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Asano Masatake  浅野 正岳

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ASANO Masatake  浅野 正岳

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Researcher Number 10231896
Other IDs
Affiliation (Current) 2025: 日本大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help 2015 – 2023: 日本大学, 歯学部, 教授
2011 – 2014: 日本大学, 歯学部, 准教授
2008: 日本大学, 歯学部, 専任講師
2006 – 2007: 日本大学, 歯学部, 講師
1999: Nihon University, Instructor
1999: 日大, 歯学部, 助手
1995 – 1998: 日本大学, 歯学部, 助手
Review Section/Research Field
Principal Investigator
Pathobiological dentistry/Dental radiology / Basic Section 57050:Prosthodontics-related / 病態科学系歯学(含放射線系歯学)
Except Principal Investigator
Pathobiological dentistry/Dental radiology / Basic Section 56010:Neurosurgery-related / Basic Section 51030:Pathophysiologic neuroscience-related / Pain science / Morphological basic dentistry / Surgical dentistry / Orthodontics/Pediatric dentistry / Surgical dentistry / Orthodontic/Pediatric dentistry / Conservative dentistry
Keywords
Principal Investigator
free secretory component / 多量体免疫グロブリンレセプター / 高齢者 / interleukin-1α / AIF-1 / IL-1 alpha / 酸性電解機能水 / alarmin / IL-1 receptor / propiece IL-1 alpha … More / interleukin-1 alpha / 殺菌効果 / 含嗽剤 / 電解酸性機能水 / NF-kB / ニッケルイオン / VEGF / IL-8 / MMP9 / ニッケル / NF-kappaB / ヌードマウス / マトリックスメタロプロテアーゼ / 口腔扁平上皮癌 / 塩化ニッケル / point mutation / IgA nephrop athy / pIgR / 点突然変異 / IgA腎症 / plgR / インターフェロン / 上皮細胞 / ロタウイルス / transfectant / 胸腺細胞 … More
Except Principal Investigator
secretory component / Transforming growth factor / Tumor necrosis factor / Interleukin 8 / Interleukin 6 / Epithelial cell / LPS / Cytokine / Secretory Component / 舌痛症 / 呼吸中枢 / basic FGF / 止血 / 髄液漏 / 脳神経外科 / hemostasis / traumatic brain injury / CSF leakage / 脳神経外科手術 / 動脈止血 / 静脈止血 / 硬膜形成 / くも膜形成 / 光ゲル化剤 / 痛み / 舌 / Pioglitazone / ミノサイクリン / マウス / 性差 / 疼痛 / 伝導ブロック / 末梢神経 / Aβ神経線維 / 神経障害性疼痛 / フラジェリン / QX-314 / A神経線維 / 炎症 / 感染 / 免疫 / micro CT / chronic arthritis / temporomandibular ioint / 慢性顎関節炎 / マイクロCT / 慢性関節炎 / 顎関節 / S-IgA / polymeric IgA / gene targeting / genomic DNA / mRNA / gene / mucosal immunity / キメラマウス / Southern blotting法 / PCR法 / neomycine / TT2 / ES cell / Disrupted mice / Northern blot analysis / secretory immune system / liver / intestine / Northerm blot analysis / Immunohistochemistry / RT-PCR / disrupted mouse / Secretory component / Cytokin / 呼吸ニューロン / McCP2 / MBD2 / MBD1 / バルプロ酸ナトリウム / レット症候群 / CpGメチル化 / プロモーター / エピジェネティクス / バルプロ酸 / ヒストンアセチル化 / 延髄呼吸中枢 / Gad1 / Mecp2 / GFRalpha3 / TLR4 / GFAP / GAP43 / satellite cell / 熱痛覚過敏 / Artemin / TRPV1 / CpG / 無呼吸 / 呼吸調節 / DNAメチル化 / MeCP2 / GAD1 / GABA / 延髄 / 嚥下 / 呼吸 / Transfection / Vaccinia virus / 歯髄細胞 / dsRNA / TLR3 / Toll-like receptor / differential display / Thy-1 / Differentially expressed genes / SV40 Large T antigen / ヒト歯髄由来細胞株 Less
  • Research Projects

