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Yamaguchi Akio  山口 明夫

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山口 明夫  ヤマグチ アキオ

YAMAGUCHI Akio  山口 明夫

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Researcher Number 10174608
Other IDs
Affiliation (Current) 2025: 福井医療大学, 保健医療学部, 学長
Affiliation (based on the past Project Information) *help 2019 – 2023: 福井医療大学, 保健医療学部, 学長
2015: 福井大学, 医学部, 教授
2012 – 2013: 福井大学, 医学部, 教授
2008 – 2011: University of Fukui, 医学部附属病院, 教授
2003 – 2006: University of Fukui, Faculty of medical Sciences, Professor, 医学部, 教授 … More
1998 – 2002: 福井医科大学, 医学部, 教授
2000: 福井医科大学, 医科部, 教授
1995 – 1996: 福井医科大学, 医学部, 助教授
1992 – 1993: 福井医科大学, 医学部, 助教授
1991: 金沢大学, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Digestive surgery / Digestive surgery / General surgery
Except Principal Investigator
Digestive surgery / Basic Section 55020:Digestive surgery-related / Digestive surgery
Keywords
Principal Investigator
大腸癌 / Aurora2 / RalBPl / Ral / Reps / colorectal cancer / liver metastasis / CD44 variant exon 8-10 / CD44 / 転移 … More / 浸潤 / Colorectal cancer / Protein phosphatasel (regulatory3) / PPP1R3 gene / FOS luciferase活性 / DNAシーケンス / Protein phosphatase 1(regulatory 3) / Protein phosphatase / Protein phoshatase 1 (regulatory 3) / PPP1R3遺伝子 / APC-ubiquitin-proteasome pathway / ubiquitination / threonine protein / gl-rine / Colorectal Cancer / スレオニンキナーゼ / セリン / APC-ユビキチン-プロテアゾーム系 / ユビキチン化 / セリン・スレオニンキナーゼ / Aurora2遺伝子 / small GTPase / EGFR / Ra1BP1 / Ra1 / RalBP1 / 低分子量G蛋白質 / adhesion molecule / CD44 variant exon 8,9,10 / Migration time / Xanthine oxidase / Carcinogenesis / Xanthine Xidase / 粘膜脱落時間 / 粘膜上皮細胞脱落時間 / Xanthine Oxidase活性 / 小腸発癌 / CXCL12 / CXCR4 / ケモカインレセプター / ケモカイン / EG-VEGF / 血管新生因子 / 消化器癌 / Variant RIN1遺伝子 / 消火器癌 … More
Except Principal Investigator
大腸癌 / colorectal cancer / 血管新生因子 / 肝転移 / EG-VEGF / liver metastasis / MADR2 / DPC4 / Prokineticin1(PROK1) / 抗体 / PROK1 / 血管新生 / PROK1-Receptor2(PK-R2) / PROK1-Receptor1(PK-R1) / 転移メカニズム / PROK1 レセプター / 予後規定因子 / 抗腫瘍効果 / 抗体療法 / PROK1遺伝子 / 血管新生増殖因子 / 転移抑制 / 抗PROK1抗体 / Prokineticin1 / RIN1 gene / シグナル伝達系 / RIN1遺伝子 / Angiogenesis / Colorectal cancer / EG-VEGF遺伝子 / PP2A protein / Protein phosphatase / PPP2R1B gene / プロテインフォスファターゼ / PP2A-A蛋白質 / PPP2R1B / PP2A蛋白質 / プロテインファスファターゼ / PPP2R1B遺伝子 / 血行性転移 / VEGF / Variant EG-VEGF / 転移 / 浸潤 Less
  • Research Projects

    (16 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (4 People)
  •  大腸癌治療:新アプローチ:PROK1分子と分子レセプター結合による未知の機能解析

    • Principal Investigator
      五井 孝憲
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      University of Fukui
  •  Inhibitory effect of an anti-prokineticin-1 antibody on liver metastases in mice

    • Principal Investigator
      Goi Takanori
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      University of Fukui
  •  Simultaneous targeting of both angiogenic growth factors(VEGF/PROK1) in colorectal cancers

    • Principal Investigator
      Goi Takanori
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Fukui
  •  CXCR4-CXCL12 signaling pathway is an important biological mediator in colorectal cancer cellsPrincipal Investigator

    • Principal Investigator
      YAMAGUCHO Akio
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Fukui
  •  Cloning of a splicing variant of EG-VEGF in colorectal cancer.

