Haraguchi Kazuhiro 原口一広

… Alternative Names

HARAGUCHI Kazuhiro) 原口一広

原口一広ハラグチカズヒロ

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Researcher Number	10218638
Other IDs
Affiliation (Current)	2025: 日本薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2014: 日本薬科大学, 薬学部, 教授 2007 – 2012: Showa University, 薬学部, 准教授 2003 – 2006: 昭和大学, 薬学部, 助教授 2000: 昭和大, 薬学部, 助教授 1998 – 1999: 昭和大学, 薬学部, 助教授 1997: 昭和大学, 薬学部, 助手 1993 – 1995: 昭和大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy Except Principal Investigator Chemical pharmacy / 医薬分子機能学
Keywords	Principal Investigator ヌクレオシド / グリカール / 抗ウイルス活性 / グリコシル化 / チオ糖 / ラジカル反応 / 求核置換反応 / 有機シリコン試剤 / glycal / nucleoside … More / チミジン / チオグリコシル化 / チオヌクレオシド / 立体選択的 / 有機アルミニウム試剤 / antiviral / antitumor / thymine / Pummerer reaction / sulfoxide / glycosidation / 置換反応 / グリコシル化反応 / 分岐糖 / スルホキシド / プンメラー反応 / anti-viral / reduction / lithiation / thymidine / thio-glycosidation / 抗ガン剤 / 血管新生阻害 / wittig反応 / リナウム化反応 / リチム化反応 / チオグリコシル化反応 / 抗ウイルス作用 / 還元 / リチウム化反応 / 求電子付加 / オキセタン / オキセタノシン / 抗腫瘍活性 / 求電子試剤 / Pummerer転位 / Pummerer転位反応 / ラジカル還元 / 保護基 / 生物活性 / 親電子付加 / 分子内オキシセレノ化反応 / 6-endo-trigonal様式 / ウリジン5'-モノセレノアセタール / 3,7-アンヒドロオクトース骨格 / オクトシルヌクレオシド / 有機スズ試薬 / モノセレノアセタール / オキシセレノ化反応 / 共役ジエン / ヌクレオシド系抗生物質 / オクトシル酸 / 立体選択的合成 / 4'-炭素置換チミジン / 炭素-炭素結合形成 / 有機スズ化合物 / 1, 2-アシルオキシ転位 / 親電子付加反応 / 4'5'-不飽和チミジン / 隣接基関与 / 有機ケイ素化合物 / 面選択的親電子付加反応 / 1',2'-不飽和ウリジン / 4'-炭素置換ヌクレオシド / アリル転位 / アリルアセテート / syn-脱離反応 / セレノキシド / フェニルセレニドアニオン … More Except Principal Investigator ラジカル反応 / 炭素-炭素結合形成反応 / アリルスズ化合物 / ウリジン / モノセレノアセタール / フラノース / 1,2-不斉誘起 / ヌクレオシド / アノメリックラジカル / 面選択的親電子付加反応 / 1,2-アシルオキシ転移 / 分岐糖ヌクレオシド / 双頭ヌクレオシド / 不飽和糖ヌクレオシド Less

Synthesis and evaluation of antiviral activities of branched oxetanosine A.Principal Investigator
- Principal Investigator
  
  HARAGUCHI kazuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nihon Pharmaceutical University
  Showa University
Synthesis of 4'-substtituted 4'-thionucleosides and evaluation of its biological activityPrincipal Investigator
- Principal Investigator
  
  HARAGUCHI Kazuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Regioselective Pummerer reacton of 4'-thionucleoside S-oxide : Synthesis of 1'-or 4'-substituted 4'-thionucleoside and its biological activityPrincipal Investigator
- Principal Investigator
  
  HARAGUCHI Kazuhiro)
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Synthesis and Biological Activities of Sugar Modified 4'-ThionucleosidesPrincipal Investigator
- Principal Investigator
  
  HARAGUCHI Kazuhiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Synthesis and Biological Activities of 4'-Thionucleosides branched at the Sugar PortionPrincipal Investigator
- Principal Investigator
  
  HARAGUCHI Kazuhiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
チオフラノイドグリカールを利用する4'-チオヌクレオシドの立体選択的合成研究Principal Investigator
- Principal Investigator
  
  原口一広
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University
共役ジエンの分子内オキシセレノ化反応を基盤とするオクトシルヌクレオシドの合成研究Principal Investigator
- Principal Investigator
  
  原口一広
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University
ヌクレオシド糖部ラジカル反応における1,2-不斉誘起に関する研究
- Principal Investigator
  
  田中博道
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University
ラジカル的アシルオキシ転位反応を基盤とする4'-炭素置換チミジンの立体選択的合成Principal Investigator
- Principal Investigator
  
  原口一広
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University
真正双頭ヌクレオシドの合成とその機能に関する研究
- Principal Investigator
  
  宮坂貞
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Showa University
面選択的親電子付加反応を基盤とする1'-炭素置換ヌクレオシドの合成に関する研究Principal Investigator
- Principal Investigator
  
  原口一広
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University
アリル転位に基づく立体選択的な4'-炭素置換ヌクレオシドの合成研究Principal Investigator
- Principal Investigator
  
  原口一広
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] Frontiers in Clininal Drug Reseach2015
- Author(s)
  Haraguchi, K.; Takeda, S.; Kubota, Y.; Kumamoto, H.; Tanaka, H.; Hamasaki, T.; E; Baba, M.; Paintsil, E.; Cheng, Y.-C.; Urata, Y.,
- Total Pages
  61
- Publisher
  Bentham Science Publishing
- Data Source
  KAKENHI-PROJECT-24590144
[Journal Article] Unlike Catalyzing Error-Free Bypass of 8-Oxo-dG, DNA Polymerase λ Is Responsible for a Major Part of Fapy-dG-Induced G→T Mutations in Human Cells2015
- Author(s)
  Pande, P.; Haraguchi, K.; Greenberg, M. M.; Basu, A. Y .
- Journal Title
  
