Inokuchi Koiti 猪口孝一

… Alternative Names

INOKUCHI Kouichi 猪口孝一

猪口孝一イノクチコウイチ

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Researcher Number	10203267
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2018 – 2019: 日本医科大学, 大学院医学研究科, 大学院教授 2017: 日本医科大学, 医学部, 教授 2016: 日本医科大学, 大学院医学研究科, 大学院教授 2014 – 2015: 日本医科大学, 医学(系)研究科(研究院), 教授 2010 – 2012: 日本医科大学, 医学部, 教授 … More 2006 – 2008: Nippon Medical School, Faculty of Medicine, Professor, 医学部, 教授 1999 – 2005: 日本医科大学, 医学部, 助教授 1997 – 1998: 日本医科大学, 医学部, 講師 1994: 日本医科大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator Hematology
Keywords	Principal Investigator mutation / abl / CML / c-kit / LEUKEMOGENESIS / bcr / c-mpl / 白血病 / thrombocytosis / calpastatin … More / bcr-abl / S100A6 / lats / YAP / leukemic stem cell / Hippo Pathway / Hippo pathway / 白血病幹細胞 / 急性骨髄性白血病 / GAP^<rac> domain / MPD / Transgenic mouse / ABL / P230 BCR / Ph陽性ET / CNL / P230bcr / STI571 / CalB / P230Bcr / Abl / P210Bcr / 病型 / endostatin / Tgマウス / transgenic mouse / p230 bcr / bcr-a61 / トランスジェニックマウス / モデルマウス / p63 / p51 / 血小板増多 / Tg / Ph / apotosis / SCF / C-kit / C-mpl / 慢性骨髄性白血病 / TPO / TK / BaF3 / 遺伝子導入 / ＭＯＣＫ / ＡＬＬ / RCSD1-ABL1 / B-ALL / Tyk2 / TKI / Ba /F3 / ALL / ABL1 / RCSD1 / 達伝子導入マウス / FLT3-D835I / TNF / AFF1 / FLT3ITD / IL24 / caspase / TNFα / MLL/AF4 / Flt3 / Hox / 32D / FLT3 / AF4 / MLL / 癌抑制遺伝子 / 接着分子 / ナチュラルキラー細胞 / 骨髄異形症候群 / 造血 / DCC … More Except Principal Investigator AF4 / MLL / 2nd hit / D835V / ITD / Flt3 / t(4;11)(q21;q23) / 32D / テロメア / 遺伝子 / 遺伝子変異 / DNAヘリカーゼ遺伝子 / ACD / TEP1 / TEP1遺伝子 / TINF2遺伝子 / ACD遺伝子 / 新規遺伝子変異 / テロメラーゼ活性 / テロメア制御遺伝子異常 / 先天性角化不全症 / leukemogenesis / Transgenic mouse / 標的薬 / アポトーシス / 32D細胞 / 白血病 / Tgマウス Less

The analysis of gene mutation acquisition and chemotherapy resistant mechanism by Hippo pathway of leukemia stem cellsPrincipal Investigator
- Principal Investigator
  
  Inokuchi Koiti
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
The identification of the novel gene mutation and development of the novel therapy for dyskeratosis congenita
- Principal Investigator
  
  Yamaguchi Hiroki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
Leukemogenicity of the RCSD1-ABL1 genePrincipal Investigator
- Principal Investigator
  
  Inokuchi Koiti
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
physiomolecular analysis of S100A6 in leukemia with MLL/AF4Principal Investigator
- Principal Investigator
  
  INOKUCHI Kouichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
Characteriztion of leukemia model mouse transdused with MLL/AF4 cDNA and a novel molecular-targeting medicinePrincipal Investigator
- Principal Investigator
  
  INOKUCHI Kouichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
Analysis of MIL-AF4 leukeinogeriesis for development of molecular target therapy.
- Principal Investigator
  
  DAN Kazuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
Analysis of function of Gap-Rac, CalB regions of the bcr/abl cDNA using bcr/abl-expressing transgenic micePrincipal Investigator
- Principal Investigator
  
  INOKUCHI Koiti
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
Analyse of oncogenic function of the MLL/AF4 gene
- Principal Investigator
  
  DAN Kazuo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
Pathophysiological analysis of bcr/abl cDNA expressing transgenic mouse and abnormal p51/p63 and calpastatinPrincipal Investigator
- Principal Investigator
  
