KOHSAKA Tetsuya 高坂哲也

… Alternative Names

高坂哲也コウサカテツヤ

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Researcher Number	10186611
Other IDs	https://orcid.org/0000-0001-9093-8243
External Links
Affiliation (Current)	2022: 大阪物療大学, 保健医療学部, 教授
Affiliation (based on the past Project Information) *help	2020: 静岡大学, 農学部, 特任教授 2015 – 2019: 静岡大学, 農学部, 教授 2013 – 2014: 静岡大学, (連合)農学研究科(研究院), 教授 2012: 静岡大学, 農学部, 教授 1999 – 2010: 静岡大学, 農学部, 教授 … More 1996: 茨城大学, 農学部, 助教授 1993 – 1994: 茨城大学, 農学部, 助教授 1992: 茨城大学, 農学部, 助手 Less
Review Section/Research Field	Principal Investigator Applied animal science / Applied animal science / 畜産学(含草地学) / Animal production science / Basic Section 42010:Animal production science-related Except Principal Investigator Applied animal science
Keywords	Principal Investigator リラキシン / 精のう腺 / ブタ / 精子 / 受精能獲得 / Relaxin / Boar / 雄豚 / 精巣 / INSL3 … More / Capacitation / Sperm / Testis / relaxin / RLF / testis / 受容体 / Apoptosis / RLF/INSL3 / TR-FIA / sperm / RLP / 精子受精能 / mRNA / 遺伝子発現 / cDNAクローニング / 塩基配列 / 発現プラスミドの構築 / 組換え遺伝子の発現 / 組換え体の単離 / 大腸菌による大量発現 / 精子への影響 / リラキシン様物質 / 遺伝子 / プロモーター領域 / 発現調節 / テストステロン / 雄特異的発現 / LGR / 関連因子 / 局在 / 精子形成 / 生理活性 / 発現 / 構造解析 / プロセシング / LGR8 / germ cells / 能動免疫 / 造精細胞 / apoptosis / 受容体LGR8 / 造精機能 / 蛍光CTC / 精子細胞膜 / Seminal vesicle / コレステロール放出 / コレステロール / アクセプター / cholesterol efflux / シグナル伝達 / 受精能獲得因子 / CTC / cAMP / Capcitation / Signaling pathways / リン酸化 / Phosphorvlation / Passive immunization / Active immunization / Sperm production / Germ cell apoptosis / RLF不活性化 / cAMP/cGMP / 精子障害モデル / RNA干渉 / 不活性化 / 精子成熟 / RXFP1 / RXFP2 / Ovary / Fertilization / RLN / 受容体RXFP1 / 受容体RXFP2 / 受精 / 卵母細胞 / Uterus / 炎症性サイトカイン / 生理的炎症反応 / 分子間相互作用 / 接着・融合 / 精子ー卵子の接着・融合 … More Except Principal Investigator マイクロアレイ / 肝臓 / ウシ / in situ hybridization / オリゴアレイ / 遺伝子 / 子宮・胎盤 Less

Existence and function of the network system surrounding fertilization of relaxin and related peptidesPrincipal Investigator
- Principal Investigator
  
  Kohsaka Tetsuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Shizuoka University
The role of relaxin-like factor (RLF)/insulin-like factor 3 (INSL3) as germ cell anti-apoptotic and maturation factor on boar sperm productionPrincipal Investigator
- Principal Investigator
  
  Kohsaka Tetsuya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Animal production science
- Research Institution
  Shizuoka University
The binding and apoptosis inhibitory action to germ cells of relaxin-like peptide expressed in the boar testisPrincipal Investigator
- Principal Investigator
  
  KOHSAKA Tetsuya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Shizuoka University
The structure of relaxin-like peptide expressed in the boar testis and the implication in testicular function via its receptor LGR8Principal Investigator
- Principal Investigator
  
  KOHSAKA Tetsuya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Shizuoka University
Protein tyrosine phosphorylation in boar sperm capacitation induced by a novel relaxin-like proteinPrincipal Investigator
- Principal Investigator
  
  KOHSAKA Tetsuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Shizuoka University
ウシ肝cDNAマイクロアレイの評価と妊娠ウシ肝の特異発現遺伝子の検索
- Principal Investigator
  
