Saito Kazuki 齋藤一樹

… Alternative Names

SAITO Kazuki 齋藤一樹

齊藤一樹サイトウカズキ

斎藤一樹

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Researcher Number	10192585
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 研究員
Affiliation (based on the past Project Information) *help	2016: 姫路獨協大学, 薬学部, 教授 2014 – 2015: 東京大学, 大学院新領域創成科学研究科, 特任准教授 2012 – 2013: 東京大学, 新領域創成科学研究科, 特任准教授 2011: 東京大学, 大学院・新領域創成科学研究科, 特任研究員 2009 – 2010: Kyoto Pharmaceutical University, 薬学部, 研究員 … More 1995: (財)サントリー生物有機科学研究所, その他部局等, 研究員 1994: (財)サントリー生物有機科学研究所, その他の部局部, 研究員 1993: Suntory Institute for Bioorganic Research, Researcher, 研究員 1992: 東京大学, 薬学部, 助手 1989 – 1990: 東京大学, 薬学部, 助手 1987 – 1988: 東京大学, 特別研究員PD Less
Review Section/Research Field	Principal Investigator 物質生物化学 / Drug development chemistry / Physical pharmacy / Bioorganic chemistry
Keywords	Principal Investigator キャピラリー電気泳動 / 親和性増強 / EGFレセプター / ループ構造模倣環状ペプチド / 二量化阻害 / レセプター創薬 / NMR / 下流ERKリン酸化の促進 / 自己リン酸化 / カイコガ … More / ジスルフィド架橋によるレセプター二量化 / チロシンキナーゼ型レセプター / Torso / 前胸腺刺激ホルモン（PTTH） / Formation of Actin Bundle / Aggregation of Chromosomes / Contical Reactions / Elevation of Fetilization Membrane / Sea Urchin Eggs(Hemicentroutus pulcherrimus) / Wasp Venom Pepides / コレラ毒素感受性Gタンパク質 / アクチン束の形成 / 染色体の凝集 / 表層反応 / 受精膜上昇 / バフンウニ卵 / ハチ毒ペプチド / 側鎖改変 / 二量化阻害ペプチド / ＥＧＦレセプター / 質量分析 / スクリーニング / 環状ペプチド / 自己リン酸化阻害 / 二量化アーム模倣ペプチド / ジスルフィド架橋形成 / 表面プラズモン共鳴 / コンビナトリアル合成 / レトロインバーソ / 二量化阻害環状ペプチド / 医薬分子設計 / トリプシン消化 / カルモデュリン / マストパラン / スズメバチ毒ペプチド / 光学鏡像体 / 包接活性 / シクロデキストリン / 光学分離 Less

Establishment of molecular basis on ligand recognition by the insect prothoracicotropic hormone receptorPrincipal Investigator
- Principal Investigator
  
  SAITO Kazuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Himeji Dokkyo University
  The University of Tokyo
Systematic structure optimization of the EGF receptor-inhibiting peptide through use of a screening technologyPrincipal Investigator
- Principal Investigator
  
  SAITO Kazuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Development of peptide inhibitors against the EGF receptor based on its structural properties.Principal Investigator
- Principal Investigator
  
  SAITO Kazuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
  Kyoto Pharmaceutical University
ペプチド光学鏡像体の生理活性および標的タンパク質との相互作用Principal Investigator
- Principal Investigator
  
  齊藤一樹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Suntory Institute for Bioorganic Research
動きを制限した多糖類の構造および包接活性の制御Principal Investigator
- Principal Investigator
  
  齋藤一樹
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Suntory Institute for Bioorganic Research
Analysis of the formation mechanism of fertilization membarane on see urchin eggs using wasp venom peptide analogsPrincipal Investigator
- Principal Investigator
  
  SAITO Kazuki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Suntory Institude for Bioorganic Research
  The University of Tokyo
ウニ卵の受精膜上昇時におけるGTP結合性制御たんぱく質の関連およびその探索Principal Investigator
- Principal Investigator
  