  INOKUCHI Koiti
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
Analysis of c-kit and novel apotosis inhibitor genes in chronic myelogenous leukemiaPrincipal Investigator
- Principal Investigator
  
  INOKUCHI Koiti
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
Mutation analysis of c-kit and c-mpl genes in chronic myelogenous leukemiaPrincipal Investigator
- Principal Investigator
  
  INOKUCHI Koiti
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
細胞接着分子DCCの解明と造血機能分析Principal Investigator
- Principal Investigator
  
  猪口孝一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School

[Book] 血液・造血器疾患のマネージメント2011
- Author(s)
  猪口孝一、室井一男, 他
- Total Pages
  219
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] Significance of FLT3-tyrosine kinase domain mutation as a prognostic factor for acute myeloid leukemia.2019
- Author(s)
  Sakaguchi M, Yamaguchi H, Kuboyama M, Najima Y, Usuki K, Ueki T, Oh I, Mori S, Kawata E, Uoshima N, Kobayashi Y, Kako S, Tajika K, Shono K, Kayamori K, Hagihara M, Kanda J, Uchiyama H, Kuroda J, Uchida N, Kubota Y, Kimura S, Kurosawa S, et al
- Journal Title
  
  Int J Hematol
  
  Volume: 110 Issue: 5 Pages: 566-574
- DOI
  10.1007/s12185-019-02720-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09851, KAKENHI-PROJECT-17K09942
[Journal Article] Importance of prognostic stratification via gene mutation analysis in elderly patients with acute myelogenous leukemia2019
- Author(s)
  Fujiwara Yusuke、Yamaguchi Hiroki、Inokuchi Koiti, et al.
- Journal Title
  
  International Journal of Laboratory Hematology
  
  Volume: 41 Issue: 4 Pages: 461-471
- DOI
  10.1111/ijlh.13025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09942
[Journal Article] Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia2017
- Author(s)
  Yamato Genki、Yamaguchi Hiroki、Handa Hiroshi、Shiba Norio、Kawamura Machiko、Wakita Satoshi、Inokuchi Koiti、Hara Yusuke、Ohki Kentaro、Okubo Jun、Park Myoung-Ja、Sotomatsu Manabu、Arakawa Hirokazu、Hayashi Yasuhide
- Journal Title
  
  Genes, Chromosomes and Cancer
  
  Volume: 56 Issue: 11 Pages: 800-809
- DOI
  10.1002/gcc.22483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10050, KAKENHI-PROJECT-17K09942, KAKENHI-PROJECT-17K10130, KAKENHI-PROJECT-16K20951
[Journal Article] D816V mutation in the KIT gene activation loop has greater cell-proliferative and anti-apoptotic ability than N822K mutation in core-binding factor acute myeloid leukemia2017
- Author(s)
  Omori Ikuko、Yamaguchi Hiroki、Miyake Koichi、Miyake Noriko、Kitano Tomoaki、Inokuchi Koiti
- Journal Title
  
  Experimental Hematology
  
  Volume: 52 Pages: 56-64.e4
- DOI
  10.1016/j.exphem.2017.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-17K09942, KAKENHI-PROJECT-26461596
[Journal Article] The kinase-activating pathways and sensitivities to TKIs vary between fusion sites of RCSD1-ABL1 in Ph-like acute lymphoblastic leukemia.2016
- Author(s)
  1.Tamai H, Yamaguchi H, Miyake K, Takatori M, Kitano T, Dan K, Inokuchi K.
- Journal Title
  
  International Journal of Recent Scientific Research
  
  Volume: 7 Pages: 9729-9733
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461434
[Journal Article] Complex molecular genetic abnormalities involving three or more genetic mutations are important prognostic factors for acute myeloid leukemia.2016
- Author(s)
  Wakita S, Yamaguchi H, Ueki T, Usuki K, Kurosawa S, Kobayashi Y, Kawata E, Tajika K, Gomi S, Koizumi M, Fujiwara Y, Yui S, Fukunaga K, Ryotokuji T, Hirakawa T, Arai K, Kitano T, Kosaka F, Tamai H, Nakayama K, Fukuda T, Inokuchi K
- Journal Title
  
