retention, / splicing, / Rhabdomyosarcoma / Antisense oligo, / Dystrophin, / Intron retention, / Splicing、 / 物理療法 / 線維芽細胞増殖 / 酸化還元電位 / 損傷電流 / 筋線維芽細胞 / 線維芽細胞 / 直流微弱電流刺激 / 創の縮小 / クロスオーバー研究 / 無作為化比較試験 / 電気刺激療法 / クロスオーバー比較試験 / 二重盲検試験 / 無作為化試験 / 直流パルス微弱電流刺激療法 / 褥瘡 / exon skipping / antisense oligonucleotide / molecular therapy / 小児神経学 / エクソン・スキッピング / 分子治療 / chimeric gene / cloning / chimera mRNA / クローニング / peptide nucleic acid / in vitro splicing assay / the SMN2 gene / the SMN1 gene / ペプチド核酸 / in vitroスプライシング / SMN2遺伝子 / SMN1遺伝子 / Malaysian / TATA-box / G493R mutation / G71R mutation / the UGT1A1 gene / Gilbert syndrome / neonatal jaundice / DHPLCスクリーニング / マレー・マレーシア人 / ジャワ・インドネシア人 / UGT1 A1遺伝子 / マレーシア人 / TATA box / G493R変異 / G71R変異 / UGT1A1遺伝子 / Gilbert症候群 / 新生児黄疸 / neonatal screeing / gene mutation / 遺伝子欠失 / E2遺伝子 / メープルシロップ尿症 / 新生児スクリーニング / Osteocalcin / Suicide gene / Adenovirus / Tissue-specific promoter / Bone Metastasis / Prostate cancer / Clinical Research / Gene Therapy / アデノウィルス / 遺伝子治療臨床試験 / バラシクロビル / チミジンキナーゼ / 局所再発 / 遺伝子治療臨床研究 / オステオカルシン / 自殺遺伝子 / アデノウイルス / 臓器特異性プロモーター / 骨転移 / 前立腺癌 / 臨床研究 / real time quantitative PCR / blood concentration / antisense / リアルタイムPCR / 血中濃度 / アンチセンス / splicing enhancer sequence / dystrophin / スプラシング / cadmium / anti-SMN antibody / mini-gene / the dsx gene / splicing enhancer sequences / pre-mRNA / 可変スプライシング / SMN蛋白 / メッセンジャーRNA前駆体 / カドミウム / 抗SMN抗体 / ミニ遺伝子 / dsx遺伝子 / メッセンジャーRNA前躯体 / Gene Analysis / Hemoglobin Abnormality / Southeast Asian Ovalocytosis / α-Thalassemia / G6PD Deficiency / Malaria / G6PD / ヘモグロビン異常 / 楕円赤血球症 / α-サラセミア / マラリア / Genetic analysis / Vietnam / Mass screening / G6PD deficiency / 赤血球 / ホルマザン法 / スクリーニング / ベトナム / マススクリーニング / mutation / G6PD deficienc / POSITIONAL CLONING / ATRIAL SPEPTAL DEFECT / FAMILIAL CATARACT / Paroxysmal kinetogenic choreoathetosis / ENGELMANN DISEASE / MESOMELIC DYSPLASIA / DISEASE LOCUS / LINKAGE ANALYSIS / 肢中部短縮型小人症 / ポジショナルクローニング / 心房中隔欠損症 / 家族性白内症 / 発作性運動誘発性コレオアテトーシス / Engelmann病 / 中間肢短縮小人症 / 疾患遺伝子座 / 連鎖解析 / myo-Inositol / Growth factor / Premature infant / イノシト-ル / 細胞増殖因子 / ミオイノシト-ル / 成長因子 / 未熟児 / 創薬スクリーニング / 骨格筋細胞 / 病態再現 / 疾患特異的iPS細胞 / 細胞内カルシウムイメージング / デュシェンヌ型筋ジストロフィー / 疾患再現 / iPS細胞 / VKORC1 / CYP2C9 / 薬物感受性遺伝子 / 遺伝子多型 / ワルファリン / テーラーメード医療 / プロトンポンプ阻害薬 / CYP2C19 / 薬物代謝酵素 / 非びらん性胃食道逆流症 / 逆流性食道炎 / テーラーメイド医療 / おくすり体質検査 / ゲノム薬理学 / 遺伝子医療 / 薬学教育 / 医学 / NF-κB / 筋ジストロフー / シグナル伝達因子 / dp140 / Duchenne型筋ジストロフィー / 人物画 / 樹木画 / 筋ジストロフィー児 / 言語能力 / 知能 / Duchenne型筋ジストロフィー児 / リンパ球 / 分散性反復配列 Less

Inhibiting myostatin may improve mortality in chronic kidney disease: effects and the mechanisms of novel antisense oligonucleotide
- Principal Investigator
  
  矢野彰三
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shimane University
Elucidation of the molecular mechanism of the myoblast-specific proliferation-promoting effect of Dp71abPrincipal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kobe Tokiwa University
Development of novel gene therapy for rhabdomyosarcoma
- Principal Investigator
  
  菊地顕
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Myostatin antisense nucleic acid therapy for rhabdomyosarcoma
- Principal Investigator
  
  Maeta Kazuhiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kobe Gakuin University
Identification of chemicals that enhance expression of myoblast growth factor Dp71abPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kobe Tokiwa University
  Kobe Gakuin University
Study on dystrophin Dp71 to regulate satellite cell divisionPrincipal Investigator
- Principal Investigator
  
  Matsuo Masafumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kobe Gakuin University
Study of personalized electrophysical therapy for stage of pressure injury healing by Monophasic Pulsed Microcurrent stimulation
- Principal Investigator
  
  Sugimoto Masaharu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Kobe Gakuin University
Dystrophin intron retention analysis to identify new targets for Antisense Oligonucleotide mediated RNA modulation in Rhabdomyosarcoma
- Principal Investigator
  