  斎藤一樹
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  物質生物化学
- Research Institution
  The University of Tokyo
ジバチ毒ペプチド・マストパランによるカルモデュリンの酵素活性調節機構の解明Principal Investigator
- Principal Investigator
  
  斎藤一樹
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  物質生物化学
- Research Institution
  The University of Tokyo
ハチ毒ペプチド・マストパランの生理活性発現の分子機構の物理化学的解明Principal Investigator
- Principal Investigator
  
  斎藤一樹
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  物質生物化学
- Research Institution
  The University of Tokyo

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] Prothoracicotropic Hormone. (Chapter 55), Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research2015
- Author(s)
  Tadafumi Konogami, Kazuki Saito, Hiroshi Kataoka
- Total Pages
  3
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-15K14720
[Book] 遺伝子医学MOOK12号「最新ペプチド合成技術とその創薬研究への応用」(木曽良明編)中の第8章第4節、「EGFレセプターの構造生物学とその二量化抑制を戦略とする阻害薬の創製」2012
- Author(s)
  斎藤一樹
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-21590129
[Book] メディカルドゥ,遺伝子医学MOOK21号「最新ペプチド合成技術とその創薬研究への応用」(木曽良明編)の第8章第4節『EGFレセプターの構造生物学とその二量化抑制を戦略とする阻害薬の創製』2012
- Author(s)
  齋藤一樹*
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Secretory expression of cabbage armyworm prothoracicotropic hormone in Brevibacillus choshinensis.2016
- Author(s)
  Yusuke Yamashita, Tadafumi Konogami, Yiwen Yang, Tamari Hoshikawa, Masatoshi Iga, Hiroshi Kataoka, Kazuki Saito
- Journal Title
  
  Peptide Science
  
  Volume: 2015 Pages: 179-180
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14720
[Journal Article] The silkworm prothoracicotropic hormone receptor, Torso, has a unique disulfide-bond-linked structure required for its ligand-dependent functions.2016
- Author(s)
  Tadafumi Konogami, Yiwen Yang, Mari H. Ogihara, Juri Hikiba, Hiroshi Kataoka, Kazuki Saito
- Journal Title
  
  Peptide Science
  
  Volume: 2015 Pages: 37-38
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14720
[Journal Article] Ligand-dependent responses of the silkworm prothoracicotropic hormone receptor, Torso, are maintained by unusual intermolecular disulfide bridges in the transmembrane region.2016
- Author(s)
  Tadafumi Konogami, Yiwen Yang, Mari H. Ogihara, Juri Hikiba, Hiroshi Kataoka, Kazuki Saito
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 22437-22437
- DOI
  10.1038/srep22437
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14720, KAKENHI-PROJECT-14J08461
[Journal Article] Studies on identification of active sites of an inhibitory cyclic peptide against EGF receptor dimerization.2015
- Author(s)
  Takaaki Mizuguchi, Yukako Yamazaki, Kazuya Kobayashi, Honami Ooe, Mika Iida, Ryunosuke Ninomiya, Kazuki Saito, Kenichi Akaji, Hirokazu Tamamura
- Journal Title
  
  Peptide Science
  
  Volume: 2014 Pages: 163-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590134
[Journal Article] Role of the disulfide bridges in the transmembrane region of the insect prothoracicotropic-hormone receptor, Torso.2015
- Author(s)
  Tadafumi Konogami, Yiwen Yang, Mari H. Ogihara, Juri Hikiba, Hiroshi Kataoka, Kazuki Saito
- Journal Title
  
  Protein Science
  
  Volume: 24 Issue: S1 Pages: 59-59
- DOI
  10.1002/pro.2823
- Data Source
  KAKENHI-PROJECT-15K14720, KAKENHI-PROJECT-14J08461
[Journal Article] Application of plug-plug technique to ACE experiments for discovery of peptides binding to a larger target protein: A model study of calmodulin-binding fragments selected from a digested mixture of reduced BSA.2014
- Author(s)
  Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Hiroshi Kataoka, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
- Journal Title
  