  Leukemia
  
  Volume: 60 Issue: 22 Pages: 545-554
- DOI
  10.1182/blood-2015-05-646240
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461434, KAKENHI-PROJECT-26893127
[Journal Article] The Kinase-Activating Pathways and Sensitivities to TKIs Vary between Fusion sites of RCSD1–ABL1 in Ph-like Acute Lymphoblastic Leukemia2016
- Author(s)
  Hayato Tamai, Hiroki Yamaguchi, Koichi Miyake, Miyuki Takatori,Tomoaki Kitano, Kazuo Dan and Koiti Inokuchi
- Journal Title
  
  International Journal of Recent Scientific Research
  
  Volume: 7 Pages: 10-20
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461434
[Journal Article] Shorter halving time of BCR-ABL1 transcripts is a novel predictor for achievement of molecular responses in newly diagnosed chronic-phase chronic myeloid leukemia treated with dasatinib: Results of the D-first study of Kanto CML study group2015
- Author(s)
  1.Iriyama N, Fujisawa S, Yoshida C, Wakita H, Chiba S, Okamoto S, Kawakami K, Takezako N, Kumagai T, Inokuchi K, Ohyashiki K, Taguchi J, Yano S, Igarashi T, Kouzai Y, Morita S, Sakamoto J, Sakamaki H
- Journal Title
  
  Am J Hematol
  
  Volume: ９０ Issue: 4 Pages: 282-287
- DOI
  10.1002/ajh.23923
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461434
[Journal Article] Efficacy of molecular response at 1 or 3 months after the initiation of dasatinib treatment can predict an improved response to dasatinib in imatinib-resistant or imatinib-intolerant Japanese patients with chronic myelogenous leukemia during the chronic phase.2014
- Author(s)
  2.Inokuchi K, Kumagai T, Matsuki E, Ohashi K, Shinagawa A, Hatta Y, Takeuchi J, Yoshida C, Wakita H, Kozai Y, Shirasugi Y, Fujisawa S, Iwase O, Yano S, Okamoto S, Oba K, Sakamoto J, Sakamaki H
- Journal Title
  
  J Clin Exp Hematop
  
  Volume: ５４ Pages: 197-204
- NAID
  130004705266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461434
[Journal Article] nhibition of S100A6 induces graft versus leukemia effects in MLL/AF4-positive ALL in human PBMC-SCID mice.2014
- Author(s)
  Tamai.H, Miyake K, Yamaguchi H, Shimada T, Dan K, Inokuchi K.
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume: 49(5) Issue: 5 Pages: 699-703
- DOI
  10.1038/bmt.2014.18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591412, KAKENHI-PROJECT-24591529, KAKENHI-PROJECT-26461434, KAKENHI-PROJECT-26461596
[Journal Article] Mutations of the epigenetics modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia2013
- Author(s)
  Wakita S, Yamaguchi H, Omori I, Terada K, Ueda T, Manabe E, Kurosawa S, Iida S, Ibaraki T, Sato Y, Todoroki T, Hirakawa T, Ryoutokuji T, Arai K, Kitano T, Mitamura Y, Kosaka F, Dan K, Inokuchi K
- Journal Title
  
  Leukemia
  
  Volume: 27 Pages: 1044-1052
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] AAV-8 vector expressing IL-24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice2012
- Author(s)
  Tamai H, Miyake K, Yamaguchi H, Takatori M, Dan K, Inokuchi K, Shimada T
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 64-71
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] AAV-8 vector expressing IL-24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice.2012
- Author(s)
  Tamai, H.
- Journal Title
  
  Blood
  
  Volume: 119 Issue: 1 Pages: 64-71
- DOI
  10.1182/blood-2011-05-354050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390212, KAKENHI-PROJECT-22591051, KAKENHI-PROJECT-23591554
[Journal Article] Disappearance of Both the <I>BCR/ABL1</I> Fusion Gene and the <I>JAK2</I>V617F Mutation with Dasatinib Therapy in a Patient with Imatinib-Resistant Chronic Myelogenous Leukemia2012
- Author(s)
  Inokuchi K
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 52 Issue: 2 Pages: 145-147
- DOI
  10.3960/jslrt.52.145
- NAID
  10031120441
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] Importance of c-kit mutation detection method sensitivity in prognostic analyses of t(8;21)(q22;q22) acute myeloid leukemia2011
- Author(s)
  Wakita S, Yamaguchi H, Miyake K, Mitamura Y, Kosaka F, Dan K, Inokuchi K
- Journal Title
  
