NAKANO HIROSHI 中野浩

… Alternative Names

Nakano Hiroshi 中野浩

NAKANO Hiroshi 中野浩

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Researcher Number	10241035
Affiliation (Current)	2025: 聖マリアンナ医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2015: 聖マリアンナ医科大学, 医学部, 准教授 2007 – 2013: St. Marianna University School of Medicine, Department of Surgery, Associate Professor 2012: 聖マリアンナ医科大学, 医学部, 医学部 2004 – 2006: 聖マリアンナ医科大学, 医学部, 講師 2000 – 2002: Showa University, Medical, Assisstant Professor, 医学部, 講師 … More 1999: 昭和大, 医学部, 講師 1997 – 1998: Showa University, School of Medicine, Iecturer, 医学部, 講師 1995 – 1996: 昭和大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Digestive surgery / Digestive surgery Except Principal Investigator Digestive surgery / Applied pharmacology
Keywords	Principal Investigator N-acetylcysteine / Proteomics / Ischemia reperfusion / Zucker rat / Ischemic preconditioning / neutrophil oxidative stress / α-glutathione-S-transferase / Steatohepatitis / ミトコンドリア蛋白 / mitochondria … More / 2D-DIGE / ischemic preconditioning / 脂肪肝 / fulminant hepatic failure / hepatocellular oxidative stress / 還元型グルタチオン / GSH / mitochondrial GSSG / endotoxin shock / プロテオミクス / 閉塞性黄疸 / Mitochoindrial protein / ミトコンドリア内膜電位 / 還元型グルタチオン比 / 酸化型 / 虚血再灌流障害 / ischemia reperfusion injury / proteomics / homozygous Zucker rat / Mitochondrial protein / Mitochoindria / Steatotic liver / 2-cystine peroxidase / superoxide dismutase 2 / ubiquinol cytochrome C reductase core protein I / 70%肝切除術 / JC-1 / 脂肪肝Zuckerラット / auxiliary temporal partial orthotopic liver transplantation / anti-intercellular adhesion molecule / reduced glutathione / choline-methionine deficient diet / α-glutathione S transferase / ヒアルロン酸 / mitochondrial oxidative stress / 抗 ICAM1 モノクローナル抗体 / N-acetlcysteine / α-glutatione S transferase / 補助的一時的部分同所性肝移植 / コリン・メチオニン欠乏食 / 激症肝不全 / hepatic microcirculatory flow / alpha-glutathione-S-transferase / Obstructive jaundice / グルタチオン / intercellular adhesion molecule-1 / N-acetylcystein / 活性酸素 / 虚血再潅流障害 / 酸化型グルタチオン / 閉塞性黄疸ラット / 好中球活性酸素産生 / 肝microcirculatory flow / CCL20 / oxaliplatin / flow cytometry / internalization kinetics / endocytic pathways / ジヌソイド内皮細胞 / defibrotide / sinusoidal obstruction / フローサイトメトリー / 共焦点顕微鏡 / ヒトジヌソイド内皮 / デフィブリド / 抗癌剤起因性肝障害 / ジヌソイド閉塞 / Oxaliplatin / Peroxiredoxin6 / Aldehyde dehydrogenase / オキザリプラチン / ジヌソイド閉塞症候群 / 化学療法関連肝障害 / Peroxiredoxin 6 / Blue liver / 肝障害 / 術前化学療法 / 肝切除 / 大腸癌肝転移 / sphingosine 1 phosphate / glutathione S-transferase M1 / sinusoidal obstruction syndrome / oxaliplatin-based chermotherapy / 大腸癌肝転移術前化学療法 / 肝組織血流量 / 外科的手術侵襲 / ミトコンドリア活性酵素障害 … More Except Principal Investigator DPD / hepatocyte growth factor / HGF / ハプロタイプ / トランスポーター / 薬物代謝酵素 / 遺伝子多型 / 抗癌薬 / テーラーメード医療 / Haplotype / Transporter / Drug metabolizing enzymes / Gene polymorphism / Anti-cancer drugs / Tailor made therapy / ecdothelial seeding / hepatectomy / reconstruction of IVC / 内皮化 / 肝切除 / 下大静脈再建 / Insulin / liver regeneration / adenovirus vector / 脾自家移植 / 肝傷害 / インスリン / 肝再生 / アデノウイルスベクター Less

