Sumi-Ichinose Chiho 一瀬千穂

… Alternative Names

SUMI-ICHINOSE Chiho 一瀬千穂

ICHINOSE Chiho 一瀬千穂

一瀬千穂イチノセチホ

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Researcher Number	10247653
Other IDs	https://orcid.org/0000-0001-5261-0853
External Links
Affiliation (Current)	2025: 藤田医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 藤田医科大学, 医学部, 准教授 2010 – 2017: 藤田保健衛生大学, 医学部, 准教授 2002 – 2005: 藤田保健衛生大学, 医学部, 助教授 1999 – 2001: 藤田保健衛生大学, 医学部, 講師 1997 – 1998: 藤田保健衛生大学, 医学部, 助手 1993: 藤田保健衛生大学, 医学部・薬理学, 助手
Review Section/Research Field	Principal Investigator General pharmacology / Pathological medical chemistry / Basic Section 48030:Pharmacology-related / Pathological medical chemistry / Neurochemistry/Neuropharmacology Except Principal Investigator Neuroscience in general
Keywords	Principal Investigator テトラヒドロビオプテリン / チロシン水酸化酵素 / 一酸化窒素 / 持続勃起症 / ドパミン神経 / 6-ピルボイルテトラヒドロプテリン合成酵素 / 自律神経 / セピアプテリン還元酵素 / 6-pyruvoyltetrahydropterin synthase / knockout mice … More / L-DOPA / ノックアウトマウス / 血管 / 交感神経 / 高血圧 / 一酸化窒素合成酵素 / 異型フェニルケトン尿症 / トランスジェニックマウス / リン酸化 / 持続勃起症 (Priapism) / 不安定高血圧症 / Priapism （持続勃起症） / 持続勃起症（Priapism） / Priapism（持続勃起症） / 徐脈 / ノルアドレナリン / transgenic mice / tyrosine hydroxylase / dopaminergic neuron / striatum / dopa-responsive dystonia / tetrahydrobiopterin / 6-ピルポイルテトラヒドロプテリン合成酸素 / 線条体 / 6-ピルボイルテロラヒドロプテリン合成酵素 / ドパ反応性ジストニア / lymphocyte / Dopamine β-hydroxylase / Malignant hyperphenylalaninemia / Tetrahydrobiopterin / 6-PTPS / リンパ球 / ドパミンβ-水酸化酵素 / 悪性高フェニルアラニン血症 / ドパミンニューロン / ドパミン / フェニルアラニン / ジストニア / 血管内皮細胞 / 生理活性物質 / ドーパ反応性ジストニア / パーキンソン病 / ジーンターゲッティング / ビオプテリン / gene targeting / 6-ピルボイルテトラヒドロプテリン合成酵素(PTPS) / クロラムフェニコールアセチントランスフェラーゼ / 組織特異的発現 / オールタナティブプロモーター / 芳香族L-アミノ酸脱炭酸酵素 … More Except Principal Investigator Nurr1 / dopaminergic neuron / tyrosine hydroxylase / Cre-loxP / Cre-ERT / ドーパミンニューロン / カテコールアミン / チロシン水酸化酵素 / nuclear receptor / 発達 / ドーパミン / 核内受容体 / catecholamine / 条件付き遺伝子破壊 / 相同組み換え Less

テトラヒドロビオプテリンによる神経・循環器系の機能調節と疾患治療への挑戦Principal Investigator
- Principal Investigator
  
  一瀬千穂
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Fujita Health University
Mutual adjustment of autonomic nervous system and nitric oxide biosynthesis via tetrahydrobiopterinPrincipal Investigator
- Principal Investigator
  
  Sumi-Ichinose Chiho
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Fujita Health University
Tetrahydrobiopterin-deficiency causes hypertension with fluctuation, bradycardia and priapism.Principal Investigator
- Principal Investigator
  
