YAMAMOTO Tohru 山本融

… Alternative Names

山本融ヤマモトトオル

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Researcher Number	10251480
Other IDs
External Links
Affiliation (Current)	2025: 香川大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 香川大学, 医学部, 教授 2013 – 2023: 香川大学, 医学部, 教授 2012: 北海道大学, 薬学研究科(研究院), 准教授 2008 – 2012: Hokkaido University, 大学院・薬学研究院, 准教授 2003 – 2004: 独立行政法人理化学研究所, 非対称細胞分裂研究グループ, 研究員 … More 2001 – 2002: 東北大学, 加齢医学研究所, 助手 2001: 東北大学, 加齢医学・研究所, 助手 1994 – 1997: 東京大学, 分子細胞生物学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy / Molecular biology / Nerve anatomy/Neuropathology / Basic veterinary science/Basic zootechnical science Except Principal Investigator Cell biology / Biological pharmacy / Biological Sciences
Keywords	Principal Investigator 神経回路 / 神経発生 / TFIID / 新規因子 / 神経分化 / 運動神経 / two-hybrid法 / 転写因子 / 転写調節 / TATAボックス結合因子 … More / CCG1 / E/Iバランス / MDGA2 / MDGA1 / 統合失調症 / 軸索ガイダンス / クロマチン転写 / MDGA / 自閉スペクトラム症 / ニューロリギン / Ｅ/Ｉバランス / シナプス形成 / Neuroligin / 自閉症スペクトラム障害 / 大脳皮質 / one-hybrid法 / NF-κB / Sp1 / Tat / HIV / Bromodomain / 細胞周期 / シナプス病 / ASD / synapse / E/I balance / 軸索輸送 / 神経変性 / Alcadein / APP / 小胞輸送 / 精神神経疾患 / 社会性行動 / 記憶 / ニューレキシン / 行動解析 / 自閉症 / 行動異常 / 自閉症スペクトラム / 組織構築 / 神経細胞 / 発生分化 / 細胞移動 / 脊髄小行路 / 神田回路綱形成 / 軸索伸長 / 伝導路 / 脊髄 / ニワトリ / 電気穿孔法 / 上行性伝導路 / 神経回路網形成 / 脊髄神経 / 脊髄小脳路 / 脊髄上行路 / ブロモドメイン / CCGl / two-bybrid法 / SW14 / ドメイン / 核 … More Except Principal Investigator MysPDZ(Myo18A) / 細胞間相互作用 / 造血幹細胞 / マイクロアレイ / 遺伝子発現プロファイル / 間質細胞 / 骨髄 / 造血微小環境 / two-hybrid法 / TFIID / 転写調節 / 転写基本因子 / 転写調節因子 / microarray / gene expression profiles / mesenchymal stem cell cell lines / hematopoietic-microenvironment / bone marrow / 間葉系幹細胞 / 間葉系肝細胞 / 間質細胞株 / two-hybrid system / co-factor / Transcriptional regulatory factor / Development of drugs / Interaction between transcription factors / Interaction between DNA and transcription factors / Transcription factor / Transcriptional regulation / CTD / TBP / TFIIB / TATAボックス結合因子 / コファクター / 医薬品開発 / 転写因子間相互作用 / DNA-転写因子相互作用 / 転写因子 / 新規ミオシン遺伝子 / 不死化細胞株 / 骨髄間質細胞 / STAT1 / STAT5 / 多能性造血幹細胞 / 共培養 / サイトカイン / 微小環境 / 可塑性 / 幹細胞 / sphingoshine-1 phosphate / tenascin-c / ephrinB2 / Myo18A / MysPDZ / 転写活性化 / 癌遺伝子 / 相互作用 Less

Development of Therapeutic Strategies for Neuropsychiatric Disorders by Modulating Inhibitory Mechanisms of SynaptogenesisPrincipal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kagawa University
Functional Analyses of 'privileged' vesicular transport carried with AlcadeinPrincipal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kagawa University
Exploration of novel excitatory/inhibitory balance control mechanisms in neural circuits for the treatment of neuropsychiatric disorders.Principal Investigator
- Principal Investigator
  
  Yamamoto Tohru
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kagawa University
Functional analysis of MDGA family proteins on regulation of synapse formation and social behavior.Principal Investigator
- Principal Investigator
  
  Yamamoto Tohru
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kagawa University
Functional analysis of MDGA family proteins on neural circuit formation of cerebral cortex.Principal Investigator
- Principal Investigator
  
  Yamamoto Tohru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kagawa University
Functional analysis of MDGA family proteins on corticogenesis.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Tohru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Ascending spinal tract formation in developing chickPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Tohru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
運動神経の特定機能単位選択的に働く新規遺伝子群の解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
運動神経の特定機能単位選択的に働く新規遺伝子群の解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
運動神経の特定機能単位選択的に働く新規遺伝子群の解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
新規遺伝子群による運動神経回路網形成機構の解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
  Tohoku University
Studies on Cellular Regulation of Hematopoietic Microembironment
- Principal Investigator
  
  OBINATA Masuo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University
運動神経分化の過程で機能単位選択的に働く遺伝子群の探索と解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
運動神経の軸索伸長経路の決定に関与する因子群の探索と解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
造血微小環境による造血幹細胞の分化制御機構
- Principal Investigator
  
  OBINATA Masuo
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
HIV転写調節因子と相互作用する新規因子群の解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
HIV転写調節因子と相互作用する新規因子群の検索Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ブロモドメインと相互作用する新規グローバル転写活性化因子の解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
転写調節機構の解析-調節因子と基本因子との相互作用を中心とした解析-
- Principal Investigator
  
