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Doi Mitsunobu  土井 光暢

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DOI Mitsunobu  土井 光暢

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Researcher Number 10183500
Other IDs
Affiliation (based on the past Project Information) *help 2010: 大阪薬科大学, 大阪薬科大学, 教授
2007 – 2010: 大阪薬科大学, 薬学部, 教授
2008 – 2009: Osaka University of Pharmaceutical Sciences, 教授
1994 – 1997: 大阪薬科大学, 薬学部, 助教授
1993: 大阪薬科大学, 薬学部, 講師
Review Section/Research Field
Principal Investigator
Physical pharmacy / 医薬分子機能学 / Chemical pharmacy
Except Principal Investigator
Drug development chemistry
Keywords
Principal Investigator
NUCLEIC ACID / HETEROMOLECULE / INTERACTION / STRUCTURE / PEPTIDE / PNA / グラミシジンS / HETEROMDLECULE / コラーゲン / コアセルベーション … More / ゲル化 / 結晶化 / CD / βアミノ酸 / 構造活性相関 / 鏡像体(エナンチオマー) / キラリティー / ペプチド / 両親媒体 / ラセミ結晶 / エナンチオマー / 両親媒性 / X線構造解析 … More
Except Principal Investigator
ペプチド / ドラッグデリバリーシステム / 有機化学 / 薬学 / 細胞膜透過性 / ヘリックス構造 / 膜透過性ペプチド / 二次構造解析 / 非天然型アミノ酸 / ヘリックス / 環状アミノ酸 / リード化合物 / 3次元立体構造 / 免疫制御分子 / 配座固定ライブラリー / ジ置換アミノ酸 Less
  • Research Projects

    (6 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (11 People)
  •  Development of cell penetrating peptide utilizing the charactaristic of disubstituted amino acid

    • Principal Investigator
      Kato Takuma
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Drug development chemistry
    • Research Institution
      Osaka University of Pharmaceutical Sciences
  •  Development of dosage form using elastin fragments by incorporation of β-amino acidsPrincipal Investigator

    • Principal Investigator
      DOI Mitsunobu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences
  •  環状ジ置換アミノ酸配座固定ペプチドライブラリーによる免疫制御分子の探索

    • Principal Investigator
      Tanaka Masakazu
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Nagasaki University
      Kyushu University
  •  Interaction between heteromolecules-Structural study and application of PNA-Principal Investigator

    • Principal Investigator
      DOI Mitsunobu
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Osaka University of Pharmaceutical Sciences (OUPS)
  •  グラミシジンSの会合状態と細胞膜への作用機構Principal Investigator

    • Principal Investigator
      土井 光暢
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences
  •  グラミシジンSの会合状態と細胞膜への作用機構-構造解析のためのアプローチ-Principal Investigator

    • Principal Investigator
      土井 光暢
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences

All 2019 2018 2017 Other

All Journal Article Presentation

  • [Journal Article] Crystal structure of N-{N-[N-(tert-butoxycarbonyl)-L-α-aspartyl]-L-α-aspartyl}-L-α-aspartic acid 14,24,34-trimethyl ester 31-2-oxo-2-phenylethyl ester {Boc-[Asp(OMe)]3-OPac}2019

    • Author(s)
      Kato Takuma、Kishimoto Saki、Asano Akiko、Doi Mitsunobu
    • Journal Title

      Acta Crystallographica Section E Crystallographic Communications

      Volume: 75 Issue: 5 Pages: 585-588

    • DOI

      10.1107/s2056989019004596

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H07269
  • [Journal Article] Left-handed helix of three-membered ring amino acid homopeptide interrupted by an N-H...ethereal O type hydrogen bond2018

    • Author(s)
      Y. Koba, A. Ueda, M. Oba, M. Doi, T. Kato, Y. Demizu, M. Tanaka*
    • Journal Title

      Org. Lett.

      Volume: 20 Issue: 24 Pages: 7830-7834

    • DOI

      10.1021/acs.orglett.8b03331

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14870, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-17H07269, KAKENHI-PROJECT-16K18847
  • [Journal Article] Crystal structure of 3-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacen-3-yl)propanoic acid2017

    • Author(s)
      Kato Takuma、Doi Mitsunobu
    • Journal Title

      Acta Crystallographica Section E Crystallographic Communications

      Volume: 73 Issue: 12 Pages: 1974-1976

    • DOI

      10.1107/s2056989017016942

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H07269
  • [Journal Article] (2010) Crystal Structure of t-Butyloxy- carbonyl-L-prolyl-L-hydroxyprolyl-glicine methyl ester (Boc-Pro-Hyp-Gly-OMe). Anal. Sci.

    • Author(s)
      Asano A., Imori K., Sakaguchi N., Doi M.
    • Journal Title

      X-Ray Structure Analysis Online 26

      Pages: 53-54

    • Data Source
      KAKENHI-PROJECT-20590023
  • [Presentation] ヘリカルペプチドフォルダマーをキラル源とする不斉触媒反応の開発2019

    • Author(s)
      梅野 智大, 上田 篤志, 加藤 巧馬, 土井 光暢, 田中 正一
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-17H07269
  • [Presentation] Design and Synthesis of Cyclic Disubstituted Amino Acids for Development of Cell Penetrating Peptide2018

    • Author(s)
      Takuma Kato, Akiko Asano, Makoto Oba, Masakazu Tanaka, Mitsunobu Doi
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H07269
  • [Presentation] 膜透過性ペプチドへの応用のための環状ジ置換アミノ酸の合成2018

    • Author(s)
      加藤巧馬、大庭 誠、田中正一、土井光暢
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-17H07269
  • [Presentation] Helical peptide-catalyzed asymmetric Michael addition reactions of malonates to cyclic enones2018

    • Author(s)
      Tomohiro Umeno, Atsushi Ueda, Takuma Kato, Mitsunobu Doi, Masakazu Tanaka
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H07269
  • [Presentation] Synthesis of a Chiral Three-Membered Ring α,α-Disubstituted α-Amino Acid Having Two Methyl Groups and Conformational Analysis of its Peptides2018

    • Author(s)
      Hikaru Ikeda, Atsushi Ueda, Makoto Oba, Takuma Kato, Mitsunobu Doi, Masakazu Tanaka
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H07269
  • 1.  Tanaka Masakazu (00227175)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 2.  ASANO Akiko (40291801)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  YAMAMOTO Daisuke (50240106)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  TOMOO Koji (70257898)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  IN Yasuko (50257896)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  ISHIDA Toshimasa (00111021)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Kato Takuma (20805296)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 8.  Oba Makoto (20396716)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  伊東 祐二 (60223195)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  樽井 麻里子 (60257897)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  出水 庸介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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