  SUMI-ICHINOSE Chiho
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fujita Health University
Study on the disease induced by imbalance of tetrahydrobiopterin-metabolism and research on the mechanisms for protection against the state.Principal Investigator
- Principal Investigator
  
  Sumi-Ichinose Chiho
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fujita Health University
Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular diseasePrincipal Investigator
- Principal Investigator
  
  SUMI-ICHINOSE Chiho
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fujita Health University
Developmental disturbance in model mice with abnormal pterin metabolismPrincipal Investigator
- Principal Investigator
  
  SUMI-ICHINOSE Chiho
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Fujita Health University
A new approach to various diseases based on abnormal metabolism of petering.Principal Investigator
- Principal Investigator
  
  ICHINOSE Chino
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Fujita Health University
テトラヒドロビオプテリン生合成系の異常と神経疾患Principal Investigator
- Principal Investigator
  
  一瀬千穂
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Fujita Health University
Alteration in neural function by an inducible knock-out of tyrosine hydroxylase.
- Principal Investigator
  
  ICHINOSE Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Fujita Health University
Role of Neurotransmitters and orphan receptors in neural cytoarchitecture of the brain..
- Principal Investigator
  
  ICHINOSE Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neuroscience in general
- Research Institution
  Fujita Health University
6-ピルボイルテトラヒドロプテリン合成酵素(PTPS)の人工的破壊:脳内ビオプテリン欠損マウスの作成Principal Investigator
- Principal Investigator
  
  一瀬千穂
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Fujita Health University
ヒト芳香族L-アミノ酸脱炭酸酵素の組織特異的発現の調節機構の解析Principal Investigator
- Principal Investigator
  
  一瀬千穂
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Fujita Health University

[Journal Article] Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin2022
- Author(s)
  K Miyajima, Y Sudo, S Sanechika, Y Hara, M Horiguchi, F Xu, M Suzuki, S Hara, K Tanda, K Inoue, M Takada, N Yoshioka, H Takebayashi, M Mori-Kojima, M Sugimoto, C Sumi-Ichinose, K Kondo, K Takao, T Miyakawa, H Ichinose
- Journal Title
  
  J Neurochemistry
  
  Volume: 161(2) Issue: 2 Pages: 129-145
- DOI
  10.1111/jnc.15600
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07331, KAKENHI-PROJECT-19H05467, KAKENHI-PUBLICLY-20H05062, KAKENHI-PROJECT-19H03335, KAKENHI-PROJECT-19H03538, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-22K19480, KAKENHI-PROJECT-20K15912, KAKENHI-PROJECT-18H05213, KAKENHI-PLANNED-22H05157, KAKENHI-PROJECT-22H04922, KAKENHI-PLANNED-20H05743
[Journal Article] Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice2022
- Author(s)
  Suganuma Yui、Sumi-Ichinose Chiho、Kano Taiki、Ikemoto Kazuhisa、Matsui Taei、Ichinose Hiroshi、Kondo Kazunao
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 150 Issue: 3 Pages: 173-179
- DOI
  10.1016/j.jphs.2022.08.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06871
[Journal Article] Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice2022
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Noriko Ihira, Hiroshi Ichinose, Kazunao Kondo
- Journal Title
  
  Journal of Inherited Metabolic Disease
  
  Volume: - Issue: 3 Pages: 621-634
- DOI
  10.1002/jimd.12489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07331
[Journal Article] Salivary neopterin and related pterins: their comparison to those in plasma and changes in individuals.2021
- Author(s)
  Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Toshiharu Nagatsu and Kazunao Kondo
- Journal Title
  