Hepatotoxicity investigated in chemo-naive patients by proteomicsPrincipal Investigator
- Principal Investigator
  
  Nakano Hiroshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  St. Marianna University School of Medicine
Proteomics analysis of a mechanism of sinusoidal endothelial cell injury after receiving oxaliplatin-based chemotherapy in colorectal liver metastases.Principal Investigator
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  St. Marianna University School of Medicine
The Practical Use Study of Tailor made medicine : Accerelate of genotyping System and Feedback System to Primary Doctor
- Principal Investigator
  
  KOBAYASHI Shinichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  St.Marianna University School of Medicine
The Tailor Made Therapy of Anti-Cancer Drugs
- Principal Investigator
  
  KOBAYASHI Shinichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  St.Marianna University School of Medicine
Therapeutic approach against surgical injury of diseased liver : Proteomics approachPrincipal Investigator
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  St.Marianna University School of Medicine
Modification of the Hepatic Mitochondrial Proteome in Response to Ischemic Preconditioning Following Ischemia-Reperfusion Injury of the Rat Steatotic Liver.Principal Investigator
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  St.Marianna University School of Medicine
Experimental study for reconstruction of portal vein and inferior vena cava in liver surgery
- Principal Investigator
  
  YAMAGUCHI Masahiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Dokkyo University School of Medicine
  Showa University
Research on gene transfer of hepatocyte growth factor in hepato-spleno-surgery
- Principal Investigator
  
  YAMAGUCHI Masahiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Showa University
閉塞性黄疸外科的侵襲時の病態解析と治療法の研究：実験と臨床応用についての検討Principal Investigator
- Principal Investigator
  
  中野浩
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Showa University
Research for investigating treatment of fulnilnant hepatic failure : An experimental study of auxiliary temporal partial orthotopic liver transplantation using living-donor partial liverPrincipal Investigator
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Showa University
Research for pathophysiology and therapeutic means of hepatic oxidatiye stress in obstructive iaundice.Principal Investigator
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Showa University

All 2015 2014 2013 2012 2011 2010 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] 大腸癌化学療法に関連した肝障害の病態とその予防対策2015
- Author(s)
  中野浩
- Journal Title
  
  日本臨床
  
  Volume: 74 Pages: 627-632
- Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462101
[Journal Article] The AST to Platelet ratio before chemotherapy predicts adverse events for FOLFOX and XELOX regimens including bevacizumab as the first-line therapy for stage IV, recurrent and metastatic colorectal cancer2013
- Author(s)
  Nakano H
- Journal Title
  
  Journal of Gstrointestinal Oncology
  
  Volume: 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] The aspartate aminotransferase to platelet ratio before chemotherapy predicts adverse events for FOLFOX and XELOX regimens including bevacizumab as the first-line therapy for stage IV, recurrent and metastatic colorectal cancer.2013
- Author(s)
  Sato S, Nakano H, et al.
- Journal Title
  
  J Gastrointest Oncol
  
  Volume: 4 (2) Pages: 203-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] Splenic Volume Increase due to Preoperative Chemotherapy may Impair Long-Term Outcome after Hepatectomy in Patients with Initially Non-Optimally Resectable Colorectal Cancer Liver Metastases.2013
- Author(s)
  Katayama M, Nakano H, et al.
- Journal Title
  
  Hepatogastroenterol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] A Splenic Volume Increase Due to Preoperative Chemotherapy May Impair the Long-Term Outcome After Hepatectomy in Patients with Initially Non-Optimally Resectable Colorectal Cancer Liver Metastases.2013
- Author(s)
  Katayama M, Nakano H, et al
- Journal Title
  
  Ｈｅｐａｔｏｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ
  
  Volume: 126 Pages: 1420-1425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462101
[Journal Article] A Splenic Volume Increase Due to Preoperative Chemotherapy May Impair the Long-Term Outcome After Hepatectomy in Patients with Initially Non-Optimally Resectable Colorectal Cancer Liver Metastases2013
- Author(s)
  Nakano H
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 126
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] Chemotherapy-induced hepatotoxicity in patients with colorectal cancer liver metastases.2011
- Author(s)
  Nakano H, et al
- Journal Title
  