  Biochemistry
  
  Volume: 54 Issue: 10 Pages: 1859-1862
- DOI
  10.1021/acs.biochem.5b00119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590144
[Journal Article] Design, Synthesis and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir2015
- Author(s)
  Imoto, S.; Kohgo, S.; Tokuda, R; Kumamoto, H.; Aoki, M.; Amano, M.; Kuwata-Higashi, N.; mitsuya, H.; Haraguchi, K.
- Journal Title
  
  Nucleosides, nucleotides & Nucleic Acids
  
  Volume: 43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590144
[Journal Article] Synthesis of 3’,4’-difluoro-3’-deoxyribonucleosides and its evaluation of the biological activities: Discovery of a novel type of anti-HCV agent 3’,4’-difluorocordycepin2014
- Author(s)
  Shimada, H.; Haraguchi, K.; Hotta, K.; Miyaike. T.; Kitagawa, Y.; Tanaka, H.; Kaneda, R.; Abe, H.; Shuto, S.; Mori, K.; Ueda, Y.; Kato, N.; Snoeck, R.; Andrei, G.; Balzarini, Y.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Pages: 6174-6182
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590144
[Journal Article] Tuning efficiency of the 4-exo-trig cyclization by the electronic effect : ring closure of 3, 3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside2012
- Author(s)
  Hiroki Kumamoto, Sachiko Kawahigashi, Hiromi Wakabayashi, Tomohiko Nakano, Tomoko Miyaike, Yasuyuki Kitagawa, Hiroshi Abe, Mika Ito. Kazuhiro Haraguchi, Jan Balzarini, Masanori Baba and Hiromichi Tanaka
- Journal Title
  
  Chemical Communication
  
  Volume: 48 Issue: 89 Pages: 10993-10995
- DOI
  10.1039/c2cc35876j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06507, KAKENHI-PROJECT-24590144
[Journal Article] Phenylsulfanylation of 3', 4'-unsaturated adenosine employing thiophenol-N-iodosuccinimide leads to 4'-phenylsulfanylcordycepin : synthesis of 4'-substituted cordycepins on the basis of substitution of the phenylsulfanyl leaving group2011
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  J.Org.Chem.
  
  Volume: 76 Issue: 21 Pages: 8710-8717
- DOI
  10.1021/jo201246y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590123, KAKENHI-PROJECT-23790141
[Journal Article] エポキシ糖の反応性を利用する立体制御された分岐糖ヌクレオシドの合成研究:抗HIV活性を有するFestinavirの開発2011
- Author(s)
  原口一広
- Journal Title
  
  昭和大学薬学雑誌
  
  Volume: 2 Pages: 15-29
- NAID
  120006711012
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Synthesis of 4 Ethynyl-2 deoxy-4 thioribonucleosides and discovery of a highly potent and less toxic NRTI2011
- Author(s)
  Haraguchi, K.; Shimada, H.; Kimura, K.; Akutsu, G.; Tanaka, H., Abe, H.; Hamasaki, T.; Baba, M.; Gullen, E. A.; Dutschman, G. E.; Cheng, Y.-C.; Balzarini, Y.
- Journal Title
  
  ACS Med. Chem. Lett
  
  Volume: 2 Pages: 692-697
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] An Access to the β-Anomer of 4'-Thio-C-ribonucleosides : Hydroboration of 1-C-Aryl- or 1-C-Heteroaryl-4-thiofuranoid Glycals and Its Regiochemical Outcome2011
- Author(s)
  Haraguchi, K.; Horii, C.; Yoshimura, Y.: Ariga, F.; Tadokoro, A.; Tanaka, H.
- Journal Title
  
  J.Org.Chem.
  
  Volume: 76 Issue: 21 Pages: 8658-8669
- DOI
  10.1021/jo201100n
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590119, KAKENHI-PROJECT-21590123
[Journal Article] Phenylsulfanylation of 3 4unsaturated adenosine employing thiophenol-N-iodosuccinimide leads to 4phenylsulfanylcordycepin : synthesis of 4substituted cordycepins on the basis of substitution of the phenylsulfanyl leaving group2011
- Author(s)
  Kubota, Y.; Ehara, M.; Haraguchi, K.; Tanaka, H.
- Journal Title
  
  J. Org. Chem
  
  Volume: 76 Pages: 8710-8717
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and discovery of a highly potent and less toxic NRTI2011
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  ACS Med.Chem.Lett
  
  Volume: 2 Issue: 9 Pages: 692-697
- DOI
  10.1021/ml2001054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] An access to the.-anomer of 4thio-C-ribonucleosides : hydrogoration of 1-C-Aryl-or 1-C-hetreoaryl-4-thiofuranoid glycals and its regiochemical outcome2011
- Author(s)
  Haraguchi, K.; Horii, C.; Yoshimura, Y.; Ariga, F.; Tadokoro, A., Tanaka, H.
- Journal Title
  
  J. Org. Chem
  
  Volume: 76 Pages: 8608-8669
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Preparation of 4benznensulfonyl-3deoxythymidine and its reaction with organoaluminum and organosilicon reagents2010
- Author(s)
  Shimada, H.; Kikuchi, S.; Haraguchi, K.; Tanaka, H.
- Journal Title
  
  Carbohydr. Res
  
  Volume: 345 Pages: 2616-2622
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Stereoselective preparation of 1-[5-0-(tert-butyldimethylsilyl)-2,3-dideoxy-3-iodo-β-D-threo-pentofuranosyl]thymine : an efficient entry to 3',4'-unsaturated nucleoside2010
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Synthetic.Commun.
  
