MIMURO Jun 三室淳

Researcher Number	10221607
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2006 – 2013: 自治医科大学, 医学部, 准教授 2003 – 2005: Jichi Medical School, Cell and molecular medicine, Assistant Professor, 医学部, 助教授 1990 – 2002: 自治医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Hematology / Hematology / Circulatory organs internal medicine Except Principal Investigator General surgery / Hematology / Hematology
Keywords	Principal Investigator 遺伝子治療 / 血友病 / adeno-associated virus vector / endothelial cell / Gene therapy / PAI-1 / gene therapy / カニクイザル / 第IX因子 / 第VIII因子 … More / gene targeting / fibrinolysis / plasminogen activator inhibitor / SIV vector / Factor IX / Factor VIII / Hemophilia / VEGF / viral vector / Adeno-associated virus vector / plasminogen activator inhibitor 2 / 細胞移植 / 血小板 / 凝固VIII因 / 遣伝子治療 / 凝固IX因子 / 凝固VIII因子 / 血友病A / ウイルスベクター / Adeno-associated virus / SIVベクター / Prostacyclin / Angiopoietin 1 / Vascular endothelial growth factor / 血管新生 / 血管内皮細胞 / plasminogen activator inhibitor 1 / thrombomodulin / thrombosis / Thrombosis / AAV vector / Endothelial cell / Thorombosis / Thrombomodulin / embryonic stem cell / Plasminogen activator inhibitor / hemophilia / 血友病Ａクローンブタ / アデノ随伴ウイルスベクター / 第IX / In situ hybridization / Immunohistochemistry / Gene targeting / Plasminogen activator inhibitor 2 / 線溶 / vitronectin / plasminogen activator / ype 1 plasminogen activator inhibitor / phorbol ester / glycoprotein IIb / 骨髄巨核芽球 … More Except Principal Investigator フィブリノゲン / hereditary dysfibrinogen / 遺伝性異常フィブリノゲン / 血栓症 / 電顕学的分析 / 異常フィブリノゲン / プラスミノゲン / fibrin / フィブリン / thrombosis / fibrinogen / フィブリンの電顕像 / フィブリン重合反応 / 血栓塞栓症 / プラスミン / fibrin ultra-structure / bleeding tendency / フィブリンの超微細構造 / 血栓性素因 / 余剰糖鎖 / フィブリン超微細構造 / 出血傾向 / 架橋結合 / 接着分子 / 構造異常 / 創傷治癒不全 / 出血性素因 / インテグリン / 細胞接着 / フィブリノゲン異常症 / 遺伝子解析 / 血管内皮細胞 / モノクロナル抗体 / アンギオスタチン / セレクチン / plasminogen-deficient mice / Plasmin / granulocyte-derived elastase / Plasminogen activator inhibitor-1 / フィブリノゲン分解産物 / 白血球エラスターゼ / フィブリン分解産物 / プラスミノゲンノックアウトマウス / 白血球由来エラスターゼ / プラスミノゲンアクチベータインヒビタ1 / gene analysis / fibrin nets / extra carbohydrate / fibrinogen structure / 停止コドンの消失 / 糖付加構造 / 余剩糖鎖 / フィブリン網 / フィブリノゲンの構造 / 遺伝性フィブリノゲン / anti-angiogenesis / monoclonal antibody / structural alteration / 抗フィブリノゲン・モノクロナル抗体 / 点変異 / 抗血管新生 / electron microscopic analysis of fibrin / plasmin / intermolecular crosslink / pulmonary embolism / deep veinthrombosis / extra oligosaccharide / fibrin gels / XIIIa因子による分子間架橋 / フィブリンの電顕学的分析 / 線溶酵素プラスミン / Xllla因子による分子間架橋 / 肺塞栓症 / 深部静脈血栓症 / 余剰糖鎖付加 / selectin / factor XIII / angiostatin / alpha2-plasmin inhibitor / plasminogen / 組織修復 / 細胞移動 / α2プラスミンインヒビタ / 細胞遊走 / XIII因子 / α2-プラスミンインヒビタ / cross-linking / extra glycosylation / ultrastructure of fibrin / dysfibrinogen / 余剰糖付加 / kininogen / beta1-integrin / adhesion molecule / electron microscopy / thromboembolism / RGD配列 / 接着分子受容体 / 一過性虚血発作 / フィブリン重合 / 分子異常 / 腫瘍の転移 / キニノゲン / β1インテグリン / 線維芽細胞 / Adhesion molecule / Cell attachment / Monoclonal antibody / Calcium-dependent structure / Crosslinking / Fibrin polymerization / Hereditary dysfibrinogen / Fibrinogen / 接着分子のレセプター / 血栓 / 出血 / 遺伝性フィブリノゲン異常症 / モノクローナル抗体 / モノクロナール抗体 / カルシウム依存性構造 / 架橋形成 / wound healing insufficiency / electron microscopy of fibrin / electron microscopy of fibrinogen / polymerization / fibrin gel / 構造機能関係 / 機能障害 / フィリン・ゲル / フィブリノゲンの電顕像 / フィブリン・ゲル / integrin / high-molecular-weight kininogen / cell adhesion / abnormal factor IX / hemophilia B / fibrin polymerization / hereditary dysfibrinogenemia / abnormal fibrinogen / フィブリン重合障害 / グリオーマ細胞 / 異常第IV因子 / 高分子キニノゲン / 異常第IX因子 / 血友病B / Regulation of thrombus formation / Vascular endothelial cells, / Thrombus formation / Thromboembolic disease, / Monoclonal antibodies, / Protein C, / Abnormal fibrinogen, / Molecular abnormality, / アミノ酸置換 / 異常プロテインC / 遺伝性分子異常症 / 血栓形成抑制機構 / プロテインC / 分子異常症 / 血栓形成 / iPS細胞 / 人工多能性幹細胞 / 血友病 / 遺伝子細胞治療 / 癌転移 / 血管新生 / 組織線溶 / シアリルルイスX構造 / α_2プラスミンインヒビタ / 基質特異性 / スタフイロキナーゼ / O結合型糖鎖 / 糖鎖構造 / N-methyl-deoxynojirimycin / alpha2-プラスミンインヒビタ / 血小板と線溶 / ビトロネクチン / ウロキナーゼ型プラスミノゲンアクチベータ / プラスミノゲンアクチベータインヒビター1 / CMK細胞 / 血管壁内皮細胞 / 血小板α顆粒 / 骨髄巨核球 / プラスミノゲンアクチベ-タインヒビタ-1 Less