  NIBA TABE EMMA EKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical genome science
- Research Institution
  Kobe University
  Kobe Gakuin University
Fluorescent detection of dystrophin mRNA with bispyrene labeled probePrincipal Investigator
- Principal Investigator
  
  Matsuo Masafumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe Gakuin University
Cloning of non-dystrophin transcript from the dystrophin genePrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe Gakuin University
Expression of dystrophin via exon skipping with a small chemicalPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe Gakuin University
Modeling Duchenne muscular dystrophy using patient-derived iPS cells
- Principal Investigator
  
  SAKURAI Hidetoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University
Dose prostaglandin-mediated inflammation commit to pathology of Duchenne muscular dystrophy?Principal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe Gakuin University
A pharmacist's strategic practical use in promotion of gene medical treatment
- Principal Investigator
  
  HIRAI Midori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical sociology
- Research Institution
  Kobe University
Duchenne型筋ジストロフィーは低分子化合物により治療できるか?Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Genes responsible for mental retardation complicating to Duchenne muscular dystrophyPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe Gakuin University
  Kobe University
Research of signal transduction system in antisense therapy for muscular dystrophy
- Principal Investigator
  
  TAKESHIMA Yasuhiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
レトロトランスポジション能を有する新規ヒト遺伝子のクローニングPrincipal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Study on treatment of Duchenne muscular dystrophy by inducing exon skippingPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
染色体Xq28に座位する精神発達遅滞の発症に関与する新しい遺伝子Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Research of antisense oligonucleotide therapy for muscular dystrophy using knockout mouse as a model
- Principal Investigator
  
  TAKESHIMA Yasuhiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
筋ジストロフィー児の認知・言語と遺伝子異常
- Principal Investigator
  
  小椋たみ子
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental psychology
- Research Institution
  Kobe University
Cellular biological study on the treatment of Duchenne muscular dystrophy with nucleic acidsPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Molecular epidemiolojial study on maple syrup urine disease in Philippine.Principal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Research of novel treatment for childhood leukemia by disrupting the chimeric gene function using RNAi
- Principal Investigator
  
  TAKESHIMA Yasuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Molecular epidemiology of neonatal Gilbert's syndrome in Malaysia
- Principal Investigator
  
  NISHIO Hisahide
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kobe University
Development of a new treatment with splicing modulators for spinal muscular atrophy
- Principal Investigator
  
  NSIHIO Hisahide
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Cloning of chimera mRNA from acute myelomegakaryocytic leukemia cell with t(1;9)
- Principal Investigator
  
  KAWASAKI Keiichiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Clinical research of gene therapy using tissue-specific promoter for the treatment of metastatic prostate cancer.
- Principal Investigator
  
  KAMIDONO Sadao
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Urology
- Research Institution
  Kobe University
Molecular genetic study on maple syrup urine disease in Philippines
- Principal Investigator
  
  TAKESHIMA Yasuhiro, 中村肇
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
ジストロフィンmRNA前駆体に結合する新規核タンパクに関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Study on the treatment of Duchenne musclar dystrophy with chimera RNA/DNAPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Molecular Epidemiological Study on Human Hereditary Resistant Factors to Malaria
- Principal Investigator
  
  SHIRAKAWA Taku
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Kobe University
Molecular genetic study of frontoethmoidal encephalocele in IndonesiaPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University Graduate School of medicine
Screening system for chemicals attacking pre-mRNA splicing machinery in cells
- Principal Investigator
  
  NISHIO Hisahide
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Kobe University Graduate School of medicine
Research for the exonic splicing enhancer sequences in dysttrophin gene
- Principal Investigator
  
  TAKESHIMA Yasuhiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University School of Medicine
Evaluation of the analytical methods of antisense oligonueleotide applicable to the antisense therapy
- Principal Investigator
  
  OKUMURA Katsuhiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KOBE UNIVERSITY
ジストロフィンmRNA前駆体のスプライシングに関与する新規タンパクのクローニングPrincipal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Establishment of treatment of Duchenne muscular dystrophyPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
The molecular epidemiological analyses of G6PD deficiency in Vietnam
- Principal Investigator
  
  NISHIYAMA Kaoru
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kobe University
Molecular genetic study on G6PD deficiency in Philippines
- Principal Investigator
  
  NAKAMURA Hajime
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
ジストロフィン遺伝子からの新規転写産物のクローニングPrincipal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Study on gene responsible for mesomelic dysplasia identified in ThailandPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Human genetics
- Research Institution
  Kobe University
Establishment of treatment of Duchenne muscular dystrophyPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
血清中DNAのマイクロサテライトを解析するがんの早期診断法の確立Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Study on dystrophin isoform expressed in heartPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
神経線維腫症1型遺伝子異常の蛋白発現ベクターを応用した診断法の確立Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
リンパ球特異的に発現するL-ジストロフィンの発現制御機構に関する研究
- Principal Investigator
  
  西尾久英
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
LINKAGE ANALYSIS OF UNKNOWN GENETIC DISEASES
- Principal Investigator
  
  NIIKAWA Norio
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human genetics
- Research Institution
  NAGASAKI UNIVERSITY
神経線維種症1型遺伝子異常の蛋白発現ベクターを応用した診断法の確立Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Cloning and study on physiological role of new dystrophin isoform.Principal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
蛋白発現ベクターを応用した神経線椎腫症1型の遺伝子異常の解析Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
メッセンジャーRNAを標的としたジストロフィン異常の分子遺伝学的研究Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
ゲノム内分散性反復配列の挿入を認めたジストロフィン遺伝子転写開始領域の構造の研究
- Principal Investigator
  
  西尾久英
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Molecular epidemiological study ovalocytosis in IndonesiaPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kobe University
Molecular biological study to establish the treatment for Duchenne muscular dystrophyPrincipal Investigator
- Principal Investigator
  
  MATSUO Masafumi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
MyoDの筋分化誘導作用を応用したジストロフィン異常の分子生物学的解析Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
メッセンジャーRNA前駆体2次構造の有するプライシング部位の制御機能Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
筋分化誘導因子を応用したジストロフィン異常の分子生物学的解析Principal Investigator
- Principal Investigator
  
  松尾雅文
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
An Application of Growth Factor for the Maturation of Premature InfantsPrincipal Investigator
- Principal Investigator
  
  UETANI Yoshiyuki, 松尾雅文
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University

[Book] RNAiとアンチセンス法-新しいRNAの科学と応用(医療の立場からのアンチセンス法)2005
- Author(s)
  松尾雅文
- Publisher
  講談社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390301
[Journal Article] Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration2024
- Author(s)
  Mamiko Yamada, Kazuhiro Maeta, Hisato Suzuki, Ryo Kurosawa, Toshiki Takenouchi, Tomonari Awaya , Masahiko Ajiro , Atsuko Takeuchi, Hisahide Nishio , Masatoshi Hagiwara , Fuyuki Miya, Masafumi Matsuo, Kenjiro Kosaki
- Journal Title
  
  Sci Rep .
  