  橋爪一善
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied animal science
- Research Institution
  Iwate University
Induction of capacitation on boar sperm for a novel relaxin-like protein and its signaling pathwayPrincipal Investigator
- Principal Investigator
  
  KOHSAKA Tetsuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Shizuoka University
Cholesterol efflux from the boar sperm for a novel relaxin-like protein and its action on their capacitationPrincipal Investigator
- Principal Investigator
  
  KOHSAKA Tetsuya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Shizuoka University
A novel relaxin-like protein discovered in boar seminal vesicle : Binding on sperm plasma membrane and physiological functionPrincipal Investigator
- Principal Investigator
  
  KOHSAKA Tetsuya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Shizuoka University
豚精のう腺で発見された新規リラキシン様物質の遺伝子構成と機能発現機構の解明Principal Investigator
- Principal Investigator
  
  高坂哲也
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Ibaraki University
豚精のう腺で発見されたリラキシン様物質の大腸菌での発現系の確立と機能解明への応用Principal Investigator
- Principal Investigator
  
  高坂哲也
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Ibaraki University
雄豚精のう腺の新規ホルモン、リラキシンのcDNAのクローニングと塩基配列の解析Principal Investigator
- Principal Investigator
  
  高坂哲也
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Ibaraki University
雄豚精のう腺におけるリラキシン遺伝子の発現とその調節構構の解明Principal Investigator
- Principal Investigator
  
  高坂哲也
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  畜産学(含草地学)
- Research Institution
  Ibaraki University

[Book] Recent advances in research on the hormone INSL3 in male goats　（In: Goat Science)2018
- Author(s)
  Kohsaka T, Siqin, Minagawa I, Sasada H　（編者：Sandor Kukovics）
- Total Pages
  24
- Publisher
  InTechOpen, London, UK
- ISBN
  9781789232028
- Data Source
  KAKENHI-PROJECT-15K07691
[Book] ホルモンハンドブック新訂eBook版(日本比較内分泌学会編)2007
- Author(s)
  高坂哲也(分担執筆)
- Total Pages
  2464
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-18580280
[Book] ホルモンハンドブック新訂eBook版(日本比較内分泌学会編)2007
- Author(s)
  高坂哲也(分担執筆)
- Total Pages
  2464
- Publisher
  南江堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Evidence for existence of insulin-like factor 3 (INSL3) hormone-receptor system in the ovarian corpus luteum and extra-ovarian reproductive organs during pregnancy in goats.2021
- Author(s)
  Pitia Ali Mohammed、Minagawa Itaru、Abe Yasuyuki、Kizaki Keiichiro、Hamano Koh-ichi、Sasada Hiroshi、Hashizume Kazuyoshi、Kohsaka Tetsuya
- Journal Title
  
  Cell and Tissue Research
  
  Volume: Feb 15 Pages: 1-17
- DOI
  10.1007/s00441-021-03410-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06379, KAKENHI-PROJECT-18H02327
[Journal Article] Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates.2020
- Author(s)
  Ivell R, Alhujaili W, Kohsaka T, Anand-Ivell R.
- Journal Title
  
  General and Comparative Endocrinology
  
  Volume: 299 Pages: 113583-113583
- DOI
  10.1016/j.ygcen.2020.113583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02327
[Journal Article] Efficacy of relaxin for cisplatin-induced testicular dysfunction and epididymal spermatotoxicity2020
- Author(s)
  Kohsaka Tetsuya、Minagawa Itaru、Morimoto Masashi、Yoshida Takuya、Sasanami Tomohiro、Yoneda Yoshitaka、Ikegaya Naoki、Sasada Hiroshi
- Journal Title
  
  Basic and Clinical Andrology
  
  Volume: 30 Pages: 3-15
- DOI
  10.1186/s12610-020-0101-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03902, KAKENHI-PROJECT-18H02327
[Journal Article] Evidence for the role of INSL3 on sperm production in boars by passive immunisation.2018
- Author(s)
  Minagawa I, Murata Y, Terada K, Shibata M, Park EY, Sasada H, Kohsaka T.
- Journal Title
  