  Leukemia
  
  Volume: 25 Pages: 1423-1432
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] Activated K-ras protein accelerates human MLL/AF4-induced leukemo-Lymphomogenicity in a transgenic mouse model2011
- Author(s)
  Tamai K, Inokuchi K, et al
- Journal Title
  
  Leuekmia
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] Resistance ofMLL-AFF1-positive acute lymphoblastic leukemia to tumor necrosisfactor-alpha is mediated by S100A6 upregulation2011
- Author(s)
  Tamai H, Miyake K, Yamaguchi H, Takatori M, Dan K, Inokuchi K, Shimada T
- Journal Title
  
  Blood Cancer Journal
  
  Volume: e38 Issue: 11 Pages: 1-7
- DOI
  10.1038/bcj.2011.37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] RCSD1-ABL1-positive B lymphoblastic leukemia is sensitive to dexamethasone and tyrosine kinase inhibitors and rapidly evolves clonally by chromosomal translocations2011
- Author(s)
  Inokuchi K, et al
- Journal Title
  
  International Journal Hematology
  
  Volume: 94 Issue: 3 Pages: 255-260
- DOI
  10.1007/s12185-011-0910-z
- NAID
  10029694299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] RCSD1-ABL1-positive B lymphoblastic leukemia is sensitive to dexamethasone and tyrosine kinaseinhibitors and rapidly evolves clonally by chromosomal translocations2011
- Author(s)
  Inokuchi K, Wakita S, Hirakawa T, Tamai H, Yokose N, Yamaguchi H, Dan K
- Journal Title
  
  Int J Hematol
  
  Volume: 94 Pages: 255-60
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] Identification of TINF2 gene mutations in adult Japanese patients With acquired bone marrow failure syndromes2010
- Author(s)
  Yamaguchi H, Inokuchi K, et al
- Journal Title
  
  British Journal Haematology
  
  Volume: 150 Pages: 725-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] Importance of maintaining the relative dose intensity of CHOP-like regimens combined with rituximab in patients with diffuse large B-cell lymphoma2010
- Author(s)
  Hirakawa T, Yamaguchi H, Yokose N, Gomi S, Inokuchi K, Dan K
- Journal Title
  
  Ann Hematol
  
  Volume: 89 Pages: 897-904
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] Multisteppathogenesis of leukemia via the MLL-AF4 chimeric gene/Flt3 gene tyrosine kinase domain (TKD)mutation-related enhancement of S100A6 expression2009
- Author(s)
  Yamaguchi H, Hanawa H, Uchida N, Inamai M, Sawaguchi K, Mitamura Y, Shimada T, Dan K, Inokuchi K
- Journal Title
  
  Exp Hematol
  
  Volume: 37 Pages: 701-714
- Data Source
  KAKENHI-PROJECT-22591051
[Journal Article] Multistep pathogenesis of leukemia via the MLL-AF4 chimeric gene/flt3 gene tyrosine kinase domain(TKD)mutation-related enhancement of S100A6 expression.2009
- Author(s)
  Yamaguchi H, Hanawa H, Uchida N, Inamai M, Sawaguchi K, Mitamura Y, Shimada T, Dan K, Inokuchi K.
- Journal Title
  
  Experimental Hematol. 37(6)
  
  Pages: 701-14
- Data Source
  KAKENHI-PROJECT-19591142
[Journal Article] Treatment of adult AML with t(6 ; 11)(q27 ; q23) by allogeneic hematopoietic SCT in the first CR.2008
- Author(s)
  Tamai H, Inokuchi K, Dan K.
- Journal Title
  
  Bone Marrow Transplant 42
  
  Pages: 553-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591142
[Journal Article] Clinical features of adult acute leukemia with 11q23 abnormali ties in Japan : a co-operative multicenter study.2008
- Author(s)
  Tamai H, Inokuchi K, Dan K.
- Journal Title
  
  Int J Hematology 87
  
  Pages: 195-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591142
[Journal Article] Analysis of the exon 12 and 14 mutations of the JAK2 gene in Philadelphia chromosome-positive leukemia2007
- Author(s)
  Inami M, Yamaguchi H, Hasegawa S, Mitamura Y, Kosaka F, Kobayashi A, Kimura S, Dan K, Inokuchi K
- Journal Title
  