  J. Biochemistry
  
  Volume: 170 Issue: 4 Pages: 559-567
- DOI
  10.1093/jb/mvab076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07331
[Journal Article] Tyrosine hydroxylase conditional knockout mice reveal peripheral tissue-dependent dofferences in dopamine biosynthetic pathways.2021
- Author(s)
  Katsuya Miyajima, Chiaki Kawamoto, Satoshi Hara, Masayo Mori-Kojima, Tamae Ohye, Chiho Sumi-Ichinose, Nae Saito, Toshikuni Sasaoka, Daniel Metzger, Hiroshi Ichinose
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: - Pages: 100544-100544
- DOI
  10.1016/j.jbc.2021.100544
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07331, KAKENHI-PROJECT-19K07902, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-16H06276
[Journal Article] Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.2017
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Hiroko Nomura, Kazuhisa Ikemoto, Tadayoshi Hata, Setsuko Katoh, Hiroshi Ichinose and Kazunao Kondo
- Journal Title
  
  Physiological Reports
  
  Volume: 5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08561
[Journal Article] Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.2014
- Author(s)
  Xu F, Sudo Y, Sanechika S, Yamashita J, Shimaguchi S, Honda S, Sumi-Ichinose C, Mori-Kojima M, Nakata R, Furuta T, Sakurai M, Sugimoto M, Soga T, Kondo K, Ichinose H.
- Journal Title
  
  FEBS Letters
  
  Volume: 588 Issue: 21 Pages: 3924-3931
- DOI
  10.1016/j.febslet.2014.09.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460346, KAKENHI-PROJECT-26462860
[Journal Article] Recovery of neurogenic amines in phenylketonuria micefollowing liver-targeted gene therapy.2012
- Author(s)
  Hiroya Yagi, Sho Sanechika, Sho Shimaguchi, Hiroshi Ichinose, Chiho Sumi-Ichinose, Hiroaki Mizukami, Masashi Urabe, Hiromi Hamada, Hiroyuki Yoshikawa,Keiya Ozawa, Akihiro Kume.
- Journal Title
  
  Neuroreport
  
  Volume: 23(1) Pages: 30-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590250
[Journal Article] Cilostazol Inhibits Cytokine-induced Tetrahydrobiopterin Biosynthesis in Human Umbilical Vein Endothelial Cells.2011
- Author(s)
  Hiroaki Shiraishi, Kazuhisa Ikemoto, Shin Tada, Yasuhiro Udagawa, Masatsugu, Ohtsuki, Chiho Sumi-Ichinose, Kazunao Kondo, and Takahide Nomura.
- Journal Title
  
  J Ather Thromb
  
  Volume: 18(4) Pages: 312-317
- NAID
  130004845370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590250
[Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection.2011
- Author(s)
  Hirofumi Tokuoka, Shin-ichi Muramatsu, Chiho Sumi-Ichinose, Hiroaki Sakane, Masayo Kojima, Yoshinori Aso, Takahide Nomura, Daniel Metzger, and Hiroshi Ichinose.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 (50) Pages: 43549-43558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590250
[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.2011
- Author(s)
  Daigo Homma, Chiho Sumi-Ichinose, Hirofumi Tokuoka, Kazuhisa Ikemoto, Takahide Nomura, Kazunao Kondo, Setsuko Katoh, and Hiroshi Ichinose.
- Journal Title
  
  J Biol Chem
  
  Volume: 286(2) Pages: 1445-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590250
[Journal Article] Regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.2010
- Author(s)
  Chiho Sumi-Ichinose, et al.
- Journal Title
  
  Journal of Pharmacological Science
  
  Volume: 114 Pages: 14-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590250
[Journal Article] Regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.2010
- Author(s)
  Chiho Sumi-Ichinose, Hiroshi Ichinose, Kazuhisa Ikemoto, Takahide Nomura, and Kazunao Kondo.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 114 Pages: 17-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590250
[Journal Article] Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities2005
- Author(s)
  Chiho Sumi-Ichinose et al.
- Journal Title
  
  Journal of Neurochemistry 95
  
  Pages: 703-714
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590255
[Journal Article] Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylaninemia and region-specific monoaminergic abnormalities2005
- Author(s)
  Chiho Sumi-Ichinose et al.
- Journal Title
  