  Andrologia
  
  Volume: 50
- DOI
  10.1111/and.13010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07691
[Journal Article] Insulin-like peptide 3 expressed in the silkworm possesses intrinsic disulfide bonds and full biological activity.2017
- Author(s)
  Miyazaki Takatsugu、Ishizaki Masaaki、Dohra Hideo、Park Sungjo、Terzic Andre、Kato Tatsuya、Kohsaka Tetsuya、Park Enoch Y.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Pages: 17339-17339
- DOI
  10.1038/s41598-017-17707-1
- NAID
  120006371042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02544, KAKENHI-PROJECT-16H06847, KAKENHI-PROJECT-15K07691
[Journal Article] Functional insulin-like factor 3 (INSL3) hormone-receptor system in the testes and spermatozoa of domestic ruminants and its potential as a predictor of sire fertility.2017
- Author(s)
  Pitia AM, Uchiyama K, Sano H, Kinukawa M, Minato Y, Sasada H, Kohsaka T.
- Journal Title
  
  Animal Science Journal
  
  Volume: 88 Pages: 678-690
- DOI
  10.1111/asj.12694
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07691
[Journal Article] Expression of insulin-like factor 3 hormone-receptor system in the reproductive organs of male goats.2015
- Author(s)
  Pitia AM, Minagawa I, Uera N, Hamano K, Sugawara Y, Nagura Y, Hasegawa Y, Oyamada T, Sasada H, Kohsaka T.
- Journal Title
  
  Cell Tissue Res
  
  Volume: 362 Pages: 407-420
- DOI
  10.1007/s00441-015-2206-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07691
[Journal Article] The Insulin-Like Factor 3 (INSL3)-Receptor (RXFP2) Network Functions as a Germ Cell Survival/Anti-Apoptotic Factor in Boar Testes.2015
- Author(s)
  Sagata D, Minagawa I, Kohriki H, Pitia AM, Uera N, Katakura Y, Sukigara H, Terada K, Shibata M, Park EY, Hasegawa Y, Sasada H, Kohsaka T.
- Journal Title
  
  Endocrinology
  
  Volume: 156 Pages: 1523-1539
- DOI
  10.1210/en.2014-1473
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24580408
[Journal Article] Protective effects of relaxin against cisplatin-induced nephrotoxicity in rats.2014
- Author(s)
  Yoshida T, Kumagai H, Kohsaka T, Ikegaya N.
- Journal Title
  
  Nephron Exp Nephrol.
  
  Volume: 128 Pages: 9-20
- DOI
  10.1159/000365852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24580408
[Journal Article] Dynamics of insulin-like factor 3 and its receptor expression in boar testes.2014
- Author(s)
  Minagawa I, Sagata D, Pitia AM, Kohriki H, Shibata M, Sasada H, Hasegawa Y, Kohsaka T
- Journal Title
  
  J Endocrinol.
  
  Volume: 220 Pages: 247-261
- DOI
  10.1530/joe-13-0430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580408
[Journal Article] Expression and localization of RLF/ INSL3 receptor RXFP2 in boar testes.2013
- Author(s)
  Kohsaka T, Sagata D, Minagawa I, Kohriki H, Pitia AM, Sugii Y, Morimoto M, Uera N, Shibata M, Sasada H, Hasegawa Y.
- Journal Title
  
  Ital J Anat Embryol
  
  Volume: 118 Pages: 23-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580408
[Journal Article] Development of two murine antibodies against Neospora caninum using phage display technology and application on the detection of N. caninum.2013
- Author(s)
  Jinhua Dong, Takahiro Otsuki, Tatsuya Kato, Tetsuya Kohsaka, Kazunori Ike, and Enoch Y. Park
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0053264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248009, KAKENHI-PROJECT-24580408
[Journal Article] Relaxin protects against renal ischemia-reperfusion injury.2013
- Author(s)
  Yoshida T, Kumagai H, Kohsaka T, Ikegaya N.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580408
[Journal Article] The active form of goat insulin-like peptide 3 (INSL3) is a single-chain structure comprising three domains B-C-A, constitutively expressed and secreted by testicular Leydig cells.2013
- Author(s)
  Siqin, Minagawa I, Okuno M, Yamada K, Sugawara Y, Nagura Y, Hamano K, Park EY, Sasada H, Kohsaka T
- Journal Title
  
  Biol Chem
  
  Volume: 394 Pages: 1181-1194
- DOI
  10.1515/hsz-2012-0357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580408
[Journal Article] Factors associated with patency of the uterine cervix in bitches with pyometra2012
- Author(s)
  Tamada H, Kawata N, Kawate N, Inaba T, Kida K, Hatoya S, Akune A, Nakama K, Kohsaka T, Takahashi M, Sawada T
- Journal Title
  