    • Principal Investigator
      GOI Takanori
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Fukui
  •  Function of New vascular endothelial growth factor (EG-VEGF) in colon cancer.Principal Investigator

    • Principal Investigator
      YAMAGUCHI Akio
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Fukui
  •  消化器癌における新規RIN1遺伝子(Variant RIN1)の解析Principal Investigator

    • Principal Investigator
      山口 明夫
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      University of Fukui
  •  Analysis of H-Ras-RIN1 signaling cascade in colorectal cancer

    • Principal Investigator
      GOI Takanori
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Fukui
  •  Angiogenesis and Tumor Proliferation/Metastasis of Human Colorectal Cancer Cell Line SW620 Transfected with Endocrine Glands-Derived-Vascular Endothelial Growth Factor, As a New Angiogenic Factor

    • Principal Investigator
      GOI Takanori
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Fukui
      福井医科大学
  •  PPP1R3 gene (Protein phosphatase 1) alterations in colorectal cancersPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Akio
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Faculty of Medical Sciences, University of Fukui
  •  The mechanism of PPP2R1B genein colorectal cancers

    • Principal Investigator
      GOI Takanori
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Fukui Medical University
  •  Aurora2 protein regulated by the anaphase-promoting complex-ubiquitin-proteasome pathway.Principal Investigator

    • Principal Investigator
      ISHIDA Makoto
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      福井医科大学
  •  Genetic alterations and reduced expression of the DPC4 molucule in colorectal cancers and relationship to liver metastasis

    • Principal Investigator
      GOI Takanori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Fukui Medical University
  •  The functions for Ras/Ral signaling cascadePrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Akio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Fukui Medical University
  •  Expression of variant CD44 in colorectal cancer and its relationship to metastasisPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Akio
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Fukui Medical School
  •  Carcinogenresistance mechanism in the small intestinal tractsPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Akio
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      FUKUI MEDICAL SCHOOL
      Kanazawa University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book

  • [Book] 手術記録の書き方S状結腸癌切除術2014

    • Author(s)
      五井孝憲、山口明夫
    • Publisher
      消化器外科
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Book] 結腸癌に対する細径化鉗子を用いた患者と医師に優しいreduced port surgery2013

    • Author(s)
      五井孝憲、飯田敦、山口明夫
    • Publisher
      臨床雑誌外科
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Book] 大腸・肛門外科における現況と今後2011

    • Author(s)
      山口明夫、五井孝憲
    • Data Source
      KAKENHI-PROJECT-22591481
  • [Book] 大腸・肛門外科における現況と今後2011

    • Author(s)
      山口明夫、五井孝憲
    • Publisher
      日本医師会雑誌
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Book] 大腸癌(大腸癌の治療戦略:高齢者の StageI-III 大腸癌の治療2010

    • Author(s)
      五井孝憲、山口明夫
    • Data Source
      KAKENHI-PROJECT-22591481
  • [Book] 大腸癌(大腸癌の治療戦略:高齢者のStageI-III大腸癌の治療)2010

    • Author(s)
      五井孝憲、山口明夫
    • Publisher
      日本臨床
    • Data Source
      KAKENHI-PROJECT-20591587
  • [Book] 2009-2010(大腸ポリープ・ポリポーシス)(消化器疾患最新治療)2009

    • Author(s)
      五井孝憲、山口明夫
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-20591587
  • [Journal Article] The anti-tumor effect is enhanced by simultaneously targeting VEGF and PROK1 in colorectal cancer2015

    • Author(s)
      Goi T, Nakazawa T, Hirono Y, Yamaguchi A
    • Journal Title

      Oncotarget

      Volume: 6(8) Issue: 8 Pages: 6053-6061

    • DOI

      10.18632/oncotarget.3474

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25462047
  • [Journal Article] Prokineticin 1 protein expression is a useful new prognostic factor for human sporadic colorectal cancer2015

    • Author(s)
      Nakazawa T, Goi T, Hirono Y, Yamaguchi A
    • Journal Title

      Annals of Surgical Oncology

      Volume: 22(5) Issue: 5 Pages: 1496-1503

    • DOI

      10.1245/s10434-014-4150-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462047
  • [Journal Article] Expression of prokineticin-receptor2(PK-R2) is a new prognostic factor in human colorectal cancer2015