次世代血友病治療法の開発と非ヒト霊長類を用いた前臨床研究Principal Investigator
- Principal Investigator
  
  三室淳
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Application of iPSCs for hemophilia therapy
- Principal Investigator
  
  OHMORI Tsukasa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Preclinical Hemophilia Gene Therapy Study with Non-human PrimatesPrincipal Investigator
- Principal Investigator
  
  MIMURO Jun
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Preclinical Study for Hemophilia Gene and Cell Therapy in Model Mice and in Non-human PrimatesPrincipal Investigator
- Principal Investigator
  
  MIMURO Jun
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Gene therapy for hemophilia and its preclinical study in cynomolgus macaquesPrincipal Investigator
- Principal Investigator
  
  MIMURO Jun
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  JICHI MEDICAL SCHOOL
Regulation of granulocyte-derived elastase-dependent fibrinolysis
- Principal Investigator
  
  SAKATA Yoichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Regulation of endothelial cell function by transgene expression and development of gene therapy for vascular diseasesPrincipal Investigator
- Principal Investigator
  
  MIMURO Jun
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jichi Medical School
Regulation of endothelial cell functions by gene transfer using viral vectorsPrincipal Investigator
- Principal Investigator
  
  MIMURO Jun
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jichi Medical School
STUDIES ON THE PATHOPHYSIOLOGY OF THROMBOEMBOLIC DISEASES WITH SPECIAL REFERENCE TO THE UNDERLYING IMPAIRED BLOOD COAGULATION AND ITS REGULATION
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School
Molecular basis for the fibrinogen structure and functions-Analysis Of hereditary dysfibrinogens and their application to the study
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School
Molecular basis for the fibrinogen structure and functions - Analysls of hereditary dysfibrinogens and their application to the study
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School
Molecular basis for the fibrinogen structure and functions-Analysis of hereditary dysfibrinogens and their application to the study
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School, School of Medicine
Analysis of the molecular mechanism in regulation of cell migration by alpha2-plasmin inhibitor
- Principal Investigator
  
  SAKATA Yoichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School, School of Medicine
Gene targeting of plasminogen activator inhibitor 2Principal Investigator
- Principal Investigator
  
  MIMURO Jun
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School, School of Medicine
血管新生抑制物質-アンギオスタンチンの機能部位の分子生物学的解析
- Principal Investigator
  
  坂田洋一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
ノックアウトマウスを用いた線溶制御因子の細胞死,発生における役割に関する研究Principal Investigator
- Principal Investigator
  
  三室淳
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Etiology and pathophysiology of thrombosis : A molecular biological aproach to elucidate disturbed mechanisms of blood coagulation and its inhibition.
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School, School of Medicine
組織における線溶反応の動的制御機構の分子生物学的解析
- Principal Investigator
  
  坂田洋一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
免疫,癌転移,細胞死,発生における線溶制御因子の役割に関す分子生物学的研究Principal Investigator
- Principal Investigator
  
  三室淳
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
スタフィロキナーゼの血栓溶解活性発現機作の分子生物学的解析
- Principal Investigator
  
  坂田洋一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Molecular basis for the fibrinogen structure and functions-Analysis of hereditary dysfibrinogens and their application to the study
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Jichi Medical School, School of Medicine
Etiology and pathophysiology of thrombosis : A molecular biological aproach to elucidate disturbed mechanisms of blood coagulation and its inhibition.
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School
線溶因子の細胞内代謝、及び生物活性に果たす糖鎖の役割の分子生物学的解析
- Principal Investigator
  
  坂田洋一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
血小板内プラスミノゲンアクチベータインヒビタの産生部位と活性化機序の解明
- Principal Investigator
  
  坂田洋一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
プラスミノゲンアクチベータインヒビタ及びビトロネクチンの構造と機能に関する研究Principal Investigator
- Principal Investigator
  
  三室淳
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Studies on the etiology and pathophysiology of thrombosis : molecular biological approaches to the perturbed blood coagulation and its regulation.
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School
プラスミノゲンアクチベ-タインヒビタの放出機序の分子、遺伝子レベルの解析
- Principal Investigator
  
  坂田洋一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
骨髄巨核芽球,及び,骨髄巨核球における凝固線溶因子の遺伝子制御Principal Investigator
- Principal Investigator
  
  三室淳
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Pathogenesis and pathophysiology of thromboembolic diseases - analysis of the mechanisms of blood coagulation and its regulation at the molecular and gene levels.
- Principal Investigator
  
