masubuchi yasuhiro 桝渕泰宏

… Alternative Names

桝渕泰宏マスブチヤスヒロ

MASUBUCHI Yasuhiro 桝渕泰宏

Less

Researcher Number	10209455
Other IDs
Affiliation (Current)	2025: 千葉科学大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 千葉科学大学, 薬学部, 教授 2012 – 2014: 千葉科学大学, 薬学部, 教授 2005 – 2010: Chiba Institute of Science, Fac.Pharm.Sci., Professor, 薬学部, 教授 2001 – 2004: 千葉大学, 大学院・薬学研究院, 助教授 2000: 千葉大学, 薬学部, 助教授 … More 1999: 千葉大, 薬学部, 講師 1997 – 1999: 千葉大学, 薬学部, 講師 1992 – 1996: Chiba Univ., Dept.Biopharm., Res.Assoc., 薬学部, 助手 1991: 千葉大学, 薬学部, 教務職員 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Biological pharmacy / Physical pharmacy / Physical pharmacy
Keywords	Principal Investigator 薬剤性肝障害 / アセトアミノフェン / シトクロムP450 / グルタチオン / インターロイキン-6 / ミトコンドリア / ジクロフェナック / 自殺基質 / CYP3A2 / Endotoxin … More / Drug-induced liver injury / エンドトキシン / サイトカイン / 四塩化炭素 / TNF-α / マウス / 共有結合 / ハプテン / 尿酸 / HMGB1 / イソニアジド / スチリペントール / バイオマーカー / 細胞障害関連分子パターン / Covalent binding / Cyclooxygenase-2 / Experimental colitis / Danger hypothesis / Hapten / Drug-induced liver Injury / ヘムオキシゲナーゼ-1 / Toll様受容体 / COX-2 / 大腸炎 / 危険信号仮説 / Idiosyncratic hepatotoxicity / Cyclosporin A / Thiazolidinediones / Troglitazone / Antidiabetic agent / Mitochondrial permeability transition / Mitochondria / シトクロムc / 酸化ストレス / 特異体質性肝障害 / シクロスポリンA / チアゾリジンジオン / トログリタゾン / 糖尿病治療薬 / ミトコンドリア透過性遷移 / Toll-like receptor 4 / Indomethacin / Heat shock proteins / Interleukin-6 / Acetaminophen / Cytokines / インターロイキン-10 / Toll様受容体4 / インドメタシン / 熱ショックタンパク質 / フロセミド / CYP2E1 / 脂質過酸化 / エストロゲン / 性差 / TNF-< / 炎症性サイトカイン / N-フセチルシステイン / Th1/Th2 / N-アセチルシステイン / Th2 / Th1 / 副作用 / 肝障害 / カルバマゼピン / フェニトイン / 特異体質 / CYP3A4 / CYP2C11 / シトクロム P450 / ジヒドララジン / 活性代謝物 / CYP1A2 / 初代培養肝細胞 / 細胞障害 / アンカップラー / 酸化的リン酸化 / ATP / 肝細胞障害 / ジフェニルアミン / 非ステロイド系抗炎症薬 / 肝灌流法 / ミクロゾーム / 代謝的活性化 / デブリソキン / CYP2D / プロプラノロール … More Except Principal Investigator MRP2 / P450BTL / プロプラノロール / glutathione / oxidative stress / グルタチオン / 酸化的ストレス / 化学発光 / 肝障害 / hepatotoxicity / hepatocyte / chemiluminescence / 脂質過酸化 / 肝細胞 / P450-1A2 / P450-2D6 / cytochrome P450 / スーパーオキシド / シトクロムP450 / bunitrolol / propranolol / Dark Agouti rat / ブニトロロール / CYP2D酵素 / nitric oxide / protein kinase C / transporter / biliary excretion / cholestasis / 一酸化窒素 / Protein kinase C / トランスポーター / 胆汁排泄 / 胆汁うっ滞 / 酸化ストレス / reactive oxygens / 4-hydroxynonenal / エタクリン酸 / 活性酸素 / 4-ヒドロキシノネナール / reactive metabolite / lipid peroxidation / ジヒドララジン / サリチル酸 / ATP / ジクロフェナック / 非ステロイド系抗炎症薬 / 活性代謝物 / 肝毒性 / Enzyme inhibition / Covalent binding / 1,4-Naphthoquinone / Superoxide / Propranolol / Human liver micosomes / スーパーオキシドディスムターゼ / 蛋白共有結合 / 代謝的活性化 / 1,4‐ナフトキノン / P450‐1A2 / P450‐2D6 / 酵素阻害 / 共有結合 / 1,4-ナフトキノン / ヒト肝ミクロゾーム / P450sudan I-1 / CYP1A subfamily / CYP2D subfamily / brain microsones / Western Blot分析 / 抗体カラム / 抗体 / P450MUT-2 / P450Male / シトクロムP-450 / Western blot分析 / NADPH依存性シトクロムP450還元酵素 / P450スダンI-1 / CYP1Aサブファミリー / CYP2Dサブファミリー / 脳ミクロゾーム / membrane transport / genetic polymorphism / debrisoquine / non-linear first-pass metabolism / ブニトロロ-ル / プロプラノロ-ル / スダンIII / リドカイン / 細胞膜透過 / 遺伝的多型 / デブリソキン / 非線形初回通過代謝 / 脱アルキル活性 / 芳香環水酸化活性 / 薬物代謝酵素活性 / CYP2E酵素 / CYP1A酵素 Less

