OTA Akira 太田明

… Alternative Names

太田明オオタアキラ

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Researcher Number	10247637
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2015: 藤田保健衛生大学, 医学部, 名誉教授 2010 – 2015: 藤田保健衛生大学, 医学部, 教授 2002 – 2007: 藤田保健衛生大学, 医学部, 教授 1998 – 1999: 藤田保健衛生大学, 医学部, 教授
Review Section/Research Field	Principal Investigator General physiology Except Principal Investigator Neurochemistry/Neuropharmacology / Neurology / Regenerative medicine / Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator Toll-like receptor / CD18 / CD14 / tumor necrotizing factorα / GTP cyclohydrolase "I" / lipopolysaccharide / 6R-tetrahydrobjopterin / NIE-115 cell line / 一酸化窒素合成酵素 / 一酸化窒素 … More / IκBキナーゼ / IκB / N1E-115細胞 / リポポリサッカライド受容体 / 腫瘍壊死因子-α / テトラヒドロビオプテリン / GTPシクロヒドロラーゼI / リポポリサッカライド / 神経芽細胞腫 … More Except Principal Investigator チロシン水酸化酵素 / Parkinson's disease / リン酸化 / パーキンソン病 / Stability / Tyrosine hydroxylase / PEST motif / 安定性 / tyrosine hydroxylase / 14-3-3プロテイン / プロテアソーム分解 / 中枢性肥満 / マウス胚性幹細胞 / 視床下部機能障害 / 間脳視床下部 / oxytocin / vasopressin / POMC / MCH / NPY / 視床下部 / マウスES細胞 / 視床下部障害 / 再生医療 / α-Synuclein / Phosphorylation / αシヌクレイン / olfactory system / TNF-α / pro-inflammatory cytokine / 嗅覚異常 / 嗅球 / TNFa / アストロサイト / アポトーシス / 神経変性疾患 / TNFα / 嗅覚系 / 炎症性サイトカイン / Dopamine / Parkinson disease / dopamine / stability / PESTモチーフ / ドーパミン / feedback inhibition / gene therapy / mutant / フィードバック抑制 / 遺伝子治療 / 変異体 / 細胞内安定性制御機構 / 細胞内安定性 / 神経分子病態学 Less

Intracellular stability of tyrosine hydroxylase regulated by proteasomal degradation of the enzyme and neurodegeneration of dopaminergic cells
- Principal Investigator
  
  NAKASHIMA AKIRA
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Fujita Health University
Regenerative therapy for hypothalamic disorders from neoplasms
- Principal Investigator
  
  NAGASAKI Hiroshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Regenerative medicine
- Research Institution
  Fujita Health University
Regulating mechanism for intracellular stability of tyrosine hydroxylase and neurodegeneration
- Principal Investigator
  
  NAKASHIMA Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Fujita Health University
The effect of pro-inflammatory cytokine on dopamine neurons in the olfactory bulb
- Principal Investigator
  
  MORI Keiji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Fujita Health University
The relationship between the intracellular stability of tyrosine hydroxylase and the neurodegeneration regulated by α-synuclein
- Principal Investigator
  
  NAKASHIMA Akira
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Fujita Health University
The relationship between the intracellular stability of tyrosine hydroxylase and the neurodegeneration on Parkison's disease
- Principal Investigator
  
  NAKASHIMA Akira
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Fujita Health University
Mutant enzymes of tyrosine hydroxylase for an effective gene therapy of PD
- Principal Investigator
  
  NAKASHIMA Akira
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Fujita Health University
Analysis of the Tetrahydrobiopterin Biosynthesizing System in Cultured Neuron-Derived CellsPrincipal Investigator
- Principal Investigator
  
  OTA Akira
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Fujita Health University

All 2016 2015 2014 2013 2012 2011 2008 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells2016
- Author(s)
  Akira Nakashima, Syuhei Ohnuma, Yu Kodani, Yoko S. Kaneko, Hiroshi Nagasaki, Toshiharu Nagatsu, Akira Ota
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 472 Issue: 4 Pages: 598-602
- DOI
  10.1016/j.bbrc.2016.03.022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] Degradation rate of tyrosine hydroxylase by ubiquitin-proteasome pathway.2015
- Author(s)
  Syuhei Ohnuma, Yuri Nonaka, Yoko S. Kaneko, Yu Kodani, Hiroshi Nagasaki, Toshiharu Nagatsu, Akira Ota and Akira Nakashima
- Journal Title
  