  堀越正美
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
細胞周期因子CCG1と相互作用する因子の機能解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
TFIID内Bromodomainの相互作用因子の機能解析Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
細胞周期因子CCG1の転写因子TEIIDサブユニットとしての役割Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
TFIID内Bromodomainの機能解析と相互作用因子の探索Principal Investigator
- Principal Investigator
  
  山本融
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Basic research for development of new type of drugs based on the mechanism of transcriptional regulation
- Principal Investigator
  
  HORIKOSHI Masami
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

[Journal Article] Early postnatal development of the MDGA2+/- mouse model of synaptic dysfunction2023
- Author(s)
  Fertan Emre、Wong Aimee A.、Montbrun Thalia S. Garvock-de、Purdon Michaela K.、Roddick Kyle M.、Yamamoto Tohru、Brown Richard E.
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 452 Pages: 114590-114590
- DOI
  10.1016/j.bbr.2023.114590
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06597, KAKENHI-PROJECT-19K07065
[Journal Article] Brain <scp>p3‐Alcβ</scp> peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide2023
- Author(s)
  Hata S, Saito H, Kakiuchi T, Fukumoto D, Yamamoto S, Kasuga K, Kimura A, Moteki K, Abe R, Adachi S, Kinoshita S, Yoshizawa-Kumagaye K, Nishio H, Saito T, Saido TC, Yamamoto T, Nishimura M, Taru H, Sobu Y, Ohba H, Nishiyama S, Harada N, Ikeuchi T, Tsukada H, Ouchi Y, Suzuki T
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: - Issue: 5 Pages: 1-15
- DOI
  10.15252/emmm.202217052
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0143, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-20H03600, KAKENHI-PROJECT-22K06597, KAKENHI-PROJECT-23K06840, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-22K15270, KAKENHI-PROJECT-23K26790
[Journal Article] Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-12023
- Author(s)
  Shiraki Yuzuha、Mitsuma Monet、Takada Ritsuko、Hata Saori、Kitamura Akira、Takada Shinji、Kinjo Masataka、Taru Hidenori、M?ller Ulrike C.、Yamamoto Tohru、Sobu Yuriko、Suzuki Toshiharu
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 34 Issue: 11
- DOI
  10.1091/mbc.e22-10-0495
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06597, KAKENHI-PROJECT-23K06840, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-22K15270, KAKENHI-PUBLICLY-22H05642, KAKENHI-PUBLICLY-22H04826, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H02498
[Journal Article] Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A 2 ε in an ex vivo murine model of brain ischemia.2022
- Author(s)
  Rahman SMK, Hussain Z, Morito K, Takahashi N, Sikder MM, Tanaka T, Ohta KI, Ueno M, Takahashi H, Yamamoto T, Murakami M, Uyama T, Ueda N.
- Journal Title
  
  Biochim. Biophys. Acta Mol. Cell Biol. Lipds
  
  Volume: 1867 Issue: 12 Pages: 159222-159222
- DOI
  10.1016/j.bbalip.2022.159222
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-22K06597, KAKENHI-PROJECT-22K06885, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H05691
[Journal Article] Ascending spinal tract formation in chick embryo originating from different spinal regions2021
- Author(s)
  Kokudo Y、Arakawa T、Takahashi H、Kobara H、Kamada M、Deguchi Ki、Touge T、Masaki T、Yamamoto T
- Journal Title
  
  Brain Research
  
  Volume: 1768 Pages: 147595-147595
- DOI
  10.1016/j.brainres.2021.147595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07065
[Journal Article] Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke2021
- Author(s)
  Takahashi Hiroo、Asahina Ryo、Fujioka Masayuki、Matsui Takeshi K.、Kato Shigeki、Mori Eiichiro、Hioki Hiroyuki、Yamamoto Tohru、Kobayashi Kazuto、Tsuboi Akio
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 32 Pages: 66-72
- DOI
  10.1073/pnas.2018850118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21664, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-19K22687, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-23K21351
[Journal Article] Visually cued fear conditioning test for memory impairment related to cortical function2020
- Author(s)
  Kuboyama K、Shirakawa Y、Kawada K、Fujii N、Ojima D、Kishimoto Y、Yamamoto T、Yamada MK.
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 40 Issue: 4 Pages: 371
- DOI
  10.1002/npr2.12146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-16H06276
[Journal Article] Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice2020
- Author(s)
  Gotoh N、Saito Yi、Hata S、Saito H、Ojima D、Murayama Ci、Shigeta M、Abe T、Konno D、Matsuzaki F、Suzuki T、Yamamoto T
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 28 Pages: 9650-9662
- DOI
  10.1074/jbc.ra119.012386
- NAID
  120007116485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07065, KAKENHI-PUBLICLY-19H04791, KAKENHI-PROJECT-18H02566, KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04003
[Journal Article] MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism: An ex vivo HPLC-ECD analysis2020
- Author(s)
  Hossain MR, Jamal M, Tanoue Y, Ojima D, Takahashi H, Kubota T, Ansary TM, Ito A, Tanaka N, Kinoshita H, Kishimoto Y, Yamamoto T.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 716 Pages: 134677-134677
- DOI
  10.1016/j.neulet.2019.134677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-19K07337, KAKENHI-PROJECT-16K08237, KAKENHI-PROJECT-16H06276
[Journal Article] Retinal ganglion cell loss in kinesin-1 cargo Alcadein α deficient mice.2020
- Author(s)
  Nakano Y, Hirooka K, Chiba Y, Ueno M, Ojima D, Hossain MR, Takahashi H, Yamamoto T, Kiuchi Y.
- Journal Title
  
  Cell Death Dis.
  
