TSUKAMOTO Ikuko 塚本郁子

… Alternative Names

TSUKSMOTO Ikuko 塚本郁子

塚本郁子ツカモトイクコ

TUKAMOTO Ikuko 塚本郁子

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Researcher Number	10183477
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2022: 香川大学, 医学部, 寄附講座教員 2017 – 2019: 香川大学, 医学部, 寄付講座教員 2016: 香川大学, 医学部薬物生体情報学講座, 客員教授 2003 – 2004: 香川大学, 医学部, 客員助教授 2002: 香川医科大学, 医学部, 客員助教授 … More 1998 – 1999: 香川医科大学, 医学部, 助手 1995 – 1996: 香川医科大学, 医学部, 助手 1993: 香川医科大学, 医学部, 助手 1988 – 1991: 香川医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies Except Principal Investigator 麻酔学 / Basic Section 58040:Forensics medicine-related / Dermatology / Drug development chemistry / Hematology / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator C57BL / ddN / 吸入麻酔薬 / genetic / prepropriomelanocortine / tyrosine hydroxylase / monoaminergic nerve / neuropetide Y / volatile anesthetics / マウス … More / 感受性 / 麻酔薬 / 遺伝子 / プレプロオピオメラノコルチン / チロシンヒドロキシラーゼ / モノアミン神経系 / ニューロペプチドY / エンケファリン … More Except Principal Investigator COA-Cl / コアクロル / fenitrothion / VEGF / Akt / Src family / PI3-kinase / 血管新生 / cholinesterase / コリンエステラ-ゼ / 急性中毒 / 有機リン / Parkinson's model / dopaminergic neuron / cell viability / cell culture / MPP / Monoamines / Mortality / PC12 / MPP+ / Nicotine / mouse brain / TH phosphorylation / dopamine metaboliies / MPTP / MPTP-treated mice / tyrosine hydroxylase / Dopamine / ethanol / dopamine / nicotine / Ethanol / 成長因子 / 核酸アナログ / 結合組織成長因子 / 線維芽細胞 / TGF-β / 全身性強皮症 / TGF / 強皮症 / CTGF / 線維化 / 皮膚 / S1P1受容体アゴニスト / 2クロル炭素環オキセタノシンA / 核酸類縁体 / 構造活性相関 / 血管新生促進作用 / ２クロル炭素環オキセタノシンＡ / 血管新生促進剤 / 血管新生促進活性 / high pressure liquid chromatography / organo-phosphate poisoning / 高圧液体クロマトグラフィ- / 高圧液体クロマトグフフィ- / 有機リン剤 / 農薬中毒 / signal transduction / peripheral blood progenitor cells / neovascularization / endothelial progenitor cells / 臍帯血 / シグナル伝達 / 末梢血幹細胞 / 血管内皮前駆細胞 / volatile poison / chemical intoxication / expired gas analysis / FT-IR spectroscopy / 長光路気体セル / FT-IR / FT IR分光分析 / 揮発性毒物 / 薬物中毒 / 呼気分析 / FT-IR分光分析 / pharmacokinetics / acetylcholinesterase / poisoning / organo-phosphate / 薬物血中濃度 / 薬物濃度 / 薬物速度論 / アセチルコリンエステラ-ゼ Less

Does the combination of nicotine and ethanol facilitate or block dopaminergic neuron damage in Parkinson's disease models?
- Principal Investigator
  
  Mostofa Jamal
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Kagawa University
A novel angigenic agent COA-Cl prohibits fibrotic effect induced by CTGF in human fibroblasts.
- Principal Investigator
  
  KUBOTA YASUO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kagawa University
Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents
- Principal Investigator
  
  Sakakibara Norikazu
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokushima Bunri University
Treatment of ischemic disorders using endothelial progenitor cells derived from peripheral blood stem cells and cord blood and analysis of the signal transduction involved in neovasculalization
- Principal Investigator
  
  KUBOTA Yoshitsugu
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kagawa University
  香川大学(医学部)
Genetic Profile of Anesthetics Susceptibility in MicePrincipal Investigator
- Principal Investigator
  
  TSUKAMOTO Ikuko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kagawa Medical University
FTIR analysis of expired gas in acute chemical poisoning
- Principal Investigator
  
  SHIRAKAWA Yoichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Ehime University
  香川医科大学
揮発性麻酔薬の脳内伝達物質の分子構造に及ぼす影響についてPrincipal Investigator
- Principal Investigator
  
  塚本郁子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  香川医科大学
Study on pathophysiology and therapy of serious organo-phosphate poisoning.
- Principal Investigator
  
  SHIRAKAWA Yoichi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  麻酔学
- Research Institution
  Kagawa Medical School
Experimental study on pathphysiology of organophosphate poisoning.
- Principal Investigator
  
  SHIRAKAWA Yoichi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  麻酔学
- Research Institution
  Kagawa Medical School