  J Physiol Sci
  
  Volume: 65
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G1 phase and protects them from UV light-induced apoptosis.2014
- Author(s)
  Yoko S Kaneko, Akira Ota, Akira Nakashima, Hiroshi Nagasaki, Yu Kodani, Keiji Mori and Toshiharu Nagatsu.
- Journal Title
  
  J Neural Transm
  
  Volume: 122 Pages: 189-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells.2014
- Author(s)
  Yoko S Kaneko, Takeshi Takayanagi, Hiroshi Nagasaki, Yu Kodani, Akira Nakashima, Keiji Mori, Atsushi Suzuki, Mitsuyasu Itoh, Kazunao Kondo, Toshiharu Nagatsu, Miyuki Ota and Akira Ota.
- Journal Title
  
  J Neural Transm
  
  Volume: Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] Intracellular stability of tyrosine hydroxylase: Phosphorylation and proteasomal digestion of the enzyme.2013
- Author(s)
  Akira Nakashima, Yoko S Kaneko, Yu Kodani, Keiji Mori, Hiroshi Nagasaki, Toshiharu Nagatsu and Akira Ota
- Journal Title
  
  Advances in Pharmacology
  
  Volume: 68 Pages: 3-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] A possible pathophysiological role of tyrosine hydroxylase in Parkinson’s disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.2013
- Author(s)
  Akira Nakashima, Akira Ota, Yoko S Kaneko, Keiji Mori, Hiroshi Nagasaki and Toshiharu Nagatsu
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 120 Pages: 49-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brainbiochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.2012
- Author(s)
  Nakashima A, Ota A, Kaneko YS, Mori K, Nagasaki H and Nagatsu T.
- Journal Title
  
  J Neural Transm.
  
  Volume: 120 Pages: 49-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Journal Article] Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.2011
- Author(s)
  Nakashima A, Mori K, Kaneko YS, Hayashi N, Nagatsu T and Ota A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 407 Pages: 343-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Journal Article] Risperidone reduces mRNA expression levels of Sulfonylurea Receptor 1 and TASK1 in PC12 cells.2007
- Author(s)
  Ota M, Nakashima A, Kaneko YS, Mori K, Takami G, Ota A
- Journal Title
  
  Neurosci Lett. 412(3)
  
  Pages: 254-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Journal Article] Risperidone reduces mRNA expression levels of Sulfonylurea Receptor 1 and TASK1 in PC12 cells2007
- Author(s)
  Miyuki Ota
- Journal Title
  
  Neurosci Lett. 412巻3号
  
  Pages: 254-258
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500281
[Journal Article] Effect of peripherally administrered lipopolysaccharide(LPS)on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice.2007
- Author(s)
  Akira Ota
- Journal Title
  
  Stress 10
  
  Pages: 131-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500281
[Journal Article] Risperidone reduces mRNA expression levels of Sulfonylurea Receptor 1 and TASK1 in PC12 cells.2007
- Author(s)
  Miyuki Ota
- Journal Title
  
  Neuroscience Letter 412.3
  
  Pages: 257-258
- Data Source
  KAKENHI-PROJECT-18500281
[Journal Article] Effect of peripherally administrered lipopolysaccharide (LPS) on GTP cyclohydrolase I,tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice2007
- Author(s)
  Akira Ota
- Journal Title
  
  Stress 10巻2号
  
  Pages: 131-136
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500281
[Journal Article] Effect of peripherally administrered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice.2007
- Author(s)
  Ota A, Kaneko YS, Mori K, Nakashima A, Nagatsu I, Nagatsu T.
- Journal Title
  
  Stress. 10(2)
  
  Pages: 131-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Journal Article] RNAi of 14-3-3eta protein increases intracellular stability of tyrosine hydroxylase.2007
- Author(s)
  Nakashima A, Hayashi N, Kaneko YS, Mori K, Sabban EL, Nagatsu T, Ota A.
- Journal Title
  
  Biochem Biophys Res Commun. 363(3)
  
  Pages: 817-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Journal Article] Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.2007
- Author(s)
  Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, Nakashima A, Nagatsu T, Ota A and Ischiropoulos H.
- Journal Title
  
  J Neurosci. 26(39)
  
  Pages: 10068-10078
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Journal Article] RNAi of 14-3-3eta protein increases intracellular stability of tyrosine hydroxylase.2007
- Author(s)
  Nakashima A, Hayashi N, Kaneko YS, Mori K, Sabban EL, Nagatsu T and Ota A.
- Journal Title
  
  Biochem Biophys Res Commun. 363(3)
  