    • Author(s)
      Goi T, Kurebayashi H, Ueda Y, Naruse T, Nakazawa T, Koneri K, Hirono Y, Katayama K, Yamaguchi A
    • Journal Title

      Oncotarget

      Volume: 6(13) Issue: 31 Pages: 31758-13766

    • DOI

      10.18632/oncotarget.5565

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25462047
  • [Journal Article] The prognosis was poorer in colorectal cancers that expressed both VEGF and PROK1 (No correlation coefficient between VEGF and PROK1)2015

    • Author(s)
      Goi T, Nakazawa T, Hirono Y, Yamaguchi A
    • Journal Title

      Oncotarget

      Volume: 6(30) Issue: 30 Pages: 28790-28799

    • DOI

      10.18632/oncotarget.4744

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25462047
  • [Journal Article] Measures for preventing wound infections during elective open surgery for colorectal cancer : scrubbing with gauze2014

    • Author(s)
      Goi T, Ueda Y, Nakazawa T, Sawai K, Morikawa M, Yamaguchi A.
    • Journal Title

      International Surgery

      Volume: 99 Pages: 35-39

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] Anti-Prokineticin1 (PROK1) Monoclonal Antibody Suppresses Angiogenesis and Tumor Growth in Colorectal Cancer2014

    • Author(s)
      Goi T, Nakazawa T, Hirono Y, Yamaguchi A.
    • Journal Title

      Annals of Surgical Oncology

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] The expression of integrins is decreased in colon cancer cells treated with polysaccharide K2013

    • Author(s)
      Aso K, Goi T, Nakazawa T, Kimura Y, Hirono Y, Katayama K, Yamaguchi A.
    • Journal Title

      International Journal of Oncology

      Volume: 42 Pages: 1175-1180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] CD44variant exon 9 plays an important role in colon cancer initiating cells2013

    • Author(s)
      Kimura Y, Goi T, Nakazawa T, Hirono Y, Katayama K, Urano T, Yamaguchi A.
    • Journal Title

      Oncotarget

      Volume: 4 Pages: 785-791

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] The expression of integrins is decreased in colon cancer cells treated with polysaccharide K2013

    • Author(s)
      K. Aso, T. Goi, T. Nakazawa, Y. Kimura, Y. Hirono, K. Katayama, A. Yamaguchi
    • Journal Title

      Int J Oncol

      Volume: 42 Pages: 1175-1180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591481
  • [Journal Article] Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines2013

    • Author(s)
      Tabata S, Goi T, Nakazawa T, Kimura Y, Katayama K, Yamaguchi A.
    • Journal Title

      Oncology Report

      Volume: 29 Pages: 459-463

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines2013

    • Author(s)
      S. Tabata, T. Goi, T. Nakazawa, Y. Kimura, K. Katayama, A. Yamaguchi
    • Journal Title

      Oncol Rep

      Volume: 29 Pages: 459-463

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591481
  • [Journal Article] Prokineticin 1 expression in gastrointestinal tumors2013

    • Author(s)
      Goi T, Nakazawa T, Hirono Y, Yamaguchi A.
    • Journal Title

      Anticancer Research

      Volume: 33 Pages: 5311-5315

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] Protein-bound polysaccharide K reduced the invasive ability of colon cancer cell lines2013

    • Author(s)
      Uwafuji S, Goi T, Naruse T, Kurebayashi H, Nakazawa T, Hirono Y, Yamaguchi A.
    • Journal Title

      Anticancer Research

      Volume: 33 Pages: 4841-4845

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] Changes in CO2 concentration increase the invasive ability of colon cancer cells2013

    • Author(s)
      Obata S, Goi T, Nakazawa T, Kimura Y, Katayama K, Yamaguchi A.
    • Journal Title

      Anticancer Research

      Volume: 33 Pages: 1881-1885

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer2012

    • Author(s)
      Y. Fujishima, T. Goi, Y. Kimura, Y. Hirono, K. Katayama, A. Yamaguchi
    • Journal Title

      Int J Oncol

      Volume: 40 Pages: 960-964

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591481
  • [Journal Article] MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer2012

    • Author(s)
      Fujishima Y, Goi T, Kimura Y, Hirono Y, Katayama K, Yamaguchi A.
    • Journal Title

      International Journal of Oncology

      Volume: 40 Pages: 960-964

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line2011

    • Author(s)
      T. Inoue, T. Goi, Y. Hirono, K. Katayama, A. Yamaguchi
    • Journal Title

      LoVo. Oncol Res.