  Electrophoresis
  
  Volume: 35 Issue: 6 Pages: 846-854
- DOI
  10.1002/elps.201300339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590134
[Journal Article] Application of plug-plug ACE method to drug discovery in the proteomic era2014
- Author(s)
  齋藤一樹
- Journal Title
  
  SEIBUTSU BUTSURI KAGAKU
  
  Volume: 58 Issue: 2 Pages: 71-73
- DOI
  10.2198/sbk.58.71
- NAID
  130004704692
- ISSN
  0031-9082, 1349-9785
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-24590134
[Journal Article] Effect of ring size and side-chain orientation of cyclic peptides for the inhibition of EGF receptor dimerization.2013
- Author(s)
  Takaaki Mizuguchi, Naho Ohara, Mika Iida, Ryunosuke Ninomiya, Shinji Wada, Yoshiaki Kiso, Kazuki Saito, Kenichi Akaji
- Journal Title
  
  Peptide Science
  
  Volume: 2012 Pages: 19-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590134
[Journal Article] Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor2012
- Author(s)
  Takaaki Mizuguchi, et al.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 20 Issue: 19 Pages: 5730-5737
- DOI
  10.1016/j.bmc.2012.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06748, KAKENHI-PROJECT-24590134
[Journal Article] Quantitative analyses of disulfide bond formation in proteins using^<18> O-labeled peptide standards2012
- Author(s)
  Kazuki Saito, Hiromasa Uchimura, YusamKim, Itsuki Yasuo, Shizuyo Koide-Yoshida, Takaaki Mizuguchi, Hiroshi Kataoka, Yoshiaki Kiso
- Journal Title
  
  Pept. Sci. 2011
  
  Pages: 77-78
- NAID
  10030204037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Intact-cell-based surface plasmon resonance measurements for ligand affinity evaluation of a membrane receptor2012
- Author(s)
  Takaaki Mizuguchi, Hiromasa Uchimura, Hiroshi Kataoka, Kenichi Akaji, YoshiakiKiso, Kazuki Saito
- Journal Title
  
  Anal. Biochem
  
  Volume: 420 Pages: 185-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Quantitative analyses of disulfide bond formation in proteins using ^<18>O-labeled peptide standards2012
- Author(s)
  Kazuki Saito, et al.
- Journal Title
  
  Peptide Science
  
  Volume: 2011 Pages: 77-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Screening methodology for discovery of inhibitory peptides against pathogenic proteins using a plug-plug affinity capillary electrophoresis technique2011
- Author(s)
  Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
- Journal Title
  
  Pept. Sci. 2010
  
  Volume: 287
- NAID
  10028238217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Isotope labeling-assisted quantitative evaluation of refolding conditions of a recombinant disulfide protein2011
- Author(s)
  Hiromasa Uchimura, Yusam Kim, Takaaki Mizuguchi, Yoshiaki Kiso, Kazuki Saito
- Journal Title
  
  Pept. Sci. 2010
  
  Volume: 148
- NAID
  10028237630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Intact cell-based SPR analyses of interactions between EGF and its receptor2011
- Author(s)
  Takaaki Mizuguchi, Hiromasa Uchimura, Yoshiaki Kiso, Kazuki Saito
- Journal Title
  
  Pept. Sci. 2010
  
  Volume: 98
- NAID
  10028237415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Screening methodology for discovery of inhibitory peptides against pathogenic proteins using a plug-plug affinity capillary electrophoresis technique2011
- Author(s)
  Kazuki Saito, et al.
- Journal Title
  
  Peptide Science
  
  Volume: 2010 Pages: 287-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Quantitative evaluation of refolding conditions for a disulfide-bond-containing protein using a concise^<18> O-labeling technique2011
- Author(s)
  Hiromasa Uchimura, Yusam Kim, TakaakiMizuguchi, Yoshiaki Kiso, Kazuki Saito
- Journal Title
  
  Protein Sci
  
  Volume: 20 Pages: 1090-1096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Verification of protein disulfide bond arrangement by in-geltryptic digestion under entirely neutral pHconditions2010
- Author(s)
  Kazuki Saito, Itsuki Yasuo, HiromasaUchimura, Shizuyo Koide-Yoshida, TakaakiMizuguchi, Yoshiaki Kiso
- Journal Title
  