  Volume: 11 Issue: 3 Pages: 166-166
- DOI
  10.1038/s41419-020-2363-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-19K07508, KAKENHI-PROJECT-16K08237, KAKENHI-PROJECT-16H06276
[Journal Article] Decrease in p3‐Alcβ37 and p3‐Alcβ40, products of Alcadein β generated by γ‐secretase cleavages, in aged monkeys and patients with Alzheimer's disease2019
- Author(s)
  Hata S、Omori C、Kimura A、Saito H、Kimura N、Gupta V、Pedrini S、Hone E、Chatterjee P、Taddei K、Kasuga K、Ikeuchi T、Waragai M、Nishimura M、Hu A、Nakaya T、Meijer L、Maeda M、Yamamoto T、Masters CL、Rowe CC、Ames D、Yamamoto K、Martins RN、Gandy S、Suzuki T
- Journal Title
  
  Alzheimer's & Dementia: Translational Research & Clinical Interventions
  
  Volume: 5 Issue: 1 Pages: 740-750
- DOI
  10.1016/j.trci.2019.09.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-19K21585, KAKENHI-PUBLICLY-18H04851, KAKENHI-PROJECT-17H03574, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-16K08237, KAKENHI-PROJECT-18H02566
[Journal Article] Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function2017
- Author(s)
  Steven A. Connor, Ina Ammendrup-Johnsen, Yasushi Kishimoto, Parisa Karimi Tari, Vedrana Cvetkovska, Takashi Harada, Daiki Ojima, Tohru Yamamoto, Yu Tian Wang, Ann Marie Craig
- Journal Title
  
  Cell Rep.
  
  Volume: 21 Issue: 13 Pages: 3637
- DOI
  10.1016/j.celrep.2017.11.109
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08215, KAKENHI-PROJECT-16K08237, KAKENHI-PROJECT-15K07910
[Journal Article] d-Allose Attenuates Overexpression of Inflammatory Cytokines after Cerebral Ischemia/Reperfusion Injury in Gerbil.2016
- Author(s)
  Shinohara N, Nakamura T, Abe Y, Hifumi T, Kawakita K, Shinomiya A, Tamiya T, Tokuda M, Keep RF, Yamamoto T, Kuroda Y.
- Journal Title
  
  J Stroke Cerebrovasc Dis.
  
  Volume: 25 Issue: 9 Pages: 2184-2188
- DOI
  10.1016/j.jstrokecerebrovasdis.2016.01.030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293324, KAKENHI-PROJECT-26460123, KAKENHI-PROJECT-16K08237, KAKENHI-PROJECT-16K08497
[Journal Article] Ryanodine receptors contribute to the induction of ischemic tolerance.2016
- Author(s)
  Nakamura-Maruyama E, Miyamoto O, Okabe N, Himi N, Feng L, Narita K, Keep RF, Yamamoto T, Nakamura T
- Journal Title
  
  Brain Research Bulletin
  
  Volume: 122 Pages: 45-53
- DOI
  10.1016/j.brainresbull.2016.02.018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09846, KAKENHI-PROJECT-25460059, KAKENHI-PROJECT-15K16382, KAKENHI-PROJECT-16K08237
[Journal Article] Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism-linked excitatory synaptic suppressor MDGA22016
- Author(s)
  S. A. Connor, I. Ammendrup-Johnsen, A. W. Chan, Y. Kishimoto, C. Murayama, N. Kurihara, A. Tada, Y. Ge, H. Lu, R. Yan, J. M. LeDue, H. Matsumoto, H. Kiyonari, Y. Kirino, F. Matsuzaki, T. Suzuki, T. H. Murphy, Y. T. Wang, T. Yamamoto, A. M. Craig
- Journal Title
  
  Neuron
  
  Volume: 91 Issue: 5 Pages: 1052-1068
- DOI
  10.1016/j.neuron.2016.08.016
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07910, KAKENHI-PROJECT-16K08237, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-16K14690
[Journal Article] Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage2015
- Author(s)
  Norio Takei, Yuriko Sobu, Ayano Kimura, Satomi Urano, Yi Piao, Yoichi Araki, Hidenori Taru, Tohru Yamamoto, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 290 Issue: 2 Pages: 987-995
- DOI
  10.1074/jbc.m114.599852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460058, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-26870464, KAKENHI-PROJECT-15K18854, KAKENHI-PROJECT-25460059
[Journal Article] Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport.2014
- Author(s)
  Chiba K, Araseki M, Nozawa K, Furukori K, Araki Y, Matsushima T, Nakaya T,Hata S, Saito Y, Uchida S, Okada Y, Nairn AC, Davis RJ, Yamamoto T, Kinjo M, Taru, H, Suzuki T.
- Journal Title
  
  Mol Biol Cell
  
  Volume: 25 Issue: 22 Pages: 3569-3580
- DOI
  10.1091/mbc.e14-06-1111
- NAID
  120005522339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25113723, KAKENHI-PROJECT-25293046, KAKENHI-PROJECT-25460058, KAKENHI-PROJECT-25460059, KAKENHI-PUBLICLY-26115721, KAKENHI-PROJECT-26293010
[Journal Article] Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease2014
- Author(s)
  Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Moroshima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T. for J-ADNI
- Journal Title
  