  Leukemia 22
  
  Pages: 216-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591142
[Journal Article] HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemia2007
- Author(s)
  Miyake K, Inokuchi K, Miyake N, Dan K, Shimada T
- Journal Title
  
  Gene Therapy 23
  
  Pages: 1662-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591142
[Journal Article] Polycythemia associated with the JAK2V617F mutation emerged during treatment of chronic myelogenous leukemia2007
- Author(s)
  Inami M, Inokuchi K, Okabe M, Kosaka F, Mitamura Y, Yamaguchi H, Dan K
- Journal Title
  
  Leukemia 21
  
  Pages: 1103-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591142
[Journal Article] Oral administration of imatinib to P230・・・2006
- Author(s)
  Inami M, Inokuchi K, et al.
- Journal Title
  
  Int J Hematol 84(4)
  
  Pages: 346-353
- Data Source
  KAKENHI-PROJECT-17591014
[Journal Article] Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl2005
- Author(s)
  Miyake K, Inokuchi K, et al.
- Journal Title
  
  Gene Therapy 12(6)
  
  Pages: 541-545
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl.2005
- Author(s)
  Koiti Inokuchi, Koichi Miyake, Noriko Miyake, Kazuo Dan, Takashi Shimada
- Journal Title
  
  Gene Ther. 12(6)
  
  Pages: 541-545
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Transgenic mouse models of BCR/ABL-positive chronic myelogenous leukemia : A review.2005
- Author(s)
  Koiti Inokuchi
- Journal Title
  
  Current Genomics [Epub ahead of print] 6(3)
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Transgenic mouse models of BCR/ABL-positive myelogenous……2005
- Author(s)
  Koiti Inokuchi
- Journal Title
  
  Current Genomics 6(3)
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl2005
- Author(s)
  Miyake K, Inokuchi K, et al.
- Journal Title
  
  Gene Therapy 12(6)
  
  Pages: 541-545
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Transgenic mouse models of BCR/ABL-positive myelogenous......2005
- Author(s)
  Koiti Inokuchi.
- Journal Title
  
  Current Genomics 6(3)
  
  Pages: 1-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl.2005
- Author(s)
  Miyake K, Inokuchi K, et al.
- Journal Title
  
  Gene Therapy 12(6)
  
  Pages: 541-545
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Transgenic mouse models of BCR/ABL-positive chronic myelogenous leukemia : A review.2005
- Author(s)
  Koiti Inokuchi
- Journal Title
  
  Current Genomics 6(2)
  
  Pages: 89-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl.2005
- Author(s)
  Koiti Inokuchi, Koichi Miyake, Noriko Miyake, Kazuo Dan, Takashi Shimada
- Journal Title
  
  Gene Ther. 12(6)
  
  Pages: 541-545
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl.2005
- Author(s)
  Miyake K, Inokuchi K, et al.
- Journal Title
  
  Gene Therapy 12(6)
  
  Pages: 541-545
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Abnormalities of p51,p53,FLT3 and N-ras genes and their prognostic value in relapsed acute myeloid leukemia.2004
- Author(s)
  Nakamura H, Inokuchi K, et al.
- Journal Title
  
  Journal of Nippon Medical School 71(4)
  
  Pages: 270-278
- NAID
  130004146745
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Near-triproidy and near-tetraploidy in hematological malignancies and mutation of the p53 gene.2004
- Author(s)
  Ayako Watanabe, Koiti Inokuchi, Hiroki Yamaguchi, Taro Mizuki, Sakae Tanosaki, Takashi Shimada, Kazuo Dan
- Journal Title
  
  Clinical and Laboratory Haematology 26(1)
  
  Pages: 25-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Abnormalities of p51,p53,FLT3 and N-ras genes and their prognostic value in relapsed acute myeloid leukemia2004
- Author(s)
  Nakamura H, Inokuchi K, et al.
- Journal Title
  
  Journal of Nippon Medical School 71(4)
  
  Pages: 270-278
- NAID
  130004146745
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Abnormalities of p51, p53, FLT3 and N-ras genes and their prognostic value in relapsed acute myeloid leukemia2004
- Author(s)
  Nakamura H, Inokuchi K, et al.
- Journal Title
  
  Journal of Nippon Medical School 71(4)
  