    (16 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (34 People)
  •  脳神経外科手術におけるb-FGF徐放化光ゲル化剤の有用性の検証と開発

    • Principal Investigator
      大谷 直樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Nihon University
  •  Basic research of the sex difference in tongue neuropathic pain caused by lingual nerve injury in mice

    • Principal Investigator
      TSUBOI Yoshiyuki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Nihon University
  •  Research on the practical use of electrolyzed acidic functional water as a mouthwash for super-elderly peoplePrincipal Investigator

    • Principal Investigator
      ASANO Masatake
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57050:Prosthodontics-related
    • Research Institution
      Nihon University
  •  Basic research on a treatment for pain targeting primary afferent A nerve fibers

    • Principal Investigator
      TSUBOI Yoshiyuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pain science
    • Research Institution
      Nihon University
  •  The possible application of Ni2+ for the oral cancer treatmentPrincipal Investigator

    • Principal Investigator
      ASANO Masatake
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Nihon University
  •  Study on the effect of wound healing by functional water

    • Principal Investigator
      OMAGARI Daisuke
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Nihon University
  •  Involvement of epigenetic regulatory factors in respiration and swallowing during the suckling period

    • Principal Investigator
      SHIRAKAWA Tetsuo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthodontics/Pediatric dentistry
    • Research Institution
      Nihon University
  •  Involvoment of satellite glial cells in trigeminal ganglion in tongue pain

    • Principal Investigator
      SHINODA Masamichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Nihon University
  •  Rotavirus infection to oral epithelial cellsPrincipal Investigator

    • Principal Investigator
      ASANO Masatake
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Nihon University
  •  Investigation of the epigenetic mechanism of swallowing and respiratory disturbances

    • Principal Investigator
      SHIRAKAWA Tetsuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthodontic/Pediatric dentistry
    • Research Institution
      Nihon University
  •  Characterization of human dental pulp-derived cell lines

    • Principal Investigator
      SUGURO Hisashi
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Conservative dentistry
    • Research Institution
      Nihon University
  •  The duration analysis of the experimental rabbit temporomandibular joint inflammation by the X ray in vivo micro CT for high-speed high resolution animals

    • Principal Investigator
      HONDA Kazuya
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Nihon University
  •  The point mutation of polymeric immunoglobulin receptor and IgA nephropathyPrincipal Investigator

    • Principal Investigator
      ASANO Masatake
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Nihon University
  •  胸腺における多量体免疫グロブリンレセプターの機能解析Principal Investigator

    • Principal Investigator
      浅野 正岳
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Nihon University
  •  Development and analysis of secretory component disrupted mouse

    • Principal Investigator
      MORO Itaru
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Nihon University
  •  A study on the expression of cytokines in epithelial cells stimulated with LPS.

    • Principal Investigator
      KUDO Itsuro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Nihon University

All 2022 2021 2018 2017 2016 2015 2013 2012 2011 2008 2007

All Journal Article Presentation

  • [Journal Article] Effectiveness of acid-electrolyzed functional water for mouth wash: an in vitro study2022

    • Author(s)
      Oikawa D, Nishio K, Tamura M, Fukasawa M, Yoshida T, Okada S, Ito T, Tsunoda M, Asano M, Iinuma T
    • Journal Title

      In vivo

      Volume: 36 Issue: 5 Pages: 2211-2217

    • DOI

      10.21873/invivo.12947

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K10219, KAKENHI-PROJECT-19K10254, KAKENHI-PROJECT-20K10057
  • [Journal Article] Establishment of interleukin-1 receptor type 1 knockout HeLa strain by CRISP/Cas9 system.2022

    • Author(s)
      Hanayama M, Ishiyama Y, Sadamura M, Moriyama A, Imaoka S, Tsunoda M, Asano M
    • Journal Title