  Volume: - Issue: 1 Pages: 6506-6506
- DOI
  10.1038/s41598-024-56704-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15873, KAKENHI-PROJECT-22KJ2023, KAKENHI-PROJECT-21K07762, KAKENHI-PROJECT-23K27379
[Journal Article] A novel splice variant of the human <i>MSTN</i> gene encodes a myostatin‐specific myostatin inhibitor2023
- Author(s)
  Maeta Kazuhiro、Farea Manal、Nishio Hisahide、Matsuo Masafumi
- Journal Title
  
  Journal of Cachexia, Sarcopenia and Muscle
  
  Volume: 14 Issue: 5 Pages: 2289-2300
- DOI
  10.1002/jcsm.13314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07762
[Journal Article] A case of infantile Barth syndrome with severe heart failure: Importance of splicing variants in the TAZ gene2023
- Author(s)
  Takeda A, Ueki M, Abe J, Maeta K, Horiguchi T, Yamazawa H, Izumi G, Chida-Nagai A, Sasaki D, Tsujioka T, Sato I, Shiraishi M, Matsuo M.
- Journal Title
  
  Mol Genet Genomic Med.
  
  Volume: 11 Issue: 7
- DOI
  10.1002/mgg3.2190
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07496, KAKENHI-PROJECT-21K07762
[Journal Article] An Antisense Oligonucleotide against a Splicing Enhancer Sequence within Exon 1 of the MSTN Gene Inhibits Pre-mRNA Maturation to Act as a Novel Myostatin Inhibitor2022
- Author(s)
  Kazuhiro Maeta, Manal Farea, Hisahide Nishio, Masafumi Matsuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23(9) Issue: 9 Pages: 5016-5016
- DOI
  10.3390/ijms23095016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07762
[Journal Article] Human dystrophin Dp71ab enhances the proliferation of myoblasts across species but not human nonmyoblast cells.2022
- Author(s)
  Farea M, Maeta K, Nishio H, and Matsuo M
- Journal Title
  
  Front Cell Dev Biol
  
  Volume: 10 Pages: 877612-877612
- DOI
  10.3389/fcell.2022.877612
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07875
[Journal Article] Dystrophin Dp71ab is monoclonally expressed in human satellite cells and enhances proliferation of myoblast cells2020
- Author(s)
  Manal Farea, Abdul Qawee Mahyoob Rani, Kazuhiro Maeta, Hisahide Nishio, Masafumi Matsuo
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 17123-17123
- DOI
  10.1038/s41598-020-74157-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07861
[Journal Article] Skipping of an exon with a nonsense mutation in the DMD gene is induced by the conversion of a splicing enhancer to a splicing silencer.2019
- Author(s)
  Zhu Y, Deng H, Chen X, Li H, Yang C, Li S, Pan X, Tian S, Feng S, Tan X, Matsuo M, Zhang Z
- Journal Title
  
  Hum Genet
  
  Volume: 138 Issue: 7 Pages: 771-785
- DOI
  10.1007/s00439-019-02036-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07861
[Journal Article] Identification of the shortest splice variant of Dp71, together with five known variants, in glioblastoma cells2018
- Author(s)
  Abdul Q Rani, Farea M, Maeta K, Kawaguchi T, Awano H, Nagai M, Nishio H, Matsuo M
- Journal Title
  
  Biochem Biophy Res Commun
  
  Volume: 508 Issue: 2 Pages: 640-645
- DOI
  10.1016/j.bbrc.2018.11.168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07861
[Journal Article] DMD transcripts in CRL-2061 rhabdomyosarcoma cells show high levels of intron retention by intron-specific PCR amplification2017
- Author(s)
  Niba ETE, Yamanaka R, Rani AQM, Awano H, Matsumoto M, Nishio H, Matsuo M
- Journal Title
  
  Cancer Cell international
  
  Volume: 17 Issue: 1 Pages: 58-73
- DOI
  10.1186/s12935-017-0428-4
- NAID
  120006373783
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07216, KAKENHI-PROJECT-17K10077
[Journal Article] Tissue and case-specific retention of intron 40 in mature dystrophin mRNA2015
- Author(s)
  Nishida.A., Minegishi.M., Takeuchi.A., Niba.ET., Awano.H., Lee.T., Iijima.K., Takeshima.Y., Matsuo.M
- Journal Title
  
  J Hum Genet
  
  Volume: in press Issue: 6 Pages: 327-333
- DOI
  10.1038/jhg.2015.24
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390267
[Journal Article] Exon deletion patterns of the dystrophin gene in 82 vietnamese duchenne/　becker muscular dystrophy patients.2013
- Author(s)
  Tran VK., Ta VT., Vu DC., Nguyen ST., Do HN., Ta MH., Tran TH., Matsuo M.
- Journal Title
  
  Journal of Neurogenetics
  
  Volume: 27 Issue: 4 Pages: 170-5
- DOI
  10.3109/01677063.2013.830616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390267
[Journal Article] Pathogenic orphan transduction created by a non-reference LINE-1retrotransposon2012
- Author(s)
  Solyom S, Ewing AD, Hancks DC, Takeshima Y, Awano H, Matsuo M, Kazazian H Jr
- Journal Title
  
  Hum. Mutat
  
  Volume: 33 Pages: 369-371
- Data Source
  KAKENHI-PROJECT-21390311
[Journal Article] athogenic orphan transduction created by a non-reference LINE-1 retrot ransposon2012
- Author(s)
  Solyom S, Ewing AD, Hancks DC, Takeshima Y, Awano H, Matsuo M, Kazazian HH Jr
- Journal Title
  
  Hum.Mutat
  
  Volume: 33 Pages: 369-371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390311
[Journal Article] Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks.2012
- Author(s)
  Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H.
- Journal Title
  
  Invest New Drugs.
  