  Volume: 40 Pages: 1758-1764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Stereoselective preparation of 1-[5-O-(tert-butyldimethylsilyl)-2, 3-dideoxy-3-iodo-.-D-threo-pentofuranosyl] thymine from thymidine : an efficient entry to 3', 4'-unsaturated nucleoside2010
- Author(s)
  Kubota, Y.; Nakamura, K.; Ishizaki, N.; Haraguchi, K.; Tanaka, H.
- Journal Title
  
  Syntheth. Commun
  
  Volume: 40 Pages: 1758-1764
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Preparation of 4'-benzenesulfonyl-3'-deoxythymidine and its reaction with organoaluminum and organosilicon reagents2010
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Carbohydrate Research
  
  Volume: 345 Pages: 2616-2622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Synthesis and anti-HIV-1 evaluation of phosphonates which mimic the 5'-monophosphate of 4'-branched 2', 3'-didehydro-2', 3'-dideoxy nucleosides2010
- Author(s)
  Kubota, Y.; Ishizaki, N.; Haraguchi, K.; Hamasaki, T.; Baba, M.; Tanaka, H.
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Pages: 7186-7192
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Electrophilic glycosidation employing 3, 5-O-(di-tert-butylsilylene)-erythro-furanoid glycal leads to exclusive formation of theβ-anomer : synthesis of 2'-deoxynucleosides and its 1'-branched analogues2010
- Author(s)
  Haraguchi, K.; Konno, K.; Yamada, K.; Kitagawa, Y.; Nakamura, K. T.; Tanaka, H.
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 4587-4600
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Synthesis and anti-HIV-1 evaluation of phosphonate which mimics the 5'-monophosphate of 4'-branched 2',3'-didehydro-2',3'-dideoxy nucleoside2010
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 7186-7192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Electrophilic glycosidation employing 3,5-0-(di-tert-butylsilylene)-erythro-furanoid glycals leads to exclusive formation of the β-Anomer: Synthesis of 2'-deoxynucleosides and its 1'-branched analogues2010
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 4587-4600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] A questionnaire survey of students who attempted the objective structured clinical examination(OSCE) at the School of Pharmacy, Showa University2010
- Author(s)
  Kogo, M.; Saito, I.; Kurata, N.; Sasaki, K.; Ishii, M.; Haraguchi, K.; Kiuchi, Y.; Yamamoto, T.
- Journal Title
  
  The Showa University Journal of Pharmaceutical Sciences
  
  Volume: 1 Pages: 63-71
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Synthesis of 4'-substituted cordycepins via benzenesulfenylation at the 4'-position as a key step2009
- Author(s)
  Kubota, Y. Ehara, M.; Shimada, H.; Haraguchi, K.; Tanaka, H.
- Journal Title
  
  Nucleic Acids Symposium Series
  
  Volume: 53 Pages: 99-100
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Additive Pummerer reaction of 3, 5-O-(di-t-butylsilylene)-4-thiofuranoid glycal : A high yield and.-selective entry to 4'-thioribonucleosides2009
- Author(s)
  Haraguchi, K.; Matsui, H.; Takami, S.; Tanaka, H.
- Journal Title
  
  J. Org. Chem
  
  Volume: 74 Pages: 2616-2619
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Synthesis and anti-HIV activity of 4'-C-ethynyl-2'-deoxy-4'-thionucleosides2009
- Author(s)
  Haraguchi, K.; Shimada, H.; Akutsu, G.; Kimura, K.; Tanaka, H.; Hamasaki, T.; Baba, M.; Gullen, E. A.; Dutschman, G. E.; Cheng, Y.-C.; Balzalini, J.
- Journal Title
  
  Nucleic Acids Symposium Series
  
  Volume: 53 Pages: 97-98
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Solvent effect observed in nucleophilic substitution of 4'-(benzoyloxy) cordycepin with AlMe3 : stereochemical evidence for SNi mechanism2009
- Author(s)
  Kubota, Y.; Kunikata, M.; Haraguchi, K.; Tanaka, H.
- Journal Title
  
  J. Org. Chem
  
  Volume: 74 Pages: 3402-3405
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Reaction of the 4'-benzenesulfonyl derivatives of thymidine with organosilicon and organoaluminum reagent2009
- Author(s)
  Shimada, H.; Kikuchi, S.; Okuda, S.; Haraguchi, K.; Tanaka, H.
- Journal Title
  
  Nucleic Acids Symposium Series
  
  Volume: 53 Pages: 1-2
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Additive Pummerer Reaction of 3,5-o-(Di-t-butylsilylene)-4-thiofuranoid Glycal : A High Yield and β-Selective Entry to 4'-Thioribonucleosides2009
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages: 2616-2619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Synthesis and antiviral evaluation of 4'-alkoxy analogues of 9-(-D-xylofuranosyl) adenine2009
- Author(s)
  Kubota, Y.; Ishizaki, N.; Kaneda, Y.; Haraguchi, K.; Odanaka, Y.; Tanaka, H.; Kato, N.; Baba, M.; Balzarini, J.
- Journal Title
  
  Antiviral Chem. Chemother
  
  Volume: 19 Pages: 201-212
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Solvent Effect Observed in Nucleophilic Substitution of 4'-(Benzoyloxy)cordycepin with A1Me32009
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages: 3402-3405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Nucleophilic Substitution Approach to 4'-Substituted Thymidines by Employing 4'-Benzenesulfonyl Leaving Group2009
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Tetrahedron 65
  
  Pages: 6008-6016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Synthesis of-(±)-4'-ethynyl-5', 5'-difluoro-2', 3'-didehydro-3'-deoxy-carbocyclic thymidine : a difluoromethylidene analogue of promising anti-HIV agent Ed4T2009
- Author(s)
  Kumamoto, H.; Haraguchi, K.; Ida, M.; Nakamura, K. T.; Kitagawa, Y.; Hamasaki, T.; Baba, M.; Shimbara Matsubayashi, S.; Tanaka, H.
- Journal Title
  
  Tetrahedron
  
  Volume: 65 Pages: 7630-7636
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Nucleophilic substitution approach to 4'-substituted thymidines by employing 4'-benzenesulfonyl leaving group2009
- Author(s)
  Shimada, H.; Kikuchi, S.; Okuda, S.; Haraguchi, K.; Tanaka, H.
- Journal Title
  