  MATSUDA Michio
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical School

All 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 Other

All Journal Article Presentation Book Patent

[Book] VI 凝固線溶系 5.血友病遺伝子治療法開発の最近の進歩 AnnualReview 血液2011
- Author(s)
  三室淳
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20591155
[Book] Annual Review血液2011
- Author(s)
  三室淳
- Total Pages
  9
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20591155
[Book] (8)研究分子病態治療研究センター分子病態研究部小児生体肝移植2010
- Author(s)
  三室淳
- Total Pages
  329
- Publisher
  日本医学館
- Data Source
  KAKENHI-PROJECT-20591155
[Book] 血液疾患最新の治療2010
- Author(s)
  三室淳
- Total Pages
  3
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-20591155
[Book] 小児生体肝移植2010
- Author(s)
  三室淳
- Total Pages
  1
- Publisher
  日本医学館
- Data Source
  KAKENHI-PROJECT-20591155
[Book] V 出血・血栓性疾患 5.その他の先天性凝固異常症・線溶異常症血液疾患最新の治療 20011-20132010
- Author(s)
  三室淳
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-20591155
[Book] 線溶系制御機構講義録血液・造血器疾患学2008
- Author(s)
  三室淳
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-20591155
[Book] イラスト血液内科第2版2004
- Author(s)
  三室淳
- Total Pages
  6
- Publisher
  文光堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590961
[Book] 血液内科診療マニアル2004
- Author(s)
  三室淳
- Total Pages
  11
- Publisher
  日本医学館
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590961
[Book] 血液の辞典2004
- Author(s)
  三室淳
- Total Pages
  6
- Publisher
  朝倉書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590961
[Journal Article] Production of functional coagulation factor VIII from iPSCs using a lentiviral vector2014
- Author(s)
  Kashiwakura Y, Ohmori T, Mimuro J, Madoiwa S, Inoue M, Hasegawa M, Ozawa K, and Sakata Y
- Journal Title
  
  Haemophilia
  
  Volume: 20
- Data Source
  KAKENHI-PROJECT-23591427
[Journal Article] Production of functional coagulation factor VIII from iPSCs using a lentiviral vector2014
- Author(s)
  Kashiwakura Y, Ohmori T, Mimuro J, Madoiwa S, Inoue M, Hasegawa M, Ozawa K, and Sakata Y.
- Journal Title
  
  Haemophilia
  
  Volume: 20 Issue: 1
- DOI
  10.1111/hae.12311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591427, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24591430
[Journal Article] Minimizing the Inhibitory Effect of Neutralizing Antibody for Efficient Gene Expression in the Liver With Adeno-associated Virus 8 Vectors2013
- Author(s)
  Mimuro J, Mizukami H, Hishikawa S, Ikemoto T, Ishiwata A, Sakata A, Ohmori T, Madoiwa S, Ono F, Ozawa K, Sakata Y
- Journal Title
  
  Mol Ther
  
  Volume: 21 Pages: 318-323
- Data Source
  KAKENHI-PROJECT-23591427
[Journal Article] Overexpression of factor VII ameliorates bleeding diathesis of factor VIII-deficient mice with inhibitors2013
- Author(s)
  Yasumoto A, Madoiwa S, Kashiwakura Y, Ishiwata A, Ohmori T, Mizukami H, Ozawa K, Sakata Y, Mimuro J
- Journal Title
  
  Thromb Res
  
  Volume: 131 Pages: 444-449
- Data Source
  KAKENHI-PROJECT-23591427
[Journal Article] Immune response against serial infusion of factor VIII antigen through an implantable venous-access device system in haemophilia A mice2012
- Author(s)
  Madoiwa, S., et al.
- Journal Title
  
  Haemophilia
  
  Volume: 18 Issue: 3
- DOI
  10.1111/j.1365-2516.2011.02686.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591249, KAKENHI-PROJECT-23591426, KAKENHI-PROJECT-23591427, KAKENHI-PROJECT-24591430
[Journal Article] Intra-articular injection of mesenchymal stem cells expressing coagulation factorameliorates hemophilic arthropathy in factor VIII-deficient mice.2012
- Author(s)
  Kashiwakura, Y
- Journal Title
  
  J Thromb Haemost.
  
  Volume: 10(9) Issue: 9 Pages: 1802-1813
- DOI
  10.1111/j.1538-7836.2012.04851.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591426, KAKENHI-PROJECT-23591427, KAKENHI-PROJECT-23659493, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24591430
[Journal Article] Porcine model of hemophilia a. PLoS One.2012
- Author(s)
  Kashiwakura Y
- Journal Title
  
  PLoS One.
  
  Volume: 7(11) Issue: 11 Pages: e49450-e49450
- DOI
  10.1371/journal.pone.0049450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591426, KAKENHI-PROJECT-23591427, KAKENHI-PROJECT-24591430
[Journal Article] FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms2012
- Author(s)
  Norimatsu Y, Ohmori T, Kimura A, Madoiwa S, Mimuro J, Seichi A, Yatomi Y, Hoshino Y, Sakata Y.
- Journal Title
  
  Am J Pathol
  
  Volume: 180(4) Issue: 4 Pages: 1625-35
- DOI
  10.1016/j.ajpath.2011.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591641, KAKENHI-PROJECT-23591426, KAKENHI-PROJECT-23591427, KAKENHI-PROJECT-24591430
[Journal Article] Porcine model of hemophilia A2012
- Author(s)
  Kashiwakura Y, Mimuro J, Onishi A, Iwamoto M, Madoiwa S, Fuchimoto D, Suzuki S, Suzuki M, Sembon S, Ishiwata A, Yasumoto A, Sakata A, Ohmori T, Hashimoto M, Yazaki S, Sakata Y
- Journal Title
  