  Volume: 30(4) Issue: 4 Pages: 1352-1360
- DOI
  10.1007/s10637-011-9699-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390105
[Journal Article] Moleculaar chaaracterizatioon of the 5'-UUTR of retinnal dysstrophin reveals a cryptiic intron thaat reggulates transslational acttivity2010
- Author(s)
  Kubokawa, I., Takeshima, Y., Ota, M., Enomoto, M., Okizuka, Y., Mori, T., Nishimura, N., Awano, H., Yagi, M., Matsuo, M
- Journal Title
  
  Mol Vis
  
  Volume: 16 Pages: 2590-2597
- Data Source
  KAKENHI-PROJECT-21390311
[Journal Article] Mutation spectrum of the dystrophin gene in 442 Duchenne/Becker muscular dystrophy cases from one Japanese referral center.2010
- Author(s)
  Takeshima Y, Yagi M, Okizuka Y, Awano H, Zhang Z, Yamauchi Y, Nishio H, Matsuo M.
- Journal Title
  
  J Hum Genet. 55
  
  Pages: 379-388
- NAID
  10030735518
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] A polymorphic mutation, c.-3279T>G, in the UGT1A1 promoter is a risk factor for neonatal jaundice in the Malay population.2010
- Author(s)
  Yusoff S, Takeuchi A, Ashi C, Tsukada M, Ma□amor NH, Alwi Zilfalil B, Mohd Yusoff N, Nakamura T, Hirai M, Sari Kusuma Harahap I, Gunadi, Jin Lee M, Yutaka Takaoka NN, Morikawa S, Morioka I, Yokoyama N, Matsuo M, Nishio H, van Rostenberghe H.
- Journal Title
  
  Pediatr Research
  
  Volume: 67 Pages: 401-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390105
[Journal Article] Molecular characterization of the 5'-UTR of retinal dystrophin reveals a cryptic intron that regulates translational activity.2010
- Author(s)
  Kubokawa I, Takeshima Y, Ota M, Enomoto M, Okizuka Y, Mori T, Nishimura N, Awano H, Yagi M, Matsuo M.
- Journal Title
  
  Mol Vis. 16
  
  Pages: 2590-2597
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] Low incidence of limb-girdle muscular dystrophy type 2C revealed by a mutation study in Japanese patients clinically diagnosed with DMD.2010
- Author(s)
  Okizuka Y, Takeshima Y, Itoh K, Zhang Z, Awano H, MarMarrar, Mar, Marma K, Kumagai T, Yagi M, Matsuo M.
- Journal Title
  
  BMC Med Genet. 30
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] Molecular characterization of the 5'-UTR of retinal dystrophin reveals a cryptic intron that regulates translational activity2010
- Author(s)
  Kubokawa, I., Takeshima, Y., Ota, M., Enomoto, M., Okizuka, Y., Mori, T., Nishimura, N., Awano, H., Yagi, M., Matsuo, M.
- Journal Title
  
  Molecular vision
  
  Volume: 16 Pages: 2590-2597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390311
[Journal Article] Contemporary retrotransposition of a novel non-coding gene induces exon-skipping in dystrophin mRNA.2010
- Author(s)
  Awano H, Malueka RG, Yagi M, Okizuka Y, Takeshima Y, Matsuo M.
- Journal Title
  
  J Hum Genet. 55
  
  Pages: 785-790
- NAID
  10030737817
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] Insertion of the IL1RAPL1 gene into the duplication junction of the dystrophin gene2009
- Author(s)
  Zhang Z., Matsuo, M., et al
- Journal Title
  
  J Him Genet 54(8)
  
  Pages: 466-73
- NAID
  10030731391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390311
[Journal Article] Insertion of the IL1RAPL1 gene into the duplication junction of the dystrophin gene.2009
- Author(s)
  Zhang Z, Yagi M, Okizuka Y, Awano H, Takeshima Y, Matsuo M.
- Journal Title
  
  J Hum Genet. 54
  
  Pages: 466-473
- NAID
  10030731391
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] In vitro splicing analysis showed that availability of a cryptic splice site is not a determinant for alternative splicing patterns caused by +1G-->A mutations in introns of the dystrophin gene.2009
- Author(s)
  Habara Y, Takeshima Y, Awano H, Okizuka Y, Zhang Z, Saiki K, Yagi M, Matsuo M.
- Journal Title
  
  J Med Genet. 46
  
  Pages: 542-547
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] Small mutations detected by multiplex ligation-dependent probe amplification of the dystrophin gene.2009
- Author(s)
  Okizuka Y, Takeshima Y, Awano H, Zhang Z, Yagi M, Matsuo M.
- Journal Title
  
  Genet Test Mol Biomarkers. 13
  
  Pages: 427-431
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] A 2-bp deletion in exon 74 of the dystrophin gene does not clearly induce muscle weakness.2008
- Author(s)
  Kimura, S. Ito, K. Ueno, H. Ikezawa, M. Takeshima,Y. Yoshioka, K.Ozasa, S. Nakamuara, K. Nomura, K. Matsukura, M. Mitsui, K. Matsuo, M. Miike, T.
- Journal Title
  
  Brain & Development. 18
  
  Pages: 672-677
- NAID
  10025578962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] A strong exonic splicing enhancer in dystrophin exon 19 achieve proper splicing without an upstream polypyrimidine tract.2008
- Author(s)
  Habara Y, Doshita M, Hirozawa S, Yokono Y, Yagi M, Takeshima Y, Matsuo M.
- Journal Title
  