  Tetrahedron
  
  Volume: 65 Pages: 6008-6016
- Data Source
  KAKENHI-PROJECT-21590123
[Journal Article] Synthesis and Antiviral Evaluation of (±)-4'-Ethynyl-5'-difluoro-carbocyclic-d4T analogue2008
- Author(s)
  Kumamoto, H. ; Haraguchi, K. ; Ida, M. ; Tanaka, H. ; Hamasaki, T. ; Baba, M.
- Journal Title
  
  Nucleic acids Symposium Series 52
  
  Pages: 609-610
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Efficient Removal of Formaraidopyrimidines by 8-Oxoguanine Glycosylases2008
- Author(s)
  Haraguchi, K., et al.
- Journal Title
  
  Biochemistry 47
  
  Pages: 1043-1050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Synthesis and Anti-HIV Activity of 4'-Substituted 4'-thiothymidines : A New Entry Based on Nucleophilic Substitution of the 4'-Acetoxy Group2008
- Author(s)
  Haraguchi, K. ; Shimada, H. ; Tanaka, H. ; Hamasaki, T. ; Baba, M. ; Gullen, E. A. ; Dutschman, G. E. ; Cheng, Y.-C.
- Journal Title
  
  J. Med. Chem. 51
  
  Pages: 1835-1893
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Synthesis and Anti-HIV Activity of 4'-Substituted 4'-thiothymidines2008
- Author(s)
  Haraguchi, K., et. al
- Journal Title
  
  J. Med. Chem. 51
  
  Pages: 1835-1893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Synthesis of 4'-Benzoyloxycorycepin from Adenosine2008
- Author(s)
  Kubota, Y. ; Kunikata, M. ; Ishizaki, N. ; Haraguchi, K. ; Odanaka, Y. ; Tanaka, H.
- Journal Title
  
  Tetrahedron 64
  
  Pages: 2391-2396
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Synthesis of 4'-Benzoyloxycordycepin from Adenosine2008
- Author(s)
  Haraguchi, K., et. al
- Journal Title
  
  Tetrahedron 64
  
  Pages: 2391-2396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Synthetic Use of Epoxy-sugar Nucleosides2007
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 26
  
  Pages: 547-554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] An Alternative Synthetic Method for 4'-C-Ethynylstavudine by Means of Nucleophilic Substitution of 4'-Benzoyloxythymone Nucleoside2007
- Author(s)
  Haraguchi, K. ; Sumino, M. ; Tanaka, H.
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 26
  
  Pages: 835-839
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Efficient Removal of Formamidopyrimidines by 8-Oxoguanine Glycosylases2007
- Author(s)
  Krishnamurthy, N. ; Haraguchi, K. ; Greenberg, M. M. ; David, S. S.
- Journal Title
  
  Biochemistry 47
  
  Pages: 1043-1050
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Additive Pummerer Reaction of 3,5-O-(di-t-butylsilylene)-4- thiofuranoid glycal and Stereoselective Synthesis of β-Anomer of 4'-Thioribonucleosides2007
- Author(s)
  Haraguchi, K. ; Matsui, H. ; Takami, S. ; Tanaka, H.
- Journal Title
  
  Nucleic Acids Research Symposium 51
  
  Pages: 143-144
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Synthetic Use of Epoxy-sugar Nucleosides2007
- Author(s)
  Tanaka, H. ; Kubota, Y. ; Takeda, S. ; Haraguchi, K.
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 26
  
  Pages: 547-554
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] Additive Pummerer Reaction of 3,5-0-(Di-t-butylsilylene)-4-thiofuranoid glycal and Stereoselective Synthesis of β-Anomer of 4'-Thioribonucleosides2007
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Nucleic Acids Symposium Series 51
  
  Pages: 143-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] An Alternative Synthetic Method for 4'-C-Ethynylstavudine by Means of Nucleophilic Substitution of 4-Benzoyloxythymine Nucleoside2007
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 26
  
  Pages: 835-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590106
[Journal Article] 4-Thiofuranoid Glycal-based Stereoselective Synthesis of 4'-Thionucleosides and its Inhibitory Effect of Angiogenesis2006
- Author(s)
  Kazuihiro Haraguchi
- Journal Title
  
  Advances in Pharmaceutical Sciences 22
  
  Pages: 39-48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Nucleophilic Substitution at the 4'-Position of Nucleosides : Access to a Promising Anti-HIV Agent 2',3',Didehydro-3'-deoxy-4'-ethynylthymidine2006
- Author(s)
  Haraguchi, K. et al.
- Journal Title
  
  J. Org.Chem. 71
  
  Pages: 4433-4438
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Nucleophilic Substitution of 4'-Acetoxy-4'-thionucleosides : A New Access to 4'-Substituted 4'-thiothymidine2006
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Nucleic Acids Symposium Series 50
  
  Pages: 115-116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Nucleophilic Substitution of at the 4'-Position of Nucleosides : New Access to a Promising Anti-HIV Agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine2006
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  J. Org. Chem. 71
  
  Pages: 4433-4438
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Nucleophilic Substitution of 4 '-Acetoxy-4'-thionucleosides : A New Access to 4'-Substituted 4'-Thiothymidines2006
- Author(s)
  Haraguchi, K. et al.
- Journal Title
  
  Nucleic Acids Symposium Series 50
  
  Pages: 115-116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] 4-Thiofuranoid Glycal-based Stereoselective Synthesis of 4'-Thionucleosides and its Inhibitory Effect of Angiogenesis2006
- Author(s)
  Haraguchi, K. et al.
- Journal Title
  
  Advances in Pharmaceutical Sciences 22
  
  Pages: 39-48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Nucleophilic Substitution at the 4'-Position of Nucleosides : New Access to a Promising Anti-HIV Agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine2006
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  J. Org. Chem. 71
  