  Proteomics
  
  Volume: 10 Pages: 1505-1509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Quantitative proteolytic ^<18>O-labeling analysis of protein disulfide bond rearrangement.2010
- Author(s)
  Kazuki Saito, et al.
- Journal Title
  
  Peptide Science
  
  Volume: 2009 Pages: 393-394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Verification of protein disulfide bond arrangement by in-gel tryptic digestion under entirely neutral pH conditions.2010
- Author(s)
  Kazuki Saito, et al.
- Journal Title
  
  Proteomics
  
  Volume: 10 Pages: 1505-1509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Quantitative proteolytic^<18> O-labeling analysis of protein disulfide bond rearrangement2010
- Author(s)
  Kazuki Saito, Itsuki Yasuo, HiromasaUchimura, Shizuyo Koide-Yoshida, TakaakiMizuguchi, Yoshiaki Kiso
- Journal Title
  
  Pept. Sci. 2009
  
  Pages: 393-394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Inhibitory effect of a dimerization-armmimeticpeptide on EGF receptor activation2009
- Author(s)
  Takaaki Mizuguchi, Hiromasa Uchimura, Taeko Kakizawa, Tooru Kimura, ShigeyukiYokoyama, Yoshiaki Kiso, Kazuki Saito
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 19 Pages: 3279-3282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] High-through screening method for ligand peptides using capillary electrophoresis-mass spectrometry.2009
- Author(s)
  Kazuki Saito, et al.
- Journal Title
  
  Peptide Science 2008
  
  Pages: 119-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] High-throughput screening method for ligand peptides using capillary electrophoresis-mass spectrometry(CE-MS)2009
- Author(s)
  Kazuki Saito, Mamiko Nakato, TakaakiMizuguchi, Hiromasa Uchimura, ShigeyukiYokoyama, Hiroshi Hirota, Yoshiaki Kiso
- Journal Title
  
  Pept. Sci. 2008
  
  Pages: 119-120
- NAID
  10027166058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Journal Article] Design and synthesis of inhibitory peptides against EGF receptor dimerization2009
- Author(s)
  Takaaki Mizuguchi, Hiromasa Uchimura, Taeko Kakizawa, Tooru Kimura, ShigeyukiYokoyama, Yoshiaki Kiso, Kazuki Saito
- Journal Title
  