  Res Vet Sci
  
  Volume: 93 Pages: 1203-1210
- DOI
  10.1016/j.rvsc.2012.05.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580408
[Journal Article] Relaxin ameliorates salt-sensitive hypertension and renal fibrosis.2012
- Author(s)
  Yoshida T, Kumagai H, Suzuki A, Kobayashi N, Ohkawa S, Odamaki M, Kohsaka T, Yamamoto T, Ikegaya N.
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 27 Pages: 2190-2197
- DOI
  10.1093/ndt/gfr618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580408
[Journal Article] Zona pellucida protein ZP2 is expressed in the oocyte of Japanese quail (Coturnix japonica).2010
- Author(s)
  Kinoshita M, Rodler D, Sugiura K, Matsushima K, Kansaku N, Tahara K, Tsukada A, Ono H, Yoshimura T, Yoshizaki N, Tanaka R, Kohsaka T, Sasanami T.
- Journal Title
  
  Reproduction 139
  
  Pages: 359-371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580308
[Journal Article] Potential actions of relaxin and its related peptide on male reproductive processes in domestic animals.2010
- Author(s)
  Kohsaka T, Yogo K, Mori M.
- Journal Title
  
  In : The 14th AAAP animal Science Congress Proceedings Vol 1
  
  Pages: 259-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580308
[Journal Article] Evidence for expression of relaxin hormone-receptor system in the boar testis.2010
- Author(s)
  Kato S, Siqin, Minagawa I, Aoshima T, Sagata D, Konishi H, Yogo K, Kawarasaki T, Sasada H, Tomogane H, Kohsaka T.
- Journal Title
  
  J.Endocrinol. 207
  
  Pages: 135-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580308
[Journal Article] Potential actions of relaxin and its related peptide on male reproductive processes in domestic animals.2010
- Author(s)
  T.Kohsaka, et al.
- Journal Title
  
  Proceedings of 14th AAAP animal Science Congress
  
  Volume: 1 Pages: 259-263
- Data Source
  KAKENHI-PROJECT-20580308
[Journal Article] Partial cDNA sequence of a relaxin-like factor (RLF) receptor, LGR8 and possible existence of the RLF ligand-receptor system in goat testes.2010
- Author(s)
  Siqin, Nakai M, Hagi T, Kato S, Pitia AM, M.Kotani, Y.Odanaka, Y.Sugawara, K.Hamano, K.Yogo, Y.Nagura, M.Fujita, H.Ssasada, E.Sato, Kohsaka T.
- Journal Title
  
  Anim.Sci.J. 81
  
  Pages: 681-686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580308
[Journal Article] Identification of Boar Testis as a Source and Target Tissue of Relaxin2009
- Author(s)
  T. Kohsaka, et al.
- Journal Title
  
  Ann. N. Y. Acad. Sci. 1160
  
  Pages: 194-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580308
[Journal Article] Identification of boar testis as a source and target tissue of relaxin.2009
- Author(s)
  Kohsaka T, Kato S, Qin S, Minagawa I, Yogo K, Kawarasaki T, Sasada H.
- Journal Title
  
  Ann.N.Y.Acad.Sci. 1160
  
  Pages: 194-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580308
[Journal Article] Effect of relaxin and IGF-I on capacitation, acrosome reaction, cholesterol efflux and utilization of labeled and unlabeled glucose in porcine spermatozoa2008
- Author(s)
  Miah, AG., Salma, U., Takagi, Y., Kohsaka, T., Hamano, K., Tsuji, H
- Journal Title
  
  Reproductive Medicine and Biology 7
  
  Pages: 29-36
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Effect of relaxin on the motility, acrosome reaction and utilization of glucose of fresh and frozen-thawed bovine spermatozoa2007
- Author(s)
  Miah, AG., Salma, U., Tareq, K., Kohsaka, T., Tsuji, H
- Journal Title
  
  Animal Science Journal 78
  
  Pages: 495-502
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Expression and cellular pattern of relaxin mRNA in porcine corpora lutea during pregnancy2007
- Author(s)
  T.Kohsaka, et. al.
- Journal Title
  