      Journal of Biomedical Science and Research

      Volume: 4 Pages: 1-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K10057
  • [Journal Article] Acid-electrolyzed functional water-induces interleukin-1α release from intracellular storage sites in oral squamous cell carcinoma.2021

    • Author(s)
      Takemoto T, Kaetsu R, Hanayama M, Ishiyama Y, Sadamura M, Nishio K, Tsunoda M, Asano M, Motoyoshi M.
    • Journal Title

      International Journal of Medical Sciences

      Volume: 18 Issue: 8 Pages: 1746-1752

    • DOI

      10.7150/ijms.53999

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K10057, KAKENHI-PROJECT-19K19143
  • [Journal Article] Nickel chloride administration prevents the growth of oral squamous cell carcinoma.2018

    • Author(s)
      Ota H, Shionome T, Suguro H, Saito S, Ueki K, Arai Y, Asano M.
    • Journal Title

      Oncotarget

      Volume: -

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K11086
  • [Journal Article] Inhibition of epithelial-mesenchymal transition by cetuximab via the EGFR-GEP100-Arf6-AMAP1 pathway in head and neck cancer.2017

    • Author(s)
      Matsumoto Y, Sakurai H, Kogashiwa Y, Kimura T, Matsumoto Y, Shionome T, AsanoM, Saito K, Kohno N.
    • Journal Title

      Head and Neck

      Volume: 39 Pages: 476-485

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K11086
  • [Journal Article] Nicotine-induced expression of low density lipoprotein receptor in oral epithelial cells.2013

    • Author(s)
      Ito S, Gojoubori T, Yamaguchi Y, Asano M, , Goke E, Koshi R, Sugano N, Yoshinuma N, Komiyama K, Ito K.
    • Journal Title

      PLOS one

      Volume: 8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Journal Article] Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma2013

    • Author(s)
      Shionome T, Endo S, Omagari D, Asano M, Toyoma H, Ishigami T, Komiyama K.
    • Journal Title

      PLOS one

      Volume: 8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Journal Article] Distinct functional regions of human polymeric immunoglobulin receptor2013

    • Author(s)
      Sunagawa K, Omagari D, Nishiyama M, Asano M, Okudera M, Sugitani M, Nemoto N, Komiyama K.
    • Journal Title

      Scand J Immunol

      Volume: 78 Pages: 339-344

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Journal Article] Distinct signaling pathways leading to the induction of human β-defensin 2 by stimulating an electrolyticaly-generated acid functional water and double strand RNA in oral epithelial cells.2013

    • Author(s)
      Gojoubori T, Nishio Y, Asano M, Nishida T, Komiyama K, Ito K.
    • Journal Title

      J Recept Signal Transduct Res

      Volume: 34 Pages: 97-103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Journal Article] Nuclear factor kappa B plays a pivotal role in polyinosinic-polycytidylic acid-induced expression of humanβ-defensin 2 in intestinal epithelial cell2011

    • Author(s)
      Omagari D, Takenouchi-Ohkubo N, Endo S, Ishigami T, Sawada A, Moro I, Asano M, Komiyama K
    • Journal Title

      Clin Exp Immunol

      Volume: 165 Pages: 85-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Journal Article] Characterization of human dental pulp-derived cell lines2008

    • Author(s)
      Suguro H, Asano M, Kaneko Y, OmagariD, Ogiso B, Moro I, Komiyama K
    • Journal Title

      Int Endod J 41

      Pages: 609-616

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18592102
  • [Journal Article] ヒト歯髄由来細胞株の樹立と解析2008

    • Author(s)
      勝呂尚, 浅野正岳, 尾曲大輔, 尾形英大,小木曽文内,茂呂周, 小宮山一雄
    • Journal Title

      消化器と免疫 44

      Pages: 24-28

    • NAID

      10019830766

    • Data Source
      KAKENHI-PROJECT-18592102
  • [Journal Article] Differential Distribution of muse polymeric immunoglobulin receptor (mpIgR) : Establishment of enzyme-linked immunosorbent assay system for mpIgR2008