  Pept. Sci. 2008
  
  Pages: 383-384
- NAID
  10027166564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] 活性型ヨトウガリコンビナントPTTHの調製2017
- Author(s)
  山下雄佑, 此上祥史, 荻原麻理, 齋藤一樹, 片岡宏誌
- Organizer
  平成29年度蚕糸・昆虫機能利用学術講演会（日本蚕糸学会第87回大会）
- Place of Presentation
  農林水産技術会議事務局筑波産学連携支援センター（茨城県つくば市）
- Year and Date
  2017-03-22
- Data Source
  KAKENHI-PROJECT-15K14720
[Presentation] Torso, an insect prothoracicotropic hormone receptor, possessing a very unique dimeric structure as a receptor tyrosine kinase.2016
- Author(s)
  Tadafumi Konogami, Hiroshi Kataoka, Kazuki Saito
- Organizer
  The 16th Akabori Conference: German-Japanese Symposium on Peptide Science
- Place of Presentation
  六甲山ホテル（兵庫県神戸市）
- Year and Date
  2016-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14720
[Presentation] ブレビバチルス菌を用いたカイコガ前胸腺刺激ホルモンの大量調製法の確立2016
- Author(s)
  此上祥史, 山下雄佑, 楊易文, 片岡宏誌, 齋藤一樹
- Organizer
  日本農芸化学会 2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-15K14720
[Presentation] Preparation of cabbage armyworm prothoracicotropic hormone in a soluble bioactive form, using secretory expression system of Brevibacillus choshinensis.2016
- Author(s)
  Yusuke Yamashita, Tadafumi Konogami, Tamari Hoshikawa, Mari H. Ogihara, Kazuki Saito, Hiroshi Kataoka
- Organizer
  1st Joint Symposium on Integrated Biosciences between Zhejiang University and The University of Tokyo
- Place of Presentation
  杭州（中国）
- Year and Date
  2016-03-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14720
[Presentation] Torso, an insect prothoracicotropic hormone receptor, possessing a very unique dimeric structure as a receptor tyrosine kinase.2016
- Author(s)
  Tadafumi Konogami, Hiroshi Kataoka, Kazuki Saito
- Organizer
  The 16th Akabori Conference: Japanese-German Symposium on Peptide Science
- Place of Presentation
  六甲山ホテル（兵庫県神戸市）
- Year and Date
  2016-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14720
[Presentation] ヨトウガ前胸腺刺激ホルモンのブレビバチルス菌による分泌発現2015
- Author(s)
  山下雄佑, 此上祥史, 楊易文, 星川珠莉, 伊賀正年, 片岡宏誌, 齋藤一樹
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚市中央公民館（神奈川県平塚市）
- Year and Date
  2015-11-17
- Data Source
  KAKENHI-PROJECT-15K14720
[Presentation] Role of the disulfide bridges in the transmembrane region of the insect prothoracicotropic-hormone receptor, Torso.2015
- Author(s)
  Tadafumi Konogami, Yiwen Yang, Mari H. Ogihara, Juri Hikiba, Hiroshi Kataoka, Kazuki Saito
- Organizer
  The 29th Annual Symposium of the Protein Society
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14720
[Presentation] カイコガ前胸腺刺激ホルモンのレセプターTorsoは、リガンド依存的な機能に必要な特有のジスルフィド架橋構造を有する2015
- Author(s)
  此上祥史, 楊易文, 荻原麻理, 引場樹里, 片岡宏誌, 齋藤一樹
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚市中央公民館（神奈川県平塚市）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K14720
[Presentation] Preparation of insect prothoracicotropic hormone with complicated disulfide-bond structure, by the heterologous expression in Brevibacillus choshinensis.2015
- Author(s)
  Kazuki Saito, Tadafumi Konogami, Yiwen Yang, Yusuke Yamashita, Masatoshi Iga, Tamari Hoshikawa, Hiroshi Kataoka
- Organizer
  The 29th Annual Symposium of the Protein Society
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14720
[Presentation] プロテオーム時代の創薬に向けたplug-plug ACE法の利用2014
- Author(s)
  齋藤一樹
- Organizer
  第65回日本電気泳動学会総会
- Place of Presentation
  横浜情報文化センター（神奈川県横浜市）
- Year and Date
  2014-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] 二量体化に着目した新規作用機序のEGFレセプター阻害薬研究2014
- Author(s)
  水口貴章, 二宮龍之介, 飯田美佳, 大江保奈美, 山崎由香子, 小林数也, 齋藤一樹, 赤路健一, 玉村啓和
- Organizer
  創薬懇話会2014
- Place of Presentation
  長良川温泉ホテルパーク（岐阜県岐阜市）
- Year and Date
  2014-07-10
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプター二量化阻害環状ペプチドの活性部位に関する研究2014
- Author(s)
  水口貴章, 山﨑由香子, 小林数也, 大江保奈美, 飯田美佳, 二宮龍之介, 齋藤一樹, 赤路健一, 玉村啓和
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学蔵本キャンパス大塚講堂（徳島県徳島市）
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] ^<18>O標識された内部標準ペプチドを用いたジスルフィド結合形成の定量的解析2011
- Author(s)
  斎藤一樹, 他
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌コンベンションセンター(札幌市)
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] ^<18> O標識された内部標準ペプチドを用いたジスルフィド結合形成の定量的解析2011
- Author(s)
  齋藤一樹,内村浩正,金裕三,安尾五起,小出静代,水口貴章,片岡宏誌,木曽良明
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌コンベンションセンター(札幌)