  J. Alzheimers Dis
  
  Volume: 39 Issue: 4 Pages: 861-870
- DOI
  10.3233/jad-131610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24500433, KAKENHI-PROJECT-24591695, KAKENHI-PROJECT-24790062, KAKENHI-PROJECT-25460058, KAKENHI-PROJECT-25460059, KAKENHI-PROJECT-26293010
[Journal Article] Mechanism of Intracellular Cleavage of Alcadeins by γ-Secretases2013
- Author(s)
  Piao Y, Kimura A, Urano S, Saito Y, Taru H, Yamamoto T, Hata S, Suzuki T
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055
[Journal Article] Constitutive cleavage of the single-pass transmembrane protein Alcadein α prevents aberrant peripheral retention of Kinesin-12012
- Author(s)
  Maruta C, Saito Y, Hata S, Gotoh N, Suzuki T, Yamamoto T
- Journal Title
  
  PLoS One
  
  Volume: 7
- NAID
  120004689031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055
[Journal Article] Membrane-microdomainlocalization of amyloid β -precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue2012
- Author(s)
  Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 19715-19724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055
[Journal Article] A small peptide sequence is sufficient for nitiating kinesin-1 activation through part of TPR region of KLC12012
- Author(s)
  Kawano T, Araseki M, Araki Y, Kinjo M, Yamamoto T, Suzuki T
- Journal Title
  
  Traffic
  
  Volume: 13 Pages: 834-848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055
[Journal Article] IgSF molecule M DGA1 is involved in radial migration and positioning of a subset of cortical upper layer neurons.2011
- Author(s)
  Ishikawa T, Gotoh N, Murayama C, Abe T, Iwashita M, Matsuzaki F, Suzuki T, Yamamoto T.
- Journal Title
  
  Dev. Dyn. 240
  
  Pages: 96-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200011
[Journal Article] Intracellular trafficking of the amyloid β-protein precursor(APP)regulated by novel function of X11-like2011
- Author(s)
  Saito Y, Akiyama M, Araki Y, Sumioka A, Shiono M, Taru H, Nakaya T, Yamamoto T, Suzuki T
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055
[Journal Article] Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons2011
- Author(s)
  Nakazawa S, Gotoh N, Matsumoto H, Murayama C, Suzuki T, Yamamoto T
- Journal Title
  
  J. Histochem. Cytochem
  
  Volume: 59 Pages: 202-213
- NAID
  120005906550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055
[Journal Article] Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons.2011
- Author(s)
  Nakazawa S, Gotoh N, Matsumoto H, Murayama C, Suzuki T, Yamamoto T.
- Journal Title
  
  J. Histochem. Cytochem. 59
  
  Pages: 202-213
- NAID
  120005906550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200011
[Journal Article] IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper layer neurons2011
- Author(s)
  Ishikawa T, Gotoh N, Murayama C, Abe T, Iwashita M, Matsuzaki F, Suzuki T, Yamamoto T
- Journal Title
  
  Dev. Dyn
  
  Volume: 240 Pages: 96-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055
[Journal Article] Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system. Mol2011
- Author(s)
  Konno T, Hata S, Hamada Y, Horikoshi-Sakuraba Y, Nakaya T, Saito Y, Yamamoto T, Yamamoto T, Maeda M, Ikeuchi T, Gandy S, Akatsu H, Suzuki T
- Journal Title
  
  Neurodegener
  
  Volume: 6 Pages: 76-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055
[Journal Article] Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain2010
- Author(s)
  Kondo M, Shiono M, Itoh G, Takei N, Matsushima T, Maeda M, Taru H, Hata S, Yamamoto T, Saito Y, Suzuki T
- Journal Title
  
  Mol. Neurodegener
  
  Volume: 5 Pages: 35-35
- NAID
  120005158908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055
[Journal Article] Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain.2010
- Author(s)
  Kondo M, Shiono M, Itoh G, Takei N, Matsushima T, Maeda M, Taru H, Hata S, Yamamoto T , Saito Y, Suzuki T.
- Journal Title
  
  Mol. Neurodegener. 5
  
  Pages: 35-35
- NAID
  120005158908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200011
[Journal Article] Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP.2009
- Author(s)
  Sakuma M, Tanaka E, Taru H, Tomita S, Gandy S, Narin AC, Nakaya T, Yamamoto T, Suzuki T.
- Journal Title
  
  J.Neurochem. 109
  
  Pages: 465-475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200011
[Journal Article] Suppression of APP-containing vesicle trafficking and production of beta-amyloid by AID/DHHC12 protein.2009
- Author(s)
  Mizumaru C, Saito Y, Ishikawa T, Yoshida T, Yamamoto T, Nakaya T, Suzuki T.
- Journal Title
  
  J.Neurochem. 111
  
  Pages: 1213-1224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200011
[Journal Article] Paths, elongation, and projections of ascending chick embryonic spinal commissural neurons after crossing the floor plate.2008
- Author(s)
  Arakawa T, Iwashita M, Matsuzaki F, Suzuki T, Yamamoto T.
- Journal Title
  
  Brain Res. 1223
  
  Pages: 25-33
- NAID
  120000947313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200011
[Journal Article] The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm.2008
- Author(s)
  Sumioka A, Saito Y, Sakuma M, Araki Y, Yamamoto T, Suzuki T.
- Journal Title
  
  Exp.Cell Res. 314
  
  Pages: 1155-1162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200011
[Journal Article] X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.2008
- Author(s)
  Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T.
- Journal Title
  