  Pages: 4433-4438
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] 4'-Ethynylstavudine(4'-Ed4T) Has Potent Anti-HIV-1 Activity with Reduced Toxicity and Shows a Unique Activity Profile against Drug-Resistant Mutants2005
- Author(s)
  Tanaka, H., Haraguchi, K., Kumamoto, H., Baba, M., Cheng, Y.C.
- Journal Title
  
  Antiviral Chemistry & Chemotherapy 16
  
  Pages: 217-221
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] A New Approach to the Synthesis of 4'-Carbon-substituted nucleosides : Development of Highly Active Anti-HIV Agent 2',3'-Didehydro-3'-deoxy-4'-ehynylthymidine2005
- Author(s)
  Haraguchi, K. et al.
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 24
  
  Pages: 343-347
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] 5-Exo versus 6-Endo Cyclization of Nucleoside 2-Sila-5-hexenyl radicals: Reaction of 6-(Bromomethyl)dimetylisilyl 1',2'-Unsaturated uridines2005
- Author(s)
  Ogamino, J., Mizunuma, H., Kumamoto, H., Takeda, S., Haraguchi, K., Nakamura, K.T., Sugiyama, H., Tanaka, H.
- Journal Title
  
  J.Org.Chem. 70
  
  Pages: 1684-1690
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Anti-human Immunodeficiency Virus Type 1 Activity and Resistant Profile of 2',3 '-Didehydro-3 '-deoxy-4 '-ethynylthymidine2005
- Author(s)
  Haraguchi, K. et al.
- Journal Title
  
  Antimicrob. Agents Chemother. 49
  
  Pages: 3355-3360
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] A New Approach to the Synthesis of 4'-Carbon-substituted Nucleosides: Development of a Highly Active Anti-HIV Agent2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine2005
- Author(s)
  Haraguchi, K., Takeda, S., Sumino, M., Tanaka, H., Dutschman G.E., Cheng, Y.-C., Nitanda, T., Baba M.
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 24
  
  Pages: 343-347
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] A New Approach to the Synthesis of 4'-Carbon-substituted nucleosides : Development of Highly Active Anti-HIV Agent 2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine2005
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 24
  
  Pages: 343-347
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Anti-human immunodeficiency virus type 1 Activity and Resistance Profile of 2',3'-didehydro3'-Deoxy-4'-ethynylthymidine in vitro2005
- Author(s)
  Nitanda, T., Wang X., Kumamoto, H., Haraguchi, K., Tanaka, H., Cheng, Y.-C., Baba, M.
- Journal Title
  
  Antimicrob. Agents Chemother 49
  
  Pages: 3355-3360
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Anti-human Immunodeficiency Virus Type 1 Activity and resistance Profile of 2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine In Vitro2005
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Antimicrob. Agents Chemother. 49
  
  Pages: 3355-3360
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] 4'-Ethynylstavudine (4'-ED4T) has potent anti-HIV Activity with reduced toxicity and shows a Unique Activity Profile against Drug-resistant Mutants2005
- Author(s)
  Kazuihiro Haraguchi
- Journal Title
  
  Antiviral Chemistry ＆ Chemotherapy 16
  
  Pages: 217-221
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Synthesis of (±)-4'-Ethnyl and 4'-Cyano carbocyclic analogues of Stavudine(d4T)2005
- Author(s)
  Kumamoto, H., Haraguchi, K., Tanaka, H., Nitanda, T., Baba M., Dutschman G.E., Cheng, Y.-C.
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 24
  
  Pages: 73-83
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] 4'-Ehtynylstavudine (4'-ED4T) has Anti-HIV Activity with Reduced Toxicity and shows a Unique Activity Profile against Drug-resistant Mutants2005
- Author(s)
  Haraguchi, K. et al.
- Journal Title
  
  Antiviral Chemistry ＆ Chemotherapy 16
  
  Pages: 217-221
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Synthesis of Oilgonucleotides Containing fapydG (N^6-(2-Deoxy-α,β-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine) using a 5'-Dimethoxytrityl Dinucleotide Phosphoroamidite2005
- Author(s)
  Jiang, Y.L., Wiederholt, C.J., Patro, J.N., Haraguchi, K., Greenberg, M.M.
- Journal Title
  
  J.Org.Chem. 70
  
  Pages: 141-149
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Synthesis and antiviral Activities of 1'-Carbon-Substituted 4'-Thiothymidines2004
- Author(s)
  Haraguchi, K. et al.
- Journal Title
  
  Bioorganic Med.Chem. 12
  
  Pages: 5309-5316
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590100
[Journal Article] Novel Stereoselective Entry to 2'-β-Carbon-Substituted 2'-deoxy-4'-thionucleosides from 4-Thiofuranoid Glycal2004
- Author(s)
  Haraguchi, K. et al.
- Journal Title
  
  Org.Lett. 6
  
  Pages: 2465-2468
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590100
[Journal Article] Synthesis and Antiviral Activities of 1'-Carbon-substituted 4'-Thiothymidines2004
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Bioorg.Med.Chem. 12
  
  Pages: 5309-5316
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590100
[Journal Article] Novel Stereoselective Entry to 2'-β-Carbon-Substituted 2'-Deoxy-4'-thionucleosides from 4-Thiofuranoid Glycals2004
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Org.Lett. 6
  
  Pages: 2465-2468
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590100
[Journal Article] Synthesis and Antiviral Activities of 1'-Carbon-substituted 4'-Thio-thymidines2004
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Bioorg.Med.Chem 12
  
  Pages: 5309-5316
- Data Source
  KAKENHI-PROJECT-15590100
[Journal Article] Novel Stereoselective Entry to 2'-β-Carbon-Substituted 2'-Deoxy-4'-thionucleoscides from 4-Thiofuranoid Glycals2004
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Org.Lett. 6
  
  Pages: 2645-2648
- Data Source
  KAKENHI-PROJECT-15590100
[Journal Article] Stereoselective Synthesis of 2'-β-Carbon-sunstituted 2'-deoxy-4'-thioribonucleosides from 4-Thiofuranoid gycal2003
- Author(s)
  Haraguchi, K. et al.
- Journal Title
  