  Nihon Rinsho
  
  Volume: 69 (3) Pages: 536-540
- NAID
  40018805587
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes.2011
- Author(s)
  Yuko Takeba, Naoki Matsumoto, Sachiko Takenoshita-Nakaya, Yoshie Harimoto, Toshio Kumai, Yuichi Kinoshita, Hiroshi Nakano, Takehito Ohtsubo, Shinichi Kobayashi
- Journal Title
  
  Journal of Pharmacological Sciences. vol.115、No.4
  
  Pages: 516-524
- NAID
  10029893533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590549
[Journal Article] Splenomegaly in FOLFOX-naive stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy.2011
- Author(s)
  Miura K, Nakano H, et al.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 16(3) Pages: 257-263
- NAID
  10029527086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] Splenimegaly in FOLFOX-naive stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by aspartate aminotransferase to platelet ratio before chemotherapy.2011
- Author(s)
  Nakano H, et al.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] 大腸癌-最新の研究動向-大腸癌化学療法に関連した肝障害2011
- Author(s)
  中野浩, 他
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 536-540
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] Comparative study of culture conditions for maintaining CYP3A4 and ATP-binding cassette transporters activity in primary cultured human hepatocytes.2011
- Author(s)
  Takeba Y, Matsumoto N, Nakano H, Kobayashi S, et al.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 115 (4) Pages: 516-524
- NAID
  10029893533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] Splenimegaly in FOLFOX-na〓ve stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by aspartate aminotransferase to platelet ratio before chemotherapy2011
- Author(s)
  Miura K, Nakano H, et al
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 16(3) Pages: 257-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] 大腸癌肝転移に対する治療のUpdate:化学療法による肝組織障害2010
- Author(s)
  中野浩, 他
- Journal Title
  
  外科治療
  
  Volume: 102 Pages: 857-862
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy2008
- Author(s)
  Nakano H, et. al.
- Journal Title
  
  Ann Surg 247(1)
  
  Pages: 118-124
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591528
[Journal Article] Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy.2008
- Author(s)
  Nakano H
- Journal Title
  
  Ann Surg 247
  
  Pages: 118-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591528
[Journal Article] Modification of the hepatic mitochondrial proteome in response to ischemic preconditioning following ischemia-reperfusion injury of the rat liver.2007
- Author(s)
  Nakano H, et al.
- Journal Title
  
  European Surgical Research (in press)
- Data Source
  KAKENHI-PROJECT-18591528
[Journal Article] Mass spectrometric analysis using 2-dimensional differential in-gel electrophoresis : difference of protein patterns between primary colon cancer cell line and lymph node metastasis-derived cell line2006
- Author(s)
  Nakano H, er al
- Journal Title
  
  Surgery Today 36・12
  
  Pages: 1085-1093
- Data Source
  KAKENHI-PROJECT-18591528
[Journal Article] Endocutter no-knife and extraparenchymal control of the main hepatic veins for major hepatectomy2005
- Author(s)
  中野浩, 他
- Journal Title
  
  Hepatogastroenterology 52(66)
  
  Pages: 1836-1839
- Data Source
  KAKENHI-PROJECT-16591367
[Journal Article] A patient undergoing pancreatico-duodenectomy in whom involved common hepatic artery anomalously arising from superior mesenteric artery was removed and reconstructed.2005
- Author(s)
  Nakano H, et al.
- Journal Title
  
  Hepatogastroenterology 52(62)
  
  Pages: 1883-1885
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591367
[Journal Article] A patient undergoing pancreaticoduodenectomy in whom involved common hepatic artery anomalously arising from superior mesenteric artery was removed and reconstructed2005
- Author(s)
  Nakano H, et al.
- Journal Title
  
  Hepatogastroenterology 52
  
  Pages: 1883-1885
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591367
[Journal Article] Pancreaticoduodenectomy in common hepatic artery anomalously arising from the superior mesenteric artery.2005
- Author(s)
  中野浩, ほか
- Journal Title
  
  Hepatogastroenterology 52(66)
  
  Pages: 1883-1885
- Data Source
  KAKENHI-PROJECT-16591367
[Journal Article] ミトコンドリアのプロテオミクスによる脂肪肝外科侵襲時における脆弱性についての検討2004
- Author(s)
  中野浩, 他
- Journal Title
  