  J. Biol.Chem. 283
  
  Pages: 35763-35771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200011
[Patent] パーキンソン病の診断指標2019
- Inventor(s)
  山本融他
- Industrial Property Rights Holder
  香川大学他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-033661
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] シナプス形成抑制因子MDGA1/2の欠失による対蹠的なE/Iバランス・行動異常と、これを抑止する薬剤の探索2023
- Author(s)
  山本融、尾嶋大喜、多田篤史、窪田剛志、髙橋弘雄、冨永貴志、岸本泰司
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06597
[Presentation] シナプス形成抑制因子MDGA1/2の欠失による対蹠的なE/Iバランス・行動異常と、これを抑止する薬剤の探索2023
- Author(s)
  山本融、尾嶋大喜、多田篤史、窪田剛志、髙橋弘雄、冨永貴志、岸本泰司
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] シナプス形成抑制因子MDGA1/2の欠失がもたらす対蹠的な興奮/抑制バランス偏移と行動異常は成年期の薬剤投与で回復する2023
- Author(s)
  山本融、尾嶋大喜、多田篤史、窪田剛志、髙橋弘雄、冨永貴志、岸本泰司
- Organizer
  第46回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] シナプス形成抑制因子MDGA1/2の欠失がもたらす対蹠的な興奮/抑制バランス偏移と行動異常は成年期の薬剤投与で回復する2023
- Author(s)
  山本融、尾嶋大喜、多田篤史、窪田剛志、髙橋弘雄、冨永貴志、岸本泰司
- Organizer
  第46回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06597
[Presentation] 脳梗塞に対する時間依存的神経保護メカニズム2023
- Author(s)
  高橋弘雄、尾嶋大喜、多田篤史、坪井昭夫、山本融
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] 脳梗塞に対する時間依存的神経保護メカニズム2023
- Author(s)
  高橋弘雄、尾嶋大喜、多田篤史、坪井昭夫、山本融
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] 脳梗塞に対する時間依存的神経保護メカニズム2023
- Author(s)
  高橋弘雄、尾嶋大喜、多田篤史、坪井昭夫、山本融
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-22K06597
[Presentation] 脳虚血に対する時間依存的な神経保護メカニズム2022
- Author(s)
  高橋弘雄、尾嶋大喜、坪井昭夫、山本融
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] 脳虚血に対する時間依存的な神経保護メカニズム2022
- Author(s)
  高橋弘雄、尾嶋大喜、坪井昭夫、山本融
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-22K06597
[Presentation] シナプス形成抑制因子ＭＤＧＡ１/２の欠失は対蹠的な興奮/抑制バランス偏移と行動異常を引き起こすが、成年期の薬剤投与により回復できる2022
- Author(s)
  山本融、尾嶋大喜、多田篤史、窪田剛志、髙橋弘雄、冨永貴志、岸本泰司
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-22K06597
[Presentation] シナプス形成抑制因子ＭＤＧＡ１/２の欠失は対蹠的な興奮/抑制バランス偏移と行動異常を引き起こすが、成年期の薬剤投与により回復できる2022
- Author(s)
  山本融、尾嶋大喜、多田篤史、窪田剛志、髙橋弘雄、冨永貴志、岸本泰司
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] 抑制性シナプス抑制因子MDGA1のヘミ欠損は海馬LTPの低下と学習・記憶異常を引き起こすが、サイクロセリンの急性投与により回復する2021
- Author(s)
  山本融, 尾嶋大喜, 多田篤史, 田之上優, 黒川直弘, 窪田剛志, 高橋弘雄,岸本泰司, 冨永貴志
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] 転写因子Npas4による低分子量Gタンパク質Gemの発現誘導は神経活動依存的な虚血耐性を引き起こす2021
- Author(s)
  高橋弘雄, 松井健, 森英一朗, 山本融, 坪井昭夫
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] MDGA1ノックアウトマウスの社会性行動に対するD-サイクロセリンの効果2021
- Author(s)
  松崎真也、萩かれん、中澤鈴菜、尾嶋大喜、山本融、窪田剛志、岸本泰司
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] パーキンソン病の新規バイオマーカーとしての血中p3-Alcadeinαに関する検討2021
- Author(s)
  國土曜平, 高田忠幸, 高橋弘雄, 羽田沙緒里, 鎌田正紀, 出口一志, 峠哲男, 正木勉, 鈴木利治, 山本融
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] シナプス形成抑制因子MDGA1の欠失による精神神経疾患様行動異常と、これを抑止する薬剤の探索2020
- Author(s)
  多田篤史, 田之上優，黒川直弘，窪田剛志，津島希海，尾嶋大喜，Razib Hossain，高橋弘雄, 岸本泰司, 山本融
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] シナプス形成抑制因子MDGA1の欠失による精神神経疾患様行動異常と、これを抑止する薬剤の探索2020
- Author(s)
  多田篤史, 田之上優，黒川直弘，窪田剛志，津島希海，尾嶋大喜，Razib Hossain，高橋弘雄, 岸本泰司, 山本融
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] ＭＤＧＡ１の欠失による抑制性シナプスの過剰形成は統合失調症様の認知・行動異常をもたらす2020
- Author(s)
  山本融, 尾嶋大喜, 多田篤史, 田之上優, 黒川直弘, 津島希海, Md. Razib Hossain, 窪田剛志, 高橋弘雄, 岸本泰司
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] マウスプラセボ鎮痛条件づけを用いたプラセボ応答の分子基盤の探索2020
- Author(s)
  岸本泰司, 中村裕子, 新開崇広, 青野仁美, 藤原友佳, 大畑南美, 松崎真也, 山本融
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] 転写因子Npas4による低分子量Gタンパク質Gemの発現誘導は神経活動依存的な虚血耐性を引き起こす2020
- Author(s)
  高橋弘雄、松井健、森英一朗、山本融、坪井昭夫
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] Enhanced β- and β’-cleavages of APP in Alcadein α knockout mouse brain.2019
- Author(s)
  Toshiharu Suzuki, Naoya Goto, Haruka Saito, Saori Hata, Tohru Yamamoto
- Organizer
  Alzheimer's Association International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] Enhanced β- and β’-cleavages of APP in Alcadein α knockout mouse brain.2019
- Author(s)
  Toshiharu Suzuki, Naoya Goto, Haruka Saito, Saori Hata, Tohru Yamamoto
- Organizer
  Alzheimer's Association International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] マウスモデルを用いたプラセボおよびノセボ反応条件づけの開発と評価2019
- Author(s)
  青野仁美, 藤原友佳, 尾嶋大喜, 山本融, 岸本泰司
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] キネシン-1によるFrizzledの軸索輸送が神経終末のWntシグナルを制御する2019
- Author(s)
  満間百音、白木柚葉、齊藤遥、高田律子、山本融、高田慎治、羽田沙緒里、鈴木利治
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] キネシン-1によるFrizzledの軸索輸送が神経終末のWntシグナルを制御する2019
- Author(s)
  満間百音、白木柚葉、齊藤遥、高田律子、山本融、高田慎治、羽田沙緒里、鈴木利治
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] シナプス形成抑制因子MDGAファミリー分子群の欠失が引き起こすE/Iバランス偏移がもたらす認知・行動異常2019
- Author(s)
  山本融，尾嶋大喜，Razib Hossain，多田篤史, 黒川直弘, 長澤研, 琢磨和晃, 中井雄規，高橋弘雄, 冨永貴志，岸本泰司
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] シナプス形成抑制因子MDGAファミリー分子群の欠失が引き起こすE/Iバランス偏移がもたらす認知・行動異常2019
- Author(s)
  山本融，尾嶋大喜，Razib Hossain，多田篤史, 黒川直弘, 長澤研, 琢磨和晃, 中井雄規，高橋弘雄, 冨永貴志，岸本泰司
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] MDGAファミリー分子群の欠失が引き起こすE/I バランス偏移に伴う認知・行動異常の解析2019
- Author(s)
  Razib Hossain, 多田篤史, 黒川直弘, 長澤研, 琢磨和晃, 尾嶋大喜, 高橋弘雄, 岸本泰司, 山本融