  PLoS One
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-23591427
[Journal Article] Lack of association between serum paraoxonase-1 activity and residual platelet aggregation during dual anti-platelet therapy2012
- Author(s)
  Ohmori, T., et al.
- Journal Title
  
  Thromb Res
  
  Volume: 129 Issue: 4 Pages: e36-e40
- DOI
  10.1016/j.thromres.2011.10.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591249, KAKENHI-PROJECT-23591426, KAKENHI-PROJECT-23591427, KAKENHI-PROJECT-24591430
[Journal Article] Immune response against serial infusion of factor VIII antigen through an implantable venous-access device system in haemophilia A mice2012
- Author(s)
  Madoiwa S, Kobayashi E, Kashiwakura Y, Sakata A, Yasumoto A, Ohmori T, Mimuro J, Sakata Y
- Journal Title
  
  Haemophilia
  
  Volume: 18
- Data Source
  KAKENHI-PROJECT-23591427
[Journal Article] Intra-articular injection of mesenchymal stem cells expressing coagulation factor ameliorates hemophilic arthropathy in factor VIII-deficient mice2012
- Author(s)
  Kashiwakura Y, Ohmori T, Mimuro J, Yasumoto A, Ishiwata A, Sakata A, Madoiwa S, Inoue M, Hasegawa M, Ozawa K, and Sakata Y
- Journal Title
  
  J Thromb Haemost
  
  Volume: 10 Pages: 1802-1813
- Data Source
  KAKENHI-PROJECT-23591427
[Journal Article] Predictive blood coagulation markers for early diagnosis of venous thromboembolism after total knee joint replacement2011
- Author(s)
  Watanabe, H. Madoiwa, S. Sekiya, H. Nagahama, Y. Matsuura, S. Kariya, Y. Ohmori, T. Mimuro, J. Hoshino, Y. Hayasaka, S. Sakata, Y.
- Journal Title
  
  Thromb Res
  
  Volume: 128 Issue: 6 Pages: e137-e143
- DOI
  10.1016/j.thromres.2011.07.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591426, KAKENHI-PROJECT-23591427
[Journal Article] Gene and cell therapy for hemophilia: recent advances2011
- Author(s)
  Mimuro, J., and Sakata, Y
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 52 Pages: 361-367
- NAID
  10029425166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591426
[Journal Article] Integration-free and stable expression of FVIII using a human artificial chromosome2011
- Author(s)
  Kurosaki H, et.al.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 56 Issue: 10 Pages: 727-733
- DOI
  10.1038/jhg.2011.88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00264, KAKENHI-PROJECT-21659238, KAKENHI-PROJECT-22590301, KAKENHI-PROJECT-23591426
[Journal Article] Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation.2011
- Author(s)
  Madoiwa, S. Tanaka, H. Nagahama, Y. Dokai, M. Kashiwakura, Y. Ishiwata, A. Sakata, A. Yasumoto, A. Ohmori, T. Mimuro, J. Sakata, Y.
- Journal Title
  
  Thromb Res
  
  Volume: 127 Issue: 4 Pages: 349-355
- DOI
  10.1016/j.thromres.2010.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591426, KAKENHI-PROJECT-23591427
[Journal Article] Local regulation of neutrophil elastase activity by endogenous alpha1-antitrypsin in lipopolysaccharide-primed hematological cells.2011
- Author(s)
  Dokai, M., Madoiwa, S., Yasumoto, A., Kashiwakura, Y., Ishiwata, A., Sakata, A., Makino, N., Ohmori, T., Mimuro, J., and Sakata, Y.
- Journal Title
  
  Thromb Res
  
  Volume: 128 Issue: 3 Pages: 283-292
- DOI
  10.1016/j.thromres.2011.04.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591426, KAKENHI-PROJECT-23591427
[Journal Article] 血栓傾向?凝固関連因子から Vascular Lab2010
- Author(s)
  三室淳
- Journal Title
  
  バスキュラー・ラボメディカル出版 Vol.7(4)
  
  Pages: 352-356
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Impact of acute cellular rejection on coagulation and fibrinolysis biomarkers within the immediate post-operative period in pediatric liver transplantation.2010
- Author(s)
  Mimuro, J.
- Journal Title
  
  Pediatr Transplant.
  
  Volume: 14(3) Pages: 369-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Mutant macaque factor IX T262A:A tool for hemophilia B gene therapy studies in macaques.2010
- Author(s)
  Ishiwata A., Mimuro J., Mizukami H., Kashiwakura Y., Yasumoto A., Sakata A., Ohmori T., Madoiwa S., Ono F., Shima M., Yoshioka A., Ozawa K., Sakata Y.
- Journal Title
  
  Thromb Res 125(6)
  
  Pages: 533-537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Vinculin activates inside-out signaling of integrin alphaIIbβ3 in Chinese hamster ovary cells.2010
- Author(s)
  Ohmori T., Kashiwakura Y., Ishiwata A,. Madoiwa S., Mimuro J., Honda S., Miyata T., Sakata Y.
- Journal Title
  
  Biochem Biophys Res Commun 400(3)
  
  Pages: 323-328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Development of platelet-directed gene modification by lentiviral vector.2010
- Author(s)
  Ohmori T., Madoiwa S., Mimuro J., Sakata Y.
- Journal Title
  
  Rinsho Ketsueki 51(8)
  
  Pages: 625-631
- NAID
  10026630183
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Impacto of acute cellular rejection on coagulation and f ibrinolysis biomarkers within the immediate post-operative reriod in pediatric liver transplantation.2010
- Author(s)
  Mimuro J., Mizuta K., Kawano Y., Hishikawa S., Hamano A., Kashiwakura Y., Ishiwata A., Ohmori T., Madoiwa S., Kawarasaki H., Sakata Y.
- Journal Title
  