  J Biochem. 143
  
  Pages: 303-310
- NAID
  10024908594
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] High incidence of electrocardiogram abnormalities in young patients with duchenne muscular dystrophy.2008
- Author(s)
  Takami Y, Takeshima Y, Awano H, Okizuka Y, Yagi M, Matsuo M.
- Journal Title
  
  Pediatr Neurol. 39
  
  Pages: 399-403
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] Dystrophin nonsense mutations can generate alternative rescue transcripts in lymphocytes.2008
- Author(s)
  Nishiyama A, Takeshima Y, Zhang Z, Habara Y, Tran TH, Yagi M, Matsuo M.
- Journal Title
  
  Ann Hum Genet. 72
  
  Pages: 717-724
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] Tandem duplications of two separate fragments of the dystrophin gene in a patient with Duchenne muscular dystrophy.2008
- Author(s)
  Zhang Z, Takeshima Y, Awano H, Nishiyama A, Okizuka Y, Yagi M, Matsuo M.
- Journal Title
  
  J Hum Genet. 53
  
  Pages: 215-219
- NAID
  10021248166
- Data Source
  KAKENHI-PROJECT-20591223
[Journal Article] In vitro splicing analysis reveals that availability of a cryptic splice site is not a determinant for alternative splicing patterns caused by +1G>A mutations in introns of the dystrophin gene.2008
- Author(s)
  Habara, Y.,Takeshima, Y., Awano, H., Okizuka, Y., Zhang, Z., Saiki, K., Yagi, M., Matsuo, M.
- Journal Title
  
  J Med Genet. in press.
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] A Strong Exonic Splicing Enhancer in Dystrophin Exon 19 achieve proper splicing without an upstream polypyrimidine tract.2008
- Author(s)
  Habara,Y.Doshita,M.Hirozawa,S. Yokono,Y.Yagi,M.Takeshima,Y. Matsuo,M.
- Journal Title
  
  J Biochem.143
  
  Pages: 303-310
- NAID
  10024908594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] Dystrophin nonsense mutations can generate alternative rescue transcrips in lymphocytes.2008
- Author(s)
  Nisiyama, A., Takeshima, Y., Zhang, Z., Habara, Y., Tran, TH., Yagi, M., Matsuo, M.
- Journal Title
  
  Ann Hum Genet. 72
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] A Strong Exonic Splicing Enhancer in Dystrophin Exon 19 achieve proper splicing without an upstream polypyrimidine tract2008
- Author(s)
  Habara, Y., Matsuo, M., et al
- Journal Title
  
  J Biochem. 143
  
  Pages: 303-310
- NAID
  10024908594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] Wide ranges of serum myostatin concentrations in Duchenne muscular dystrophy patients.2008
- Author(s)
  Awano, H., Takeshima, Y., Okizuka, Y., Saiki, K., Yagi, M., Matsuo, M.
- Journal Title
  
  Clin Chim Acta. 391
  
  Pages: 115-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] Tandem duplications of two separate fragments of the dystrophin gene in a patient with Duchenne muscular dystrophy.2008
- Author(s)
  Zhang,Z. Takeshima,Y. Awano,H. Nishiyama,A. Okizuka,Y. Yagi,M. Matsuo,M.
- Journal Title
  
  J Hum Genet. 53
  
  Pages: 215-219
- NAID
  10021248166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] Early diagnosis of maple syrup urine disease by PCR-based mutation detection2008
- Author(s)
  CATHERINE LYNN, T.SILAO, MD, PhD, CARMENCITA D.PADILLA, MD MASAFUMI MATSUO, MD, PhD
- Journal Title
  
  Pediatric international (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406031
[Journal Article] In vitro splicing analysis reveals that availability of a cryptic splice site is not a determinant for alternative splicing patterns caused by+1G>Amutations in introns of the dystrophin gene.2008
- Author(s)
  Habara, Y., Matsuo, M., et al
- Journal Title
  
  J Med Genet. (Web)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] A nonsense mutation-created intraexonic splice site is active in the lymphocytes, but not in the skeletal muscle of a DMD patient.2007
- Author(s)
  Tran VK. Takeshima Y, Zhang Z, Habara Y, Haginoya K, Nishiyama A, Yagi M, Matsuo M.
- Journal Title
  
  Hum Genet. 120
  
  Pages: 737-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] Two novel missense mutations in the myostation gene identified in Japanese patients with Duchenne muscular dystrophy.2007
- Author(s)
  Nishiyama A, Takeshima Y, Saiki K, Narukage A, Ouazato Y, Yagi M, Matsuo M.
- Journal Title
  
  BMC Medical Genetics.
  
  Pages: 624-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] In vitro and silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sites.2007
- Author(s)
  Sahashi K, Masuda A, Matsuure T, Shinmi J, Zhang Z, Takeshima Y, Matsuo M, Sobue G, Ohno K.
- Journal Title
  
  Nucleic Acids Res.
  
  Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] Multi-exon skipping leading to an artificial DMD protein lacking amino acids from exons 45 through 55 could rescue up to 63% of patients with Duchenne Muscular Dystrophy.2007
- Author(s)
  Beroud C, Giraud TS, Matsuo M, Hamroun D., Humbertclaude V, Monnier N, Moizard MP, Voelckel MA, Calemard LM, Boisseau P, Blayau M, Philippe C, Cossee M, Pages M, Rivier F, Danos O, Garcia L, Claustres M.
- Journal Title
  
  Hum Mutat. 28
  
  Pages: 196-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390284
[Journal Article] Rescue of dystrophin mRNA of Duchenne muscular dystrophy by inducing exon skipping2005
- Author(s)
  Matsuo, M
- Journal Title
  
  Acta Myologica XXIV
  
  Pages: 110-114
- Data Source
  KAKENHI-PROJECT-16653066
[Journal Article] Rescue of dystrophin mRNA of Duchenne muscular dystrophy by inducing exon skipping.2005
- Author(s)
  Matsuo, M., et al.
- Journal Title
  