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] Alcadein α欠損マウスにおけるAPPのアミロイド生成的代謝の促進機構2019
- Author(s)
  鈴木利治、後藤直也、林理沙、羽田沙緒里、山本融
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] 神経活動依存的な転写因子Npas4は脳梗塞に伴う細胞死を抑制する2019
- Author(s)
  高橋弘雄，朝比奈諒，山本融，坪井昭夫
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07065
[Presentation] 神経活動依存的な転写因子Npas4は脳梗塞に伴う細胞死を抑制する2019
- Author(s)
  高橋弘雄，朝比奈諒，山本融，坪井昭夫
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] Alcadein α欠損マウスにおけるAPPのアミロイド生成的代謝の促進機構2019
- Author(s)
  鈴木利治、後藤直也、林理沙、羽田沙緒里、山本融
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] Alcadein αノックアウトマウスは加齢で網膜神経節細胞が脱落する2018
- Author(s)
  中野裕貴　小野葵　小林守　高砂縁　村山千明　尾嶋大喜　山本融　廣岡一行
- Organizer
  第122回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] Retinal Ganglion Cell Loss in Alcadeinα Knockout Mice.2018
- Author(s)
  Yuki Nakano, Aoi Ono, Mamoru Kobayashi, Yukari Takasago, Chiaki Murakami, Daiki Ozima, Tohru Yamamoto, Kazuyuki Hirooka
- Organizer
  ARVO 2018: The Association for Research in Vision and Ophthalmology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] Synaptopathies associated with loss of MDGAs.2018
- Author(s)
  Steven Connor, Ina Ammendrup-Johnsen, Yasushi Kishimoto, Parisa Karimi Tari, Vedrana Cvetkovska, Takashi Harada, Daiki Ojima, Tohru Yamamoto, Yu Tian Wang, Ann Marie Craig
- Organizer
  17th Annual Molecular and Cellular Cognition Society Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] MDGA1は抑制性シナプス形成抑制因子であり、その欠損は興奮性の抑制と学習・記憶能力の障害をもたらす2018
- Author(s)
  山本融　Steven A. Connor　岸本泰司　Ina Ammendrup-Johnsen　原田岳　尾嶋大喜　Razib Hossain　 Ann Marie Craig
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] シナプス形成抑制因子ＭＤＧＡ１の欠損は興奮/抑制バランスの抑制側へのシフトによる学習・記憶障害をもたらす2018
- Author(s)
  山本融　Steven A. Connor　 Ina Ammendrup-Johnsen　岸本泰司　原田岳　尾嶋大喜　Razib Hossain　Ann Marie Craig
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] シナプス形成抑制因子ＭＤＧＡ２のヘミ欠損は興奮/抑制バランスの興奮側へのシフトによるＡＳＤ様の社会性行動異常をもたらす2017
- Author(s)
  山本融　Steven A. Connor　岸本泰司　Ina Ammendrup-Johnsen　栗原直和　村山千明　尾嶋大喜　Razib Hossain　鈴木利治　Ann Marie Craig
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] MDGA2は興奮性シナプス形成抑制因子であり、そのヘミ欠損は興奮性の亢進とASD様の行動異常をもたらす2017
- Author(s)
  山本融　Steven A. Connor　岸本泰司　Ina Ammendrup-Johnsen　栗原直和　村山千明　尾嶋大喜　Razib Hossain　鈴木利治　Ann Marie Craig
- Organizer
  日本薬学会第137年
- Place of Presentation
  仙台国際センター・東北大学
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] Haploinsufficiency of the neuronal surface protein MDGA2 enhances excitatory synapse development, alters cortical circuit dynamics and yields behavioral phenotypes consistent with autism in mice.2016
- Author(s)
  Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Ojima D, Kurihara N, Tada A, Ge Y, Lu H, Yan R, LeDue JM, Matsumoto H, Kiyonari H, Kirino Y, Matsuzaki F, Suzuki T, Murphy TH, Wang YT, Yamamoto T, Craig AM.
- Organizer
  Society for Neuroscience annual meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] シナプス形成抑制因子MDGA2のヘミ欠失マウスは興奮性入力の亢進によりもたらされる自閉症スペクトラム障害のモデルとなる2016
- Author(s)
  山本融　Steven A. Connor　岸本泰司　Ina Ammendrup-Johnsen　栗原直和　村山千明　鈴木利治　Ann Marie Craig
- Organizer
  第39回分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08237
[Presentation] Absence of MDGA1 Enhances Inhibitory Drive and Confers Resistance to Increased Excitation in Mouse Hippocampus2015
- Author(s)
  Steven A. Connor, Ina Ammendrup-Johnsen, Parisa Karimi Tari, Tohru Yamamoto, Yu Tian Wang, and Ann Marie Craig
- Organizer
  9th Annual Canadian Neuroscience Meeting
- Place of Presentation
  Westin Bayshore, Vancouver, Canada
- Year and Date
  2015-05-24
- Data Source
  KAKENHI-PROJECT-25460059
[Presentation] アルカデインはX11Lと協働して内在性APPのアミロイド産生的代謝を抑制する2015
- Author(s)
  山本融　後藤直也　齋藤有紀　村山千明　鈴木利治
- Organizer
  第38回分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460059
[Presentation] JIP1を介したAPP軸索順行輸送の制御機構解析2015
- Author(s)
  加藤優実　千葉杏子　山本融　鈴木利治
- Organizer
  第38回分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460059
[Presentation] 大脳新皮質形成時における放射状細胞移動の細胞種による多様性2015
- Author(s)
  尾嶋大喜　山本融
- Organizer
  第38回分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460059
[Presentation] 脊髄上行性伝導路の形成機構2013
- Author(s)
  山本融
- Organizer
  第118回日本解剖学会総会・全国学術集会
- Place of Presentation
  サンポートホール高松・かがわ国際会議場（香川）
- Invited
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] 脊髄上行性伝導路の形成機構2013
- Author(s)
  山本融
- Organizer
  第118回日本解剖学会総会・全国学術集会
- Place of Presentation
  サンポートホール高松・かがわ国際会議場
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] Constitutive cleavage of a single pass transmembrane protein Alcadeinα prevents aberrant peripheral retention of kinesin-1.2012
- Author(s)
  Tohru Yamamoto
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2012
- Place of Presentation
  Ernest N. Morial Convention Center ( USA)
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] Constitutive cleavage of a single pass transmembrane protein Alcadeinα prevents aberrant peripheral retention of kinesin-12012
- Author(s)
  Yamamoto T
- Organizer
  Society for Neuroscience annual meeting
- Place of Presentation