The roles and regulation of damage-associated molecular pattern in drug-induced liver injuryPrincipal Investigator
- Principal Investigator
  
  桝渕泰宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Chiba Institute of Science
Gender as a susceptibility factor for drug-induced liver injuryPrincipal Investigator
- Principal Investigator
  
  MASUBUCHI Yasuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba Institute of Science
Th1/Th2 balance as a determinant of drug-induced liver injuryPrincipal Investigator
- Principal Investigator
  
  MASUBUCHI Yasuhiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba Institute of Science
Elucidation of Mechanism of Drug-Induced Liver Injury Based on Danger HypothesisPrincipal Investigator
- Principal Investigator
  
  MASUBUCHI Yasuhiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba Institute of Science
MRP2 mediated defense against oxidative stress in liver
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Role of Mitochondria as Signal Sensors in Drug-Induced Liver InjuryPrincipal Investigator
- Principal Investigator
  
  MASUBUCHI Yasuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  CHIBA INSTITUTE OF SCIENCE
  Chiba University
Involvement of cytokines in drug-induced liver injuryPrincipal Investigator
- Principal Investigator
  
  MASUBUCHI Yasuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  CHIBA UNIVERSITY
Evaluation of drug-induced hepatotoxicity by chemiluminescence and the role of MRP2 in the hepatotoxicity
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
薬剤性肝障害発現におけるシトクロムP450介在過程の同定Principal Investigator
- Principal Investigator
  
  桝渕泰宏
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
薬剤によるアレルギー性肝障害におけるシトクロムP450の役割に関する研究Principal Investigator
- Principal Investigator
  
  桝渕泰宏
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
非ステロイド系抗炎症薬の肝毒性の評価とその発現機序に関する研究Principal Investigator
- Principal Investigator
  
  桝渕泰宏
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
The drug-induced hepatotoxicity
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
交感神経β-受容体遮断薬プロプラノロールによる肝薬物代謝酵素活性変動の機構解明
- Principal Investigator
  
  NARIMATSU Shizuo
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
β遮断薬のシトクロムP450自殺基質としての作用機構と肝初回通過代謝における意義Principal Investigator
- Principal Investigator
  
  桝渕泰宏
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
THE ROLE OF CYP2D SUBFAMILY IN METABOLIC ACTIVATION OF THE DRUGS THAT CONTAIN NITROGEN ATOM IN THEIR CHEMICAL STRUCTURES
- Principal Investigator
  
  NARIMATSU Shizuo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  CHIBA UNIVERSITY
Pharnacological and physiological sihnificance of cytochrome P450 isozymes in mammalian brain tissues
- Principal Investigator
  
  NARIMATSU Shizuo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
Molecular mechanism of non-linear first-pass metabolism
- Principal Investigator
  
  SUZUKI Tokuji
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University

All 2024 2023 2022 2014 2013 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Time-Dependent Inhibition of CYP1A2 by Stiripentol and Structurally Related Methylenedioxyphenyl Compounds via Metabolic Intermediate Complex Formation2023
- Author(s)
  Masubuchi Yasuhiro、Takahashi Chieko、Gendo Rina
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 52 Issue: 1 Pages: 63-68
- DOI
  10.1124/dmd.123.001511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06749
[Journal Article] Protection of mice against carbon tetrachloride-induced acute liver injury by endogenous and exogenous estrogens2022
- Author(s)
  Yasuhiro Masubuchi, Ayaka Ihara
- Journal Title
  
  Drug Metab. Pharmacokinet .
  