      Volume: 19 Pages: 527-534

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591481
  • [Journal Article] RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line LoVo2011

    • Author(s)
      Inoue T, Goi T, Hirono Y, Katayama K, Yamaguchi A.
    • Journal Title

      Oncology Research

      Volume: 19 Pages: 527-534

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591957
  • [Journal Article] The effectiveness of transverse coloplasty in patients with ultra-lower rectal cancer.2010

    • Author(s)
      Goi T, Honda K, Katayama K, Yamaguchi A.
    • Journal Title

      Int Surg. 95

      Pages: 210-214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591587
  • [Journal Article] The effectiveness of transverse coloplasty in patients with ultra-lower rectal cancer2010

    • Author(s)
      T. Goi, K. Honda, K. Katayama, A. Yamaguchi
    • Journal Title

      Int Surg

      Volume: 95 Pages: 201-214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591481
  • [Journal Article] Survivin-3B gene decreases the invasion-inhibitory effect of colon cancer cells with 5-fluorouracil.2010

    • Author(s)
      Sawai K, Goi T, Hirono Y, Katayama K, Yamaguchi A.
    • Journal Title

      Oncol Res. 18

      Pages: 541-547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591587
  • [Journal Article] Survivin-3B gene decreases the invasion-inhibitory effect of colon cancer cells with 5-fluorouracil2010

    • Author(s)
      K. Sawai, T. Goi, Y. Hirono, K. Katayama, A. Yamaguchi
    • Journal Title

      Oncol Res

      Volume: 18 Pages: 541-547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591481
  • [Journal Article] Clinicopathological analysis of colorectal cancers in the elderly.2009

    • Author(s)
      Goi T, Kawasaki M, Inoue T, Fujioka M, Hirono Y, Katayama K, Yamaguchi A
    • Journal Title

      Int Surg. 94

      Pages: 189-195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591587
  • [Journal Article] Clinicopathological analysis of invading muscularis propria (T2) cancers <or =20 mm in diameter.2008

    • Author(s)
      Goi T, Kawasaki M, Hirono Y, Katayama K, Yamaguchi A.
    • Journal Title

      Int Surg. 93

      Pages: 1-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591587
  • [Journal Article] Analysis of RIN1 gene expression in colorectal cancer2007

    • Author(s)
      Katsunori SENDA, Takanori GOI, Yasuo HIRONO, Kanji KATAYAMA, Akio YAMAGUCHI
    • Journal Title

      Oncology Report 17

      Pages: 1171-1175

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591384
  • [Journal Article] Analysis of RIN1 gene expression in colorectal cancer.2007

    • Author(s)
      Katsunori SENDA, Takanori GOI, Yasuo HIRONO, Kanji KATAYAMA, Akio YAMAGUCHI
    • Journal Title

      Oncology Report 17

      Pages: 1171-1175

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591384
  • [Presentation] 消化器癌における新規血管新生増殖因子:EG-VEGF(endocrine glands-derived-venous endothelial growth factor) の発現と臨床応用への可能性2012

    • Author(s)
      五井孝憲,山口明夫 他
    • Organizer
      第112回日本外科学会定期学術集会
    • Year and Date
      2012-04-12
    • Data Source
      KAKENHI-PROJECT-22591481
  • [Presentation] 大腸癌肝転移と血管新生増殖因子:EG-VEGF との関連性について2010

    • Author(s)
      五井孝憲, 山口明夫, 他
    • Organizer
      第65回日本消化器外科学会総会:シンポジウム
    • Place of Presentation
      下関
    • Year and Date
      2010-07-15
    • Data Source
      KAKENHI-PROJECT-20591587
  • [Presentation] 大腸癌においてEG-VEGF(endocrine glands-derived-venousendothelial growth factor) 遺伝子は細胞増殖に関与する.2009

    • Author(s)
      五井孝憲, 山口明夫, 他
    • Organizer
      第109回日本外科学会定期学術集会:サージカルフォーラム
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-02
    • Data Source
      KAKENHI-PROJECT-20591587
  • 1.  GOI Takanori (60225638)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 36 results
  • 2.  HIROSE Kazuo (00181199)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  米村 豊 (20167042)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  石田 誠 (00311689)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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