All 2019 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis.2019
- Author(s)
  Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, and Kubota Y
- Journal Title
  
  J Dermatol Sci
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10210
[Journal Article] Synthesis and evaluation of novel cyclopropane nucleoside as potential tube formation agents.2017
- Author(s)
  Sakakibara, N.; Igarashi, J.; Takata, M.; Konishi, R.; Kato, Y.; Tsukamoto, I.
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 未定
- NAID
  130005631529
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts2016
- Author(s)
  Igarashi, J.; Okamoto, R.; Yamashita, T.; Hashimoto, T.; Karita, S.; Nakai, K.; Kubota, Y.; Takata, M.; Yamaguchi, F.; Tokuda, M.; Sakakibara, N.; Tsukamoto, I.; Konishi, R.; Hirano, K.
- Journal Title
  
  Physiological reports
  
  Volume: 4(6)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.2016
- Author(s)
  Igarashi, J.; Okamoto, R.; Yamashita, T.; Hashimoto, T.; Karita, S.; Nakai, K.; Kubota, Y.; Takata, M.; Yamaguchi, F.; Tokuda, M.; Sakakibara, N.; Tsukamoto, I.; Konishi, R.; Hirano, K.
- Journal Title
  
  Physiological reports
  
  Volume: 4(6)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] Design, synthesis, and evaluation of novel 2-halogenated or aminated carbocyclic oxetanocin A analogs as potential angiogenic agents2015
- Author(s)
  Sakakibara, N.; Igarashi, J.; Takata, M.; Konishi, R.; Suzue, N.; Kato, Y.; Maruyama, T.; Tsukamoto, I.
- Journal Title
  
  Heterocycles
  
  Volume: 91(9) Pages: 1823-1832
- NAID
  40020609194
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents2015
- Author(s)
  Sakakibara, N.; Igarashi, J.; Takata, M.; Demizu, Y.; Misawa, T.; Kurihara, M.; Konishi, R.; Kato, Y.; Maruyama, T.; Tsukamoto, I.
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 63(9) Pages: 701-709
- NAID
  130005096030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells2014
- Author(s)
  Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 2 Issue: 5 Pages: 68-68
- DOI
  10.1002/prp2.68
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PROJECT-24591654, KAKENHI-PROJECT-24790123, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25461132, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26220203
[Journal Article] Delayed administration of the nucleic acid analog 2Cl-C.OXT-A attenuates brain damage and enhances functional recovery after ischemic stroke.2013
- Author(s)
  Okabe, N.; Nakamura, E.; Himi, N.; Narita, K.; Tsukamoto, I.; Maruyama, T.; Sakakibara, N.; Nakamura, T.; Itano, T.; Miyamoto, O.
- Journal Title
  
  Brain Research
  
  Volume: 1506 Pages: 115-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] A New Method for Synthesis and Angiogenic Evaluation of Leteprinim Potassium and Its Novel Analogs.2013
- Author(s)
  Sakakibara, N.; Tsukamoto, I.; Isono, Y.; Takata, M.; Konishi, R.; Kato, Y.; Maruyama, T.
- Journal Title
  
  Heterocycles
  
  Volume: 87(11) Pages: 2369-2384
- NAID
  40019844853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] Novel Synthesis of Carbocyclic Oxetanocin Analogs (2-Alkoxy-C.OXT-A) and Their Tube Formation Activities of Human Umbilical Vein Endothelial Cells (HUVEC).2012
- Author(s)
  Sakakibara, N.; Tsukamoto, I.; Tsurura, T; Takata, M; Konishi, R; Maruyama, T.
- Journal Title
  