  Nucleic Acids Research Suppl. 3
  
  Pages: 7-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590100
[Journal Article] Stereoselective Synthesis of 2'-β-Carbon-substituted 2'-deoxy-4'-thio-ribonucleosides from 4-Thiofuranoid glycal2003
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Nucleic Acids Research Supplement 3
  
  Pages: 7-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590100
[Journal Article] Stereoselective Synthesis of 2'-β-Carbon-substituted 2'-deoxy-4'-thio-ribonucleosides from 4-Thiofuranoid glical2003
- Author(s)
  Kazuhiro Haraguchi
- Journal Title
  
  Nucleic Acids Research Supplement 3
  
  Pages: 7-8
- Data Source
  KAKENHI-PROJECT-15590100
[Presentation] gem-ジフルオロシクロブタンヌクレオシドの合成とその抗ウイルス活性2013
- Author(s)
  熊本浩樹、川東祥子、若林宏美、中野智彦、宮池智子、北川康行、阿部洋、伊藤美香、原口一広、Jan Balzalini、馬場昌範、田中博道
- Organizer
  第２３回抗ウイルス療法研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590144
[Presentation] ビニルスルホンに対する共役付加および脱硫的スタニル化を利用する3’-置換BCAの合成研究2013
- Author(s)
  熊本浩樹、川東祥子、若林宏美、中野智彦、宮池朋子、阿部　洋、原口一広、田中博道
- Organizer
  日本薬学会１３３年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590144
[Presentation] ビニルスルホンに対する共役付加および脱硫的スタニル化を利用する3’-置換BCAの合成研究2013
- Author(s)
  熊本浩樹、川東祥子、若林宏美、中野智彦、宮池朋子、阿部　洋、原口一広、田中博道
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590144
[Presentation] KAY-2-41: A novel nucleoside analog as inhibitor of orthopoxviruses in vitro and in vivo2012
- Author(s)
  S. Duraffour, K. Haraguchi, R. Drillien, K. Yamada, H. Tanaka, R. Snoeck, G Andrei
- Organizer
  XIX International Poxvirus, Asfavirus and Iridovirus Conference
- Place of Presentation
  France
- Data Source
  KAKENHI-PROJECT-24590144
[Presentation] Synthesis of 4’-ethynyl-2’-deoxy-4’-thioribonucleosides and discovery of a highly potent and less toxic NRTI2012
- Author(s)
  K. Haraguchi, H. Shimada, G. Akutsu, K. Kimura, H. Tanaka, T. Mamasaki, M. Baba, E. A. Gullen, G. E. Dutschman, Y.-C. Cheng, J. Balzarini
- Organizer
  International Conference on Antiviral Research 2012
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-24590144
[Presentation] 糖部1'位にメチル基を有するジオキソラニルヌクレオシドの合成とその抗ウイルス活性2011
- Author(s)
  窪田豊、金田有里、原口一広、加藤宣、馬場昌範、田中博道
- Organizer
  第131年回
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] A 1'-methyl substituted 4'-thiothymidine as promising inhibitor of orthopoxviruses in vitro and in vivo2011
- Author(s)
  S. Duraffour, K. Haraguchi, K. Yamada, H. Tanaka, R. Snoeck, G. Andrei
- Organizer
  6th European Meeting on Viral Zoonoses
- Place of Presentation
  Raphael, France
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] Synthesis and anti-HIV-1 activity of 4'-ethynyl-2'-deoxy-4'-thionucleosides2011
- Author(s)
  K. Haraguchi, H. Shimada, G. Akutsu, K. Kimura, H. Tanaka, H. Abe, T. Hamasaki, M. Baba, E. A. Gullen, G. E. Dutschman, Y.-C. Cheng, J. Balzalini
- Organizer
  The 2nd International Conference of Medchem 2011
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 長期投薬患者に対する薬剤師の電話による治療支援の有用性評価2011
- Author(s)
  新田光代、原和夫、山本信夫、亀井美和子、木内祐二、原口一広
- Organizer
  第131年回
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] Synthesis and anti-HIV-1 activity of 4'-ethynyl-2'-deoxy-4'-thionucleosides2011
- Author(s)
  原口一広
- Organizer
  the 2nd International Conference of Medchem 2011
- Place of Presentation
  北京
- Year and Date
  2011-08-10
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 1'位にメチル基を有するジオキソラニルヌクレオシドの合成とその抗HCV活性2011
- Author(s)
  窪田豊、金田有里、原口一広、加藤宣之、田中博道
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 有機アルミニウム試剤を用いる糖部修飾ヌクレオシドの新規合成法の開発2010
- Author(s)
  原口一広
- Organizer
  第8回次世代を担う有機合成シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] Synthesis and anti-HIV-1 activity of 4'-C-ethynyl-2'-deoxy-4'-thioribonucleosides2010
- Author(s)
  Kazuhiro Haraguchi
- Organizer
  the 19th International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Lyon, France
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 糖部4'位に置換基を有するヌクレオシドホスホネート誘導体の合成とその抗ウイルス活性2010
- Author(s)
  原口一広
- Organizer
  第19回抗ウイルス療法研究会
- Place of Presentation
  熊本
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 糖部4'位に置換基を有するヌクレオシドホスホネート誘導体の合成とその抗HIV活性2010
- Author(s)
  窪田豊、石崎伸英、中村拡司、原口一広、田中博道、濱崎隆之、馬場昌範
- Organizer
  第20回抗ウイルス療法研究会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] m-CPBAによるエリスロフラノイドグリカールのタンデム型エポキシ化/m-クロロベンゾイルオキシ化反応: psicofuranose誘導体の新規合成法の開発と糖供与体としての利用2010
- Author(s)
  原口一広、紺野奇重、田中博道
- Organizer
  第130年回
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 4'置換ヌクレオシド5'モノリン酸のミミックであるホスホネートの合成とその抗HIV活性2010
- Author(s)
  原口一広
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] m-CPBAによるエリスロフラノイドグリカールのタンデム型エポキシ化/m-クロロベンゾイルオキシ化:psicofuranose誘導体の新規合成法の開発と糖供与体としての利用2010
- Author(s)
  原口一広
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 糖部4'位に置換基を有するヌクレオシドホスホネート誘導体の合成とその抗ウイルス活性2010
- Author(s)
  窪田豊、石崎伸英、原口一広、田中博道
- Organizer
  第130年回
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] Synthesis and anti-HIV activity of 4'-C-Ethynyl-2'-deoxy-4'-thionucleosides2010
- Author(s)
  K. Haraguchi, H. Shimada, G. Akutsu, K. Kimura, H. Tanaka, T. Hamasaki, M. Baba, E. A. Gullen, G. E. Dutschman, Y.-C. Cheng, J. Balzalini
- Organizer
  XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Lyon, France
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] エポキシ糖の反応性を利用する立体制御された分岐糖ヌクレオシドの合成法の確立:抗HIV活性を有するFestinavirの開発2010
- Author(s)
  原口一広
- Organizer
  第130年回
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 糖部4'位に置換基を有するヌクレオシドホスホネート誘導体の合成とその抗ウイルス活性2010
- Author(s)
  原口一広
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] エポキシ糖の反応性を利用する立体制御された分岐糖ヌクレオシドの合成法の確立抗HIV活性を有するFestinavirの開発2010
- Author(s)
  原口一広
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] Synthesis and anti-HIV activity of 4'-C-ethynyl-2'-deoxy-4'-thionucleosides2009
- Author(s)
  K. Haraguchi, H. Shimada, G. Akutsu, K. Kimura, H. Tanaka, T. Hamasaki, M. Baba, E. A. Gullen, G. E. Dutschman, Y.-C. Cheng, J. Balzalini
- Organizer
  Gordon Research Conference on Purine, Pyrimidine and Related Substance
- Place of Presentation
  Rhode Island
