Nosaka Kazuto 野坂和人

… Alternative Names

NOSAKA Kazuto 野坂和人

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Researcher Number	10228314
Other IDs
External Links
Affiliation (Current)	2025: 武庫川女子大学, 薬学部, 教授 2025: 京都府立医科大学, 医学(系)研究科(研究院), 准教授
Affiliation (based on the past Project Information) *help	2015 – 2023: 武庫川女子大学, 薬学部, 教授 2011: 兵庫医科大学, 医学部, 教授 2006 – 2007: 京都府立医科大学, 医学研究科, 准教授 2006: 京都府立医科大学, 医学研究科, 助教授 2003: Kyoto Prefectural University of Medicine, Grad. Sch. Med., Associate Professor, 医学研究科, 助教授 1999 – 2002: 京都府立医科大学, 医学部, 助教授 1996 – 1997: 京都府立医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Environmental and hygienic pharmacy / Applied biochemistry / 内分泌・代謝学 Except Principal Investigator Chemical pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Dermatology
Keywords	Principal Investigator チアミン / thiamin pyrophosphokinase / thiamin-responsive megaloblastic anemia / thiamin / チアミン輸送タンパク質 / チアミンピロホスホキナーゼ / チアミン反応性貧血症候群 / チアミンピロリン酸 / thiamin transport protein / 感染 … More / PnuT / トランスポーター / ヘリコバクター・ピロリ / keratinocvte / genomic analysis / ultra violet / toxicology / cosmetic additives / 酵母 / 転写調節 / 情報伝達 / thiamin transporter / thiamin pyrophosphate … More Except Principal Investigator SARS / 阻害剤 / 炎症性サイトカイン / Fasシグナル / IL-17 / IL-1β / 炎症性サイトカインIL-1β / ヘルパーT細胞 / Fasシグナル経路 / Tリンパ球 / 炎症応答 / 細菌感染 / aziridine / miraziridine A / inhibitor / 3CL-protease / Tokaramide A / アジリジン / Miraziridine A / 3CLプロテアーゼ / Gene trageting / ES cells / Skin barrier function / Stratum corneum lipid / Knockout mice / Cornified envelope / Ichthyosis / Transglutaminase / 分子病態 / 皮膚疾患 / 脂質 / 角質 / 形態形成 / 角化症 / 標的遺伝子組換え / ES細胞 / 皮膚バリアー機能 / 角質細胞間脂質 / ノックアウトマウス / 周辺帯 / 魚鱗癬 / トランスグルタミナーゼ / プロテアーゼ / Retro-Inverso / Dアミノ酸 / 構造解析 / プロテアーゼ阻害剤 / HTLV-1 Less

細菌感染におけるFasシグナル依存的な新規ヘルパーT細胞の誘導とその役割の解析
- Principal Investigator
  
  内山良介
- Project Period (FY)
  2018 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Mukogawa Women's University
Mechanism of thiamin transport in Helicobacter pylori providing a basis for complementary therapy for the infection.Principal Investigator
- Principal Investigator
  
  Nosaka Kazuto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Mukogawa Women's University
Development of a novel persistent protease inhibitor containing D-amino acid
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
  Kyoto Prefectural University of Medicine
Signal transduction mechanism underlying thiamin starvation-induced metabolic regulation in Saccharomyces cerevisiaePrincipal Investigator
- Principal Investigator
  
  NOSAKA Kazuto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Kyoto Prefectural University of Medicine
Development of SARS virus inhibitor using unusual amino acid-containing natural products as seeds
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Prefectural University of Medicine
Analysisof Thiamin-Responsive Megaloblastic Anemia Syndrome Pathogenesis by Targeted Gene DisruptionPrincipal Investigator
- Principal Investigator
  
  NOSAKA Kazuto
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto Prefectural University of Medicine
Molecular pathogenesis of transglutaminase deficiency
- Principal Investigator
  
  YAMANISHI Kiyofumi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Kyoto Prefecture! University of Medicine
Isolation and Characterization of Thiamin Pyrophosphokinase cDNA and the Expression in Thiamin-Responsive Megaloblastic AnemiaPrincipal Investigator
- Principal Investigator
  
  NOSAKA Kazuto
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto Prefectural University of Medicine
Isolation and Characterization of Thiamin-Responsive Megaloblastic Anemia GenePrincipal Investigator
- Principal Investigator
  
  NOSAKA Kazuto
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2020 2019 2018 2017 2016 2011 2010 2009 2007 2006