  日本外科学会雑誌 105・1
  
  Pages: 333-333
- Data Source
  KAKENHI-PROJECT-16591367
[Presentation] A Splenic Volume Increase Due to Preoperative Chemotherapy May Impair the Long-Term Outcome After Hepatectomy in Patients with Initially Non-Optimally Resectable Colorectal Cancer Liver Metastases.2014
- Author(s)
  Nakano H, et al
- Organizer
  12th IHPBA
- Place of Presentation
  Seoul
- Data Source
  KAKENHI-PROJECT-25462101
[Presentation] The aspartate aminotransferase to platelet ratio before chemotherapy predicts adverse events for FOLFOX and XELOX regimens including bevacizumab as the first-line therapy for stage IV, recurrent and metastatic colorectal cancer.The best oral Session2012
- Author(s)
  Nakano H, et al.
- Organizer
  The 10thConcreass of the International Hepato-Pancreato-Biliary Association.
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-22591509
[Presentation] 進行・再発大腸癌の化学療法関連肝障害:脾容積、 AST/ 血小板比によるchemotherapy-naive patients の抽出2012
- Author(s)
  中野浩
- Organizer
  第112回日本外科学会総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22591509
[Presentation] Splenomegaly in oxaliplatin-naive patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy in stage IV or recurrent colorectal cancer2012
- Author(s)
  Nakano H
- Organizer
  10th Internation Hepato-Pancreato-Biliary Association
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-22591509
[Presentation] 進性・再発大腸癌の化学療法関連肝障害:脾容積、AST/血小板比、プロテオミクス解析によるchemotherapy-naive patientsの抽出2012
- Author(s)
  中野浩
- Organizer
  日本外科学会
- Place of Presentation
  千葉・幕張(幕張メッセ)
- Year and Date
  2012-04-13
- Data Source
  KAKENHI-PROJECT-22591509
[Presentation] Blue liver syndrome increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy2008
- Author(s)
  Nakano H, et. al.
- Organizer
  8th International Congress of the International Hepato-Pancreato-Biliary Association
- Place of Presentation
  Mumbai,India
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591528
[Presentation] Blue liver syndrome increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy. Mumbai, India2008
- Author(s)
  Nakano H, et. al.
- Organizer
  8th International Congress of the International Hepato-Pancreato-Biliary Association
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591528

1. KOBAYASHI Shinichi (20129836)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
2. YAMAGUCHI Masahiko (00266149)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KUMAI Toshio (40139671)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. TANAKA Masami (00171801)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KUMADA Kaoru (00025602)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAKENOSHITA Sachiko (10386948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MIDORIKAWA Takemasa (10255797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKANO HIROSHI 中野 浩

Nakano Hiroshi 中野 浩

NAKANO Hiroshi 中野 浩

Research Projects

Research Products

Co-Researchers

Hepatotoxicity investigated in chemo-naive patients by proteomicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteomics analysis of a mechanism of sinusoidal endothelial cell injury after receiving oxaliplatin-based chemotherapy in colorectal liver metastases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Practical Use Study of Tailor made medicine : Accerelate of genotyping System and Feedback System to Primary Doctor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Tailor Made Therapy of Anti-Cancer Drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic approach against surgical injury of diseased liver : Proteomics approachPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modification of the Hepatic Mitochondrial Proteome in Response to Ischemic Preconditioning Following Ischemia-Reperfusion Injury of the Rat Steatotic Liver.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental study for reconstruction of portal vein and inferior vena cava in liver surgery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on gene transfer of hepatocyte growth factor in hepato-spleno-surgery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

閉塞性黄疸外科的侵襲時の病態解析と治療法の研究：実験と臨床応用についての検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for investigating treatment of fulnilnant hepatic failure : An experimental study of auxiliary temporal partial orthotopic liver transplantation using living-donor partial liverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for pathophysiology and therapeutic means of hepatic oxidatiye stress in obstructive iaundice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 大腸癌化学療法に関連した肝障害の病態とその予防対策2015

Author(s)

Journal Title

Data Source

[Journal Article] The AST to Platelet ratio before chemotherapy predicts adverse events for FOLFOX and XELOX regimens including bevacizumab as the first-line therapy for stage IV, recurrent and metastatic colorectal cancer2013

Author(s)

Journal Title

Data Source

NAKANO HIROSHI 中野浩

Nakano Hiroshi 中野浩

NAKANO Hiroshi 中野浩