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] フラノイドグリカールを利用する面選択的なグリコシル化反応:アノマー位が分岐したチミジン誘導体の合成研究2009
- Author(s)
  原口一広、紺野奇重、田中博道
- Organizer
  第129年回
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 4'-C-エチニル-2'-デオキシ-4'-チオヌクレオシドの合成とその抗HIV活性2009
- Author(s)
  原口一広、島田央、阿久津源太、木村圭吾、田中博道、濱崎隆之、馬場昌範、Elizabeth A. Gullen、Ginger E. Dutschman、Yung-Chi Cheng、Jan Balzarini
- Organizer
  第19回抗ウイルス療法研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 糖部4'位のベンゼンスルフェニル化を鍵反応とする4'-置換コルジセピンの新規合成法の開発2009
- Author(s)
  窪田豊、江原真理子、熊本浩樹、島田央、原口一広、田中博道
- Organizer
  第129年回
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] Reaction of the 4'-benzenesulfonyl derivatives of thymidine with organosilicon and organoaluminum reagent2009
- Author(s)
  Shimada, H.; Kikuchi, S.; Okuda, S.; Haraguchi, K.; Tanaka, H.
- Organizer
  第36回核酸化学シンポジウム(第7回国際核酸化学シンポジウム)
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] Synthesis and anti-HIV activity of 4'-C-ethynyl-2'-deoxy-4'-thionucleoside2009
- Author(s)
  Haraguchi, K.; Shimada, H.; Akutsu, G.; Kimura, K.; Tanaka, H.; Hamasaki, T.; Baba, M.; Gullen, E. A.; Dutschman, G. E.; Cheng, Y.-C.; Balzalini, J
- Organizer
  第36回核酸化学シンポジウム(第7回国際核酸化学シンポジウム)
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] Synthesis of 4'-substituted cordycepins via benzenesulfenylation at the 4'-position as a key step2009
- Author(s)
  Kubota, Y. Ehara, M.; Shimada, H.; Haraguchi, K.; Tanaka, H.
- Organizer
  第36回核酸化学シンポジウム(第7回国際核酸化学シンポジウム)
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] Synthesis and Anti-HIV Activity of 4'-C-Ethynyl-2'-deoxy-4'-thionucleosides2009
- Author(s)
  Kazuhiro Haraguchi
- Organizer
  Gordon Research Conference
- Place of Presentation
  Rhode Island
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-21590123
[Presentation] 4'位にシアノ基およびエチニル基を有する4'-チオチミジンの合成とその抗HIV活性2008
- Author(s)
  原口一広
- Organizer
  第18回抗ウイルス療法研究会
- Place of Presentation
  鹿児島
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] Synthesis and antiviral evaluation of (±)-4'-ethnyl-5'-difluoro-carbocyclic-D4T analogue2008
- Author(s)
  H. Kumamoto, K. Haraguchi, M. Ida, H. Tanaka, T. Hamasaki and M. Baba
- Organizer
  第35回核酸化学シンポジウム(第6回国際核酸化学シンポジウム)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] 4'位にシアノ基およびエチニル基を有する4'-チオチミジンの合成とその抗HIV活性2008
- Author(s)
  原口一広、島田央、田中博道、濱崎隆之、馬場昌範、Elizabeth A. Gullen、Ginger E. Dutschman、Yung-Chi Cheng
- Organizer
  第18回抗ウイルス化学療法研究会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] Synthesis and Anti-HIV Activity of 4'-Substituted 4'-thiothymidines2008
- Author(s)
  原口一広
- Organizer
  International Symposium on Medicinal Chemistry
- Place of Presentation
  オーストリア
- Year and Date
  2008-08-31
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] トリメチルアルミニウムを用いる4'-ベンゾイルオキシコルジセピンの求核置換反応2008
- Author(s)
  窪田豊、國方真由美、石崎伸英、大石亜佑美、原口一広、田中博道
- Organizer
  日本薬学会第128年会
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] Synthesis and Antiviral Evaluation of (±)-4'-Ethynyl-5'-difluoro-carbocyclic D4T analogues2008
- Author(s)
  原口一広
- Organizer
  第6回国際核酸化学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] Synthesis and anti-HIV activity of 4'-substituted 4'-thiothymidines: a new entry based on nucleophilic substitution of 4'-acetoxy Group2008
- Author(s)
  K. Haraguchi, H. Shimada, H. Tanaka, T. Hamasaki, M. Baba, E. A. Gullen, G. E. Dutschman, and Y.-C. Cheng
- Organizer
  International Symposium on Medicinal Chemistry (ISMC07)
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] Nucleophilic Substitution of 4'-Acetoxy-4'-thionucleosides:A New Access to 4'-Substituted 4'-thiothymidines2007
- Author(s)
  Kazuhiro Haraguchi
- Organizer
  International Symposium on Advances in Synthetic and Medicinal Cheuistry
- Place of Presentation
  St.Petersburg,Russia
- Year and Date
  2007-08-28
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] 2'位にアジド基ならびにメトキシ基を有する2'-デオキシ-4'-チオリボヌクレオシドの合成とその抗HCV活性2007
- Author(s)
  原口一広、屋敷千穂、島田央、田中博道、S. K. Jang
- Organizer
  第17回抗ウイルス化学療法研究会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] 4'-チオフラノイドグリカールを利用する4'-チオ-C-ヌクレオシドの合成研究2007
- Author(s)
  原口一広、堀井周文、吉村祐一、有賀史子、田所綾、田中博道
- Organizer
  日本薬学会第127年会
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] Nucleophilic Substitution of 4'-Acetoxy-4'-thionucleosides: a new access to 4'-substituted 4'-thiothymidines2007
- Author(s)
  K. Haraguchi, H. Shimada, H. Tanaka
- Organizer
  International Symposium on Advances in Synthetic and Medicinal Chemistry (ASMC07)
- Place of Presentation
  St. Pertersburg, Rissia
- Data Source
  KAKENHI-PROJECT-19590106
[Presentation] 4’-MODIFIED NUCLEOSIDE ANALOGS: Potent Inhibitors Active against Entecavir-resistant Hepatitis B Virus (HBVETV-RL180M/S202G/M204V)
- Author(s)
  Takamatsu, Y.; Tanaka, Y.; Kohgo, S.; Murakami, S.; Singh, K.; Das, D.; Venzon, D. J.; Amano, M.; Kuwata, N.; Aoki, M.; Delino, N. S.; Hayashi, S.; Takahashi, S.; Haraguchi, K.; Sarafianos, S. G.; Maeda, K.; Mitsuya, H.
- Organizer
  4th International Conference on Antiviral Microbial Agents and Chemotherapy
- Place of Presentation
  Washington, DC
- Year and Date
  2014-09-05 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-24590144
[Presentation] 4’-Ethynyl-2-fluoro-2’-deoxyadenosine (EFdA) has an extremely high genetic barrier, persistently exerting highly potent activity against a variety of HIV-1 isolates including EFdA-selected HIV-1 variants
- Author(s)
  Maeda, K.; Takamatsu, Y.; Kohgo, S.; Haraguchi, K.; Delino, N. S.; Chang, S. B.; Das, D.; Li, Z.; Kirby, K. A.; Sarafianos, S. G.; Mitsuya, H.
- Organizer
  Conference on Retroviruses and Opportunistic Infections
- Place of Presentation
  Seattle, Washington
- Year and Date
  2015-02-23 – 2015-02-26
- Data Source
  KAKENHI-PROJECT-24590144
[Presentation] スピロ[2.4]ヘプタン骨格を有する炭素環ヌクレオシドの合成と抗ウイルス作用の評価
- Author(s)
  熊本浩樹、深野美里、徳田　亮、天野将之、鍬田（東）伸好、原口一広、満屋裕明、福原　潔
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590144
[Presentation] エンテカビルとアデホビルのハイブリッド型化合物：メチレンアシクロヌクレオシド誘導体の合成と抗HBV活性
- Author(s)
  井本修平、向後　悟、徳田　亮、熊本浩樹、青木　学、天野将之、鍬田（東）伸好、満屋裕明、原口一広
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590144