  Journal of Neurochemistry 95
  
  Pages: 703-714
- Data Source
  KAKENHI-PROJECT-16590255
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスで観察されるチロシン水酸化酵素Ser40のリン酸化亢進2023
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、一瀬　宏、近藤一直
- Organizer
  第36回日本プテリジン研究会 2024/2/23、東京
- Data Source
  KAKENHI-PROJECT-22K06871
[Presentation] Is the priapism of sepiapterin reductase-deficient mice caused by nitric oxide overproduction ?2022
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Noriko Ihira, Hiroshi Ichinose, Kazuno Kondo
- Organizer
  第95回日本薬理学会年会（2022年3月7－9日、福岡）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] セピアプテリン還元酵素のタンパク質量が減少してもビオプテリン量は変化しない。2022
- Author(s)
  一瀬（鷲見）千穂、狩野泰輝、菅沼由唯、池本和久、井平典子、一瀬　宏、近藤一直
- Organizer
  第35回日本プテリジン研究会 2022年12月３日、大阪（オンライン）
- Data Source
  KAKENHI-PROJECT-22K06871
[Presentation] セピアプテリン還元酵素遺伝子欠損マウスに発症する重篤な持続勃起症(Priapism)のメカニズム2021
- Author(s)
  一瀬（鷲見）千穂，菅沼由唯，狩野泰輝，池本和久，井平典子，一瀬　宏，近藤一直
- Organizer
  第34回日本プテリジン研究会（2021年11月20日、豊明（オンライン））
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] 唾液中のネオプテリンおよび関連するプテリン類の分析2021
- Author(s)
  池本和久、狩野泰輝、菅沼由唯、一瀬千穂、近藤一直
- Organizer
  第34回日本プテリジン研究会（2021年11月20日、豊明（オンライン））
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] 5-hydroxytryptophan supplement recovers impaired platelet aggregation in Quinonoid dihydropteridine reductase deficient mouse.2021
- Author(s)
  Yui Suganuma, Taiki Kano1, Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Hiroshi Ichinose and Kazunao Kondo
- Organizer
  第94回日本薬理学会年会2021年3月8－10日、札幌（ハイブリッド）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスの持続勃起症とテトラヒドロビオプテリン反復投与の効果2021
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、池本和久、近藤一直
- Organizer
  第139回日本薬理学会近畿部会（2021年6月16日、名古屋（オンライン））
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] セピアプテリン還元酵素欠損が血液系に及ぼす影響2021
- Author(s)
  狩野泰輝、菅沼由唯、池本和久、一瀬-鷲見千穂、一瀬宏、近藤一直
- Organizer
  第34回日本プテリジン研究会（2021年11月20日、豊明（オンライン））
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] Differential reduction of monoamine neurotransmitters and PTSD-like behavior in mice defective in the regeneration of tetrahydrobiopterin.2021
- Author(s)
  M Suzuki, K Miyajima, Y Sudo, S Sanechika, Y Hara, M Horiguchi, S Hara, C Sumi-Ichinose, K Kondo, K Tanda, K Takao, T Miyakawa, H Ichinose
- Organizer
  第51回日本神経精神薬理学会第43回日本生物学的精神医学会合同年（2021年7月14－16日、京都）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] BH4経口投与によりマウス全血でみられた血小板凝集抑制のメカニズム2021
- Author(s)
  菅沼由唯、狩野泰輝、池本和久、一瀬-鷲見千穂、近藤一直
- Organizer
  第34回日本プテリジン研究会（2021年11月20日、豊明（オンライン））
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] 血小板機能に対して三種混合麻酔が与える影響2020
- Author(s)
  狩野泰輝、菅沼由唯、池本和久、一瀬千穂、松井太衛、近藤一直
- Organizer
  第42回日本血栓止血学会学術集会2020年6月18-20日、大阪（誌上）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] Effect of three mixed anesthesia (MMB) for platelet function.2020
- Author(s)
  Taiki Kano, Yui Suganuma, Kazuhisa Ikemoto, Chiho Ichinose, Taei Matsui, Kazunao, Kondo
- Organizer
  ISTH 2020（the XXVIII Congress of the International Society on Thrombosis and Haemostasis） July 11-15, 2020Milano, Italy (On Line)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] キノノイド型ジヒドロプテリジン還元酵素欠損マウスの血小板凝集能低下におけるセロトニンの関与2020
- Author(s)
  菅沼由唯、狩野泰輝、池本和久、一瀬‐鷲見千穂、一瀬宏、近藤一直
- Organizer
  第42回日本血栓止血学会学術集会2020年6月18-20日、大阪（誌上）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] 唾液中のネオプテリンおよび関連するプテリン類2020