  Pages: 817-821
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Journal Article] The phosphorylation of Ser^<40> of tyrosine hydroxylase has no effect on the stability of the enzyme in PC12 cells.2005
- Author(s)
  Nakashima A, Kaneko YS, Mori K, Nagatsu T, Ota A
- Journal Title
  
  Biogenic Amines 19(4-5)
  
  Pages: 279-288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Corticotropin-releasing factor receptor antagonist attenuates LPS-induced increase of GTP cyclohydrolase I expression at murine locus coeruleus.2005
- Author(s)
  Kaneko YS, Mori K, Nakashima A, Nagatsu I, Nagatsu T, Ota A
- Journal Title
  
  Biogenic Amines 19(4-5)
  
  Pages: 289-297
- NAID
  130005448571
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells.2005
- Author(s)
  Nakashima A, Hayashi N, Kaneko YS, Mori K, Egusa H, Nagatsu T, Ota A.
- Journal Title
  
  J Neurosci Res 81(1)
  
  Pages: 110-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Peripheral lipopolysaccharide induces apoptosis in the murine olfactory bulb.2005
- Author(s)
  Mori K, Kaneko YS, Nakashima A, Nagatsu I, Takahashi H, Ota A.
- Journal Title
  
  Brain Res 1039(1-2)
  
  Pages: 116-129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus : possible role of increased norepinephrine turnover.2005
- Author(s)
  Kaneko YS, Mori K, Nakashima A, Sawada M., Nagatsu I, Ota A
- Journal Title
  
  J Neurochem 94(2)
  
  Pages: 393-404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Intracellular stability of tyrosine hydroxylase: Phosphorylation and proteasomal digestion of the enzyme.
- Author(s)
  Nakashima A, Kaneko YS, Kodani Y, Mori K, Nagasaki H, Nagatsu T and Ota A.
- Journal Title
  