  Heterocycles
  
  Volume: 85(5) Pages: 1105-1116
- NAID
  40019238576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA (COA-Cl)の新規2-置換型類縁体の創製研究2016
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，小西良士，鈴江奈月,加藤善久，丸山徳見，塚本郁子
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規2-置換型類縁体の合成とその血管新生促進作用2016
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，小西良士，鈴江奈月，加藤善久，丸山徳見，塚本郁子
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 新規核酸アナログCOA-Cl の神経保護栄養作用2016
- Author(s)
  塚本郁子，高田麻紀，窪田泰夫，徳田雅明，榊原紀和，五十嵐淳介，小西良士
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] アデノシンアナログCOA-Clの神経栄養／保護作用-(2)2016
- Author(s)
  塚本郁子，榊原紀和，五十嵐淳介，徳田雅明，窪田泰夫，高田麻紀，小西良士
- Organizer
  第89回日本生化学会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] A Key Role of PGC-1α Co-transcription Factor, but not HIF1α Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-Cl in Cultured Human Fibroblasts2015
- Author(s)
  Okamoto, R., Igarashi, J., Yamashita, T., Hashimoto, T., Karita, S., Shoji, K., Kubota, Y., Takata, M., Yamaguchi, F., Tokuda, M., Sakakibara, N., Tsukamoto, I., Konishi, R., Hirano, K.
- Organizer
  The American Heart Association’s Scientific Sessions 2015
- Place of Presentation
  アメリカ・フロリダ
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規誘導体の合成とその血管新生促進作用2015
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
- Organizer
  第45回複素環化学討論会
- Place of Presentation
  東京
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 血管新生促進作用を有する新規2-クロル炭素環オキセタノシンA (COA-Cl)誘導体の創製2015
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA(COA-Cl)の新規誘導体の創製研究2015
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
- Organizer
  第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高知
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] アデノシンアナログCOA-Clの神経栄養／保護作用2013
- Author(s)
  塚本郁子，榊原紀和，丸山徳見，五十嵐淳介，小坂博昭，徳田雅明，窪田泰夫，高田麻紀，小西良士
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] A newly synthesized adenosine analogue, COA-Cl has angiogenic potency2013
- Author(s)
  Tsukamoto, I., Takata, M., Sakakibara, N., Maruyama, T., Igarashi, J., Kosaka, H., Kubota, Y., Tokuda, M., Ashino, H., Hattori, K., Tanaka, S., Kawata, M., and Konishi, R.
- Organizer
  International Pharmaceutical Federation
- Place of Presentation
  Dublin, Ireland.
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] Synthesis of carbocyclic oxetanocin analogs (2-alkoxy- C.OXT-A) and their tube formation activities of human umbilical vein endothelial cells (HUVEC)2012
- Author(s)
  Norikazu Sakakibara, Ikuko Tsukamoto, Takashi Tsuruta, Maki Takata, Ryoji Konishi, and Tokumi Maruyama
- Organizer
  The 6th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 新規開発した方法による2-アルコキシ-C.OXT-Aの合成と血管新生促進活性評価2012
- Author(s)
  榊原紀和，塚本郁子，鶴田崇，丸山徳見
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] HUVECにおけるCOA-Clの血管新生作用に対するS1Pレセプターの関与
- Author(s)
  塚本郁子，五十嵐淳介，橋本剛，山下哲生，榊原紀和，丸山徳見，高田麻紀，窪田泰夫，平野勝也，小西良士
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] Physiological activities of the rare sugar derivatives
- Author(s)
  Tsukamoto, I., Takata, M., Kubota, Y., Kawanami, Y., Sakakibara, N., Maruyama, T., Tokuda, M., and Konishi, R.
- Organizer
  Rare Sugar Symposium 2014 in Kagawa
- Place of Presentation
  高松
- Year and Date
  2014-04-29 – 2014-04-30
- Data Source
  KAKENHI-PROJECT-24790123

1. SHIRAKAWA Yoichi (90134600)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. AMENO Kiyoshi (50019626)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SEKI Keisuke (20226632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. IGARASHI Junsuke (20346638)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
5. NISHIYAMA Takashi (60243771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NOGAYA Junko (70263902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KUBOTA Yoshitsugu (90178054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KITANAKA Akira (70343308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OHNISHI Hiroaki (90223891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TANAKA Terukazu (20155146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OGURA Shinji (30185566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Sakakibara Norikazu (10441594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
13. KUBOTA YASUO (10126047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. Mostofa Jamal (50418802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中井浩三 (40363204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 多久和典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 岡本安雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 多久和陽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUKAMOTO Ikuko 塚本 郁子

TSUKSMOTO Ikuko 塚本 郁子

塚本 郁子 ツカモト イクコ

TUKAMOTO Ikuko 塚本 郁子

Research Projects

Research Products

Co-Researchers

Does the combination of nicotine and ethanol facilitate or block dopaminergic neuron damage in Parkinson's disease models?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel angigenic agent COA-Cl prohibits fibrotic effect induced by CTGF in human fibroblasts.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Treatment of ischemic disorders using endothelial progenitor cells derived from peripheral blood stem cells and cord blood and analysis of the signal transduction involved in neovasculalization

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic Profile of Anesthetics Susceptibility in MicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

FTIR analysis of expired gas in acute chemical poisoning

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

揮発性麻酔薬の脳内伝達物質の分子構造に及ぼす影響についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on pathophysiology and therapy of serious organo-phosphate poisoning.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental study on pathphysiology of organophosphate poisoning.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis.2019

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and evaluation of novel cyclopropane nucleoside as potential tube formation agents.2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts2016

Author(s)

Journal Title

Data Source

[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.2016

Author(s)

Journal Title

Data Source

[Journal Article] Design, synthesis, and evaluation of novel 2-halogenated or aminated carbocyclic oxetanocin A analogs as potential angiogenic agents2015

Author(s)

TSUKAMOTO Ikuko 塚本郁子

TSUKSMOTO Ikuko 塚本郁子

塚本郁子ツカモトイクコ

TUKAMOTO Ikuko 塚本郁子