  Volume: 46 Pages: 100460-100460
- DOI
  10.1016/j.dmpk.2022.100460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06749
[Journal Article] ストレス応答MAPキナーゼと薬剤性肝障害2014
- Author(s)
  桝渕泰宏
- Journal Title
  
  千葉科学大学紀要
  
  Volume: 7 Pages: 151-158
- NAID
  120005465162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590207
[Journal Article] Time-dependent inhibition of CYP3A4 by sertraline, a selective serotonin reuptake inhibitor2013
- Author(s)
  Masubuchi Y, Kawaguchi Y
- Journal Title
  
  Biopharmaceutics and drug disposition
  
  Volume: 34 Issue: 8 Pages: 423-430
- DOI
  10.1002/bdd.1857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590207
[Journal Article] Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine.2011
- Author(s)
  Masubuchi, Y., Nakayama, J., Watanabe, Y.
- Journal Title
  
  Toxicology in press
- Data Source
  KAKENHI-PROJECT-20590157
[Journal Article] Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury2011
- Author(s)
  Yasuhiro Masubuchi
- Journal Title
  
  Biological & pharmaceutical bulletin
  
  Volume: 34 Pages: 366-70
- NAID
  130000657814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590157
[Journal Article] Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury.2011
- Author(s)
  Masubuchi, Y., Nakayama, J., Sadakata, Y.
- Journal Title
  
  Biol Pharm Bull 34
  
  Pages: 366-370
- NAID
  130000657814
- Data Source
  KAKENHI-PROJECT-20590157
[Journal Article] Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury.2009
- Author(s)
  Masubuchi, Y., Sugiyama, S., Horie, T.
- Journal Title
  
  Chem Biol Interact 179
  
  Pages: 273-279
- Data Source
  KAKENHI-PROJECT-20590157
[Journal Article] Resistance to acetaminophen-induced hepatotoxicity in female CD-1 mice2009
- Author(s)
  Yasuhiro Masubuchi
- Journal Title
  
  Drug Metabolism Reviews 41
  
  Pages: 66-66
- Data Source
  KAKENHI-PROJECT-20590157
[Journal Article] Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury2009
- Author(s)
  Yasuhiro Masubuchi
- Journal Title
  
  Chemico-Biological interactions 179
  
  Pages: 273-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590157
[Journal Article] Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis2008
- Author(s)
  Masubuchi, Y., K, Enoki, and T, Horie
- Journal Title
  
  Drug Metab Dispos 36
  
  Pages: 597-603
- NAID
  130005024164
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590153
[Journal Article] Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced cohtis2008
- Author(s)
  Yasuhiro Masubuchi
- Journal Title
  
  Drug Metabolism and Disposition 36
  
  Pages: 597-603
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590153
[Journal Article] Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis2008
- Author(s)
  Yasuhiro Masubuchi
- Journal Title
  
  Drug Metabolism and Disposition 36
  
  Pages: 597-603
- NAID
  130005024164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590153
[Journal Article] Th1/Th2 cytokine balance as a determinant of acetaminopher-induced liver injury.2008
- Author(s)
  Yasuhiro Masubuchi
- Journal Title
  
  Chemico-biological interactions 179
  
  Pages: 273-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590157
[Journal Article] Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury2007
- Author(s)
  Fujiyama, N., Y, Shitara, K, Ito, Y, Masubuchi, and T, Horie
- Journal Title
  
  Biol Pharm Bull 30
  
  Pages: 556-61
- NAID
  110006239203
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590153
[Journal Article] Toxicological significance of mechanism-based inactivation of cytochrome P450 enzymes by drugs2007
- Author(s)
  Masubuchi, Yasuhiro
- Journal Title
  
  Critical Reviews in Toxicology 37(印刷中)
- Data Source
  KAKENHI-PROJECT-18590153
[Journal Article] Mitochondrial permeability transition as a potential determinant of hepatotoxicity of antidiabetic thiazolidinediones.2006
- Author(s)
  Masubuchi, Yasuhiro
- Journal Title
  
  Toxicology 222・3
  
  Pages: 233-239
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590106
[Journal Article] Mitochondrial permeability transition as a potential determinant of hepatotoxicity of antidiabetic thiazolidinediones2006
- Author(s)
  Masubuchi, Yasuhiro
- Journal Title
  