  Acta Myologica XXIV
  
  Pages: 110-114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390301
[Journal Article] Discontinuation of Methotrexate after Related Bone Marrow Transplantation ntensify the Graft-versus-Leukemia Effect in a Case of Juvenile Myelomonocytic Leukemia without Obvious Graft-versus-Host Disease2005
- Author(s)
  Keiichiro Kawasaki, Takeshi Mori, Hironobu Takahashi, Wakako Ogino, Akira Hayakawa, Yoshiyuki Kosaka, Yasuhiro Takeshima, Masafumi Matsuo
- Journal Title
  
  The Japanese Journal of Pediatric Hematology Vol.19, No.3(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591107
[Journal Article] Rescue of dystrophin mRNA of Duchenne muscular dystrophy by inducing exon skipping.2005
- Author(s)
  Matsuo, M. et al.
- Journal Title
  
  Acta Myologica XXIV
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390301
[Journal Article] Rescue of dystrophin mRNA of Duchenne muscular dystrophy by inducing exon skipping.2005
- Author(s)
  Matsuo, M.
- Journal Title
  
  Acta Myologica XXIV
  
  Pages: 110-114
- Data Source
  KAKENHI-PROJECT-16390301
[Journal Article] C-terminal Truncated Dystrophin Identified in Skeletal Muscle of an Asymptomatic Boy with a Novel Nonsense Mutation of the Dystrophin Gene2004
- Author(s)
  Suminaga R, Takeshima Y, Wada H, Yagi M, Matsuo M
- Journal Title
  
  Pediatric Research 56
  
  Pages: 739-743
- Data Source
  KAKENHI-PROJECT-16653066
[Journal Article] Cloning of cDNA Encoding Regeneration-associated Muscle Protease Whose Expression is Attenuated in Cell Lines Derived from Duchenne Muscular Dystrophy Patients2004
- Author(s)
  Nakayama Y, Nara N, Kawakita Y, Takeshima Y, Arakawa M, Katoh M, Morita S, Iwatsuki K, Tanaka K, Okamoto S, Kitamura T, Seki N, Matsuda R, Matsuo M, Saito K, Hara T.
- Journal Title
  
  American Journal of Pathology 164
  
  Pages: 1773-1782
- Data Source
  KAKENHI-PROJECT-16653066
[Journal Article] Successful treatment of two cases of juvenile myelomonocytic leukemia with Neurofibromatosis type followed by unrelated allogeneic bone marrow transplantation2004
- Author(s)
  Keiichiro Kawasaki, Takeshi Mori, Hironobu Takahashi, Wakako Ogino, Kazuko Uchide, Akira Hayakawa, Yoshiyuki Kosaka, Yasuhiro Takeshima, Masafumi Matsuo
- Journal Title
  
  The Japanese Journal of Pediatric Hematology Vol.18, No.5
  
  Pages: 554-560
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591107
[Journal Article] Duchenne型筋ジストロフィーのgentamicin治療2004
- Author(s)
  松尾雅文
- Journal Title
  
  脳と発達 36巻2号
  
  Pages: 125-129
- Data Source
  KAKENHI-PROJECT-16591027
[Journal Article] Chimeric RNA and 2'-O, 4'-C-ethylene-bridged nucleic acids have stronger activity than phosphorothioate oligodeoxynucleotides in induction of exon-19 skipping in dystrophin mRNA2004
- Author(s)
  Yagi M, Takeshima Y, Surono A, Takagi M, Koizumi M, Matsuo M.
- Journal Title
  
  Oligonucleotides 14
  
  Pages: 33-40
- Data Source
  KAKENHI-PROJECT-16653066
[Journal Article] Chimeric RNA/ethylene bridged nucleic acids promote dystrophin expression in myocytes of Duchenne muscular dystrophy by inducing skipping of the nonsense-mutation-encoding exon2004
- Author(s)
  Surono A, Khanh TV, Takeshima Y, Wada H, Yagi M, Takagi M, Koizumi M, Matsuo M
- Journal Title
  
  Hum Gene Ther 15
  
  Pages: 749-757
- Data Source
  KAKENHI-PROJECT-16653066
[Journal Article] Early diagnosis of maple syrup urine disease by PCR-based mutation detection
- Author(s)
  CATHERINE, LYNN T.SILAO, MD, PhD, CARMENCITA D.PADILLA, MD, MASAFUMI MATSUO, MD, PhD
- Journal Title
  