  Pages: 270-278
- NAID
  130004146745
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Abnormalities of p51, p53, FLT3 and N-ras genes and their prognostic value in relapsed acute myeloid leukemia2004
- Author(s)
  Nakamura H, Inokuchi K, et al.
- Journal Title
  
  Journal of Nippon Medical School 71(4)
  
  Pages: 270-278
- NAID
  130004146745
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypie leukemia.2003
- Author(s)
  Mitsuharu Inami, Koiti Inokuchi, Kazutaka Nakayama, Hideo Yamura, Takashi Shimada, Kazuo Dan
- Journal Title
  
  International Journal of Hematology 78(2)
  
  Pages: 173-175
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] P230BCR/ABLトランスジェニックマウス2003
- Author(s)
  猪口孝一
- Journal Title
  
  血液・腫瘍科 46
  
  Pages: 436-443
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis and mild leukocytosis2003
- Author(s)
  Inokuchi K, Dan K, et al.
- Journal Title
  
  Blood 102
  
  Pages: 320-322
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypie leukemia.2003
- Author(s)
  Mitsuharu Inami, Koiti Inokuchi, Kazutaka Nakayama, Hideo Yamura, Takashi Shimada, Kazuo Dan
- Journal Title
  
  International Journal of Hematology 78(2)
  
  Pages: 173-175
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Novel transgenic mice expressing P230 Bcr/Abl developed myeloproliferative disorder : longer disease latency, thrombocytosis and mild leukocytosis2003
- Author(s)
  Koiti Inokuchi, Kazuo Dan, Miyuki Takatori, Hidemasa Takahuji, Naoya Uchida, Mitsuharu Inami, Koichi Miyake, Hiroaki Honda, Hisamaru Hirai, Takashi Shimada
- Journal Title
  
  Blood 102(1)
  
  Pages: 320-323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] P230BCR/ABLトランスジェニックマウス2003
- Author(s)
  猪口孝一
- Journal Title
  
  血液・腫瘍科 46
  
  Pages: 436-443
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Novel transgenic mice expressing P230 Bcr/Abl developed myeloproliferative disorder : longer disease latency, thrombocytosis and mild leukocytosis2003
- Author(s)
  Koiti Inokuchi, Kazuo Dan, Miyuki Takatori, Hidemasa Takahuji, Naoya Uchida, Mitsuharu Inami, Koichi Miyake, Hiroaki Honda, Hisamaru Hirai, Takashi Shimada
- Journal Title
  
  Blood 102(1)
  
  Pages: 320-323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Loss of DCC gene expression is of prongostic importantce in acute myelogenous leukemia.2002
- Author(s)
  Koiti Inokuchi, Hiroki Yamaguchi, Hideki Hanawa, Tanosaki S, Nakamura K, Miki Tarusawa, Miyake K, Shimada T, Kazuo Dan
- Journal Title
  
  Clinical Cancer Research 8(6)
  
  Pages: 1882-1888
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Journal Article] Abnormality of c-Kit Oncoprotein in Certain Patients With Chronic Myelogenous Leukemia - Potential Clinical Significance.2002
- Author(s)
  Koiti Inokuchi, Hiroki Yamaguchi, Miki Tarusawa, Makoto Futaki, Hideki Hanawa, Sakae Tanosaki, Kazuo Dan
- Journal Title
  
  Leukemia 16
  
  Pages: 170-177
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Loss of DCC gene expression is of prongostic importantce in acute myelogenous leukemia.2002
- Author(s)
  Koiti Inokuchi, Hiroki Yamaguchi, Hideki Hanawa, Tanosaki S, Nakamura K, Miki Tarusawa, Miyake K, Shimada T, Kazuo Dan
- Journal Title
  
  Clinical Cancer Research 8(6)
  
  Pages: 1882-1888
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591028
[Journal Article] Abnormality of c-Kit Oncoprotein in Certain Patients With Chronic Myelogenous Leukemia - Potential Clinical Significance.2002
- Author(s)
  Koiti Inokuchi, Hiroki Yamaguchi, Miki Tarusawa, Makoto Futaki, Hideki Hanawa, Sakae Tanosaki, Kazuo Dan
- Journal Title
  