- Author(s)
  池本和久、狩野泰輝、菅沼由唯、一瀬千穂、近藤一直
- Organizer
  第138回日本薬理学会近畿部会 2020年11月14日、大阪(オンライン）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] 新規混合麻酔がマウス血小板凝集に与える影響2020
- Author(s)
  狩野泰輝, 菅沼由唯, 池本和久, 一瀬千穂, 近藤一直
- Organizer
  第93回日本薬理学会年、2020年3月16-18日、横浜（誌上開催）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] Platelet aggregation is suppressed in the quinonoid dihydropteridine reductase knockout mice.2020
- Author(s)
  Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Taei Matsui, Hiroshi Ichinose and Kazunao Kondo.
- Organizer
  ISTH 2020（the XXVIII Congress of the International Society on Thrombosis and Haemostasis） July 11-15, 2020Milano, Italy (On Line)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] 三種混合麻酔はアドレナリンα2刺激を介して血小板凝集を増強する2020
- Author(s)
  近藤一直、狩野泰輝、菅沼由唯、池本和久、一瀬千穂
- Organizer
  第137回日本薬理学会近畿部会2020年6月20日、岡山(オンライン）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] 低酸素環境におけるヒト血管内皮細胞の増殖について2019
- Author(s)
  池本和久、狩野泰輝、菅沼由唯、一瀬千穂、近藤一直
- Organizer
  第135回日本薬理学会近畿部会、2019年6月21日、岐阜（じゅうろくプラザ）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] セピアプテリン還元酵素遺伝子欠損マウスで観察される重篤なPriapism（持続勃起症）の発症機序2019
- Author(s)
  一瀬（鷲見）千穂，菅沼由唯，狩野泰輝，井平典子，池本和久，一瀬　宏，近藤一直
- Organizer
  第33回日本プテリジン研究会、2019年11月2日、東京（キャンパス・イノベーションセンター東京）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] Sepiapterin reductase gene disrupted mice suffered from severe priapism.2019
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, Hiroshi Ichinose and Kazunao Kondo
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] マウスにおけるキノノイド型ジヒドロプテリジン還元酵素の欠損が血小板凝集におよぼす影響2019
- Author(s)
  菅沼由唯、狩野泰輝、池本和久、一瀬‐鷲見千穂、一瀬宏、近藤一直
- Organizer
  第41回日本血栓止血学会学術集会、2019年6月20日～22日、津（三重県総合文化センター）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] 唾液中と血液中におけるネオプテリンおよびビオプテリンの相関について2019
- Author(s)
  池本和久、一瀬千穂、菅沼由唯、狩野泰輝、近藤一直
- Organizer
  第4回日本臨床薬理学会東海・北陸地方会、2019年6月8日、静岡（静岡県立大学草薙キャンパス）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] キノノイド型ジヒドロプテリジン還元酵素欠損はセロトニン減少を介した血小板凝集抑制を引き起こす2019
- Author(s)
  近藤一直，菅沼由唯，狩野泰輝，池本和久，一瀬‐鷲見千穂，一瀬宏
- Organizer
  第33回日本プテリジン研究会、2019年11月2日、東京（キャンパス・イノベーションセンター東京）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] マウス向血栓性に三種混合麻酔が与える影響2019
- Author(s)
  狩野泰輝、菅沼由唯、池本和久、一瀬千穂、近藤一直
- Organizer
  第136回日本薬理学会近畿部会、2019年11月23日、枚方（摂南大学枚方キャンパス）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] 三種混合麻酔がマウス循環機能におよぼす影響2019
- Author(s)
  狩野泰輝, 菅沼由唯, 池本和久, 一瀬千穂, 近藤一直
- Organizer
  第29回日本循環薬理学会第29回日本循環薬理学会、2019年11月29日、高松（高松センタービル）
- Data Source
  KAKENHI-PROJECT-19K07331
[Presentation] Effect of methotrexate on pteridine-contents and relaxation response of the aorta from quinonoid-dihydropteridine reductase (QDPR) knockout mice.2018
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, Ichinose Hiroshi, and Kazunao Kondo
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] テトラヒドロビオプテリン欠損マウスは、重篤な持続勃起症を発症する2018
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、近藤一直
- Organizer
  第134回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスの血圧変動の機序2017
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第131回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] メトトレキサート投与が、キノノイド型ジヒドロビオプテリン還元酵素遺伝子ノックアウトマウス大動脈のプテリジン含量と弛緩反応におよぼす影響2017
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、一瀬　宏、近藤一直
- Organizer
  第31回日本プテリジン研究会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] Sepiapterin reductase gene disrupted mice suffered from hypertension with fluctuation and bradycardia.2017