  Toxicology (印刷中)
- Data Source
  KAKENHI-PROJECT-16590106
[Journal Article] Metabolic and non-metabolic factors determining troglitazone hepatotoxicity : a review2006
- Author(s)
  Masubuchi, Yasuhiro
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 21・5
  
  Pages: 347-356
- NAID
  10018306832
- Data Source
  KAKENHI-PROJECT-18590153
[Journal Article] Mitochondrial permeability transition as a potential determinant of hepatotoxicity of antidiabetic thiazolidinediones.2006
- Author(s)
  Masubuchi, Yasuhiro et al.
- Journal Title
  
  Toxicology 222(3)
  
  Pages: 233-239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590106
[Journal Article] Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice2005
- Author(s)
  Masubuchi, Yasuhiro
- Journal Title
  
  Journal of Hepatology 42・1
  
  Pages: 110-116
- Data Source
  KAKENHI-PROJECT-16590106
[Journal Article] Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice.2005
- Author(s)
  Masubuchi, Yasuhiro
- Journal Title
  
  Journal of Hepatology 42・1
  
  Pages: 110-116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590106
[Journal Article] Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice.2005
- Author(s)
  Masubuchi, Yasuhiro et al.
- Journal Title
  
  Journal of Hepatology 42(1)
  
  Pages: 110-116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590106
[Journal Article] Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice2005
- Author(s)
  Masubuchi Y, Suda C, Horie T
- Journal Title
  
  J.Hepatol. 42(1)
  
  Pages: 110-116
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in rat model of dextran sulfate sodium-induced experimental colitis2004
- Author(s)
  Masubuchi Y, Horie T
- Journal Title
  
  Drug Metab.Dispos. 32(4)
  