  Adv Pharmacol.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] マウスES細胞由来-視床下部培養系におけるNERP1の作用2015
- Author(s)
  長崎　弘、須藤　湧太、小谷　侑、須賀英隆、山本直樹、金子葉子、中島　昭、太田　明
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  ホテルニューオータニ東京
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25505008
[Presentation] マウス胚性幹細胞由来バゾプレシン細胞のライブセルイメージング2015
- Author(s)
  須藤湧太、長崎弘、小谷侑、山本直樹、須賀英隆、金子葉子、中島昭、太田明
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  ホテルニューオータニ東京
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25505008
[Presentation] ES細胞由来-視床下部培養系におけるMCHニューロンの形態および組織学的特徴2014
- Author(s)
  小谷　侑、長崎　弘、須賀英隆、綿谷武史、金子葉子、中島昭、大磯ユタカ、笹井芳樹、太田明
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス
- Data Source
  KAKENHI-PROJECT-25505008
[Presentation] 7. マウスES由来バゾプレシン細胞の異種移植2014
- Author(s)
  長崎　弘、小谷　侑、須賀英隆、金子葉子、中島　昭、太田　明
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス
- Invited
- Data Source
  KAKENHI-PROJECT-25505008
[Presentation] マウスESC由対視床下部細胞のラット脳移植2013
- Author(s)
  長崎　弘、小谷　侑、金子葉子、中島　昭、須賀　英隆、太田　明
- Organizer
  第６０回中部生理学会
- Place of Presentation
  岐阜大学　医学部記念会館ホール
- Data Source
  KAKENHI-PROJECT-25505008
[Presentation] チロシン水酸化酵素のリン酸化とプロテアソーム分解2013
- Author(s)
  中島昭、金子葉子、小谷侑、長崎弘、太田明
- Organizer
  第45回藤田学園医学会　総会
- Place of Presentation
  愛知県豊明市藤田保健衛生大学
- Data Source
  KAKENHI-PROJECT-25461296
[Presentation] Intracellular degradation and localization of tyrosine hydroxylase.2012
- Author(s)
  Nakashima A, Mori K, Kaneko YS, Nagasaki N, Nagatsu T and Ota A.
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Phosphorylation and proteasomal digestion of tyrosine hydroxylase.2012
- Author(s)
  Nakashima A, Kaneko YS, Mori K, Nagasaki H, Nagatsu T and Ota A.
- Organizer
  The 11th Biennial Meeting of APSN and 55th Meeting of JSN
- Place of Presentation
  Kobe, Japan
- Year and Date
  2012-10-01
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Intracellular stability of tyrosine hydroxylase: phosphorylation and proteasomal digestion of the enzyme.2012
- Author(s)
  Nakashima A, Kaneko YS, Mori K, Nagasaki H, Nagatsu T and Ota A.
- Organizer
  The Tenth International Catecholamine Symposium
- Place of Presentation
  Asilomar, CA. USA.
- Year and Date
  2012-09-11
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Intracellular degradation and localization of tyrosine hydroxylase; phosphorylation and proteasomal digestion of the enzyme.2011
- Author(s)
  Nakashima A, Mori K, Kaneko YS, Nagasaki H, Hayashi H, Nagatsu T and Ota A.
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington D.C., USA
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Down-regulation of 14-3-34 protein by RNAi increases stability of exogenous tyrosine hydroxylase in PC12D cells2008
- Author(s)
  Akira Nakashima, Nobuhiro Hayashi, Yoko S. Kaneko, Keiji Mori, Esther L. Sabban, Toshiharu Nagatsu, Akira Ota
- Organizer
  The 85th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] N-terminus of tyrosine hydroxylase regulates the intracellular stability of the enzyme.2007
- Author(s)
  Nakashima A, Hayashi T, Kaneko YS, Mori K, Nagatsu T, Ota A
- Organizer
  The 50st Annual Meeting of Japanese Society for Neurochemistry.
- Place of Presentation
  Yokohama.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] The PEST motif in the N-terminus of tyrosine hydroxylase affects the intracellular stability of the enzyme.2007
- Author(s)
  Nakashima A, Kaneko YS, Mori K, Nagatsu T, Ota A
- Organizer
  The 84th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] Stress due to peripheral lipopolysaccharide affects the olfactory dopamine system in mice.2007
- Author(s)
  Ota, A., Mori, K., Kaneko, Y. S., Nagatsu, I., Nagatsu, T.
- Organizer
  9th Symposium on Catecholamines and Other Neurotransmitters in Stress.
- Place of Presentation
  Smolenice Castle, Slovakia
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] N-terminus of tyrosine hydroxylase regulates the intracellular stability of the enzyme2007
- Author(s)
  Nakashima Akira, Hayashi Nobuhiro, Kaneko Yoko, Mori Keiji, Nagatsu Toshiharu, Ota Akira
- Organizer
  The 50th Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] The PEST motif in the N-terminus of tyrosine hydroxylase affects the intracellular stability of the enzyme2007
- Author(s)
  Nakashima Akira, Kaneko Yoko, Mori Keiji, Nagatsu Toshiharu, Ota Akira
- Organizer
  The 84th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] Down-regulation of 14-3-3 eta protein by RNAi increases stability of exogenous tyrosine hydroxylase in PC12D cells2007
- Author(s)
  Akira Nakashima, Nobuhiro Hayashi, Yoko S. Kaneko, Keiji Mori, Esther L. Sabban, Toshiharu Nagatsu, Akira Ota
- Organizer
  Society for Neuroscience meeting 2007
- Place of Presentation
  San Diego, CA, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] Down-regulation of 14-3-3 eta protein by RNAi increases stability of exogenous tyrosine hydroxylase in PC12D cells.2007
- Author(s)
  Nakashima A, Hayashi N, Kaneko YS, Mori K, Sabban EL, Nagatsu T, Ota A
- Organizer
  37th Neuroscience Meeting 2007
- Place of Presentation
  San Diego, CA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] Peripheral lipopolysaccharide injection induces apoptosis in the murine olfactory bulb.2006
- Author(s)
  Mori K, Kaneko YS, Nakashima A, Nagatsu I, Takahashi H, Ota A.
- Organizer
  36th Neuroscience Meeting 2006
- Place of Presentation
  Atalnta, GA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] The phosphorylation of Ser40 of tyrosine hydroxylase has no effect on the stability of the enzyme.2006
- Author(s)
  Nakashima A, Kaneko YS, Mori K, Nagatsu T, Ota A
- Organizer
  The 49st Annual Meeting of Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] Analysis of bodyweight change in risperidone-injectet rats.2006
- Author(s)
  Ota M., Mori K, Nakashima A, Kaneko YS, Takami G, Ota A
- Organizer
  The 30th Annual Meeting of JSBP
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] Analysis of bodyweight change in risperidone-injectet rats2006
- Author(s)
  太田美雪
- Organizer
  第28回日本生物学的精神医学会
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] The effect of astrocyte produced TNFa in the process of apoptosis in the murine olfactory bulb.2006
- Author(s)
  Mori K, Kaneko YS, Nakashima A, Nagatsu I, Ota A
- Organizer
  The 49st Annual Meeting of Japanese Society for Neurochemistry.
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] CRF receptor antagonist attenuates LPS-induced increase of GTP cyclohydrolase I expression.2006
- Author(s)
  Kaneko YS, Mori K, Nakashima A, Nagatsu I, Ota A
- Organizer
  The 49st Annual Meeting of Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500281
[Presentation] The phosphorylation of Ser40 of tyrosine hydroxylase has no effect on the stability of the enzyme.2006
- Author(s)
  Nakashima Akira, Kaneko Yoko, Mori Keiji, Nagatsu Toshiharu, Ota Akira
- Organizer
  The 49th Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] ES細胞由来-視床下部培養系におけるMCHニューロンの特徴
- Author(s)
  長崎　弘、小谷　侑、金子葉子、中島　昭、須賀　英隆、太田　明
- Organizer
  第８７回日本内分泌学会学術総会
- Place of Presentation
  福岡県福岡市福岡国際会議場
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25505008
[Presentation] Degradation rate of tyrosine hydroxylase by ubiquitin-proteasome pathway.
- Author(s)
  Syuhei Ohnuma, Yuri Nonaka, Yoko S. Kaneko, Yu Kodani, Hiroshi Nagasaki, Toshiharu Nagatsu, Akira Ota and Akira Nakashima
- Organizer
  第９２回日本生理学会
- Place of Presentation
  兵庫県神戸市・神戸国際会議場・展示場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25461296
[Presentation] Influence of endogenous Akt/β-catenin signaling in hypothalamic differentiation from mouse embryonic stem cells
- Author(s)
  Yu Kodani, Hiroshi Nagasaki, Hidetaka Suga, Yoko Kaneko, Akira Nakashima, Akira Ota
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  兵庫県神戸市神戸国際会議場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25505008
[Presentation] Calcium imaging of vasopressin neuron in the hypothalamic culture derived from mouse embryonic stem cell
- Author(s)
  Hiroshi Nagasaki, Yu Kodani, Naoki Yamamoto, Hidetaka Suga, Yoko Kaneko, Akira Nakashima, Akira Ota
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  兵庫県神戸市神戸国際会議場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25505008
[Presentation] 遺伝子改変によるマウス胚性幹細胞由来バゾプレシン細胞の蛍光標識
- Author(s)
  長崎　弘、小谷　侑、須賀英隆、山本直樹、金子葉子、中島　昭、太田　明
- Organizer
  第61回中部日本生理学会
- Place of Presentation
  愛知県名古屋市名古屋市立大学桜山キャンパス
- Year and Date
  2014-11-07 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-25505008