  Cell and Tissue Research 330
  
  Pages: 303-312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Expression and cellular pattern of relaxin mRNA in porcine corpora lutea during pregnancy2007
- Author(s)
  T. Kohsaka, et. al.
- Journal Title
  
  Cell and Tissue Research 330
  
  Pages: 303-312
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Expression and cellular pattern of relaxin mRNA in porcine corpora lutea during pregnancy2007
- Author(s)
  Kohsaka, T., Singh, UP., Yogo, K., Sasada, H., Taya, K., Hashizume, K
- Journal Title
  
  Cell and Tissue Research 330
  
  Pages: 303-312
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Effect of relaxin on acrosome reaction and utilization of glucose in boar spermatozoa2006
- Author(s)
  Miah, AG., Tareq, KM., Hamano, K., Kohsaka, T., Tsuji, H
- Journal Title
  
  Journal of Reproduction and Development 52
  
  Pages: 773-779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Effect of relaxin on in vitro fertilization of porcine oocytes2006
- Author(s)
  Young-Joon, H., Miah, AG., Yoshida, M., Sasada, H., Hamano, K., Kohsaka, T
- Journal Title
  
  Journal of Reproduction and Development 52
  
  Pages: 657-662
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Park EY Identification of epitope on DNA-binding protein expressed in insect cell infected by baculovirus2006
- Author(s)
  Suzuki, M., Kohsaka, T
- Journal Title
  
  Molecular Biology Reports 33
  
  Pages: 97-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Effect of relaxin on motility, acrosome reaction and viability of cryopreserved boar spermatozoa2006
- Author(s)
  Miah, AG., Sharoare, MD., Tareq, KM., Salma, U., Hamano, K., Kohsaka, T
- Journal Title
  
  Reproductive Medicine and Biology 5
  
  Pages: 215-220
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Identification of relaxin and its receptor LGR7 in the boar testis2006
- Author(s)
  Maroyama, K., Kato, S., Aoshima, T., Suchin, Itoh, H., Yogo, K., Kawarasaki, T., Yamada, K., Kitayama, Y., Kohsaka, T
- Journal Title
  
  Proceedings of 12th AAAP Animal Science Congress XII
  
  Pages: 1-3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580280
[Journal Article] Assessment of bovine X-and Y-bearing spermatozoa in fractions by discontinuous percoll gradients with rapid Fluorescence in situ hybridization2004
- Author(s)
  J.Kobayashi, H.Oguro, H.Uchida, T.Kohsaka, H.Sasada, E.Sato
- Journal Title
  
  J.Reprod.Dev 50
  
  Pages: 463-469
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580247
[Journal Article] Seminal immunoreactive relaxin in domestic animals and its relationship to sperm motility as a possible index for predicting fertilizing ability of sires2003
- Author(s)
  T.Kohsaka et al.
- Journal Title
  
  International Journal of Andrology 26
  
  Pages: 115-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15580247
[Journal Article] Seminal immunoreactive relaxin in domestic animals and its relationship to sperm motility as a possible index for Predicting the fertilizing ability of sires2003
- Author(s)
  T.Kohsaka, K.Hamano, H.Sasada, S.Watanabe, T.Ogine, E.Suzuki, S.Nishida, H.Takahara, E.Sato
- Journal Title
  
  International Journal of Andrology 26
  
  Pages: 115-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580247
[Journal Article] Relaxin-like protein as a Key regulatory factor of boar sperm Capacitation (in Japanese)2003
- Author(s)
  K.ARAI, T.Kohsaka, S.Watanabe, H.Sasada, K.Bamba
- Journal Title
  