    • Author(s)
      Omagari D, Iijima M, SuguroH , Sato I, AsanoM , Moro I
    • Journal Title

      Scand J Immunol 68

      Pages: 543-551

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18592102
  • [Journal Article] 口腔内感染症2007

    • Author(s)
      浅野 正岳
    • Journal Title

      臨床消化器内科 22巻

      Pages: 1169-1175

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18592071
  • [Journal Article] 口腔内感染症2007

    • Author(s)
      浅野正岳
    • Journal Title

      臨床消化器内科 22巻

      Pages: 1169-1175

    • Data Source
      KAKENHI-PROJECT-18592071
  • [Journal Article] Infectious diseases in oral cavity2007

    • Author(s)
      Asano, M
    • Journal Title

      Clinical Gastroenterology

      Pages: 1169-1175

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592071
  • [Presentation] IL-1aの核内輸送における分子制御機構の解明2022

    • Author(s)
      和気清尊、山本亜希子、角田麻里子、浅野正岳
    • Organizer
      第111回 日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K10057
  • [Presentation] IL-1R1の核局在とその役割について2022

    • Author(s)
      森山鮎子、浅野正岳
    • Organizer
      第15回 日本口腔検査学会
    • Data Source
      KAKENHI-PROJECT-20K10057
  • [Presentation] IL-1αの細胞外放出におけるHAX-1の関与2022

    • Author(s)
      今岡沙耶、浅野正岳
    • Organizer
      第15回 日本口腔検査学会
    • Data Source
      KAKENHI-PROJECT-20K10057
  • [Presentation] IL-1α の processing と機能2021

    • Author(s)
      角田麻里子、浅野正岳
    • Organizer
      第32回 日本臨床口腔病理学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K10057
  • [Presentation] IL-1α N末断片の機能解明2021

    • Author(s)
      角田麻里子、工藤 圭紘、浅野正岳
    • Organizer
      第110回 日本病理学会
    • Data Source
      KAKENHI-PROJECT-20K10057
  • [Presentation] 酸性電解機能水の創傷治癒促進メカニズム2017

    • Author(s)
      浅野 正岳
    • Organizer
      日本機能水学会第16回学術大会
    • Data Source
      KAKENHI-PROJECT-15K11087
  • [Presentation] Mecp2欠損マウス延髄呼吸中枢でのGad1 mRNA発現に対するバルプロ酸の効果2017

    • Author(s)
      白川哲夫,石山未紗,岩佐聡子,伊藤寿典,木舩崇,武井浩樹,浅野正岳,伊藤雅之
    • Organizer
      レット症候群国際シンポジウム2017 in KOBE
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2017-03-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26463120
  • [Presentation] 強心配糖体による口腔扁平上皮癌細胞のIL-8産生抑制メカニズムの解析2017

    • Author(s)
      齋藤五月、浅野正岳、尾曲大輔、月村直樹、石上友彦
    • Organizer
      .第69回日本大学歯学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-15K11086
  • [Presentation] 電解酸性機能水による EMMPRIN 分泌について2016

    • Author(s)
      楠 正文、五條堀 孝廣、太田 裕崇、菅野 直之、浅野 正岳、佐藤 秀一
    • Organizer
      日本機能水学会第 15 回学術大会
    • Place of Presentation
      国立京都国際会館ルームA(京都府京都市)
    • Year and Date
      2016-09-10
    • Data Source
      KAKENHI-PROJECT-15K11087
  • [Presentation] 口腔癌細胞由来IL-8のマクロファージに対する機能2015

    • Author(s)
      浅野正岳、尾曲大輔、小宮山一雄
    • Organizer
      第69回 日本口腔科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-05-13
    • Data Source
      KAKENHI-PROJECT-15K11086
  • [Presentation] Diurnal increase of apnea and reduced GAD1 mRNA expression in respiratory nuclei of Mecp2-deficient mice2013