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Hiroko Nomura, Kazuhisa Ikemoto, Tadayoshi Hata, Setsuko Katoh, Hiroshi Ichinose and Kazunao Kondo
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール(長崎県・長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] ビオプテリン欠損がひきおこす不安定な高血圧・徐脈とPriapism（持続勃起症）2016
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第135回日本薬理学会関東部会
- Place of Presentation
  アクトシティ浜松交流センター(静岡県・浜松市)
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスの加齢と循環器系フェノタイプの変化2016
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第130回日本薬理学会近畿部会
- Place of Presentation
  京都大学百周年時計記念館(京都府・京都市）
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスは変動の大きい高血圧、徐脈とpriapism（持続勃起症）を生じる2016
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第30回日本プテリジン研究会
- Place of Presentation
  名古屋大学環境学研究科環境総合館レクチャーホール１Ｆ(愛知県・名古屋市）
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] Sepiapterin reductase knockout mice suffered from unstable hypertension and serious priapism.2016
- Author(s)
  ①Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, and Kazunao Kondo.
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25460346
[Presentation] キノノイド型ジヒドロプテリン還元酵素遺伝子ノックアウトマウス大動脈リング標本の血管弛緩反応2015
- Author(s)
  ③一瀬―鷲見千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、一瀬　宏、近藤一直
- Organizer
  第29回日本プテリジン研究会
- Place of Presentation
  多摩　日本医科大学多摩永山病院会議室
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460346
[Presentation] Hypoxiaが血管内皮細胞における細胞内テトラヒドロビオプテリン量と細胞増殖に及ぼす影響2015
- Author(s)
  ②池本和久、菅沼由唯、狩野泰輝、野村隆英、一瀬千穂、近藤一直
- Organizer
  第29回日本プテリジン研究会
- Place of Presentation
  多摩　日本医科大学多摩永山病院会議室
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460346
[Presentation] マウス全血におけるテトラヒドロビオプテリンの抗血小板作用2013
- Author(s)
  菅沼由唯、池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Characterization of dihydropteridine reductase knockout mice.2012
- Author(s)
  Hiroshi Ichinose
- Organizer
  15th International Symposium on Pteridines and Folates
- Place of Presentation
  Antalya, Turkey
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Chiho Sumi-Ichinose, Takahide Nomura, Daniel Metzger.2012
- Author(s)
  Hiroshi Ichinose, Hirofumi Tokuoka,Shin-ichi Muramatsu
- Organizer
  Regulation of dopamine contein in the striatum after ablation of the tyrosine hydroxylase gene in the substantia nigra. 10th International Catecholamine Symposium.
- Place of Presentation
  Asilomar,USA
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Regulation of dopamine contein in the striatum after ablation of the tyrosine hydroxylase gene in the substantia nigra.2012
- Author(s)
  Hiroshi Ichinose
- Organizer
  10th International Catecholamine Symposium
- Place of Presentation
  Asilomar, USA
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] マウス血小板凝集にテトラヒドロビオプテリンが及ぼす影響2012
- Author(s)
  菅沼由唯、池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第22回循環器薬理学会年会
- Place of Presentation
  富山
- Year and Date
  2012-11-30
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] シンポジウム 1 ビタミン研究の最前線2012
- Author(s)
  一瀬宏、本間大悟、一瀬(鷲見)千穂、近藤一直
- Organizer
  ビオプテリンによる脳内ドーパミン系の発達および神経機能との関連第10回日本機能性食品医用学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] テトラヒドロビオプテリンがマウス血小板凝集に及ぼす影響2012
- Author(s)
  菅沼由唯、池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第121回日本薬理学会近畿部会