  Sperm Research 35
  
  Pages: 11-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580247
[Presentation] 精子受精能におけるリラキシンの役割2019
- Author(s)
  皆川至・Hoang Xuan Khoi・小林仁・佐々田比呂志・高坂哲也
- Organizer
  日本畜産学会　第126回大会
- Data Source
  KAKENHI-PROJECT-18H02327
[Presentation] 精子受精能におけるINSL3の役割2019
- Author(s)
  皆川至・山崎美悠・高橋綾乃・阿部由衣夏・鄭周榮・中山香菜子・佐々田比呂氏・高坂哲也
- Organizer
  日本畜産学会　125回大会
- Data Source
  KAKENHI-PROJECT-18H02327
[Presentation] ブタ精子形成におけるリラキシン関連ペプチドINSL3の役割解明2018
- Author(s)
  高橋綾乃・皆川至・寺田圭・柴田昌利・佐々田比呂志・高坂哲也
- Organizer
  第23回日本生殖内分泌学会
- Data Source
  KAKENHI-PROJECT-18H02327
[Presentation] 受精におけるブタ卵胞液由来INSL3の精子側での作用2018
- Author(s)
  飯塚真大・皆川至・山崎美悠・高橋綾乃・Ali M Pitia・佐々田比呂志・橋爪一善・高坂哲也
- Organizer
  日本畜産学会
- Data Source
  KAKENHI-PROJECT-15K07691
[Presentation] 受精におけるブタ卵胞液由来のリラキシンファミリーペプチドの精子側での作用2018
- Author(s)
  山崎美悠・飯塚真大・高橋綾乃・村田陽子・皆川至・佐々田比呂志・高坂哲也
- Organizer
  第23回日本生殖内分泌学会
- Data Source
  KAKENHI-PROJECT-18H02327
[Presentation] 受動免疫法によるINSL3の中和化がブタ造精機能と精液性状に及ぼす影響2017
- Author(s)
  皆川至、村田陽子、寺田圭、柴田昌利、佐々田比呂志、高坂哲也
- Organizer
  日本畜産学会第122回大会
- Place of Presentation
  神戸大学鶴甲第1キャンパス（兵庫県・神戸市）
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-15K07691
[Presentation] 脂質過酸化を誘起させたブタ精子におけるリラキシンの影響2017
- Author(s)
  高坂哲也・高橋綾乃・山崎美悠・飯塚真大・村田陽子・皆川至・佐々田比呂志
- Organizer
  日本畜産学会
- Data Source
  KAKENHI-PROJECT-15K07691
[Presentation] Two relaxin family peptides, relaxin (RLN) and insulin-like factor 3 (INSL3) in porcine follicular fluid are involved in sperm fertility via their receptor signaling2016
- Author(s)
  Murata Y, Minagawa I, Pitia AM, Shibata M, Sasada H, Hashizume K, Kohsaka T
- Organizer
  The 17th Asian-Australasian Association of Animal Production Societies Animal Science Congress
- Place of Presentation
  九州産業大学（福岡県・福岡市）
- Year and Date
  2016-08-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07691
[Presentation] The corpus luteum is a source and target of insulin-like factor 3 (INSL3) in pregnant goats2016
- Author(s)
  Pitia AM, Minagawa I, Sasada H, Hashizume K, Kohsaka T
- Organizer
  The 17th Asian-Australasian Association of Animal Production Societies Animal Science Congress
- Place of Presentation
  九州産業大学（福岡県・福岡市）
- Year and Date
  2016-08-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07691
[Presentation] Action of insulin-like factor 3 (INSL3) as a germ cell survival factor in boars2016
- Author(s)
  Kohsaka T, Minagawa I, Sagata D, Pitia AM, Terada K, Shibata M, Hasegawa Y, Sasada H
- Organizer
  The 17th Asian-Australasian Association of Animal Production Societies Animal Science Congress
- Place of Presentation
  九州産業大学（福岡県・福岡市）
- Year and Date
  2016-08-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07691
[Presentation] The effect of relaxin on ischemia-reperfusion injury in the rat testis2015
- Author(s)
  Hiroyuki Sukigara, Masashi Morimoto,Shintaro Shimojima, Takuya Yoshida, Naoki Ikegaya, and Tetsuya Kohsaka
- Organizer
  7th International Congress on Relaxin and Related peptides
- Place of Presentation
  クチン、マレーシア
- Year and Date
  2015-09-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07691
[Presentation] SiRNA knockdown of a novel INSL3 receptor splice variant RXFP2.X6 alters INSL3-induced cAMP signaling in RXFP2-expressing HEK293 cells2015
- Author(s)
  Yuta Katakura, Aya Tazawa, Itaru Minagawa, and Tetsuya Kohsaka
- Organizer
  7th International Congress on Relaxin and Related peptides
- Place of Presentation
  クチン、マレーシア
- Year and Date
  2015-09-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07691
[Presentation] Identification, characterization, and possible function of a novel INSL3 receptor splice variant RXFP2.X6 in testes2015
- Author(s)
  Tetsuya Kohsaka, Hiroshi Kohriki, Naoto Uera, Aya Tazawa, Yuta Katakura, Ali M Pitia, Itaru Minagawa, Yoshihisa Hasegawa, Hiroshi Sasada
- Organizer
  7th International Congress on Relaxin and Related peptides
- Place of Presentation
  クチン、マレーシア
- Year and Date
  2015-09-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07691
[Presentation] LGR8-ectodomainは精巣で発現するリラキシン関連因子受容体LGR8のスプライスバリアントでアンタゴニストとして機能する2013
- Author(s)
  植羅直人・高力宙・皆川至・佐々田比呂志・長谷川喜久・高坂哲也
- Organizer
  第18回日本生殖内分泌学会
- Place of Presentation
  東京砂防会館・シェーンバッハサボー(東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24580408
[Presentation] Cisplatin投与で精子形成障害を誘起したラット精巣におけるリラキシンのアポトーシス抑制効果2013
- Author(s)
  森本昌志・吉田卓也・池谷直樹・佐々田比呂志・長谷川喜久・高坂哲也
- Organizer
  第18回日本生殖内分泌学会
- Place of Presentation