  New Orleans Ernest N. Morial Convention Center, New Orleans, USA
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] Enhanced amyloidogenic p rocessing of APP in Alcadeinα-defic ient mice2011
- Author(s)
  Yamamoto T
- Organizer
  Society for Neuroscience annual meeting
- Place of Presentation
  Walter E. Washington Convention Cen ter,Washington DC, USA
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] Alcadeinαの欠失によりAPPのアミロイド産生的代謝は亢進する2011
- Author(s)
  山本融
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] Alcadein αの欠失によりAPPのアミロイド産生的代謝は亢進する2011
- Author(s)
  山本融
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] からだと脳はどのように結ばれるか-脊髄上行路形成機構の解析2011
- Author(s)
  山本融
- Organizer
  日本生理学会・日本解剖学会合同年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20200011
[Presentation] からだと脳はどのように結ばれるか-脊髄上行路形成機構の解析2011
- Author(s)
  山本融
- Organizer
  第88回日本生理学会・第116回日本解剖学会合同年会
- Place of Presentation
  パシフィコ横浜(招待講演誌上開催)
- Data Source
  KAKENHI-PROJECT-20200011
[Presentation] WD motif : A small peptide motif is sufficient for initiating Kinesin-1 activation through part of the tetratricopeptide repeat region of KLC12011
- Author(s)
  Yamamoto T
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] Enhanced amyloidogenic processing of APP in Alcadein α-deficient mice2011
- Author(s)
  Yamamoto T
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2011
- Place of Presentation
  Walter E.Washington Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] からだと脳はどのように結ばれるか-脊髄上行路形成機構の解析2011
- Author(s)
  山本融
- Organizer
  第88回日本生理学会・第116回日本解剖学会合同年会
- Place of Presentation
  パシフィコ横浜(誌上開催) 招待講演
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] WDモチーフはキネシン1モーター活性化の開始に十分であり、その際キネシン軽鎖TPR領域のすべては必要とされない2011
- Author(s)
  山本融
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] からだと脳はどのように結ばれるか-脊髄上行路形成機構の解析2011
- Author(s)
  山本融
- Organizer
  日本生理学会・日本解剖学会合同年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] IgSF molecule MDGA1 is i nvolved in radial migration and posi tioning of a subset of cortical upper-layer neurons2010
- Author(s)
  Yamamoto T
- Organizer
  Society for Neurosc ience annual meeting
- Place of Presentation
  San Diego Convention Center, San Diego USA
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] Novel IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons.2010
- Author(s)
  Yamamoto T
- Organizer
  Neuro 2010
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] IgSF molecule MDGA1 is in volved in radial migration and positioning of a subset of cortical upper-layer neurons2010
- Author(s)
  Yamamoto T
- Place of Presentation
  San Diego USA
- Data Source
  KAKENHI-PROJECT-20200011
[Presentation] IaSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons.2010
- Author(s)
  Yamamoto T
- Organizer
  Society for Neuroscience annual meeting
- Place of Presentation
  San Diego USA
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] Novel IgSF molecule MDGA1 is involved in radial migration an d positioning of a subset of cortical upper-layer neurons2010
- Author(s)
  Yamamoto T
- Organizer
  Neuro 2010
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22590055
[Presentation] Novel IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons.2010
- Author(s)
  Yamamoto T
- Organizer
  Neuro 2010
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-20200011
[Presentation] Novel IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons2010
- Author(s)
  Yamamoto T
- Organizer
  Neuro 2010
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-20200011
[Presentation] IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer, neurons.2010
- Author(s)
  Yamamoto T
- Organizer
  Society for Neuroscience annual meeting
- Place of Presentation
  San Diego USA
- Data Source
  KAKENHI-PROJECT-20200011
[Presentation] Spinocerebellar tract formation of developing chick : Paths, elongation, and projections of ascending embryonic spinal commissural neurons after crossing the floor plate.in neuronal cells and tissues2009
- Author(s)
  Yamamoto, T
- Organizer
  Keystone Symposia : Axonal Connections : Molecular Cues for Development and Reaeneration
- Place of Presentation
  Keystone Resort
- Data Source
  KAKENHI-PROJECT-20200011
[Presentation] Spinocerebellar tract formation of developing chick : Paths, elongation, and projections of ascending embryonic spinal commissural neurons after crossing the floor plate.2009
- Author(s)
  Yamamoto, T
- Organizer
  in neuronal cells and tissues, Key stone Symposia
- Place of Presentation
  Key stone, USA
- Data Source
  KAKENHI-PROJECT-20200011
[Presentation] Alcadein drives kinesin-1 and undergoes constitutive limited proteolysis to maintain proper distribution of kineisn-1.
- Author(s)
  山本融　豊島哲彦　丸田千明　荒関雅彦　鈴木利治
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25460059
[Presentation] Ameliorative effects of Yokukansan on behavioral deficits following transient forebrain ischemia in gerbils
- Author(s)
  劉亜南　中村丈洋　豊島哲彦　山本融　板野俊文
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25460059