- Place of Presentation
  徳島
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Characterization of dihydropteridine reductase knockout mice15th2012
- Author(s)
  Hiroshi Ichinose, Sho Sanechika, Yoshitaka Hara, Yusuke Sudo, Feng Xu, Shun-ichiro Honda, Sho Shimaguchi, Shigeki Matsuki, Mieko Horiguchi, MasayoKojima, Takahide Nomura, Kazunao Kondo, Chiho Sumi-Ichinose.
- Organizer
  International Symposium onPteridines and Folates
- Place of Presentation
  Antalya Turkey
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] テトラヒドロビオプテリンの欠乏はモノアミン神経系の生後発達を阻害する2012
- Author(s)
  一瀬(鷲見)千穂、菅沼由唯、池本和久、野村隆英、近藤一直
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] テトラヒドロビオプテリンによる血小板凝集抑制効果のメカニズム解明2012
- Author(s)
  菅沼由唯、池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第122回日本薬理学会近畿部会
- Place of Presentation
  豊中
- Year and Date
  2012-11-16
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] テトラヒドロビオプテリンの欠乏はモノアミン神経系の生後発達を阻害する2012
- Author(s)
  一瀬(鷲見)千穂, ほか4名
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] チロシン水酸化酵素の転写促進因子 V-1 はドーパ脱炭酸酵素の遺伝子発現を増強する2012
- Author(s)
  来延新、川畑伊知郎、一瀬千穂、近藤一直、加藤成樹、一瀬宏、小林和人、山國徹
- Organizer
  第51回日本薬学会東北支部大会
- Place of Presentation
  青森
- Year and Date
  2012-10-07
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Disturbance in the biosynthesis of monoamines andPTSD-like phenotype in the dihydrpterinr reductase-deficient mice.2012
- Author(s)
  Hiroshi Ichinose, Yusuke Sudo, ShoSanechika, Koichi Tanda, Kenzo Takao, Yoshitaka Hara, Shun-ichiro Honda, Sho Shimaguchi, Masayo Kojima, ChihoSumi-Ichinose, Takahide Nomura, KazunaoKondo, Tsuyoshi Miyakawa
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system2011
- Author(s)
  D. Homma, C. Sumi-Ichinose, H. Tokuoka, K. Ikemoto, T. Nomura, K. Kondo, H. Ichinose
- Organizer
  10th International Conference on Alzheimer's and Parkinson's Diseases
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Tetrahydrobiopterin and reactive oxygen species in cutokine-stimulated HUVEC2011
- Author(s)
  K. Ikemoto, C. Sumi-Ichinose, T. Nomura, K. Kondo
- Organizer
  Gordon Research Conference, Vascular Cell Biology
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Neuronal activity of the basal ganglia in a transgenic mouse model of dopa-responsive dystonia.2011
- Author(s)
  Satomi Chiken, Chiho Sumi-Ichinose, Hiroshi Ichinose, Kazunao Kondo, Atsushi Nambu
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] 統合失調症様行動異常を呈する APC1638T マウスの脳におけるモノアミンの動態2010
- Author(s)
  千田隆夫、尾之内高慶、唐沢延幸、一瀬千穂、高雄啓三、近藤一直、宮川剛
- Organizer
  日本解剖学会第70回中部支部学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] テトラヒドロビオプテリン欠損マウスの生後発達と生化学的変化2010
- Author(s)
  一瀬(鷲見)千穂、池本和久、野村隆英、近藤一直
- Organizer
  第118回日本薬理学会近畿部会
- Place of Presentation
  大阪
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] プテリン類の分析に関する 3 項目の検討2010
- Author(s)
  池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第24回日本プテリジン研究会シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Aortic relaxation by acethlcholine is maintained against hyper dihydrobiopterinemia in quinonoid-dihydrobiopterin reductase knockout mice
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, Takahide Nomura, and Kazunao Kondo
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  Naggoya, Japan
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25460346