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] 生細胞を用いたSPR測定によるEGFレセプターとリガンドとの相互作用解析2011
- Author(s)
  水口貴章,内村浩正,片岡宏誌,赤路健一,木曽良明,齋藤一樹
- Organizer
  BIASymposium 2011「～カイネティクス×サーモダイナミクス×構造情報～発展するBiophysical Interaction Analysis
- Place of Presentation
  ホテルモントレグラスミア大阪(大阪)
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] 表面プラズモン共鳴を用いた細胞表面EGFレセプターへの親和性評価2011
- Author(s)
  水口貴章,内村浩正,木曽良明,齋藤一樹,赤路健一
- Organizer
  第1回四大学連携研究フォーラム
- Place of Presentation
  京都工芸繊維大学60周年記念館(京都)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] タンパク質間相互作用を標的としたペプチド性阻害薬リードの探索のための高速スクリーニング手法の開発2010
- Author(s)
  齋藤一樹,水口貴章,中戸真巳子,内村浩正,横山茂之,木曽良明
- Organizer
  日本ヒトプロテオーム機構第8回大会(日本プロテオーム学会2010年会)
- Place of Presentation
  東京ベイホテル東急(浦安)
- Year and Date
  2010-07-27
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] 同位体ラベルした内部標準を用いたジスルフィド・タンパク質のリフォールディング条件の定量的検証法の確立2010
- Author(s)
  内村浩正,金裕三,水口貴章,木曽良明,齋藤一樹
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター(札幌)
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Intact cell-based SPR analyses of interactions between EGF and its receptor2010
- Author(s)
  Takaaki Mizuguchi, Hiromasa Uchimura, Yoshiaki Kiso, Kazuki Saito
- Organizer
  5th International Peptide Symposium(5th IPS) in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Versatile screening method for inhibitory peptide leads against protein-protein interactions2010
- Author(s)
  Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Hiromasa Uchimura, Shigeyuki Yokoyama, Yoshiaki Kiso
- Organizer
  The 13th Akabori Conference : German-Japanese Symposium on Peptide Science
- Place of Presentation
  Breitenfelder Hof, Leipzig, Germany
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] EGFレセプターを過剰に発現しているA431細胞とそのリガンドとの相互作用の表面プラズモン共鳴解析2010
- Author(s)
  水口貴章,内村浩正,木曽良明,齋藤一樹
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山県桃太郎アリーナ(岡山)
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] EGFレセプター細胞外領域の二量化阻害に着目した新規ペプチド性抗がん薬リードの開発2010
- Author(s)
  水口貴章,内村浩正,柿澤多惠子,木村徹,横山茂之,木曽良明,齋藤一樹
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都薬科大学愛学館(京都)
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Improvement of affinity capillary electrophoresis-mass spectrometry (ACE-MS) for screening of inhibitory peptides against protein-protein interactions.2010
- Author(s)
  Kazuki Saito, et at
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Improvement of affinity capillary electrophoresis-massspectrometry(ACE-MS) for screening of inhibitory peptides against protein-proteininteractions. 2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)2010
- Author(s)
  Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
- Organizer
  Biological Chemistry Division "Polypharmacology for Drug Discovery"
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] タンパク質間相互作用を標的としたペプチド性阻害薬リード探索のための高速スクリーニング手法の開発2010
- Author(s)
  齋藤一樹, 他
- Organizer
  日本ヒトプロテオーム機構第8回大会(日本プロテオーム学会 2010年会)
- Place of Presentation
  東京ベイホテル東急(東京都)
- Year and Date
  2010-07-27
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Versatile screening method for inhibitory peptide leads against protein-protein interactions.2010
- Author(s)
  Kazuki Saito, et al.
- Organizer
  The 13th Akabori Conference : German-Japanese Symposium on Peptide Science
- Place of Presentation
  Breitenfelder Hof, Leipzig, Germany
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] タンパク質問相互作用の阻害を標的としたペプチドの高速スクリーニング法の開発2010
- Author(s)
  齋藤一樹, 他
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都薬科大学(京都市)
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Screening methodology for discovery of inhibitory peptides against pathogenic proteins using aplug-plug affinity capillary electrophoresis technique2010
- Author(s)
  Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
- Organizer
  5th International Peptide Symposium(5th IPS) in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Quantitative evaluation of refolding conditions of a disulfide protein using an isotopically labeled internal standard. 2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)2010
- Author(s)
  Hiromasa Uchimura, Yusam Kim, Takaaki Mizuguchi, Yoshiaki Kiso, Kazuki Saito
- Organizer