  Pediatric international (In press)(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406031
[Patent] ミオスタチンスプライスバリアント由来タンパク質によるミオスタチンシグナル阻害とその利用2021
- Inventor(s)
  松尾雅文、岡崎宏亮、前田和宏
- Industrial Property Rights Holder
  神戸天然物化学株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Acquisition Date
  2024
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] MSTN遺伝子のスプライシングをスイッチするアンチセンス核酸はデュシェンヌ型筋ジストロフィーモデルマウスの所見を改善する2023
- Author(s)
  前田和宏、竹内敦子、西尾久英、松尾雅文
- Organizer
  第9回日本筋学会学術集会、第10回筋ジストロフィー医療研究会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] ミオスタチン新規アイソフォームはミオスタチンを特異的に阻害し筋芽細胞増殖を促進する2021
- Author(s)
  前田和宏、Manal Farea、西尾久英、松尾雅文
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] Spontaneous development of spindle cell sarcoma in mdx mice2018
- Author(s)
  : Satoru Takafuji, Emma Niba, Khin Kyae Mon Thwin, Nobuyuki Yamamoto, Hiroyuki Awano, Suguru Uemura, Takeshi Mori, Shoji Fukushima, Kyoko Itoh, Hisahide Nishio, Masafumi Matsuo, Kazumoto Iijima, Noriyuki Nishimura
- Organizer
  International Society of Pediatric Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07216
[Presentation] Glioma from a DMD patient exhibits differential splicing pattern including exon 71 skipping and intron 40 retention2018
- Author(s)
  : Emma E.T. Niba, Hiroyuki Awano, Masashi Nagai, Masaaki Taniguchi, Rani Adul Qawee, Masakazu Shinohara, Hisahide Nishio, Masafumi Matsuo
- Organizer
  Molecular Biology Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07216
[Presentation] DMD transcription profiling in spontaneously developed tumor from three mdx mice revealed extensive intron retentions and Dp71 isoform expression2018
- Author(s)
  Emma E.T. Niba, Noriyuki Nishimura, Satoru Takafuji, Khin Kyae Mon Thwin, Nobuyuki Yamamoto, Hiroyuki Awano, Shoji Fukushima, Kyoko Itoh, Hisahide Nishio, Masafumi Matsuo
- Organizer
  American Society of Cell Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07216
[Presentation] Dystrophin Dp427 is lost due to multiple DMD intron retentions in rhabdomyosarcoma CRL-2061 cells2017
- Author(s)
  Emma Tabe Eko Niba1,3, Ryo Yamanaka1, Abdul Qawee Mahyoob Rani1, Hiroyuki Awano2, Masaaki Matsumoto2, Hisahide Nishio3, Masafumi Matsuo1
- Organizer
  22nd international congress of the WORLD MUSCLE SOCIETY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07216
[Presentation] Multi-intron retentions in DMD transcripts in CRL-2061 rhabdomyosarcoma cells identified by intron specific RT-PCR amplification2017
- Author(s)
  Emma Tabe Eko Niba1,2, Ryo Yamanaka2, Abdul Qawee Mahyoob Rani2, Hiroyuki Awano3, Masaaki Matsumoto3, Hisahide Nishio1, Masafumi Matsuo2
- Organizer
  Japan Society of Human Genetics
- Data Source
  KAKENHI-PROJECT-16K07216
[Presentation] 筋ジストロフィー患者の尿中プロスタグランジンD2代謝物の定量2012
- Author(s)
  垣内涼平, 成田哲也, 竹内敦子, 鎌内慎也, 裏出良博, 松尾雅文
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659521
[Presentation] Long-term administration of antisense oligonucleotide against dystrophin exon 19 for the treatment of Duchenne muscular dystrophy with exon 20 deletion.2010
- Author(s)
  Matsuo M, Takeshima Y, Yagi M, Awano H.
- Organizer
  XII International Congress on Neuromusular Diseases.
- Place of Presentation
  Naples.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Genotype-phenotype correlation of the dystrophinopathy cases with small mutations in the dystrophin gene.2010
- Author(s)
  Awano H, Takeshima Y, Yagi M, Yamauchi Y, Malueka RG, Dwianingsih EK, Matsuo M.
- Organizer
  Pediatric Academic Societies' 2010 Annual Meeting.
- Place of Presentation
  Vancouver.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Antisense RNA/ENA chimera against dystrophin exon 45 leads exon 45 skipping followed by dystrophin expression in cells from duchenne muscular dystrophy.2010
- Author(s)
  Yagi M, Takeshima Y, Awano H, Ota M, Malueka RG, Dwianingsih EK, Nishida A, Lee T, Matsuo M.
- Organizer
  6th Annual Meeting of the Oligonucleotide Therapeutics Society.
- Place of Presentation
  Southern California
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Antisense RNA/ethylene-bridged nucleic acids chimera induces exon 45 skipping and restores dystrophin expression in myocytes of Duchenne muscular dystrophy.2010
- Author(s)
  Yagi M, Ota M, Awano H, Takeshima Y, Matsuo M.
- Organizer
  15th International Congress of The World Muscle Society.
- Place of Presentation
  Kumamoto
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Antisense RNA/ethylene- bridged nucleic acid chimera induces exon 45 skipping and restores dystrophin expression in DMD muscle cells.2010
- Author(s)
  Yagi M, Ota M, Awano H, Takeshima Y, Matsuo M.
- Organizer
  XII International Congress on Neuromusular Diseases.
- Place of Presentation
  Naples.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Mutation spectrum of the dystrophin gene in 456 Duchienne/Becker muscular dystrophy cases from one Japanese referral center.2010
- Author(s)
  Takeshima Y, Yagi M, Ota M, Awano H, Yamauchi Y, Malueka RG, Dwianingsih EK, Nishio H, Matsuo M.
- Organizer
  15th International Congress of The World Muscle Society.
- Place of Presentation
  Kumamoto.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Chemical treatment of muscular dystrophy that enhances skipping of the mutated exon in the dystrophin gene.2010
- Author(s)
  Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano H, Ota M, Itoh K, Hagiwara M, Matsuo M.
- Organizer
  The American Society of Human Genetics 60th Annual Meeting.
- Place of Presentation
  Washigton, DC.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Chemical treatment of muscular dystrophy that enhances skipping of the mutated exon in the dystrophin gene.2010
- Author(s)
  Nishida, A., Kataoka, N., Takeshima, Y, Yagi, M., Awano, H., Ota, M., Itoh, K., Hagiwara, Y., Matsuo, M.
- Organizer
  The American Society of Human Genetics 60th Annual Meeting
- Place of Presentation
  Washington D.C.
- Data Source
  KAKENHI-PROJECT-22659194
[Presentation] Chemical treatment of muscular dystrophy that enhances skiping of the mutated exon in the dystrophin gene2010
- Author(s)
  Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano H, Ota M, Itoh K, Hagiwara M, Matsuo M
- Organizer
  The American Society of Human Genetics60th Anual Meeting
- Place of Presentation
  Washigton, DC
- Data Source
  KAKENHI-PROJECT-21390311
[Presentation] High incidence of outlier from the reading-frame rule in dystrophinopathy patients with duplication mutations in the dystrophin gene.2009
- Author(s)
  Yagi M, Awano H, Okizuka Y, Takeshima Y, Matsuo M.
- Organizer
  Pediatric Academic Societies' 2009 Annual Meeting.
- Place of Presentation
  Baltimore.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] In vitro splicing analysis reveals that availability of a cryptic splice site is not a determinant for alternative splicing patterns caused by +1G>A mutations in introns of the dystrophin gene.2009
- Author(s)
  Matsuo M, Habara Y, Takeshima Y, Awano H, Okizuka Y, Zhang Z, Yagi M.
- Organizer
  14th International Congress of The World Muscle Society.
- Place of Presentation
  Geneva.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Antisense RNA/ethylene-bridged nucleic acids chimera induces exon skipping and restores dystrophin expression in myocytes of Duchenne muscular dystrophy.2009
- Author(s)
  Yagi M, Yamauchi Y, Awano H, Takeshima Y, Matsuo M.
- Organizer
  The American Society of Human Genetics 59th Annual Meeting.
- Place of Presentation
  Hawaii.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Splicing errors casued by small mutations in the dystrophin gene are different between lymphocytes and muscle tissues.2008
- Author(s)
  Okizuka Y, Awano H, Yagi M, Takeshima Y, Matsuo M.
- Organizer
  Pediatric Academic Societies' 2008 Annual Meeting.
- Place of Presentation
  Hawaii.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Mutation spectrum of the dystrophin gene in 433 Japanese dystrophinopathy cases.2008
- Author(s)
  Takeshima, Y. Yagi, M. Okizuka, Y. Awano, H. Zang, Z. Saiki, K. Matsuo, M.
- Organizer
  The American Society of Human Genetics 58th Annual Meeting.
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19390284
[Presentation] A novel retrotransposon that was recently inserted into exon 67 of the dystrophin gene.2008
- Author(s)
  Awano H, Yagi M, Okizuka Y, Zhang Z, Takeshima Y, Matsuo M.
- Organizer
  Joint 7th Human Genome Organization (HUGO)-Pacific Meeting and the 8th Asia-Pacific Conference on Human Genetics.
- Place of Presentation
  Cebu.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Mutation spectrum of the dystrophin gene in 433 Japanese dystrophinopathy cases.2008
- Author(s)
  Takeshima Y, Yagi M, Okizuka Y, Awano H, Zang Z, Saiki K, Matsuo M.
- Organizer
  The American Society of Human Genetics 58th Annual Meeting.
- Place of Presentation
  Philadelphia.
- Data Source
  KAKENHI-PROJECT-20591223
[Presentation] Chronological changes of serum creatine kinase(CK)levels in molecularly confirmed Duchenne muscular dystrophy cases and examination of the cases with deviated CK levels.2007
- Author(s)
  Okizuka,Y. Takeshima,Y. Yagi,M. Oyazato,Y. Awano,H. Zhang,Z. Matsuo,M.
- Organizer
  57th The American Society of Human Genetics.
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-19390284
[Presentation] The Xq28 inversion breakpoint interrupted a novel noncoding gene in a patient with Duchenne muscular dystrophy with severe mental retardation.2007
- Author(s)
  Yagi,M. Tran Thi,H.T. Zhang,Z. Nishiyama,A. Oyazato,Y. Okinaga,T. Takeshima,Y. Matsuo,M.
- Organizer
  57th The American Society of Human Genetics.
- Year and Date
  2007-10-24
- Data Source
  KAKENHI-PROJECT-19390284
[Presentation] A complex insertion event produced a chimeric dystrophin-IL1RAPL1 transcript in the dystrophin gene.2007
- Author(s)
  Zhang,Z. Takeshima,Y. Yagi,M. Nishiyama,A. Okizuka,Y. Awano,H. Matsuo,M.
- Organizer
  57th The American Society of Human Genetics.
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-19390284
[Presentation] A novel retrotransposon that was recently inserted into exon 67 of the dystrophin gene.2007
- Author(s)
  Awano,H. Yagi,M. Okizuka,Y. Zhang,Z. Takeshima,Y. Matsuo,M.
- Organizer
  57th The American Society of Human Genetics.
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-19390284
[Presentation] Evolutionary acquired alternative splicing in the 5'-UTR of retinal dystrophin transcript is a default pathway with weaker translational activity than nonspliced retina specific form
- Author(s)
  Kubokawa I, Yagi M, Awano H, Ota M, Nishida A, Dwianingsih EK, Malueka RG, Takeshima Y, Matsuo M
- Data Source
  KAKENHI-PROJECT-21390311