All Journal Article Presentation

[Journal Article] Synthesis of Tokaramide A, a Cysteine Protease Inhibitor from Marine Sponge Theonella aff2011
- Author(s)
  Konno, H.; Nosaka, K.; Akaji, K
- Journal Title
  
  Mirabilis. Tetrahedron
  
  Volume: 67 Pages: 9067-9071
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster2010
- Author(s)
  Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, K.; Nosaka, K.; Akaji, K
- Journal Title
  
  Bioorg.Med.Chem
  
  Volume: 18 Pages: 2720-2727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010
- Author(s)
  Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 7946-7953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxylethyl amine isoster2010
- Author(s)
  Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, K.; Nosaka, K.; Akaji, K
- Journal Title
  
  Bioorg Med. Chem
  
  Volume: 18 Pages: 2720-2727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010
- Author(s)
  Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Tetrahedoron
  
  Volume: 66 Pages: 7946-7953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthetic studies on callipeltins : Stereoselective syntheses of(3S, 4R)-3, 4-Dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine from serine derivatives2010
- Author(s)
  Konno, K.; Takebayashi, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 79-89
- NAID
  40016913697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthetic studies on callipeltins : Stereoselective syntheses of(3S,4R)-3,4-Dimethyl-L-pyroglutamic acid and Fmoc-D- allothreonine from serine derivatives2010
- Author(s)
  Konno, K.; Takebayashi, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 79-89
- NAID
  40016913697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of [19, 35, 36-13C3]-labeled TAK779 as a Molecular Probe.2009
- Author(s)
  Konno H, ; Aimoto S, ; Smith SO, ; Nosaka K, ; Akaji K
- Journal Title
  
  Bioorg Med. Chem
  
  Volume: 17 Pages: 5769-5774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of [19,35,36-13C3]-labeled TAK779 as a Molecular Probe2009
- Author(s)
  Konno H, Aimoto S, Smith S.O, Nosaka K, Akaji K
- Journal Title
  
  Bioorg.Med.Chem 17
  
  Pages: 5769-5774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Recent Progress in Understanding Thiamin Biosynthesis and Its Genetic Regulation in saccharomyces cerevisiae.2006
- Author(s)
  Nosaka K.
- Journal Title
  