  Pediatr Transplant 14(3)
  
  Pages: 369-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Vinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function.2010
- Author(s)
  Ohmori, T., Kashiwakura,Y., Ishiwata, A., Madoiwa,S., Mimuro,J., Furukawa, Y., Sakata, Y.
- Journal Title
  
  J Biol Chem 285(41)
  
  Pages: 31763-31773
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] 幡種性血管内凝固症候群内科疾患の診断基準病型分類重症度 X 血液2010
- Author(s)
  三室淳
- Journal Title
  
  内科臨床雑誌南江堂 105(6)
  
  Pages: 1453-1457
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] 血栓性血小板減少性紫斑病2010
- Author(s)
  三室淳
- Journal Title
  
  今日の診断指針第6 版医学書院
  
  Pages: 1125-1127
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Induction of factor VIII-specific unresponsiveness by intrathymic factor VIII injection in murine hemophilia A.2009
- Author(s)
  Madoiwa S., Yamauchi T., Kobayashi E., Hakamata Y., Dokai M., Makino N., Kashiwakura Y., Ishiwata A., Ohmori T., Mimuro J., Sakata Y.
- Journal Title
  
  J Thromb Haemost 7(5)
  
  Pages: 811-824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Liver-restricted expression of the canine factor VIII-gene facilitates prevention of inhibitor formation in factor VIII-deficient mice.2009
- Author(s)
  Ishiwata A., Mimuro J., Mizukami H., Kashiwakura Y., Takano K., Ohmori T., Madoiwa S., Ozawa K., Sakata Y.
- Journal Title
  
  J Gene Med 11(11)
  
  Pages: 1020-1029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Unbalanced expression of ADAMTS13 and von Willebrand factor in mouse endotoxinemia.2008
- Author(s)
  Mimuro, J
- Journal Title
  
  Thromb Res. ; 122(1) : 122(1)
  
  Pages: 91-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Unbalanced Expression of ADAMTS1 3 and von Willebrand Factor in Mouse Endotoxinemia.2008
- Author(s)
  Mimuro J
- Journal Title
  
  Thrombosis Res.2007 doi:10.1016/j.thrombosis.2007.09.011 (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591084
[Journal Article] Determinants of thrombbbbf thrombthrombof thrombthrombf thromb thrombrombrombhrombeneration, fibrinolytic activity, and endothelial dysfunction in dual-antiplatelet therapy : nvolvement of factors other than platelet aggregability in Virchow's triad.2008
- Author(s)
  Yano Y., Ohmori T., Hoshide S., Madoiwa S., Yamamoto K., Katsuki T., Mitsuhashi T., Mimuro J., Shimada K., Kario K., Sakata Y.
- Journal Title
  
  European Heart Journal Jul 29(14)
  
  Pages: 1729-1738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain infarction.2008
- Author(s)
  Kimura.,A., Ohmori,T., Kashiwakura.Y., Ohkawa,R., Madoiwa,S., Mimuro,J., Shimazaki,K., Hoshino,Y., Yatomi,Y., Sakata,Y.
- Journal Title
  
  Stroke. Dec 39(12)
  
  Pages: 3411-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Phenotypic orrection of hemophilia A by ectopic expression of activated factor FVII in platelets.2008
- Author(s)
  Ohmori,T., Ishiwata,A., Kashiwakura,Y., Madoiwa, S., Mitomo,K., Suzuki,H., Hasegawa,M., Mimuro,J.,Sakata,Y.
- Journal Title
  
  Mol Ther 16(8)
  
  Pages: 1359-1363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] Unbalanced Expression of ADAMTS13 and von Willebrand Factor in Mouse Endotoxinemia2008
- Author(s)
  Mimuro J
- Journal Title
  
  Thrombosis Res.2007 doi:10.1016/j.thrombosis.2007.09.01 (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591084
[Journal Article] Unbalanced expression of ADAMTS13 and von Willebrand factor in mouse2008
- Author(s)
  Mimuro J., Niimura M., Kashiwakura Y., Ishiwata A., Ono T., Ohmori T., Madoiwa S., Okada K., Matsuo O., Sakata Y.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Journal Article] フィブリノゲン異常症と血栓症2007
- Author(s)
  三室淳
- Journal Title
  
  Annual Review 血液 2007
  
  Pages: 281-281
- Data Source
  KAKENHI-PROJECT-18591084
[Journal Article] Unbalanced Expression of ADAMTS13 and von Willebrand Factor in Mouse Endotoxinemia2007
- Author(s)
  Mimuro, J
- Journal Title
  
  Thrombosis Res 10
  
  Pages: 1016-1016
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591084
[Journal Article] 「血友病遺伝子治療最近の進歩」 VI凝結・線溶系2005
- Author(s)
  三室淳
- Journal Title
  
  Annual Review 血液 2005
  
  Pages: 296-302
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590961
[Journal Article] 遺伝子治療-現状と展望-血液疾患に対する遺伝子治療血友病2005
- Author(s)
  三室淳
- Journal Title
  
  日本臨床 63巻増刊号12
  
  Pages: 646-654
- Data Source
  KAKENHI-PROJECT-16590961
[Journal Article] 【遺伝子診療学遺伝子診断の進歩と遺伝子治療の展望】遺伝子治療 -現状と展望- 血液患者に対する遺伝子治療血友病2005
- Author(s)
  三室淳
- Journal Title
  
  日本臨床 63巻増刊号12
  
  Pages: 646-654
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590961
[Journal Article] 血栓溶解のメカニズムとその異常による病態血栓と循環2004
- Author(s)
  三室淳
- Journal Title
  