1. TANAKA Hiromichi (50109477)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. 宮坂貞 (70053808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 吉村祐一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Haraguchi Kazuhiro 原口 一広

HARAGUCHI Kazuhiro) 原口 一広

原口 一広 ハラグチ カズヒロ

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Co-Researchers

Synthesis and evaluation of antiviral activities of branched oxetanosine A.Principal Investigator

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Synthesis of 4'-substtituted 4'-thionucleosides and evaluation of its biological activityPrincipal Investigator

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Regioselective Pummerer reacton of 4'-thionucleoside S-oxide : Synthesis of 1'-or 4'-substituted 4'-thionucleoside and its biological activityPrincipal Investigator

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Synthesis and Biological Activities of Sugar Modified 4'-ThionucleosidesPrincipal Investigator

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Synthesis and Biological Activities of 4'-Thionucleosides branched at the Sugar PortionPrincipal Investigator

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チオフラノイドグリカールを利用する4'-チオヌクレオシドの立体選択的合成研究Principal Investigator

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共役ジエンの分子内オキシセレノ化反応を基盤とするオクトシルヌクレオシドの合成研究Principal Investigator

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ヌクレオシド糖部ラジカル反応における1,2-不斉誘起に関する研究

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ラジカル的アシルオキシ転位反応を基盤とする4'-炭素置換チミジンの立体選択的合成Principal Investigator

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真正双頭ヌクレオシドの合成とその機能に関する研究

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面選択的親電子付加反応を基盤とする1'-炭素置換ヌクレオシドの合成に関する研究Principal Investigator

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アリル転位に基づく立体選択的な4'-炭素置換ヌクレオシドの合成研究Principal Investigator

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[Book] Frontiers in Clininal Drug Reseach2015

Author(s)

Haraguchi Kazuhiro 原口一広

HARAGUCHI Kazuhiro) 原口一広

原口一広ハラグチカズヒロ