  Biological Chemistry Division "Protein Alteration by Mutagenesis and Chemical Modification : Applications in Biochemistry, Drug Discovery, Diagonostics, and Nutrition"
- Place of Presentation
  Honolulu, Hawaii, USA.
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] EGFレセプターを過剰発現した細胞そのものをアナライトとしたリガンドEGFとのSPR相互作用解析2010
- Author(s)
  水口貴章,内村浩正,木曽良明,齋藤一樹
- Organizer
  BIASymposium 2010「アフィニティーのその先へ～Biophysical Interaction Analysis～」
- Place of Presentation
  品川プリンスホテル(東京)
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Application of surface plasmon resonance measurements to intact A431 cells for analysis of the interaction between EGF receptor and itsligands. 2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)2010
- Author(s)
  Takaaki Mizuguchi, Hiromasa Uchimura, Yoshiaki Kiso, Kazuki Saito
- Organizer
  Biological Chemistry Division "Protein, Peptide, and Peptidomimetics Design"
- Place of Presentation
  Honolulu, Hawaii, USA.
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Screening methodology for discovery of inhibitory peptides against pathogenic proteins using plug-plug affinity capillary electrophoresis technique.2010
- Author(s)
  Kazuki Saito, et al.
- Organizer
  5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  京都国際会館(京都市)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] タンパク質間相互作用の阻害を標的としたペプチドの高速スクリーニング法の開発2010
- Author(s)
  齋藤一樹,中戸真巳子,水口貴章,和田真治,内村浩正,横山茂之,木曽良明
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都薬科大学愛学館(京都)
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Isotope labeling-assisted quantitative evaluation of refolding conditions of a recombinant disulfide protein2010
- Author(s)
  Hiromasa Uchimura, Yusam Kim, Takaaki Mizuguchi, Yoshiaki Kiso, Kazuki Saito
- Organizer
  5th International Peptide Symposium(5th IPS) in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] An efficient peptide screening method using capillary electrophoresis-mass spectrometry2009
- Author(s)
  Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
- Organizer
  3rd Asia-Pacific International Peptide Symposium(3rd APIPS)
- Place of Presentation
  ShinevilleLuxury Resort, Jeju, Korea
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] An inhibitory cyclic peptide against EGF receptor dimerization2009
- Author(s)
  Takaaki Mizuguchi, Hiromasa Uchimura, Taeko Kakizawa, Tooru Kimura, Shigeyuki Yokoyama, Yoshiaki Kiso, Kazuki Saito
- Organizer
  3rd Asia-Pacific International Peptide Symposium(3rdAPIPS)
- Place of Presentation
  Shineville Luxury Resort, Jeju, Korea
- Year and Date
  2009-11-08
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] An efficient peptide screening method using capillary electrophoresis-mass spectrometry.2009
- Author(s)
  Kazuki Saito, et al.
- Organizer
  3rd Asia-Pacific International Peptide Symposium
- Place of Presentation
  Shineville Luxury Resort, Jeju, Korea
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] EGFレセプターの二量化阻害に着目した新規抗がん薬リードの設計2009
- Author(s)
  水口貴章,内村浩正,柿澤多惠子,木村徹,横山茂之,木曽良明,齋藤一樹
- Organizer
  第59回日本薬学会近畿支部総会・大会
- Place of Presentation
  近畿大学(東大阪)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21590129
[Presentation] Application of proteolytic 18O-labeling to quantification of native disulfide bond formation in a folding protein by MALDI-MS.
- Author(s)
  Kazuki Saito, Hiromasa Uchimura, Hiroshi Kataoka, Yoshiaki Kiso
- Organizer
  The 14th Akabori Conference: German-Japanese Symposium on Peptide Science
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプターの二量化阻害を示す環状ペプチドの構造的特徴
- Author(s)
  水口貴章, 大原菜穂, 二宮龍之介, 山崎由香子, 飯田美佳, 大江保奈美, 齋藤一樹, 赤路健一
- Organizer
  日本薬学会第133回年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプターの二量化阻害ペプチドをもとにしたアラニン置換ペプチドの細胞増殖抑制効果
- Author(s)
  二宮龍之介, 水口貴章, 大原菜穂, 飯田美佳, 齋藤一樹, 赤路健一
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学浜甲子園キャンパス（西宮市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプターの二量化阻害に必要な環状ペプチドの環の大きさと側鎖配置の効果
- Author(s)
  水口貴章, 大原菜穂, 飯田美佳, 二宮龍之介, 和田真治, 木曽良明, 齋藤一樹, 赤路健一
- Organizer
  第49回ペプチド討論会
- Place of Presentation
  かごしま県民交流センター（鹿児島市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプターの二量化阻害活性を示す環状ペプチドの環サイズと側鎖配置の評価
- Author(s)
  大原菜穂, 水口貴章, 二宮龍之介, 飯田美佳, 齋藤一樹, 赤路健一
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学浜甲子園キャンパス（西宮市）
- Data Source
  KAKENHI-PROJECT-24590134