    • Author(s)
      Nishiyama M, Asano M, Iwasa S, Suzuki A, Wada T, Takiguchi H, Shirakawa T
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23593045
  • [Presentation] Diurnal increase of apnea and reduced GAD1 mRNA expression in the respiratory nuclei in Mecp2-deficient mice2013

    • Author(s)
      Nishiyama M, Asano M, Iwasa S, Auzuki A, Wada T, Takiguchi H, Shirakawa T
    • Organizer
      43rd annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, U.S.A.
    • Data Source
      KAKENHI-PROJECT-23593045
  • [Presentation] ASSESSMENT OF ANTI-VIRAL ACTIVITY OF ACID-ELECTROLYZED FUNCTIONAL WATER (FW)2013

    • Author(s)
      Asano M, Iwasa S, Nishiyama M, Sato G, Gojoubori T, Komiyama K
    • Organizer
      5^<th> European rotavirus biology meeting
    • Place of Presentation
      Valencia (Spain)
    • Year and Date
      2013-10-06
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Presentation] EVALUATION OF PREVENTIVE EFFECT OF TYPE I AND TYPE III IFN ON ROTAVIRUS INFECTION2013

    • Author(s)
      Sato G, Gojoubori T, Omagari D, Asano M, Komiyama K
    • Organizer
      5^<th> European rotavirus biology meeting
    • Place of Presentation
      Valencia (Spain)
    • Year and Date
      2013-10-07
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Presentation] Assessment of anti-viral activity of acid electrolyzed functional water.2013

    • Author(s)
      Asano M, Iwasa S, Nishiyama M, Sato G, Gojoubori T, Komiyama K.
    • Organizer
      5th European Rotavirus Meeting
    • Place of Presentation
      Valensia, Spain
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Presentation] Abnormal breathing and occlusal disharmony in a mouse model of Rett syndrome2012

    • Author(s)
      Nishiyama M, Wada T, Takiguchi H, Takamori K, Asano M, Iwasa S, Suzuki A, Shirakawa T
    • Organizer
      Congress of the Inter- national Association for Disability and Oral Health
    • Place of Presentation
      Melbourne, Australia
    • Data Source
      KAKENHI-PROJECT-23593045
  • [Presentation] PRODUCTION OF TYPE III IFNS BY ROTAVIRUS INFECTED INTESTINAL EPITHELIAL CELLS2012

    • Author(s)
      Asano M, Omagari D, Gojoubori T, Komiyama K
    • Organizer
      11^<th> International symposium on double-stranded RNA viruses
    • Place of Presentation
      Puerutoriko (USA)
    • Year and Date
      2012-11-30
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Presentation] Production of type III IFNs in rotavirus infected intestinal epithelial cells2012

    • Author(s)
      Asano M
    • Organizer
      The 11th International Symposium on Double-stranded RNA virus
    • Place of Presentation
      Pueruto Rico, USA
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Presentation] Rotavirus infection and type III interferon2011

    • Author(s)
      Asano M
    • Organizer
      15th International Congress of Mucosal Immunology
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-23592778
  • [Presentation] Ionomycin inhibited the ER-Golgi transport of polymeric immunoglobulin receptor(pIgR)2007

    • Author(s)
      Asano M
    • Organizer
      13th International Congeress of Mucosal Immunology
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18592071
  • [Presentation] lonomycm inhibited the Eft-Uolgi transport of polymeric immunoglobulin receptor (pIgR)2007

    • Author(s)
      Asano, M
    • Organizer
      13tn international Congress of Mucosal Immunology
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592071
  • [Presentation] Ionomycin inhibited the ER-Golgi transport of polymeric immunoglobulin receptor(pIgR).2007

    • Author(s)
      Asano M
    • Organizer
      International Congress of Mucosal Immunology
    • Place of Presentation
      品川プリンスホテル
    • Data Source
      KAKENHI-PROJECT-18592071
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