  特集(線溶療法) 12(2)
  
  Pages: 10-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590961
[Journal Article] Specific detection of human coagulation factor IX in cynomolgus macaques.2004
- Author(s)
  Mimuro J
- Journal Title
  
  J.Thromb.Haemost. 2
  
  Pages: 275-280
- Data Source
  KAKENHI-PROJECT-16590961
[Journal Article] Impact of acute cellular rejection on coagulation and fibrinolysis biomarkers within the immediate post-operative period in pediatric liver transplantation
- Author(s)
  Mimuro, J.
- Journal Title
  
  Pediatr Transplant. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591155
[Patent] 血友病Aモデルブタの作出2010
- Inventor(s)
  自治医科大学:教授坂田洋一自治医科大学:准教授三室淳農業生物資源生物研究所:上級研究員大西彰プライムテック(株):チームリーダー岩本正樹プライムテック(株):チーム員大石貴嗣
- Industrial Property Rights Holder
  自治医科大学農業生物資源生物研究所プライムテック(株)
- Industrial Property Number
  2010-102569
- Filing Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-20591155
[Patent] 血友病A モデルブタの作出2010
- Inventor(s)
  自治医科大学:教授坂田洋一自治医科大学:准教授三室淳農業生物資源生物研究所: 上級研究員大西彰プライムテック(株):チームリーダー岩本正樹プライムテック(株):チーム員大石貴嗣
- Industrial Property Rights Holder
  自治医科大学農業生物資源生物研究所プライムテック(株)
- Industrial Property Number
  2010-102569
- Filing Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] 血友病Aクローンブタ2013
- Author(s)
  柏倉裕志、三室淳、大西彰、岩元正樹、窓岩清治、淵本大一郎、鈴木俊一、鈴木美佐枝、千本昭一郎、石渡彰、安本篤史、坂田飛鳥、大森司、橋本径子、矢崎智子、坂田洋一
- Organizer
  第35回日本血栓止血学会学術集会, (日本血栓止血学会誌)
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-23591427
[Presentation] FVIII遺伝子導入MSCの関節内移植は血友病Aマウスの血友病性関節症を改善する2012
- Author(s)
  柏倉裕志,大森司,三室淳,安本篤史,石渡彰,坂田飛鳥,窓岩清治,井上誠,長谷川護,小澤敬也,坂田洋一
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591427
[Presentation] Dose-respnse relationship of factor IX expression in non-human orimates using AAV8-based vector2012
- Author(s)
  水上浩明、三室淳、塚原智典、卜部匡司、久米晃浩、大森司、窓岩清治、坂田洋一、小澤敬也
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591427
[Presentation] 第VIII因子感作血友病マウスにおけるマイクロポートを用いた連続的抗原投与モデルの構築2012
- Author(s)
  窓岩　清治，小林　英司，坂田　飛鳥，柏倉　裕志，大森　司，三室　淳，坂田　洋一
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591427
[Presentation] 人工多能性幹細胞を用いた新規血友病治療法に対する基礎的検討2012
- Author(s)
  柏倉裕志、大森司、坂田飛鳥、窓岩清治、井上誠、長谷川護、三室淳、坂田洋一
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591427
[Presentation] Intra-articular injection of autologous mesenchymal stem cells ameliorates hemophilic arthropathy in factor VIII-deficient mice2011
- Author(s)
  Kashiwakura Y, Ohmori T, Mimuro J, Yasumoto A, Ishiwata A, Sakata A, Madoiwa S, Inoue M, Hasegawa M, Watanabe N, Tatsumi K, Ohashi K, Okano T and Sakata Y
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23591427
[Presentation] Intra-articular injection of autologous mesenchymal stem cells ameliorates hemophilic arthropathy in factor VIII-deficient mice.2011
- Author(s)
  Y. Kashiwakura., T.,Ohmori., J. Mimuro., A.,Yasumoto., Akira,Ishiwata., A.,Sakata., S.Madoiwa., M.Inoue., M.,Hasegawa., N.,Watanabe.,K.Tatsumi., K.Ohashi., T.Okano., Y.Sakata
- Organizer
  ISTH2011.XXIII Congress of the International Society on Thrombosis and Haemostasis.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23591426
[Presentation] Leukocyte elastase as an alternative pathway for fibrinolysis.2011
- Author(s)
  Seiji, Madoiwa., Hideyuki, Tanaka., Yutaka, Nagahama., Atsushi, Yasumoto., Asuka, Sakata., Yuji, Kashiwakura., Tsukasa, Ohmori., Jun, Mimuro., Yoichi, Sakata.
- Organizer
  57th Annual SSC Meetin
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23591426
[Presentation] Post marketing surveillance of the safety and effectiveness of thrombomodulin alfa in Japanese patients with DIC2011
- Author(s)
  Yoichi, Sakata., Hoyu,Takahashi., Hajime,Tsuji., Jun, Mimuro., Yutaka,Eguchi.,Isao,Kitajima.,Tadashi,Matsusits.,Tatsuhiko,Kuroda
- Organizer
  ISTH2011.XXIII Congress of the International Society on Thrombosis and Haemostasis.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23591426
[Presentation] Intra-articular injection of autologous mesenchymal stem cells ameliorates hemophilic arthropathy in factor VIII-deficient mice2011
- Author(s)
  Kashiwakura Y, Ohmori T, Mimuro J, Yasumoto A, Ishiwata A, Sakata A, Madoiwa S, Inoue M, Hasegawa M, Watanabe N, Tatsumi K, Ohashi K, Okano T, Sakata Y
- Organizer
  ISTH2011.XXIII Congress of the International Society on Thrombosis and Haemostasis.57^<th> Annual SSC Meeting
- Data Source
  KAKENHI-PROJECT-23591427
[Presentation] Silencing of A targeted protein in platelets using A lentiviral vector delivering short hairpin RNA sequence.2010
- Author(s)
  大森司,柏倉裕志, 石渡彰, 窓岩清治, 三室淳, 坂田洋一
- Organizer
  第16回日本遺伝子治療学会学術集会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice.2010
- Author(s)
  Jun Mimuro, Akira Ishiwata, Hiroaki Mizukami, Yuji Kashiwakura, Katsuhiro Takano, Tsukasa Ohmori, Seiji Madoiwa, Keiya Ozawa, Yoichi Sakata
- Organizer
  第16回日本遺伝子治療学会学術集会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Robust and sustained factor IX expression following IV injection of AAV8-based vectors in magaques.2010
- Author(s)
  水上浩明、三室淳、石渡彰、八木洋也、大森司、窓岩清治、卜部匡司、久米晃浩、坂田洋一、小澤敬也
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Impact of acute cellular rejection on biomarkers in liver transplantation2010
- Author(s)
  三室淳
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] レンチウィルスベクターを用いた血小板標的遺伝子導入法の開発(シンポジウム)2010
- Author(s)
  大森司、窓岩清治、三室淳、坂田洋一
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Successful factor IX expression by IV administration of AAV8 vectors in macaques.2010
- Author(s)