  東京砂防会館・シェーンバッハサボー(東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24580408
[Presentation] リラキシン関連因子（ＲＬＦ）の中和化が造精機能に及ぼす影響2013
- Author(s)
  皆川至・佐方醍・柴田昌利・高坂哲也
- Organizer
  第106回日本繁殖生物学会
- Place of Presentation
  東京農工大学(東京都府中市）
- Data Source
  KAKENHI-PROJECT-24580408
[Presentation] 精子核クロマチンの性状解析に基づく新しいウシ精子受精能評価法の確立2013
- Author(s)
  王軍・保田宗行・内山京子・絹川将史・高坂哲也
- Organizer
  第106回日本繁殖生物学会
- Place of Presentation
  東京農工大学(東京都府中市）
- Data Source
  KAKENHI-PROJECT-24580408
[Presentation] ブタ精巣におけるリラキシン関連因子（RLF）の発現・分泌動態と生殖細胞に対するパラクリン因子としての機能2012
- Author(s)
  皆川至・佐方醍・柴田昌利・高坂哲也
- Organizer
  第105回日本繁殖生物学会大会
- Place of Presentation
  筑波大学大学会館　（茨城県）
- Data Source
  KAKENHI-PROJECT-24580408
[Presentation] Expression of RLF/INSL3 receptor LGR8 (RXFP2) and function of RLF/INSL3-RXFP2 signaling in germ cells of boar testes2012
- Author(s)
  Tetsuya Kohsaka, Dai Sagata, Itaru Minagawa, Hiroshi Kohriki, Ali Mohammed Pitia, Yusuke Sugii, Masashi Morimoto, Naoto Uera, Masatoshi Shibata, Hiroshi Sasada, and Yoshihisa Hasegawa
- Organizer
  6th International Conference on Relaxin and Related peptides
- Place of Presentation
  Chiostro del Maglio, Florence (Italy)
- Data Source
  KAKENHI-PROJECT-24580408
[Presentation] ブタ精巣で発現するリラキシン関連因子(RLF)は生物活性を持った前駆体として単離され、内分泌、傍分泌または自己分泌因子として機能する2010
- Author(s)
  皆川至、高力宙、佐方醍、柴田昌利、河原崎達雄、高坂哲也
- Organizer
  第103回日本繁殖生物学会大会
- Place of Presentation
  北里大学獣医学部(十和田市)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] Potential actions of relaxin and its related peptide on male reproductive2010
- Author(s)
  Kohsaka T, Yogo K, Mori M.
- Organizer
  processes in domestic animals.
- Place of Presentation
  屏東科技大学(屏東市、台湾)
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] Potential actions of relaxin and its related peptide on male reproductive processes in domestic animals.2010
- Author(s)
  T.Kohsaka, et al.
- Organizer
  The 14th AAAP animal Science Congress, Key Speech
- Place of Presentation
  屏東科技大学(屏東市、台湾)
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] Hormone Relaxin as a possible reagent/drug improving the fertilizing ability of sires2009
- Author(s)
  Tetsuya KOHSAKA
- Organizer
  2009 International Workshop on Current Status and Prospects of Animal Reproduction
- Place of Presentation
  内モンゴル農業大学、フフホト、中国
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] Purification and characterization of testicular relaxin-like factor in boars2009
- Author(s)
  Tetsuya KOHSAKA, ら
- Organizer
  The 3rd Asia-Pacific Forum on Andrology
- Place of Presentation
  国際会議ホテル、南京、中国
- Year and Date
  2009-10-12
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] ブタ精巣で発現するリラキシン関連因子の単離とその特性2009
- Author(s)
  皆川至、高力宙、石毛久子、与語圭一郎、河原崎達雄、高坂哲也
- Organizer
  日本畜産学会
- Place of Presentation
  琉球大学、沖縄
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] Purification and characterization of testicular relaxin-like factor in boars.2009
- Author(s)
  Kohsaka T, Minagawa I, Ishige H, Kohriki H, Yogo K, Kawarasaki T, Sasada H.
- Organizer
  The 3rd Asia-Pacific Forum on Andrology
- Place of Presentation
  国際会議ホテル、南京、中国
- Year and Date
  2009-10-12
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] Boar testis acts as a source and target tissue of relaxin2008
- Author(s)
  T. Kohsaka, et al.
- Organizer
  5th International Conference on relaxin and related peptides
- Place of Presentation
  Maui, Hawaii, USA
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] Evaluation of the fertilizing ability of boar sperm by acridine orange staining technique2008
- Author(s)
  T. Kohsaka, et al.
- Organizer
  1st World Congress on Reproductive Biology
- Place of Presentation
  Kailua-Kona, Hawaii, USA
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] Boar testis acts as a source and target tissue of relaxin.2008
- Author(s)
  Kohsaka T, Kato S, Qin S, Minagawa I, Yogo K, Kawarasaki T, Sasada H.
- Organizer
  5th International Conference on relaxin and related peptides.
- Place of Presentation
  Maui, Hawaii, USA
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-20580308
[Presentation] Identification of relaxin and its receptor LGR7 in the boar testis.2006
- Author(s)
  K. Maruyama, S. Kato, T. Aoshima, Suchin, H. Itoh, K. Yogo, T. Kawarasaki, K. Yamada, Y. Kitayam, T. Kohsaka
- Organizer
  XIIth AAAP Animal Science Congress
- Place of Presentation
  Korea
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580280