  Leukemia 16
  
  Pages: 170-177
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591029
[Patent] ヒト MLL/AF4 融合遺伝子導入トランスジェニック非ヒト動物2008
- Inventor(s)
  猪口孝一
- Industrial Property Rights Holder
  日本医科大学医学部
- Industrial Property Number
  2008-319606
- Filing Date
  2008-12-16
- Data Source
  KAKENHI-PROJECT-22591051
[Presentation] Efficacy of allo-HSCT in CR1 for low allelic ratio FLT3-ITD and NPM1 mutation in AML.2019
- Author(s)
  Masahiro Sakaguchi, Hiroki Yamaguchi, Koiti Inokuchi, et al.
- Organizer
  第41回日本造血細胞移植学会総会.
- Data Source
  KAKENHI-PROJECT-17K09942
[Presentation] DKCの診断におけるTERT遺伝子変異の機能解析の重要性2017
- Author(s)
  Kazuki Terada, Hiroki Yamaguchi, Koichi Miyake, Noriko Miyake, Yoshiki Osaki, Takashi Okada, Seiji Kojima, Etsuro Ito, Koiti Inokuchi.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09832
[Presentation] The examination of RCSD1-ABL1- leukemogenicity2015
- Author(s)
  Tamai H,Miyake K, Yamaguchi H, Dan K, Inokuchi K.
- Organizer
  The 76th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-26461434
[Presentation] Clinical study of nilotinib in CML-CP patients with imatinib resistance or intolerance. TSSG study.2012
- Author(s)
  Inokuchi K
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591051
[Presentation] Clinical study of nilotinib in CML-CP patients with imatinib resistance or intolerance. TSSG study2012
- Author(s)
  Inokuchi k, et al
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591051
[Presentation] Activated K-ras protein accelerates human MLL/AF4-induced leukemo-lymphomogenicity in a transgenic mouse model2010
- Author(s)
  Tamai H, Inokuchi K, et al.
- Organizer
  第52回アメリカ血液学会
- Place of Presentation
  Orlando, Florida, USA
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22591051
[Presentation] 遺伝子発現profilingによるMLL/AF4キメラ遺伝子とFlt3 D835V遺伝子異常による白血病発症機序の検討2007
- Author(s)
  山口博樹、猪口孝一、ほか7名
- Organizer
  日本血液学会総会
- Data Source
  KAKENHI-PROJECT-19591142

1. DAN Kazuo (90142538)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. Yamaguchi Hiroki (90297937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 玉井勇人 (40465349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 三宅弘一 (90267211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. Terada Kazuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KAWAMURA Machiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 林泰秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 三宅紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 久保田寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inokuchi Koiti 猪口 孝一

INOKUCHI Kouichi 猪口 孝一

猪口 孝一 イノクチ コウイチ

Research Projects

Research Products

Co-Researchers

The analysis of gene mutation acquisition and chemotherapy resistant mechanism by Hippo pathway of leukemia stem cellsPrincipal Investigator

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The identification of the novel gene mutation and development of the novel therapy for dyskeratosis congenita

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Leukemogenicity of the RCSD1-ABL1 genePrincipal Investigator

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physiomolecular analysis of S100A6 in leukemia with MLL/AF4Principal Investigator

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Characteriztion of leukemia model mouse transdused with MLL/AF4 cDNA and a novel molecular-targeting medicinePrincipal Investigator

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Analysis of MIL-AF4 leukeinogeriesis for development of molecular target therapy.

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Analysis of function of Gap-Rac, CalB regions of the bcr/abl cDNA using bcr/abl-expressing transgenic micePrincipal Investigator

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Analyse of oncogenic function of the MLL/AF4 gene

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Pathophysiological analysis of bcr/abl cDNA expressing transgenic mouse and abnormal p51/p63 and calpastatinPrincipal Investigator

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Analysis of c-kit and novel apotosis inhibitor genes in chronic myelogenous leukemiaPrincipal Investigator

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Mutation analysis of c-kit and c-mpl genes in chronic myelogenous leukemiaPrincipal Investigator

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細胞接着分子DCCの解明と造血機能分析Principal Investigator

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[Book] 血液・造血器疾患のマネージメント2011

Author(s)

Inokuchi Koiti 猪口孝一

INOKUCHI Kouichi 猪口孝一

猪口孝一イノクチコウイチ

[Journal Article] The Kinase-Activating Pathways and Sensitivities to TKIs Vary between Fusion sites of RCSD1–ABL1 in Ph-like Acute Lymphoblastic Leukemia2016