  Hiroaki Mizukami, Jun Mimuro, Akira Ishiwata, Hiroya Yagi, Tsukasa Ohmori, Masashi Urabe, Akihiro Kume, Yoichi Sakata, Keiya Ozawa
- Organizer
  第16回日本遺伝子治療学会学術集会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Platelet-directed gene modification by lentiviral vector:Application to therapies for inherited bleeding disorders and research into platelet signal. シンポジウム2010
- Author(s)
  大森司、窓岩清治、三室淳、坂田洋一
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Impact ofacute cellular rejection onbiomarkers in liver transplantation2010
- Author(s)
  三室淳、水田耕一、川野陽一、菱川修司、浜野明栄、柏倉裕志、石渡彰、坂田飛鳥、安本篤史、大森司、窓岩清治、河原崎秀雄、坂田洋一
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] 非ヒト霊長類を用いた血友病B 遺伝子治療研究:末梢静脈投与AAV8 ベクターによる第IX 因子遺伝子導入2010
- Author(s)
  石渡彰、三室淳、水上浩明、小野文子、安本篤史、坂田飛鳥、柏倉裕志、大森司、窓岩清治、久米晃啓、保富康宏、小澤敬也、坂田洋一
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Promoter selection formuscle-directed self-complementary AAV toward hemophilia B gene therapy.2010
- Author(s)
  久米晃浩、八木洋也、水上浩明、卜部匡司、塚原智典、石渡彰、三室淳、窓岩清治、大森司、坂田洋一、小澤敬也
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Vinculin is indispensadle forrepopulation by hematopoietic stem cells.2010
- Author(s)
  Tsukasa Ohmori, Yuji Kashiwakura, Akira Ishiwata, Seiji Madoiwa, Jun Mimuro, Yusuke Furukawa, Yoichi Sakata
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Vinculin は巨核球分化とintegrin αIIb3 の活性化に関与する2010
- Author(s)
  大森司、柏倉裕志、石渡彰、坂田飛鳥、安本篤史、窓岩清治、三室淳、本田繁則、宮田敏行、坂田洋一
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Hemophilia gene therapy study with mice and non-human primates.2010
- Author(s)
  三室淳, 坂田洋一
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] The chicken hypersensitive site-4 chromatin insulator sequence protects clonal domina of hematopoietic stem cells transduced with a self-inactivating SIV vector in platelet-directed gene therapy.2010
- Author(s)
  Tsukasa Ohmori, Yuji Kashiwakura, Akira Ishiwata, Seiji Madoiwa, Eiji Akiba, Mamoru Hasegawa, Jun Mimuro, Keiya Ozawa, Yoichi Sakata
- Organizer
  第16回日本遺伝子治療学会学術集会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] マイクロポート植え込み成体血友病 A マウスを用いた持続的第VIII 因子刺激に対する免疫応答能の解析2010
- Author(s)
  窓岩清治、小林英司、石渡彰、柏倉裕志、大森司、三室淳、坂田洋一
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Choice of small-sized promother for AAV-medlated factor IX expression in skeletal muscle.2010
- Author(s)
  Akihiro Kume, Hiroya Yagi, Hiroaki Mizukami, Masashi Urabe, Tomonori Tsukahara, Akira Ishiwata, Jun Mimuro, Seiji Madoiwa, Tsukasa Ohmori, Yoichi Sakata, Keiya Ozawa
- Organizer
  第16回日本遺伝子治療学会学術集会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] 非ヒト霊長類を用いた血友病A伝子治療研究に向けたヒトBDDFVIII特異的検出法の確立2010
- Author(s)
  柏倉裕志、三室淳、石渡彰、安本篤史、坂田飛鳥、大森司、窓岩清治、水上浩明、小野文子、小澤敬也、坂田洋一
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] GPIba 遺伝子近傍のクロマチンインスレーター配列の同定2009
- Author(s)
  大森司、青木慎也、Thasinas Dissayabutra、石渡彰、柏倉裕志、窓岩清治、秋葉栄治、長谷川護、三室淳、坂田洋一
- Organizer
  第32回日本血栓止血学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] 中和抗体法と相関性のある抗AAV2抗体検出試験の開発2009
- Author(s)
  伊東哲男、林司、古寺美加、水上浩明、小澤敬也、三室淳、坂田洋一、村松慎一
- Organizer
  第32回日本血栓止血学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] 高純度AAV8、AAV9 ベクター精製法ノ確立2009
- Author(s)
  石渡彰、三室淳、柏倉裕志、大森司、窓岩清治、水上浩明、久米晃啓、小澤敬也、坂田洋一
- Organizer
  第32回日本血栓止血学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] 血小板への遺伝子発現増強を目的としたGPIba プロモーターの改変2009
- Author(s)
  Thasinas Dissayabutra、大森司、青木慎也、石渡彰、柏倉裕志、窓岩清治、秋葉栄治、長谷川護、三室淳、坂田洋一
- Organizer
  第32回日本血栓止血学会学術集
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] AAV ベクターを用いた遺伝子導入法と免疫反応血友病B に関する検討を中心に2008
- Author(s)
  水上浩明, 八木洋也, 三室淳, 石渡彰, 窓岩清治, 卜部匡司, 久米晃啓, 坂田洋一, 小澤敬也
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] 異常第VIII 因子遺伝子正常化による血友病A 遺伝子治療の試み2008
- Author(s)
  柏倉裕志, 三室淳, 石渡彰, 山中一央, 土海桃子, 青木慎也, 大森司, 窓岩清治, 坂田洋一
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] 非ヒト霊長類モデルにおける血友病B 遺伝子治療の基礎的検討2008
- Author(s)
  石渡彰, 三室淳, 水上浩明, 小野文子,柏倉裕志, 大森司, 諏合輝子, 窓岩清治, 保富康宏, 小澤敬也, 坂田洋一
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] エンドトキシン症における血栓性微小血管障害の発症機序の解析2008
- Author(s)
  柏倉裕志, 三室淳, 新村真則, 小野智子, 石渡彰, 土海桃子, 大森司, 窓岩清治, 岡田清孝, 松尾理, 坂田洋一
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] 血小板への活性化型血液凝固第VII 因子の発現による血友病遺伝子治療2008
- Author(s)
  大森司, 石渡彰, 柏倉裕志, 窓岩清治, 鈴木英紀, 見供克之, 長谷川護,三室淳, 坂田洋一
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] AAV を利用した第19 番染色体AAVS1 領域特異的遺伝子組込み法導入遺伝子の発現期間に関する検討2008
- Author(s)
  小原陽子, 卜部匡司, 伊藤孝幸, 水上浩明, 三室淳, 坂田洋一, 久米晃啓, 小澤敬也
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Regulation of plasminogen activator-plasmin system and inflammation.2008
- Author(s)
  窓岩清治, 三室淳, 大森司, 坂田洋一
- Organizer
  第31回日本血栓止血学会学術集会(シンポジウム)
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591155
[Presentation] Development of cell-based therapy for treating hemophilic arthropathy by local injection of transduced MSCs
- Author(s)
  Ohmori T, Kashiwakura Y, Mimuro J, Yasumoto A, Ishiwata A, Sakata A, Madoiwa S, Inoue M, Hasegawa M, Ozawa K, and Sakata Y
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Invited
- Data Source
  KAKENHI-PROJECT-23591427
[Presentation] 血友病Aクローンブタ
- Author(s)
  柏倉裕志，三室　淳，大西　彰，岩本正樹，窓岩清治，渕本大一郎，鈴木俊一，鈴木美佐枝，千本昭一郎，石渡　彰，安本　篤，坂田飛鳥，大森　司，橋本経子，矢崎智子，坂田洋一
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-23591427
[Presentation] Overexpression of factor VII ameliorates bleeding diathesis of FVIII-deficient mice with inhibitors
- Author(s)
  安本篤史、窓岩清治、柏倉裕志、石渡彰、大森司、水上浩明、小澤敬也、坂田洋一、三室淳
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591427