1. HORIKOSHI Masami (70242089)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. OBINATA Masuo (10099971)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SHOJI Wataru (40250831)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 葛原隆 (00260513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 矢内信昭 (80200525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HASHIDA Ryouichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Craig Ann Marie

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. HATA Saori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. TARU Hidenori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. HIMI Naoyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. MIYAMOTO Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. NARITA Kazuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. OUCHI Yasuomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. KISHIMOTO Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 岡田康志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 日置寛之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 田宮隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岡部直彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 丸山恵美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 鈴木利治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAMOTO Tohru 山本 融

山本 融 ヤマモト トオル

Research Projects

Research Products

Co-Researchers

Development of Therapeutic Strategies for Neuropsychiatric Disorders by Modulating Inhibitory Mechanisms of SynaptogenesisPrincipal Investigator

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Functional Analyses of 'privileged' vesicular transport carried with AlcadeinPrincipal Investigator

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Exploration of novel excitatory/inhibitory balance control mechanisms in neural circuits for the treatment of neuropsychiatric disorders.Principal Investigator

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Functional analysis of MDGA family proteins on regulation of synapse formation and social behavior.Principal Investigator

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Functional analysis of MDGA family proteins on neural circuit formation of cerebral cortex.Principal Investigator

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Functional analysis of MDGA family proteins on corticogenesis.Principal Investigator

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Ascending spinal tract formation in developing chickPrincipal Investigator

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運動神経の特定機能単位選択的に働く新規遺伝子群の解析Principal Investigator

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Project Period (FY)

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Review Section

Research Institution

運動神経の特定機能単位選択的に働く新規遺伝子群の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

運動神経の特定機能単位選択的に働く新規遺伝子群の解析Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

新規遺伝子群による運動神経回路網形成機構の解析Principal Investigator

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Project Period (FY)

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Studies on Cellular Regulation of Hematopoietic Microembironment

Principal Investigator

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運動神経分化の過程で機能単位選択的に働く遺伝子群の探索と解析Principal Investigator

Principal Investigator

Project Period (FY)

YAMAMOTO Tohru 山本融

山本融ヤマモトトオル