1. TAKESHIMA Yasuhiro (40281141)

# of Collaborated Projects: 28 results

# of Collaborated Products: 50 results
2. NISHIO Hiashide (80189258)

# of Collaborated Projects: 18 results

# of Collaborated Products: 0 results
3. SHIRAKAWA Taku (30171044)

# of Collaborated Projects: 8 results

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4. NISHIYAMA Kaoru (00150061)

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5. YAGI Mariko (60362787)

# of Collaborated Projects: 6 results

# of Collaborated Products: 40 results
6. LIEE Jin (20273766)

# of Collaborated Projects: 3 results

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7. ISHIDA Takafumi (20184533)

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8. UETANI Yoshiyuki (40168620)

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9. NAKAMURA Hajime (40030978)

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10. FUKUSHIMA Yoshimitsu (70273084)

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11. AYAKI Hitoshi (80222701)

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MATSUO MASAFUMI 松尾 雅文

MATSUO Masafumi 松尾 雅文

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Elucidation of the molecular mechanism of the myoblast-specific proliferation-promoting effect of Dp71abPrincipal Investigator

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Identification of chemicals that enhance expression of myoblast growth factor Dp71abPrincipal Investigator

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Study on dystrophin Dp71 to regulate satellite cell divisionPrincipal Investigator

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Fluorescent detection of dystrophin mRNA with bispyrene labeled probePrincipal Investigator

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Cloning of non-dystrophin transcript from the dystrophin genePrincipal Investigator

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Expression of dystrophin via exon skipping with a small chemicalPrincipal Investigator

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Dose prostaglandin-mediated inflammation commit to pathology of Duchenne muscular dystrophy?Principal Investigator

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MATSUO MASAFUMI 松尾雅文

MATSUO Masafumi 松尾雅文