1. SAKATA Yoichi (40129028)

# of Collaborated Projects: 21 results

# of Collaborated Products: 0 results
2. MADOIWA Seiji (70296119)

# of Collaborated Projects: 10 results

# of Collaborated Products: 57 results
3. MATSUDA Michio (50048980)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
4. SUGO Teruko (60183844)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
5. ASAKURA Shinji (70245033)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. OHMORI Tsukasa (70382843)

# of Collaborated Projects: 4 results

# of Collaborated Products: 58 results
7. WEISEL John W

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. MURAMATSU Shin-ichi (10239543)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. MAEKAWA Hisato (10221574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MOSESSON Michael W.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. AROCHA Pinan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. AROCHA-PINANGO Carmen Lo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. AROCHAーPINAN ピニャンゴカルメンルイ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. CARMEN Louis

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MOSESSON Mic

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KIMURA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIMURO Jun 三室 淳

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次世代血友病治療法の開発と非ヒト霊長類を用いた前臨床研究Principal Investigator

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Preclinical Hemophilia Gene Therapy Study with Non-human PrimatesPrincipal Investigator

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Preclinical Study for Hemophilia Gene and Cell Therapy in Model Mice and in Non-human PrimatesPrincipal Investigator

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Gene therapy for hemophilia and its preclinical study in cynomolgus macaquesPrincipal Investigator

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Regulation of endothelial cell function by transgene expression and development of gene therapy for vascular diseasesPrincipal Investigator

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Regulation of endothelial cell functions by gene transfer using viral vectorsPrincipal Investigator

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Gene targeting of plasminogen activator inhibitor 2Principal Investigator

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MIMURO Jun 三室淳