1. NAKASHIMA Akira (20180276)

# of Collaborated Projects: 6 results

# of Collaborated Products: 27 results
2. MORI Keiji (40239596)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. HAYASHI Nobuhiro (80267955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. NAGATSU Toshiharu (40064802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. NAGASAKI Hiroshi (30420384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. KODANI Yu (60644622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. SUGA Hidetaka (20569818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. OISO Yutaka (40203707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

OTA Akira 太田 明

太田 明 オオタ アキラ

Research Projects

Research Products

Co-Researchers

Intracellular stability of tyrosine hydroxylase regulated by proteasomal degradation of the enzyme and neurodegeneration of dopaminergic cells

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Regenerative therapy for hypothalamic disorders from neoplasms

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Regulating mechanism for intracellular stability of tyrosine hydroxylase and neurodegeneration

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The effect of pro-inflammatory cytokine on dopamine neurons in the olfactory bulb

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The relationship between the intracellular stability of tyrosine hydroxylase and the neurodegeneration regulated by α-synuclein

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The relationship between the intracellular stability of tyrosine hydroxylase and the neurodegeneration on Parkison's disease

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Mutant enzymes of tyrosine hydroxylase for an effective gene therapy of PD

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Analysis of the Tetrahydrobiopterin Biosynthesizing System in Cultured Neuron-Derived CellsPrincipal Investigator

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[Journal Article] Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells2016

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[Journal Article] Degradation rate of tyrosine hydroxylase by ubiquitin-proteasome pathway.2015

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[Journal Article] Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G1 phase and protects them from UV light-induced apoptosis.2014

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[Journal Article] Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells.2014

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[Journal Article] Intracellular stability of tyrosine hydroxylase: Phosphorylation and proteasomal digestion of the enzyme.2013

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[Journal Article] A possible pathophysiological role of tyrosine hydroxylase in Parkinson’s disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.2013

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Data Source

[Journal Article] A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brainbiochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.2012

Author(s)

OTA Akira 太田明

太田明オオタアキラ