1. 橋爪一善 (10355737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 木崎景一郎 (40337994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 森松正美 (70241370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SASADA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. SHIBATA Masatoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. TERADA Kei

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. KATO Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. PARK Enoch Y.

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 宮崎剛亜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. Deo VipinKumar

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 阿部靖之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 笹浪知宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOHSAKA Tetsuya 高坂 哲也

高坂 哲也 コウサカ テツヤ

Research Projects

Research Products

Co-Researchers

Existence and function of the network system surrounding fertilization of relaxin and related peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of relaxin-like factor (RLF)/insulin-like factor 3 (INSL3) as germ cell anti-apoptotic and maturation factor on boar sperm productionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The binding and apoptosis inhibitory action to germ cells of relaxin-like peptide expressed in the boar testisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The structure of relaxin-like peptide expressed in the boar testis and the implication in testicular function via its receptor LGR8Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Protein tyrosine phosphorylation in boar sperm capacitation induced by a novel relaxin-like proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ウシ肝cDNAマイクロアレイの評価と妊娠ウシ肝の特異発現遺伝子の検索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of capacitation on boar sperm for a novel relaxin-like protein and its signaling pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cholesterol efflux from the boar sperm for a novel relaxin-like protein and its action on their capacitationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel relaxin-like protein discovered in boar seminal vesicle : Binding on sperm plasma membrane and physiological functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

豚精のう腺で発見された新規リラキシン様物質の遺伝子構成と機能発現機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

豚精のう腺で発見されたリラキシン様物質の大腸菌での発現系の確立と機能解明への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

雄豚精のう腺の新規ホルモン、リラキシンのcDNAのクローニングと塩基配列の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

雄豚精のう腺におけるリラキシン遺伝子の発現とその調節構構の解明Principal Investigator

Principal Investigator

Project Period (FY)

KOHSAKA Tetsuya 高坂哲也

高坂哲也コウサカテツヤ

[Book] Recent advances in research on the hormone INSL3 in male goats　（In: Goat Science)2018

[Book] ホルモンハンドブック新訂eBook版(日本比較内分泌学会編)2007