  Appl Microbiol Biotechnol 72・1
  
  Pages: 30-40
- Data Source
  KAKENHI-PROJECT-18580095
[Presentation] Fasシグナルを介した炎症性サイトカイン産生経路の解析2024
- Author(s)
  内山良介、林麻利亜、宮田義巳、野坂和人
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-18K06675
[Presentation] Fasシグナル経路を介した炎症応答におけるcaspaseの関与2023
- Author(s)
  内山良介、筒井ひろ子、林麻利亜、宮田義巳、野坂和人
- Organizer
  日本薬学会第143回年会、札幌
- Data Source
  KAKENHI-PROJECT-18K06675
[Presentation] Fasシグナル依存的な炎症性サイトカイン産生のメカニズム2020
- Author(s)
  内山良介、筒井ひろ子、林麻利亜、遠藤祐里奈、宇治田純子、鎌苅美郷、野坂和人
- Organizer
  日本薬学会　第１４０年会（京都市）
- Data Source
  KAKENHI-PROJECT-18K06675
[Presentation] Fasシグナルを介した炎症応答メカニズムの解析2019
- Author(s)
  内山良介、筒井ひろ子、林麻利亜、遠藤祐里奈、中村友香、花島有紗、川瀬史恵、田辺凌子、田村友紀、田所真貴子、野坂和人
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06675
[Presentation] ピロリ菌のチアミン輸送タンパク質PnuTの生化学的性質と基質認識部位2018
- Author(s)
  只野響、内山良介、小林数也、林麻利亜、遠藤祐里奈、赤路健一、野坂和人
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08053
[Presentation] ピロリ菌のチアミン要求性とチアミンピロリン酸オペロンの同定2017
- Author(s)
  野坂和人、林麻利亜、遠藤祐里奈、内山良介、三室仁美
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15K08053
[Presentation] ピロリ菌のチアミン輸送系の性質2017
- Author(s)
  野坂和人、内山良介、三室仁美
- Organizer
  第447回ビタミンB研究協議会
- Data Source
  KAKENHI-PROJECT-15K08053
[Presentation] ピロリ菌のチアミン要求性とチアミンピロリン酸オペロンも同定2017
- Author(s)
  野坂和人、林麻利亜、遠藤祐里奈、内山良介、三室仁美
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-15K08053
[Presentation] ピロリ菌のチアミン輸送系の性質2017
- Author(s)
  野坂和人、内山良介、三室仁美
- Organizer
  第447回ビタミンＢ研究協議会
- Place of Presentation
  大坂大学中之島センター（大阪府大阪市）
- Year and Date
  2017-03-04
- Data Source
  KAKENHI-PROJECT-15K08053
[Presentation] ピロリ菌のチアミン要求性とチアミン輸送系について2016
- Author(s)
  野坂和人、内山良介
- Organizer
  第443回ビタミンＢ研究協議会
- Place of Presentation
  キャンパスプラザ京都（京都府京都市）
- Year and Date
  2016-01-30
- Data Source
  KAKENHI-PROJECT-15K08053
[Presentation] SARS 3CLプロテアーゼ阻害剤創成を目指したペプチドアルデヒドの合成と阻害能評価2010
- Author(s)
  今野博行、石井学、服部恭尚、野坂和人、赤路健一
- Organizer
  日本農芸化学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 構造解析に基づくSARS 3CL Protease阻害剤の設計とその阻害能評価2010
- Author(s)
  今野博行、石井学、野坂和人、服部恭尚、赤路健一
- Organizer
  東北支部第145回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] Synthesis and Evaluation of Small PeptideInhibitors for SARS 3CL Protease2010
- Author(s)
  Hiroyuki Konno, Manabu Ishii, Yasunao Hattori, Kazuto Nosaka, Kenichi Akaji
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 固相法によるペプチドアルデヒド類の実践的合成法の検討2009
- Author(s)
  今野博行、石井学、服部恭尚、野坂和人、赤路健一
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] Design of small molecular inhibitor for SARS 3CL protease besed on structure analysis2009
- Author(s)
  Akaji K, Nosaka K, Hattori Y, Mitsui H, Konno H, Kusunoki M, Ozaki T, Sanjo A
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 構造解析に基づくペプチドアルデヒド型SARS 3CLプロテアーゼ阻害剤の合成と評価2009
- Author(s)
  今野博行、野坂和人、小野塚真理、三井寛典、赤路健一、楠木正巳、尾崎健、三城明
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] SARS 3CLプロテアーゼ阻害に必要なチオール反応性官能基の評価2009
- Author(s)
  三井寛法、高橋麻矢子、今野博行、野坂和人、赤路健一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 酵母のチアミンピロリン酸シグナルによる発現制御機構2007
- Author(s)
  野坂和人
- Organizer
  ビタミンB研究委員会第410回研究協議会
- Place of Presentation
  京都
- Year and Date
  2007-11-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580095
[Presentation] 出芽酵母の多機能酵素THI20が持つチアミナーゼII活性の生理機能2007
- Author(s)
  野坂和人
- Organizer
  日本ビタミン学会第59回大会
- Place of Presentation
  佐世保
- Year and Date
  2007-05-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580095

1. KONNO Hiroyuki (50325247)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
2. AKAJI Kenichi (60142296)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. YAMANISHI Kiyofumi (10182586)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NISHIMURA Hiroshi (60117900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 内山良介 (20456891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Nosaka Kazuto 野坂 和人

NOSAKA Kazuto 野坂 和人

Research Projects

Research Products

Co-Researchers

細菌感染におけるFasシグナル依存的な新規ヘルパーT細胞の誘導とその役割の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of thiamin transport in Helicobacter pylori providing a basis for complementary therapy for the infection.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel persistent protease inhibitor containing D-amino acid

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Signal transduction mechanism underlying thiamin starvation-induced metabolic regulation in Saccharomyces cerevisiaePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of SARS virus inhibitor using unusual amino acid-containing natural products as seeds

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysisof Thiamin-Responsive Megaloblastic Anemia Syndrome Pathogenesis by Targeted Gene DisruptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathogenesis of transglutaminase deficiency

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation and Characterization of Thiamin Pyrophosphokinase cDNA and the Expression in Thiamin-Responsive Megaloblastic AnemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation and Characterization of Thiamin-Responsive Megaloblastic Anemia GenePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis of Tokaramide A, a Cysteine Protease Inhibitor from Marine Sponge Theonella aff2011

Author(s)

Journal Title

Data Source

[Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster2010

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010

Author(s)

Journal Title

Data Source

[Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxylethyl amine isoster2010

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010

Author(s)

Journal Title

Data Source

[Journal Article] Synthetic studies on callipeltins : Stereoselective syntheses of(3S, 4R)-3, 4-Dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine from serine derivatives2010

Nosaka Kazuto 野坂和人

NOSAKA Kazuto 野坂和人

[Presentation] Fasシグナル依存的な炎症性サイトカイン産生のメカニズム2020