1. Ichinose Hiroshi (90192492)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
2. KONDO Kazunao (90270983)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
3. OHYE Tamae (10247661)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. INAGAKI Hidehito (70308849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SUZUKI Takahiro (70298545)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. IKEMOTO Kazuhisa (40351019)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SHIRAISHI Hiroaki (80319285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NOMURA Takahide (20156227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Ihira Noriko

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results

Sumi-Ichinose Chiho 一瀬 千穂

SUMI-ICHINOSE Chiho 一瀬 千穂

ICHINOSE Chiho 一瀬 千穂

一瀬 千穂 イチノセ チホ

Research Projects

Research Products

Co-Researchers

テトラヒドロビオプテリンによる神経・循環器系の機能調節と疾患治療への挑戦Principal Investigator

Principal Investigator

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Review Section

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Mutual adjustment of autonomic nervous system and nitric oxide biosynthesis via tetrahydrobiopterinPrincipal Investigator

Principal Investigator

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Review Section

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Tetrahydrobiopterin-deficiency causes hypertension with fluctuation, bradycardia and priapism.Principal Investigator

Principal Investigator

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Study on the disease induced by imbalance of tetrahydrobiopterin-metabolism and research on the mechanisms for protection against the state.Principal Investigator

Principal Investigator

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Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular diseasePrincipal Investigator

Principal Investigator

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Developmental disturbance in model mice with abnormal pterin metabolismPrincipal Investigator

Principal Investigator

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A new approach to various diseases based on abnormal metabolism of petering.Principal Investigator

Principal Investigator

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テトラヒドロビオプテリン生合成系の異常と神経疾患Principal Investigator

Principal Investigator

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Research Institution

Alteration in neural function by an inducible knock-out of tyrosine hydroxylase.

Principal Investigator

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Role of Neurotransmitters and orphan receptors in neural cytoarchitecture of the brain..

Principal Investigator

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6-ピルボイルテトラヒドロプテリン合成酵素(PTPS)の人工的破壊:脳内ビオプテリン欠損マウスの作成Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

ヒト芳香族L-アミノ酸脱炭酸酵素の組織特異的発現の調節機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin2022

Sumi-Ichinose Chiho 一瀬千穂

SUMI-ICHINOSE Chiho 一瀬千穂

ICHINOSE Chiho 一瀬千穂

一瀬千穂イチノセチホ