1. MIZUGUCHI Takaaki (30732557)

# of Collaborated Projects: 2 results

# of Collaborated Products: 39 results
2. KISO Yoshiaki (40089107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 30 results
3. AKAJI Kenichi (60142296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. KATAOKA Hiroshi (60202008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KONOGAMI Tadafumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
6. YAMASHITA Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. 片岡宏志

# of Collaborated Projects: 0 results

# of Collaborated Products: 14 results

Saito Kazuki 齋藤 一樹

SAITO Kazuki 齋藤 一樹

齊藤 一樹 サイトウ カズキ

斎藤 一樹

Research Projects

Research Products

Co-Researchers

Establishment of molecular basis on ligand recognition by the insect prothoracicotropic hormone receptorPrincipal Investigator

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Systematic structure optimization of the EGF receptor-inhibiting peptide through use of a screening technologyPrincipal Investigator

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Development of peptide inhibitors against the EGF receptor based on its structural properties.Principal Investigator

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ペプチド光学鏡像体の生理活性および標的タンパク質との相互作用Principal Investigator

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動きを制限した多糖類の構造および包接活性の制御Principal Investigator

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Analysis of the formation mechanism of fertilization membarane on see urchin eggs using wasp venom peptide analogsPrincipal Investigator

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ウニ卵の受精膜上昇時におけるGTP結合性制御たんぱく質の関連およびその探索Principal Investigator

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ジバチ毒ペプチド・マストパランによるカルモデュリンの酵素活性調節機構の解明Principal Investigator

Principal Investigator

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ハチ毒ペプチド・マストパランの生理活性発現の分子機構の物理化学的解明Principal Investigator

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[Book] Prothoracicotropic Hormone. (Chapter 55), Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research2015

Author(s)

Total Pages

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Data Source

[Book] 遺伝子医学MOOK12号「最新ペプチド合成技術とその創薬研究への応用」(木曽良明編)中の第8章第4節、「EGFレセプターの構造生物学とその二量化抑制を戦略とする阻害薬の創製」2012

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Data Source

[Book] メディカルドゥ,遺伝子医学MOOK21号「最新ペプチド合成技術とその創薬研究への応用」(木曽良明編)の第8章第4節『EGFレセプターの構造生物学とその二量化抑制を戦略とする阻害薬の創製』2012

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Data Source

[Journal Article] Secretory expression of cabbage armyworm prothoracicotropic hormone in Brevibacillus choshinensis.2016

Author(s)

Journal Title

Data Source

[Journal Article] The silkworm prothoracicotropic hormone receptor, Torso, has a unique disulfide-bond-linked structure required for its ligand-dependent functions.2016

Author(s)

Journal Title

Saito Kazuki 齋藤一樹

SAITO Kazuki 齋藤一樹

齊藤一樹サイトウカズキ

斎藤一樹