  Pages: 437-441
- Data Source
  KAKENHI-PROJECT-16390014
[Presentation] イソニアジド誘発特異体質性肝障害におけるCYP2E1の役割2024
- Author(s)
  桝渕泰宏、宮内恭兵
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06749
[Presentation] Protection of mice against acetaminophen-induced liver injury by the Nrf2 activator oltipraz2022
- Author(s)
  Yasuhiro Masubuchi, Kenji Mikami
- Organizer
  The 37th Annual Meeting of the Japanese Society for the Study of Xenobiotics
- Data Source
  KAKENHI-PROJECT-22K06749
[Presentation] 薬剤性肝障害の性差モデルとしてのアセトアミノフェンとフロセミドの比較2014
- Author(s)
  桝渕泰宏、柳橋正哉、渡邉靖子
- Organizer
  日本薬学会第13４年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590207
[Presentation] 内因性ならびに外因性エストロゲンによる四塩化炭素誘発肝障害の抑制2013
- Author(s)
  桝渕泰宏、井原彩佳、岡村壮一朗
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590207
[Presentation] GSH合成阻害下での雌マウスのアセトアミノフェン肝障害高感受性因子の検討2011
- Author(s)
  渡邉靖子、桝渕泰宏
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] マウスにおける四塩化炭素誘発肝障害の性差に対するIL-6の役割2011
- Author(s)
  桝渕泰宏、井原彩佳、島田薫
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] アセトアミノフェン誘発肝障害に対するグルタチオンならびに関連チオール化合物の防御効果の比較2010
- Author(s)
  桝渕泰宏、中山潤平、渡邉靖子
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] アセトアミノフェン肝障害感受性の性差におけるグルタミン酸システインリガーゼとMrp4の役割2010
- Author(s)
  桝渕泰宏、渡邉靖子
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  さいたま
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] Roles of glutamate-cysteine ligase and Mrp4 in gender-dependent susceptibility to acetaminophen hepatotoxicity2010
- Author(s)
  桝渕泰宏
- Organizer
  日本薬物動態学会
- Place of Presentation
  さいたま
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] Protective effects of glutathione and the related thiols against hepatotoxicity of acetaminophen and furosemide in mice.2010
- Author(s)
  Yasuhiro Masubuchi, Junpei Nakayama, Yuka Sadakata
- Organizer
  16th World Congress on Basic and Clinical Pharmacology
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] 雌マウスにおけるアセトアミノフェン肝障害低感受性とBSO高感受性2010
- Author(s)
  渡邉靖子、中山潤平、桝渕泰宏
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] マウスにおけるエチニルエストラジオールによるアセトアミノフェン誘発肝毒性防御のメカニズム2009
- Author(s)
  桝渕泰宏、小林良樹、渡邉靖子
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] マウスにおけるアセトアミノフェン誘発肝障害の性差とその要因2009
- Author(s)
  中山潤平、牧田枝里子、桝渕泰宏
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] Resistance to acetaminophen-induced hepatotoxicity in female CD-1 mice.2009
- Author(s)
  桝渕泰宏, 中山潤平, 牧田枝里子
- Organizer
  11th European ISSX Meeting
- Place of Presentation
  Lisbon,Portugal
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] フロセミドによる肝障害誘発ならびにN-アセチルシステインによる防御2009
- Author(s)
  桝渕泰宏、中山潤平、渡邉靖子
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] Mechanisms of protection by ethynylestradiol against acetaminophen-induced hepatotoxicity in mice2009
- Author(s)
  桝渕泰宏
- Organizer
  日本薬物動態学会
- Place of Presentation
  京都
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] フロセミド誘発マウス肝障害モデル : 反応性代謝物の役割ならびにアセトアミノフェンとの比較2008
- Author(s)
  桝渕泰宏
- Organizer
  第23回日本薬物動態学会
- Place of Presentation
  熊本
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] フロセミド誘発マウス肝障害モデル2008
- Author(s)
  桝渕泰宏、浅野早紀、貞方優佳、森田雅之
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-20590157
[Presentation] Roles of covalent adduct of reactive metabolite and other factors indiclofenac-induced hepatotoxicitv2007
- Author(s)
  Yasuhiro Masubuchi
- Organizer
  11th International Congress of Toxicology
- Place of Presentation
  Montreal,Canada
- Data Source
  KAKENHI-PROJECT-18590153
[Presentation] Roles of covalent adduct of reactive metabolite and other factors in diclofenac-induced hepatotoxicity2007
- Author(s)
  Yasuhiro, Masubuchi
- Organizer
  11th International Congress of Toxicology
- Place of Presentation
  Montreal, Canada
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590153
[Presentation] Roles of covalent adduct of reactive metabolite and other factors in diclofenac-induced henatotoxicity2007
- Author(s)
  Yasuhiro Masubuchi
- Organizer
  11th International Congress of Toxicology
- Place of Presentation
  Montreal,Canada
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590153
[Presentation] ゲニステインによる四塩化炭素誘発肝障害の抑制：内因性エストロゲンとの比較
- Author(s)
  野村美里、林優馬、桝渕泰宏
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸（兵庫）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590207
[Presentation] Strain and sex differences in carbon tetrachloride-induced liver injury in mice.
- Author(s)
  Yasuhiro Masubuchi and Ayaka Ihara
- Organizer
  19th North American ISSX / 29th JSSX Meeting
- Place of Presentation
  San Francisco (USA)
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590207
[Presentation] マウスにおける四塩化炭素誘発肝障害の性差発現における酵素的要因
- Author(s)
  永井良平、林裕樹、桝渕泰宏
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸（兵庫）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590207

1. HORIE Toshiharu (90120154)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
2. NARIMATSU Shizuo (20113037)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. ITO Kousei (30323405)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SUZUKI Tokuji (40010219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHITARA Yoshihisa (00306656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SEKINE Shuichi (70401007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

masubuchi yasuhiro 桝渕 泰宏

桝渕 泰宏 マスブチ ヤスヒロ

MASUBUCHI Yasuhiro 桝渕 泰宏

Research Projects

Research Products

Co-Researchers

The roles and regulation of damage-associated molecular pattern in drug-induced liver injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Gender as a susceptibility factor for drug-induced liver injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Th1/Th2 balance as a determinant of drug-induced liver injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of Mechanism of Drug-Induced Liver Injury Based on Danger HypothesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MRP2 mediated defense against oxidative stress in liver

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Mitochondria as Signal Sensors in Drug-Induced Liver InjuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of cytokines in drug-induced liver injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of drug-induced hepatotoxicity by chemiluminescence and the role of MRP2 in the hepatotoxicity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

薬剤性肝障害発現におけるシトクロムP450介在過程の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

薬剤によるアレルギー性肝障害におけるシトクロムP450の役割に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

非ステロイド系抗炎症薬の肝毒性の評価とその発現機序に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The drug-induced hepatotoxicity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

交感神経β-受容体遮断薬プロプラノロールによる肝薬物代謝酵素活性変動の機構解明

Principal Investigator

masubuchi yasuhiro 桝渕泰宏

桝渕泰宏マスブチヤスヒロ

MASUBUCHI Yasuhiro 桝渕泰宏